| Tag | Content |
|---|
| EKPD ID | EKS-RAN-00015 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/PHK | 523.5 | 1.3E-157 | 24 | 291 | 268 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000025419 |
| UniProt Accession | P31325; A1A5L8; |
| Protein Name | Phosphorylase b kinase gamma catalytic chain, testis/liver isoform |
| Protein Synonyms/Alias | PHK-gamma-T; Phosphorylase kinase subunit gamma-2; Serine/threonine-protein kinase PHKG2; |
| Gene Name | Phkg2 |
| Gene Synonyms/Alias | Phkg2; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Catalytic subunit of the phosphorylase b kinase (PHK),which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase (PYGB, PYGL or PYGM). May regulate glycogeneolysis in the testis. In vitro, phosphorylates TNNI3, TNNT2, MAPT/TAU, GAP43 and NRGN/RC3. |
| Protein Length | 406 |
Protein Sequence
(FASTA) | | MTLDVGPEDE LPDWAAAKEF YQKYDPKDII GRGVSSVVRR CVHRATGDEF AVKIMEVSAE 60 | | RLSLEQLEEV RDATRREMHI LRQVAGHPHI ITLIDSYESS SFMFLVFDLM RKGELFDYLT 120 | | EKVALSEKET RSIMRSLLEA VNFLHVNNIV HRDLKPENIL LDDNMQIRLS DFGFSCHLEP 180 | | GEKLRELCGT PGYLAPEILK CSMDETHPGY GKEVDLWACG VILFTLLAGS PPFWHRRQIL 240 | | MLRMIMEGQY QFSSPEWDDR SNTVKDLIAK LLQVDPNARL TAEQALQHPF FERCKGSQPW 300 | | NLTPRQRFRV AVWTILAAGR VALSSHRLRP LTKNALLRDP YALRPVRRLI DNCAFRLYGH 360 | | WVKKGEQQNR AALFQHQPPR PFPIIATDLE GDSSAITEDE VTLVRS 406 |
|
Nucleotide Sequence
(FASTA) | | ATGACGTTGG ACGTGGGGCC AGAGGATGAA CTCCCAGACT GGGCTGCGGC CAAAGAGTTT 60 | | TACCAGAAGT ATGACCCCAA GGACATCATT GGCAGAGGAG TGAGCTCTGT GGTCCGCCGC 120 | | TGTGTCCATC GAGCTACTGG TGATGAGTTT GCAGTGAAGA TCATGGAGGT GTCAGCTGAA 180 | | CGGCTGAGTC TTGAGCAGCT GGAGGAGGTG CGGGATGCCA CACGGCGAGA GATGCACATC 240 | | CTTCGCCAGG TCGCTGGCCA CCCCCACATC ATCACTCTCA TCGATTCCTA CGAGTCTTCT 300 | | AGCTTCATGT TCCTGGTGTT TGACCTGATG CGGAAAGGAG AGCTGTTTGA CTATCTCACA 360 | | GAGAAAGTGG CCCTCTCAGA AAAGGAAACC AGGTCCATTA TGAGGTCTCT GCTGGAGGCG 420 | | GTGAACTTTC TTCATGTCAA CAACATTGTA CATCGAGACC TGAAGCCTGA GAATATCCTC 480 | | CTAGATGACA ATATGCAGAT CCGCCTTTCA GATTTTGGGT TCTCCTGCCA TTTGGAACCT 540 | | GGCGAGAAGC TTCGAGAGCT GTGTGGGACT CCGGGATATC TAGCACCAGA GATCCTTAAA 600 | | TGCTCCATGG ATGAAACCCA CCCAGGCTAT GGCAAGGAAG TCGACCTCTG GGCTTGTGGG 660 | | GTAATCCTGT TCACACTTCT GGCTGGCTCG CCACCATTCT GGCATCGACG CCAAATCCTG 720 | | ATGCTACGCA TGATCATGGA AGGCCAATAT CAGTTTAGTT CACCCGAGTG GGATGATCGT 780 | | TCAAACACCG TCAAAGACCT GATCGCAAAG CTGCTGCAGG TGGATCCTAA CGCACGCTTG 840 | | ACCGCTGAGC AAGCCCTACA GCACCCCTTC TTTGAGCGCT GTAAAGGCAG CCAGCCCTGG 900 | | AACCTCACAC CTCGCCAGCG GTTCCGGGTG GCAGTGTGGA CAATACTGGC TGCTGGACGA 960 | | GTAGCCTTAA GCAGTCACCG TTTACGGCCA CTAACTAAGA ATGCACTCTT GAGAGACCCC 1020 | | TATGCACTGC GGCCAGTACG GCGCCTCATT GACAACTGTG CCTTCCGGCT CTATGGACAC 1080 | | TGGGTGAAGA AGGGGGAGCA GCAGAACCGG GCGGCCCTCT TCCAGCACCA GCCTCCTAGG 1140 | | CCTTTCCCCA TCATTGCCAC TGACCTGGAA GGAGACTCCA GTGCTATCAC AGAGGATGAA 1200 | | GTTACCTTGG TACGGAGCTA G 1221 |
|
| Domain Profile | S: 1 yepkeilGrGvssvvrrciekatgqefavkiidvsaeklseeevkelreatlkeveilrq 60 | y+pk+i+GrGvssvvrrc+++atg+efavki++vsae+ls e+++e+r+at++e++ilrq | Q: 24 YDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMHILRQ 83 | 9*********************************************************** |
| S: 61 vsGhpsiiklkdvyesssflflvfdlmkkGelfdyltekvtlseketrkimralleavey 120 | v+Ghp+ii+l+d+yesssf+flvfdlm+kGelfdyltekv+lseketr+imr+lleav++ | Q: 84 VAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVNF 143 | ************************************************************ |
| S: 121 lhaknivhrdlkpenillddneniklsdfGfstqleeGeklrelcGtpgylapeilkcsm 180 | lh +nivhrdlkpenillddn++i+lsdfGfs++le+GeklrelcGtpgylapeilkcsm | Q: 144 LHVNNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSM 203 | ************************************************************ |
| S: 181 deeapGyskevdlwalGvilytllaGsppfwhrkqllmlrlimeGkyqftspewddisee 240 | de++pGy+kevdlwa+Gvil+tllaGsppfwhr+q+lmlr+imeG+yqf+spewdd+s++ | Q: 204 DETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSNT 263 | ************************************************************ |
| S: 241 vkdliskllvvdpekrltaeealahpff 268 | vkdli+kll+vdp++rltae+al+hpff | Q: 264 VKDLIAKLLQVDPNARLTAEQALQHPFF 291 | ***************************8 |
|
Domain Sequence
(FASTA) | | YDPKDIIGRG VSSVVRRCVH RATGDEFAVK IMEVSAERLS LEQLEEVRDA TRREMHILRQ 60 | | VAGHPHIITL IDSYESSSFM FLVFDLMRKG ELFDYLTEKV ALSEKETRSI MRSLLEAVNF 120 | | LHVNNIVHRD LKPENILLDD NMQIRLSDFG FSCHLEPGEK LRELCGTPGY LAPEILKCSM 180 | | DETHPGYGKE VDLWACGVIL FTLLAGSPPF WHRRQILMLR MIMEGQYQFS SPEWDDRSNT 240 | | VKDLIAKLLQ VDPNARLTAE QALQHPFF 268 |
|
| Keyword | ATP-binding; Calmodulin-binding; Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |