EKS-RAN-00034
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00034
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak330.51.0E-988181091274
StatusUnreviewed
Ensembl ProteinENSRNOP00000025312
UniProt AccessionD3ZUV6;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJak3
Gene Synonyms/Alias Jak3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000018669ENSRNOP00000025312ENSRNOT00000025312
OrganismRattus norvegicus
Functional Description
Protein Length1100
Protein Sequence
(FASTA)
MAPPSEETPL ISQRSCSLSS SEAGALHVLL PPRGPGPPQR LSFSFGDYLA EDLCVRAAKA 60
CGILPVYHSL FALATEDLSC WFPPSHIFSI EDVDTQVLVY RLRFYFPGWF GLETCHRFGL 120
HKDLTSAILD VHVLEHLFAQ HRSDLVSGRL PVGLSLKDQG EFLSLAVLDL AQMARKQAQR 180
PGELLKSVSY KACLPPSLRD LIQGQSFVTR RRIRRTVVQA LRRVVACQAD RYALMAKYIL 240
DLERLHPAAT TESFLVGLPG AQEEPGCLRV TGDNGIAWSS KDQELFQTFC DFPEIVDVSI 300
KQAPRVGPAG EHRLVTITRM DGHILEAEFP GLPEALSFVA LVDGYFRLIC DSRHFFCKEV 360
APPRLLEEEA ELCHGPITLD FAIHKLKAAG SLPGSYILRR SPQDYDSFLL TACVQTPLGP 420
DYKGCLIRQD PSGAFSLVGL SQLHRSLQEL LTACWHSGLQ VDGTALNLTS CCVPRPKEKS 480
NLIVVRRGRN PTPAPGHSPS CCALTKLSFH TIPADSLEWH ENLGHGSFTK IFHGHRREVV 540
DGETHDTEVL LKVMDSRHQN CMESFLEAAS LMSQVSYPHL VLLHGVCMAG DSIMVQEFVY 600
LGAIDTYLRK RGHLVPASWK LQVTKQLAYA LNYLEDKGLP HGNVSARKVL LAREGVDGNP 660
PFIKLSDPGV SPTVLSLEML TDRIPWVAPE CLQEAGTLNL EADKWGFGAT TWEVFSGAPM 720
HITSLEPAKK LKFYEDRGQL PALKWTELEG LIAQCMAYDP GRRPSFRAIL RDLNGLITSD 780
YELLSDPTPG IPNPRDELCG GAQLYACQDP AIFEERHLKY ISLLGKGNFG SVELCRYDPL 840
GDNTGPLVAV KQLQHSGPEQ QRDFQREIQI LKALHCDFIV KYRGVSYGPG RQSLRLVMEY 900
LPSGCLRDFL QRHRARLHND RLLLFAWQIC KGMEYLGARR CVHRDLAARN ILVESEAHVK 960
IADFGLAKLL PLGKDYYVVR EPGQSPIFWY APESLSDNIF SRQSDVWSFG VVLYELFTYS 1020
DKSCSPSTEF LRMMGPEREG SPLCHLLELL AEGRRLPPPS TCPTEVQELM QLCWSPNPQD 1080
RPAFDTLSPQ LDALWRGSPG 1100
Nucleotide Sequence
(FASTA)
ATGGCACCTC CAAGCGAGGA GACACCTCTC ATCTCTCAGC GCTCTTGTAG CCTCTCATCC 60
TCAGAAGCAG GAGCCCTGCA TGTGCTCCTT CCTCCCCGGG GACCTGGGCC TCCCCAGCGA 120
CTGTCATTCT CTTTTGGGGA CTACTTGGCT GAGGACCTGT GTGTGCGGGC TGCCAAGGCC 180
TGTGGCATCC TGCCCGTTTA TCATTCGCTC TTCGCTCTGG CCACCGAGGA CTTGTCTTGC 240
TGGTTCCCCC CAAGCCACAT CTTCTCCATA GAGGACGTGG ACACTCAAGT CTTGGTCTAC 300
AGGCTACGCT TTTATTTTCC TGGTTGGTTT GGACTGGAGA CCTGTCACCG CTTTGGGTTA 360
CACAAAGATT TGACCAGTGC CATCCTTGAC GTACATGTTT TAGAACACCT CTTTGCCCAG 420
CACCGCAGTG ACCTGGTGAG TGGGCGTCTC CCAGTAGGCC TTAGCCTGAA GGACCAGGGA 480
GAGTTCCTGA GCCTAGCTGT GCTGGACCTG GCCCAGATGG CTCGTAAGCA GGCCCAGCGG 540
CCAGGAGAGC TGCTGAAGTC CGTCAGTTAC AAAGCCTGTC TGCCGCCCAG CCTGCGCGAC 600
CTGATCCAGG GCCAGAGCTT CGTGACGCGC AGGCGCATCC GCAGGACCGT GGTCCAGGCG 660
CTGCGCCGTG TAGTAGCCTG CCAAGCCGAC CGCTACGCAC TCATGGCCAA GTACATCCTA 720
GACCTTGAGC GGCTGCATCC AGCGGCCACC ACTGAGTCCT TCCTCGTGGG ACTCCCGGGC 780
GCCCAGGAGG AGCCGGGTTG CCTGCGTGTG ACAGGGGATA ATGGCATCGC CTGGAGCTCC 840
AAGGACCAGG AGCTTTTCCA GACCTTCTGT GACTTTCCAG AAATCGTGGA TGTCAGCATC 900
AAGCAGGCTC CACGCGTGGG TCCGGCAGGG GAGCACCGGC TAGTCACCAT CACCAGGATG 960
GACGGTCACA TCCTGGAAGC GGAGTTCCCG GGGCTGCCTG AGGCGCTGTC TTTCGTGGCG 1020
CTCGTGGATG GGTACTTTCG CCTGATCTGC GACTCCAGGC ATTTCTTCTG CAAGGAGGTG 1080
GCACCGCCAC GGCTGCTGGA GGAAGAGGCG GAGCTGTGCC ATGGACCCAT CACGTTAGAC 1140
TTTGCCATCC ACAAGCTGAA GGCTGCTGGC TCCCTCCCGG GCTCCTACAT TCTCCGACGC 1200
AGCCCGCAGG ACTATGACAG CTTTCTTCTT ACTGCCTGTG TCCAGACTCC TCTTGGCCCC 1260
GACTACAAGG GCTGCCTCAT CCGCCAAGAC CCCAGTGGGG CTTTCTCCCT GGTTGGTCTC 1320
AGCCAGCTGC ACAGAAGCCT ACAGGAGCTG CTCACAGCCT GCTGGCATTC TGGACTGCAA 1380
GTAGACGGCA CTGCCCTGAA CCTCACATCT TGCTGCGTCC CCAGACCCAA GGAAAAGTCC 1440
AATTTGATCG TGGTGCGTAG GGGCCGCAAC CCCACGCCTG CCCCCGGGCA CTCCCCATCC 1500
TGCTGTGCGC TGACTAAGTT GAGCTTCCAC ACAATCCCAG CAGACAGCCT GGAGTGGCAC 1560
GAGAATCTTG GTCACGGCTC TTTTACCAAG ATCTTCCATG GCCATAGGCG GGAGGTTGTG 1620
GATGGTGAGA CACATGACAC AGAAGTCCTC CTGAAGGTTA TGGACTCCAG ACACCAGAAC 1680
TGCATGGAGT CCTTTCTGGA AGCCGCAAGC TTGATGAGCC AAGTATCCTA CCCGCACCTG 1740
GTGTTGCTGC ATGGAGTCTG CATGGCTGGA GACAGCATCA TGGTGCAGGA ATTTGTGTAC 1800
CTTGGAGCAA TTGACACGTA CCTGCGCAAG CGTGGTCACC TGGTGCCGGC CAGCTGGAAA 1860
CTGCAGGTGA CCAAGCAGCT GGCCTATGCC CTTAACTACT TGGAGGACAA AGGCCTCCCT 1920
CATGGCAACG TCTCAGCGAG GAAGGTGCTG CTAGCTCGTG AGGGGGTTGA TGGGAATCCA 1980
CCTTTCATCA AGCTGAGTGA TCCTGGTGTC AGCCCAACTG TTTTGAGCCT GGAAATGCTC 2040
ACTGACAGGA TTCCCTGGGT GGCCCCGGAG TGTCTCCAGG AAGCTGGAAC GCTCAACTTG 2100
GAGGCTGACA AGTGGGGCTT TGGCGCCACC ACGTGGGAGG TGTTCAGCGG GGCACCCATG 2160
CACATTACCT CGCTGGAGCC CGCCAAGAAG CTGAAGTTCT ATGAGGACCG GGGACAGCTG 2220
CCGGCCCTCA AATGGACAGA GCTGGAGGGG CTCATCGCAC AGTGCATGGC GTATGATCCT 2280
GGCCGGCGCC CCTCCTTCCG AGCCATCCTC AGAGACCTCA ACGGCCTCAT TACATCAGAT 2340
TACGAGCTCC TCTCAGACCC CACACCTGGC ATCCCGAATC CCCGAGATGA GCTGTGTGGT 2400
GGTGCCCAGC TCTATGCCTG CCAGGACCCC GCCATCTTCG AGGAGAGACA CCTTAAGTAC 2460
ATCTCCCTGC TGGGCAAGGG GAACTTCGGC AGCGTGGAGC TGTGCCGCTA CGACCCTCTG 2520
GGAGACAATA CGGGACCCCT GGTAGCAGTG AAGCAGTTAC AGCACAGCGG GCCAGAACAG 2580
CAGAGGGACT TCCAGCGAGA GATTCAGATC CTCAAGGCTC TACACTGTGA CTTCATCGTC 2640
AAGTACCGGG GAGTCAGCTA TGGGCCTGGT CGCCAGAGCC TGCGGTTAGT GATGGAGTAC 2700
CTGCCCAGCG GCTGCCTGCG GGACTTCCTG CAGCGCCACC GCGCGCGCCT GCACAACGAC 2760
CGCCTACTGC TGTTCGCCTG GCAGATCTGC AAGGGCATGG AGTACCTGGG CGCACGCCGC 2820
TGCGTGCATC GTGACCTGGC TGCGCGCAAC ATCCTGGTGG AGAGTGAGGC GCATGTGAAG 2880
ATTGCTGACT TCGGCCTCGC TAAGCTGCTG CCTCTCGGAA AAGACTACTA CGTGGTCCGC 2940
GAGCCGGGCC AAAGTCCCAT CTTCTGGTAC GCCCCTGAGT CCCTATCTGA CAACATCTTC 3000
TCCCGCCAAT CTGACGTGTG GAGCTTCGGC GTGGTGCTGT ATGAGCTCTT CACCTACAGC 3060
GACAAGAGCT GCAGCCCATC CACTGAGTTC CTGCGCATGA TGGGGCCTGA GCGTGAGGGA 3120
TCCCCGCTCT GCCACCTCTT GGAGCTGCTG GCAGAGGGCC GCCGTCTCCC ACCACCCTCC 3180
ACCTGCCCTA CTGAGGTTCA AGAGCTCATG CAGCTGTGCT GGTCGCCCAA CCCACAAGAC 3240
CGGCCAGCAT TTGACACCCT GAGCCCCCAG CTGGATGCGC TGTGGCGCGG AAGCCCCGGA 3300
TAG 3303
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk+i+ Lgkg+f++v+++r+d+ gd+t+  va+k+L++sg++++rdf+re++il++l+ +
Q: 818   LKYISLLGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPEQQRDFQREIQILKALHCD  877
         799*********************************************************
S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         +ivk++gv++ +g++  rlVmey++sG+L+++L++++++l+  +ll +a+q++k+meYL+
Q: 878   FIVKYRGVSYGPGRQslRLVMEYLPSGCLRDFLQRHRARLHNDRLLLFAWQICKGMEYLG  937
         ************************************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177
         ++++vhrd+aarn+Lve+e++      vk++d+glak+++ + +Yy+vre+++s+i+w+a
Q: 938   ARRCVHRDLAARNILVESEAH------VKIADFGLAKLLPLGkDYYVVREPGQSPIFWYA  991
         *********************......*********************************
S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225
         pe+ls++  +s++sdvWsFgv+lyel+t  +k++sp    lr++++e       ++lell
Q: 992   PESLSDNI-FSRQSDVWSFGVVLYELFTySDKSCSPstefLRMMGPEregsplcHLLELL  1050
         ********.*******************999*****************************
S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265
          e++rlp p+ cp+e++elm+ c+s +p++rp+F ++  +l
Q: 1051  AEGRRLPPPStCPTEVQELMQLCWSPNPQDRPAFDTLSPQL  1091
         ************************************98876
Domain Sequence
(FASTA)
LKYISLLGKG NFGSVELCRY DPLGDNTGPL VAVKQLQHSG PEQQRDFQRE IQILKALHCD 60
FIVKYRGVSY GPGRQSLRLV MEYLPSGCLR DFLQRHRARL HNDRLLLFAW QICKGMEYLG 120
ARRCVHRDLA ARNILVESEA HVKIADFGLA KLLPLGKDYY VVREPGQSPI FWYAPESLSD 180
NIFSRQSDVW SFGVVLYELF TYSDKSCSPS TEFLRMMGPE REGSPLCHLL ELLAEGRRLP 240
PPSTCPTEVQ ELMQLCWSPN PQDRPAFDTL SPQL 274
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-EQC-00030
EKS-FEC-00029
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LOA-00032
EKS-MAM-00030
EKS-MOD-00032
EKS-MUM-00033
EKS-MUP-00033
EKS-MYL-00033
EKS-NOL-00031
EKS-ORA-00026
EKS-OTG-00032
EKS-PAT-00027
EKS-POA-00030
EKS-PTV-00031
EKS-SAH-00030
EKS-SUS-00027
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030183; P:B cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775; Tyr_kinase_non-rcpt_Jak3.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR01826; JANUSKINASE3.
PR00109; TYRKINASE.
Created Date20-Feb-2013