EKS-RAN-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	337.4	8.1E-101	12	295	284

Status

Unreviewed

Ensembl Protein

ENSRNOP00000025026

UniProt Accession

F1LQC8;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase 7;

Gene Name

Cdk7

Gene Synonyms/Alias

Cdk7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000018510	ENSRNOP00000067592	ENSRNOT00000071234
ENSRNOG00000018510	ENSRNOP00000025026	ENSRNOT00000025026

Organism

Rattus norvegicus

Functional Description

Protein Length

346

Protein Sequence
(FASTA)

MAVDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL 60

REIKLLQELS HPNIIGIMTA IGQRTNDTLF FNHLILEIHV IIKDNSLVLT PSHIKAYMLM 120

TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA 180

PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM 240

CSLPDYVTFK SFPGIPLQHI FIAAGDDLLE LIQGLFLFNP CTRITASQAL RTKYFSNRPG 300

PTPGCQLPRP NCPVEALKEQ SNPAMATKRK RAEALEQGIL PKKLIF 346

Nucleotide Sequence
(FASTA)

ATGGCTGTGG ACGTGAAATC TCGAGCGAAG CGCTATGAGA AACTGGACTT CCTCGGAGAG 60

GGACAGTTTG CTACTGTCTA TAAGGCCAGA GATAAGAACA CCAACCAGAT CGTCGCCATT 120

AAGAAAATCA AACTTGGACA CAGGTCAGAA GCTAAAGATG GTATAAATAG AACAGCCTTA 180

AGGGAGATAA AGCTCTTGCA GGAACTAAGT CATCCAAATA TAATTGGTAT TATGACGGCT 240

ATTGGTCAGA GGACCAATGA TACTCTTTTT TTTAACCACC TAATTCTGGA AATTCATGTT 300

ATCATAAAGG ATAACAGTCT CGTGTTGACC CCATCCCACA TTAAAGCCTA CATGCTGATG 360

ACTCTTCAGG GCTTGGAATA TTTACATCAG CACTGGATTC TACACAGGGA TCTGAAACCA 420

AACAACTTGT TGTTAGATGA GAATGGAGTT CTGAAACTGG CAGATTTTGG CCTGGCCAAA 480

TCATTTGGGA GCCCCAATAG GGCTTACACA CATCAAGTTG TGACCAGGTG GTACCGGGCC 540

CCCGAGTTAC TGTTTGGAGC TAGGATGTAC GGTGTGGGAG TGGACATGTG GGCTGTCGGT 600

TGTATCTTAG CAGAATTGCT TCTAAGGGTT CCTTTTTTGC CTGGAGATTC AGACCTTGAT 660

CAGCTAACAA GAATATTTGA AACTCTGGGT ACACCAACCG AAGAACAGTG GCCTGACATG 720

TGTAGTCTTC CAGATTACGT GACGTTCAAG AGTTTCCCTG GCATCCCCCT GCAGCACATC 780

TTCATTGCAG CTGGAGACGA CCTGCTTGAG CTCATACAAG GCTTGTTCTT ATTCAACCCA 840

TGTACTAGAA TTACAGCTTC ACAGGCGTTG AGGACCAAGT ACTTCAGTAA TCGTCCAGGG 900

CCAACACCTG GATGCCAGCT TCCAAGACCA AACTGTCCAG TGGAAGCATT AAAGGAACAG 960

TCAAATCCAG CCATGGCGAC AAAACGGAAA AGAGCGGAGG CCTTAGAACA AGGAATATTG 1020

CCCAAGAAGC TAATTTTTTA G 1041

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk+t+++vA+Kki+l +++e   g++ talrEi+ll+el+h

Q: 12    YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEakdGINRTALREIKLLQELSH  71

         99********************************88764444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ ++  +  ++++ +L f++l  +++ ++k+++   l+++++k ++l+ l+gl+ylH

Q: 72    PNIIGIMTAIG-QRTNDTLFFNHLILEIHVIIKDNSL-VLTPSHIKAYMLMTLQGLEYLH  129

         ***********.888889******************9.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++++g+lklaDfGla++f+sp+++yt++vvT+wYraPelL+ga+

Q: 130   QHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARM  189

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p+++g+s+ dql+rif++lgtp+e++wp++ +lp+y  +

Q: 190   YGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV-T  248

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f++ +   l++ + ++ ++ l+l++ l+ ++p +Ri+a++al++kyf

Q: 249   FKSFPGIPLQHIFIAAGDDLLELIQGLFLFNPCTRITASQALRTKYF  295

         9999999******99999****************************8

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KNTNQIVAIK KIKLGHRSEA KDGINRTALR EIKLLQELSH 60

PNIIGIMTAI GQRTNDTLFF NHLILEIHVI IKDNSLVLTP SHIKAYMLMT LQGLEYLHQH 120

WILHRDLKPN NLLLDENGVL KLADFGLAKS FGSPNRAYTH QVVTRWYRAP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRVP FLPGDSDLDQ LTRIFETLGT PTEEQWPDMC SLPDYVTFKS 240

FPGIPLQHIF IAAGDDLLEL IQGLFLFNPC TRITASQALR TKYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005675	; C:holo TFIIH complex
GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0008094	; F:DNA-dependent ATPase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006366	; P:transcription from RNA polymerase II promoter

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013