EKS-RAN-00137
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00137
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/Akt503.22.0E-151152409258
StatusUnreviewed
Ensembl ProteinENSRNOP00000025303
UniProt AccessionQ3HSE5;
Protein Name
Protein Synonyms/Alias Protein kinase B beta; RAC-beta serine/threonine-protein kinase; Thymoma viral proto-oncogene 2, isoform CRA_b;
Gene NameAkt2
Gene Synonyms/Alias Akt2; rCG_53945;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000018677ENSRNOP00000025303ENSRNOT00000025303
OrganismRattus norvegicus
Functional Description
Protein Length481
Protein Sequence
(FASTA)
MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 60
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWI RAIQMVANSL KQRGPGEDAM 120
DYKCGSPSDS STSEMMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 180
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH 240
LSRERVFTED RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 300
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 360
LILMEEIRFP RTLGPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK 420
KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG SLELDQRTHF PQFSYSASIR 480
E 481
Nucleotide Sequence
(FASTA)
ATGAATGAGG TATCTGTCAT CAAAGAAGGC TGGCTCCACA AACGTGGTGA ATACATCAAG 60
ACCTGGAGGC CCCGGTACTT CCTTCTGAAG AGTGATGGAT CTTTTATTGG GTATAAAGAG 120
AGACCTGAGG CCCCCGACCA GACCCTACCC CCCCTTAACA ATTTCTCTGT AGCAGAATGC 180
CAGCTGATGA AGACTGAGAG GCCACGACCC AACACCTTTG TCATACGCTG CCTGCAGTGG 240
ACCACAGTCA TCGAGAGGAC CTTCCATGTC GACTCTCCAG ATGAGAGGGA AGAGTGGATA 300
CGGGCTATCC AGATGGTAGC CAACAGTCTG AAGCAGCGGG GCCCCGGGGA GGATGCCATG 360
GATTACAAGT GTGGCTCCCC CAGTGACTCT TCCACATCTG AGATGATGGA GGTAGCGGTC 420
AGCAAGGCAC GGGCCAAAGT GACCATGAAC GACTTCGATT ATCTCAAACT CCTCGGCAAG 480
GGCACCTTCG GCAAAGTCAT TCTAGTTCGA GAGAAGGCCA CTGGCCGCTA TTATGCCATG 540
AAGATCCTGC GGAAGGAGGT CATCATTGCA AAGGATGAAG TCGCCCACAC AGTCACAGAG 600
AGCCGAGTCC TACAGAATAC CAGGCACCCC TTCCTTACAG CCCTGAAGTA TGCCTTCCAG 660
ACCCATGACC GCCTGTGCTT TGTGATGGAG TATGCCAACG GGGGCGAGCT GTTTTTCCAC 720
CTCTCTCGGG AGCGAGTCTT CACGGAGGAT CGGGCACGCT TTTATGGAGC AGAGATTGTG 780
TCAGCTCTGG AGTACTTGCA CTCGAGGGAT GTGGTGTACC GCGACATCAA GCTGGAAAAC 840
CTTATGCTGG ACAAAGATGG CCACATCAAG ATCACTGACT TTGGCTTGTG CAAAGAGGGC 900
ATCAGTGATG GGGCCACCAT GAAAACCTTC TGTGGTACCC CGGAGTACTT GGCGCCTGAG 960
GTGCTAGAGG ACAATGACTA CGGGCGTGCA GTGGACTGGT GGGGACTGGG CGTGGTCATG 1020
TACGAGATGA TGTGCGGCCG CCTGCCCTTC TACAACCAGG ACCACGAGCG CCTCTTCGAG 1080
CTCATCCTCA TGGAGGAGAT CCGGTTCCCA CGCACGCTTG GGCCAGAGGC CAAGTCCCTG 1140
CTGGCTGGAC TGCTCAAGAA GGACCCTAAG CAGAGGCTCG GTGGGGGTCC CAGTGATGCA 1200
AAGGAGGTCA TGGAGCATCG GTTCTTCCTC AGCATCAACT GGCAGGATGT GGTACAGAAG 1260
AAGCTCCTGC CACCCTTCAA ACCTCAGGTC ACTTCAGAAG TGGACACAAG GTACTTTGAT 1320
GATGAATTCA CCGCCCAGTC CATCACAATC ACACCCCCAG ACCGATATGA CAGCCTGGGC 1380
TCGCTGGAAC TGGACCAGCG CACACACTTC CCCCAGTTCT CCTACTCAGC CAGCATCCGA 1440
GAGTGA 1446
Domain Profile
S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60
         fd+lkllGkGtfGkvilvrekat+++ya+kil+kevi+akdevaht+te+rvl++t+hpf
Q: 152   FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF  211
         9***********************************************************
S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120
         l+alky+fqt+++lc+v+ey+nGGelffhls+ervf+edrarfygaeivsal+ylhs+dv
Q: 212   LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDV  271
         ************************************************************
S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180
         vyrd+klenl+ldkdGhikitdfGlcke+i+dg+++ktfcGtpeylapevled+dyg+av
Q: 272   VYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAV  331
         ************************************************************
S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240
         dwwglGvv+yem+cGrlpfyn+dhe+lfelil+ee++fpr+l++eaksll+Gllkkdpk+
Q: 332   DWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQ  391
         ************************************************************
S: 241   rlGggkddakeireheff  258
         rlGgg++dake++eh+ff
Q: 392   RLGGGPSDAKEVMEHRFF  409
         *****************9
Domain Sequence
(FASTA)
FDYLKLLGKG TFGKVILVRE KATGRYYAMK ILRKEVIIAK DEVAHTVTES RVLQNTRHPF 60
LTALKYAFQT HDRLCFVMEY ANGGELFFHL SRERVFTEDR ARFYGAEIVS ALEYLHSRDV 120
VYRDIKLENL MLDKDGHIKI TDFGLCKEGI SDGATMKTFC GTPEYLAPEV LEDNDYGRAV 180
DWWGLGVVMY EMMCGRLPFY NQDHERLFEL ILMEEIRFPR TLGPEAKSLL AGLLKKDPKQ 240
RLGGGPSDAK EVMEHRFF 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00132
EKS-ANC-00134
EKS-BOT-00140
EKS-CAJ-00144
EKS-CAF-00146
EKS-CAP-00139
EKS-DAR-00423
EKS-DAN-00010
EKS-ECT-00022
EKS-EQC-00137
EKS-FEC-00131
EKS-GAM-00069
EKS-GAA-00163
EKS-GOG-00141
EKS-HOS-00145
EKS-ICT-00133
EKS-LOA-00138
EKS-MAM-00139
EKS-MOD-00139
EKS-MUM-00144
EKS-MUP-00143
EKS-MYL-00150
EKS-ORN-00172
EKS-ORL-00161
EKS-OTG-00145
EKS-POA-00135
EKS-PTV-00130
EKS-SUS-00123
EKS-TAR-00182
EKS-TEN-00173
EKS-XET-00128
EKS-XIM-00167
Gene Ontology
GO:0030027; C:lamellipodium
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008286; P:insulin receptor signaling pathway
GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport
GO:0032287; P:peripheral nervous system myelin maintenance
GO:2000147; P:positive regulation of cell motility
GO:0032000; P:positive regulation of fatty acid beta-oxidation
GO:2001275; P:positive regulation of glucose import in response to insulin stimulus
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0072659; P:protein localization to plasma membrane
GO:0046328; P:regulation of JNK cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013