EKS-RAN-00344

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00344

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	317.2	1.0E-94	28	294	267

Status

Unreviewed

Ensembl Protein

ENSRNOP00000025053

UniProt Accession

D3ZZK7;

Protein Name

Protein Synonyms/Alias

Protein Myo3a;

Gene Name

Myo3a

Gene Synonyms/Alias

Myo3a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000018478	ENSRNOP00000025053	ENSRNOT00000025053

Organism

Rattus norvegicus

Functional Description

Protein Length

1621

Protein Sequence
(FASTA)

PVTETFAMLP LIGKTIIFDN FPDPSDTWEI TETIGKGTYG KVFKVLNKKN GQKAAVKILD 60

PIHDIDEEIE AEYNILRTLS DHPNVVRFYG IYFKKDKING DKLWLVLELC NGGSVTDLVK 120

GFLKRGERMS EPIIAYILHE ALMGLQHLHS NKTIHRDVKG NNILLTTEGG VKLVDFGVSA 180

QLSSTRHRLN TSVGTPFWMA PEVIACEQQL DTTYDARCDT WSLGITAIEL GDGDPPLAEL 240

HPMRALFKIP RNPPPKLRQP ELWSAEFNDF ISKCLTKDYE KRPTVSDLLK HKFITQIEGR 300

DAILQKQLME FIDIHQCLGS TEKARHERIH TKKGNLNRSL ISSLKDVDDL ATLDVLDENT 360

VSEHLEKCYS RDQIYIYVGD ILIALNPFQS LGLYSTKLSK LYIGAKRTAN PPHIFAVADL 420

GYQSMVTYNA DQCIVISGES GAGKTESAHL LVQHLTVLGK ANNRTLQEKI LQMNNLVEAF 480

GNACTIINDN SSRFGKYLEM KFTSSGAVVG AQISEYLLEK SRVIHQAIGE KNFHIFYYIY 540

AGLAEKKKLA LYKLPENKPP RYLQNDNLRT VQDMMNNSFY KSQYELIEQC FKVIGFTMEQ 600

LGSVYSVLAA ILNVGNIEFS SVATEYQMDK SYICNHTALE NSASLLCIQA DELQEALTSH 660

CVVTRGETII RPNTVEKATD VRDATAKTLY GRLFSWIVNC INSLLKHDTS PSGNEELNIG 720

ILDIFGFENF KKNSFEQLCI NIANEQIQYY FNQHVFAWEQ NEYLNEDVDA RVIEYEDNRP 780

LLDMFLQKPM GLLFLLDEES RFPKATDQTL VEKFEDNLKS QYFWRPKRME LSFGIHHYAG 840

KVLYSASGFL AKNRDTLPTD IVLLLRSSEN SVIRQLVNHP LTKTGNLPLS KTKNIVNYQM 900

QNSEKSTNLN KSETRDVTRH AYETTNVKTQ TVSSYFRYSL MDLLSKMVVG QPHFVRCIKP 960

NNDRQARKYD KEKVLIQLRC TGILETARIR RLGYSHRILF ANFIKRYYVL CYKSSEEPPV 1020

SPDTCATILE KAGLDNWALG KTKVFLKYYH VEQLNLMRKE AIDKLVLIQA SVRAFLGAKR 1080

YQELQQKRKT SAVIIQSAAR RHLLRKQGKK TSNVQSTAGM SVRAKDQEFD YKKNFETKRE 1140

SFVKKHTENA VPTNESNIPT PNNKESPSAG KTAPFRAEAK ATNVESNNRK YQTQKKMSNV 1200

YAEGQNQELY IVGDSWVEVS PRQKYVQDLE ESRKLRKEEK GDAVIQSYCQ WYTEGSNFEE 1260

SKATCLEGKA TWEKPSCPGL WLTEEIYLRK TLDPSLSQKS VYQNANSNEK EKKTSVVTQS 1320

APLGNLGKDY HLHGFLGEKD TGPVDQAQEE DKAAVFIQSK YRNSKQKQQL GKDNLSPPFK 1380

NEKILSSPTE VARNTRNVYS CPTKQEGIHH LKMVDERESK LTSKKEACDL AMFSRQISKL 1440

SEEYFILQKN LNEIILAQQL KPLYLGICRH KPINRHISTH QYLSGVSKGE ESKILRPPRR 1500

PRKPKTLNNP EDSTYYYLLH KSTQEEKRRP RKDSQGKLLG LEDFYYKELF PTHFGPKAHS 1560

SNAREWKAQE EPQDQRIESN ERCWTASESE IPEEERISAN PYDYRRLLRK TSQRQRLLQQ 1620

L 1621

Nucleotide Sequence
(FASTA)

CCAGTGACAG AAACCTTTGC CATGCTTCCG TTAATTGGAA AAACAATCAT CTTTGATAAC 60

TTTCCTGATC CTTCTGATAC ATGGGAAATC ACTGAAACCA TCGGCAAAGG AACTTACGGG 120

AAGGTTTTTA AAGTCCTAAA CAAGAAAAAT GGCCAGAAAG CAGCAGTCAA AATTTTGGAT 180

CCAATCCATG ATATCGATGA AGAGATTGAA GCAGAGTATA ACATCTTAAG AACACTTTCT 240

GACCACCCGA ATGTGGTCAG ATTCTATGGG ATTTACTTTA AGAAGGACAA GATAAATGGA 300

GATAAGCTAT GGCTGGTTCT TGAGCTGTGC AATGGAGGAT CAGTGACTGA TCTTGTGAAA 360

GGATTTCTGA AGAGGGGAGA AAGGATGAGC GAGCCTATAA TTGCATACAT TTTACATGAA 420

GCACTAATGG GACTTCAGCA TCTGCATAGC AACAAAACCA TCCACCGTGA TGTCAAAGGA 480

AATAACATCC TGTTGACTAC TGAAGGTGGA GTCAAACTGG TAGATTTTGG TGTGTCTGCA 540

CAGCTCAGCA GCACGCGTCA TCGCCTGAAC ACCTCTGTAG GAACACCGTT TTGGATGGCT 600

CCCGAGGTGA TTGCTTGCGA ACAGCAATTA GATACCACTT ACGATGCTAG GTGTGACACG 660

TGGTCCCTGG GCATCACGGC TATCGAACTT GGTGACGGAG ATCCTCCACT AGCTGAGCTG 720

CATCCCATGC GGGCACTCTT CAAAATACCA AGGAATCCAC CCCCTAAACT CCGGCAGCCT 780

GAGCTGTGGT CCGCAGAGTT CAATGACTTC ATTAGCAAAT GCTTGACCAA AGATTACGAG 840

AAGCGTCCAA CAGTGTCAGA TCTCTTGAAG CATAAATTCA TTACTCAGAT CGAAGGCAGA 900

GATGCAATAC TGCAGAAACA ACTCATGGAA TTCATTGATA TTCACCAATG CCTGGGAAGC 960

ACAGAGAAGG CCAGGCATGA ACGAATTCAT ACCAAGAAAG GTAACTTAAA TAGATCTCTC 1020

ATTTCCAGTC TGAAGGATGT AGATGATTTG GCCACCCTAG ATGTTTTGGA TGAGAACACA 1080

GTGTCTGAAC ACCTTGAGAA GTGTTATTCC AGAGATCAGA TCTATATCTA TGTGGGAGAT 1140

ATACTCATTG CACTTAACCC TTTTCAGAGT CTGGGTCTTT ATTCCACAAA GCTTTCGAAG 1200

TTGTATATTG GAGCAAAGAG AACTGCCAAC CCCCCTCACA TTTTCGCAGT GGCTGACTTG 1260

GGATACCAGT CTATGGTGAC ATATAATGCA GACCAGTGCA TCGTTATTTC TGGAGAAAGT 1320

GGTGCTGGCA AGACAGAGAG TGCTCATCTT CTGGTCCAAC ACCTCACTGT GCTTGGAAAG 1380

GCTAATAATA GAACCCTGCA AGAGAAGATT TTACAAATGA ACAATTTGGT TGAAGCCTTT 1440

GGCAACGCGT GCACTATTAT AAATGATAAT TCCAGCAGAT TTGGAAAATA CTTAGAAATG 1500

AAATTTACCT CTTCTGGAGC TGTAGTTGGA GCACAGATTT CTGAATATCT CCTGGAAAAA 1560

TCCCGTGTCA TTCATCAAGC CATAGGAGAA AAAAATTTCC ATATTTTTTA CTACATTTAT 1620

GCTGGGTTAG CAGAAAAGAA AAAACTGGCC CTTTACAAAT TGCCTGAAAA TAAGCCGCCC 1680

AGGTACTTAC AAAATGATAA CCTCAGAACG GTACAGGACA TGATGAACAA TAGTTTCTAT 1740

AAATCCCAGT ATGAATTAAT TGAACAATGT TTCAAAGTCA TAGGTTTTAC AATGGAGCAA 1800

CTTGGAAGTG TATATAGTGT GCTCGCAGCC ATCTTGAATG TTGGGAACAT TGAATTCTCC 1860

TCTGTGGCAA CTGAATACCA GATGGACAAG AGCTACATCT GCAACCACAC GGCTCTGGAA 1920

AACTCCGCTT CTTTGCTTTG CATTCAAGCA GATGAGCTGC AGGAAGCGCT CACCTCACAC 1980

TGTGTGGTCA CTAGAGGAGA AACAATCATA CGACCCAACA CAGTGGAAAA GGCTACGGAT 2040

GTCCGAGATG CCACAGCTAA AACTTTATAC GGACGTCTCT TTAGCTGGAT AGTCAATTGT 2100

ATTAACAGTT TGCTGAAGCA TGACACATCA CCAAGTGGGA ACGAGGAGCT AAACATCGGC 2160

ATTCTTGATA TATTTGGCTT TGAAAATTTC AAAAAGAACT CCTTTGAGCA GCTGTGCATT 2220

AACATTGCAA ATGAACAGAT CCAGTATTAC TTTAATCAGC ACGTGTTTGC ATGGGAGCAG 2280

AATGAATACC TAAATGAAGA TGTAGATGCT AGAGTTATTG AATACGAAGA CAACCGCCCT 2340

CTCTTAGACA TGTTTCTACA GAAGCCCATG GGCTTATTGT TTCTGCTTGA TGAGGAAAGC 2400

AGGTTTCCCA AGGCCACTGA CCAGACTCTT GTAGAAAAAT TTGAAGATAA CCTGAAATCA 2460

CAATACTTCT GGAGACCCAA AAGGATGGAG CTCAGTTTTG GCATTCACCA CTATGCAGGA 2520

AAAGTCCTCT ATAGTGCTAG TGGGTTCTTG GCTAAAAACA GAGACACTCT CCCAACTGAT 2580

ATTGTGTTGC TTTTGAGGTC ATCAGAAAAC AGTGTAATTC GGCAGCTTGT CAACCACCCT 2640

CTGACCAAAA CAGGTAATTT GCCACTGTCT AAAACTAAAA ATATAGTAAA CTATCAGATG 2700

CAAAATTCAG AAAAATCTAC AAACCTGAAC AAGAGTGAAA CTAGAGACGT CACGCGCCAT 2760

GCCTATGAAA CCACCAATGT GAAAACGCAA ACGGTCTCAT CATACTTTAG ATACTCCCTG 2820

ATGGATTTGT TATCTAAAAT GGTGGTGGGC CAACCTCATT TTGTCCGTTG CATCAAGCCA 2880

AATAATGATC GACAGGCAAG GAAGTATGAC AAAGAGAAAG TTCTGATACA GCTGCGCTGC 2940

ACCGGGATTT TGGAAACAGC AAGAATTCGA AGGCTTGGTT ACTCACATCG GATACTGTTT 3000

GCTAACTTTA TAAAGAGGTA CTATGTTCTC TGCTACAAAT CGAGTGAAGA GCCCCCAGTG 3060

AGCCCAGACA CCTGTGCTAC CATTTTGGAA AAGGCTGGTC TTGATAATTG GGCTCTTGGA 3120

AAAACGAAAG TGTTCCTTAA ATATTATCAT GTAGAACAGT TGAATCTAAT GCGAAAGGAA 3180

GCCATTGACA AGCTTGTTTT GATTCAAGCC AGTGTCAGAG CATTCTTGGG TGCCAAAAGA 3240

TACCAAGAAC TACAGCAGAA GAGGAAGACT AGTGCTGTAA TAATACAATC AGCTGCAAGA 3300

AGACATCTCT TGCGAAAACA AGGAAAAAAG ACATCTAACG TGCAAAGCAC AGCAGGAATG 3360

AGTGTCCGTG CCAAGGATCA GGAATTTGAC TACAAGAAAA ACTTTGAAAC TAAAAGGGAA 3420

TCTTTTGTGA AGAAACACAC AGAAAATGCA GTGCCTACTA ATGAATCCAA CATTCCAACT 3480

CCAAACAATA AAGAGAGCCC ATCTGCTGGG AAGACAGCTC CCTTCAGAGC GGAAGCAAAA 3540

GCCACCAATG TTGAGAGTAA CAACAGAAAA TACCAGACTC AGAAGAAAAT GAGCAATGTG 3600

TACGCAGAAG GACAGAATCA AGAGCTGTAT ATTGTGGGGG ACTCTTGGGT AGAAGTAAGC 3660

CCCAGGCAGA AGTATGTGCA AGACCTGGAA GAAAGCAGAA AGCTGAGGAA AGAGGAGAAA 3720

GGAGATGCTG TGATCCAGAG TTACTGTCAG TGGTACACAG AGGGGAGCAA CTTTGAAGAA 3780

TCAAAAGCAA CATGTCTAGA AGGGAAGGCA ACATGGGAAA AGCCAAGCTG CCCAGGACTG 3840

TGGCTGACAG AGGAGATTTA CCTGAGGAAA ACTTTGGATC CTAGTCTTAG CCAAAAGTCA 3900

GTCTATCAAA ATGCAAACAG CAATGAAAAA GAAAAGAAAA CATCAGTGGT TACCCAGAGT 3960

GCACCGCTGG GCAACCTAGG GAAAGACTAT CACCTGCATG GGTTCCTTGG AGAAAAAGAC 4020

ACTGGACCAG TGGACCAGGC CCAGGAGGAA GACAAGGCTG CTGTGTTCAT TCAGAGCAAA 4080

TACCGGAATT CCAAGCAAAA GCAACAGCTG GGAAAGGACA ATCTGTCCCC TCCCTTTAAG 4140

AATGAAAAGA TCCTTTCATC ACCCACAGAA GTAGCAAGAA ACACTCGCAA TGTTTATTCC 4200

TGTCCGACCA AGCAGGAGGG GATCCATCAT CTCAAGATGG TGGATGAAAG AGAGTCAAAA 4260

CTGACTTCCA AAAAAGAAGC ATGCGATTTG GCAATGTTTT CAAGACAGAT ATCAAAGTTA 4320

TCTGAAGAAT ATTTCATTCT GCAGAAAAAC TTGAACGAAA TTATTTTGGC CCAGCAACTG 4380

AAGCCACTTT ATCTGGGTAT CTGTCGACAT AAACCTATCA ACAGACACAT TTCTACTCAT 4440

CAATACCTCT CAGGTGTCTC TAAAGGAGAA GAGTCAAAAA TATTGAGACC TCCAAGACGA 4500

CCTCGGAAAC CTAAAACATT AAATAACCCT GAAGACTCCA CATACTACTA TCTACTCCAT 4560

AAGTCAACCC AAGAAGAAAA ACGAAGACCA AGAAAAGACA GTCAAGGAAA GTTATTAGGT 4620

TTGGAAGATT TCTATTATAA GGAACTTTTT CCCACTCATT TCGGACCCAA GGCACATAGC 4680

TCTAATGCAA GAGAATGGAA AGCACAGGAG GAACCCCAGG ATCAGCGCAT TGAGAGTAAT 4740

GAGAGGTGTT GGACCGCTTC AGAGAGTGAG ATCCCTGAGG AAGAGAGGAT TTCAGCCAAC 4800

CCTTATGATT ACAGGAGGCT CCTGCGCAAA ACCTCCCAGC GGCAGCGCCT CCTGCAGCAG 4860

TTGTAG 4866

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +e++e+igkG++gkv++  +kk+g+++a+k+++  + +  ee++ e+++l++l++ pn+v

Q: 28    WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIH-DIDEEIEAEYNILRTLSDhPNVV  86

         7999*****************************998.9999**********98755****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++++k      ++lwlv+e+++gGs++dlvk   ++ ++++E  iayil+e+l +L+

Q: 87    RFYGIYFKkdkinGDKLWLVLELCNGGSVTDLVKgfLKRGERMSEPIIAYILHEALMGLQ  146

         ********99998899******************7778889*******************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lHs+k+iHrd+k++niLlt+eg VkL+dfgv+aql++tr++ +t vgtp+wmAPEvia+

Q: 147   HLHSNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPEVIAC  206

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D wslGItaiel +g+pP+++l+p++al+ki++n+ppkl++++ +s e

Q: 207   EqqlDTTYDARCDTWSLGITAIELGDGDPPLAELHPMRALFKIPRNPPPKLRQPELWSAE  266

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f++kcl+k++ekRp++s+llkhkF+

Q: 267   FNDFISKCLTKDYEKRPTVSDLLKHKFI  294

         ***************************7

Domain Sequence
(FASTA)

WEITETIGKG TYGKVFKVLN KKNGQKAAVK ILDPIHDIDE EIEAEYNILR TLSDHPNVVR 60

FYGIYFKKDK INGDKLWLVL ELCNGGSVTD LVKGFLKRGE RMSEPIIAYI LHEALMGLQH 120

LHSNKTIHRD VKGNNILLTT EGGVKLVDFG VSAQLSSTRH RLNTSVGTPF WMAPEVIACE 180

QQLDTTYDAR CDTWSLGITA IELGDGDPPL AELHPMRALF KIPRNPPPKL RQPELWSAEF 240

NDFISKCLTK DYEKRPTVSD LLKHKFI 267

Keyword

ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031941	; C:filamentous actin
GO:0030175	; C:filopodium
GO:0016459	; C:myosin complex
GO:0030898	; F:actin-dependent ATPase activity
GO:0043531	; F:ADP binding
GO:0005524	; F:ATP binding
GO:0060002	; F:plus-end directed microfilament motor activity
GO:0004672	; F:protein kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007605	; P:sensory perception of sound

KEGG

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00612	; IQ; 1.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 3.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013