EKS-RAN-00304
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00304
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/IRE446.73.3E-134510770261
StatusUnreviewed
Ensembl ProteinENSRNOP00000025699
UniProt AccessionD3ZTI7;
Protein Name
Protein Synonyms/Alias Endoplasmic reticulum (ER) to nucleus signalling 2 (Predicted); Protein Ern2;
Gene NameErn2
Gene Synonyms/Alias Ern2; Ern2_predicted; rCG_40723;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000018974ENSRNOP00000025699ENSRNOT00000025699
OrganismRattus norvegicus
Functional Description
Protein Length927
Protein Sequence
(FASTA)
MARPVQSFQL WSALGFLLQL AIFLGKLGPQ VQSVRPESLL FVSTLDGSLH ALNKQTGDLK 60
WTVKDDPIIQ GPMYVTEMAF LSDPADGSLY ILGTQKQQGL MKLPFTIPEL VHASPCRSSD 120
GVFYTGRKQD AWFVVDPESG ETQMTLTTEG FSTPQLYIGR TQYTVSMHDP RTPTLRWNTT 180
YRRYSAPPVD GSPGKYMSHL TSCGMGLLLT VDPGSGTVLW TQDLGVPVTG IYTWHQDGLR 240
QLPHLTLARD TLHFLVLRWG HIRLPASSSQ DTVTQFSSLD TELLMTLYVG KEEAGFYVSK 300
ALVHAGVALV PRGLTLAPMD GPTTDEVTVQ VSGEREGSPS TAVRYPSGSV ALPSQWLLIG 360
YHEPPPVLHT TMLRVQRTPG KGSADTRDSD DLHAPALSFE FLNLKREEPW DPELHPEEKA 420
DTYPGLGSQD LLAASFTAIL LGAWVLYLMR QQQQSPSAPA GPSDLPQDTQ VQLSRDTLQN 480
QRRFQSPPEP VQPAHDPEAE QPTVVGKISF NPKDVLGRGA GGTFVFRGQF EGRAVAVKRL 540
LRECFSLVQR EVQLLQESDR HPNVLRYFCT EQGPQFHYIA LELCQASLQE YVESPDLDRW 600
GLGPTMVLQQ MMSGLAHLHS LHIVHRDLKP GNILMAGPDS QGQGRVVISD FGLCKKLPAG 660
RCSFSLHSGI PGTEGWMAPE LLQLPPDSPT SAVDIFSAGC VFYYVLSGGS HPFGESLYRQ 720
ANILSGDHCL AQLQEETHDK VVALDLVKAM LSLLPQDRPS AGWVLAHPLF WSRAKELQFF 780
QDVSDWLEKE PEQGPLVTAL EAGSYKVVRE NWYKHISAPL QEDLKRFRSY KGTSVRDLLR 840
AMRNKKHHYR ELPTEVRQTL GQLPAGFAQY FTQRFPRLLL HTHRAMRTCA SESLFLPYYP 900
AALEARGSCQ VPQRAETPRG PKGRPRS 927
Nucleotide Sequence
(FASTA)
ATGGCGAGAC CAGTCCAGAG TTTCCAACTG TGGTCTGCCC TCGGGTTCCT GCTGCAGCTT 60
GCAATCTTTC TGGGGAAACT CGGTCCACAG GTCCAATCCG TCAGGCCAGA GAGCCTTCTG 120
TTTGTCTCTA CCTTGGATGG AAGTCTCCAT GCACTGAACA AGCAGACAGG GGACTTGAAG 180
TGGACAGTGA AGGATGACCC CATCATCCAG GGACCAATGT ATGTCACAGA AATGGCCTTC 240
CTCTCTGACC CAGCTGATGG CAGCCTGTAC ATCTTGGGAA CCCAGAAACA ACAGGGGCTG 300
ATGAAACTGC CATTTACCAT CCCAGAGCTG GTTCACGCCT CTCCTTGTCG CAGCTCTGAT 360
GGTGTCTTCT ACACGGGCCG GAAGCAGGAT GCCTGGTTTG TGGTGGACCC TGAGTCAGGG 420
GAGACTCAGA TGACACTGAC CACAGAGGGC TTTTCTACTC CTCAACTCTA CATTGGCCGG 480
ACACAGTACA CAGTCTCCAT GCATGACCCA CGGACCCCAA CCCTGCGCTG GAACACAACC 540
TACCGCCGCT ACTCTGCGCC CCCCGTGGAC GGCTCACCTG GGAAATACAT GAGCCACTTG 600
ACATCCTGTG GGATGGGCCT GCTTCTCACT GTGGATCCAG GAAGTGGAAC TGTGCTGTGG 660
ACACAGGACC TGGGAGTGCC TGTGACAGGG ATCTACACAT GGCATCAGGA TGGTCTGCGA 720
CAGCTGCCCC ATCTTACCCT GGCTCGGGAC ACCCTACATT TCCTTGTCCT CCGCTGGGGC 780
CACATCCGTC TTCCTGCCTC CAGCTCCCAG GACACAGTCA CCCAGTTCTC TTCCTTAGAC 840
ACCGAACTTT TGATGACACT GTATGTGGGG AAAGAAGAAG CTGGTTTCTA TGTCTCTAAA 900
GCACTGGTCC ATGCTGGGGT GGCCCTTGTG CCCCGTGGAC TGACCCTGGC ACCCATGGAT 960
GGCCCCACAA CAGATGAGGT AACAGTTCAA GTCTCGGGGG AGCGAGAGGG CTCACCCAGC 1020
ACTGCTGTCA GATACCCCTC GGGCAGCGTG GCCCTTCCCA GCCAGTGGCT ACTCATTGGA 1080
TACCATGAAC CTCCCCCTGT CCTGCACACC ACCATGCTAA GGGTTCAGCG TACCCCAGGG 1140
AAAGGGTCTG CTGACACAAG AGACTCAGAC GACCTCCATG CTCCAGCTCT CTCCTTTGAG 1200
TTCCTAAACC TGAAGAGGGA GGAACCTTGG GATCCAGAAC TACATCCTGA AGAGAAAGCT 1260
GACACTTATC CAGGGCTAGG ATCCCAAGAC CTGCTAGCAG CTAGCTTCAC TGCCATTCTC 1320
TTGGGAGCCT GGGTCCTCTA CCTGATGAGG CAGCAGCAGC AGAGTCCTTC AGCACCTGCA 1380
GGCCCTTCAG ACCTCCCACA AGACACTCAG GTGCAGCTCT CAAGGGACAC CCTACAGAAC 1440
CAGAGGAGAT TTCAAAGCCC CCCAGAGCCA GTCCAGCCAG CCCATGATCC TGAAGCAGAG 1500
CAGCCCACTG TAGTGGGGAA GATTTCCTTC AACCCCAAGG ATGTGCTGGG CCGTGGGGCA 1560
GGAGGAACTT TTGTTTTCCG AGGACAGTTT GAGGGACGGG CAGTAGCTGT GAAGAGGCTC 1620
CTCCGAGAGT GCTTCAGCTT GGTTCAGCGA GAGGTGCAGC TGCTGCAAGA GTCTGACAGG 1680
CACCCCAATG TGCTGCGCTA CTTCTGCACG GAGCAGGGCC CCCAGTTCCA CTACATTGCC 1740
TTGGAACTCT GCCAGGCCTC CTTGCAAGAG TATGTGGAGA GCCCAGACCT AGACCGCTGG 1800
GGCCTTGGGC CTACCATGGT GCTGCAACAG ATGATGTCCG GCCTGGCCCA CCTGCATTCT 1860
TTACACATAG TACACCGTGA CCTCAAGCCG GGCAACATTC TCATGGCTGG GCCTGACAGC 1920
CAGGGCCAAG GCAGAGTGGT CATCTCTGAC TTCGGCCTCT GCAAGAAGTT ACCTGCTGGC 1980
CGTTGTAGCT TCAGTCTCCA TTCTGGTATT CCCGGCACAG AAGGCTGGAT GGCTCCAGAG 2040
CTACTGCAAC TGCCCCCAGA CAGCCCGACC AGCGCGGTGG ATATCTTCTC TGCAGGCTGT 2100
GTGTTTTATT ATGTGCTTTC TGGTGGCAGC CACCCCTTCG GAGAGAGTCT CTACCGCCAG 2160
GCCAACATCC TCTCAGGGGA CCACTGTCTG GCTCAACTGC AGGAAGAGAC CCATGACAAG 2220
GTTGTGGCAC TGGACTTAGT GAAAGCCATG CTGAGCCTGC TGCCCCAGGA TCGTCCCTCA 2280
GCAGGATGGG TGCTGGCTCA CCCCCTCTTT TGGAGCAGAG CTAAGGAACT CCAGTTCTTC 2340
CAGGATGTCA GTGACTGGTT GGAGAAGGAA CCAGAGCAGG GACCTCTCGT GACGGCGCTG 2400
GAGGCAGGAA GCTACAAGGT GGTCCGGGAA AACTGGTACA AGCACATCTC AGCACCTCTG 2460
CAGGAAGACC TGAAAAGGTT CCGGTCATAT AAAGGGACAT CAGTGCGAGA CCTGCTCCGT 2520
GCCATGAGGA ACAAGAAGCA CCACTACAGG GAGCTCCCAA CCGAGGTGCG CCAGACACTG 2580
GGCCAACTTC CTGCTGGCTT CGCCCAATAC TTCACACAGC GCTTTCCCAG GCTGCTACTG 2640
CACACTCACC GTGCCATGAG GACCTGTGCT TCTGAGAGCC TCTTCCTGCC CTACTATCCA 2700
GCAGCATTGG AAGCCAGGGG CTCCTGCCAG GTGCCACAAA GAGCGGAGAC ACCCAGAGGC 2760
CCCAAAGGCA GACCAAGGAG TTGA 2784
Domain Profile
S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60
         f+pkdvlG+Ga+Gt+vfrG+fegr+vavkrll+e+++l++rev+ll+esd+hpnv+ryfc
Q: 510   FNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFSLVQREVQLLQESDRHPNVLRYFC  569
         799*********************************************************
S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120
         te+++qf+yialelc+aslq+yve++dl+ +++l p+ +l+q++sGlahlhsl+ivhrdl
Q: 570   TEQGPQFHYIALELCQASLQEYVESPDLD-RWGLGPTMVLQQMMSGLAHLHSLHIVHRDL  628
         *****************************.******************************
S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180
         kp nil++ pd++g+ rv+isdfGlckkl++G++sfs +sg++GteGw+apell+ l+++
Q: 629   KPGNILMAGPDSQGQGRVVISDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQ-LPPD  687
         *******************************************************.9***
S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240
         ++tsavdifs+Gcvfyyvls+G+hpfG+sl+rqanilsg+ +l++l+ee++++v+a dl+
Q: 688   SPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDHCLAQLQEETHDKVVALDLV  747
         ************************************************************
S: 241   skmidkdplkrpsakkvlkhplf  263
         ++m++  p++rpsa +vl+hplf
Q: 748   KAMLSLLPQDRPSAGWVLAHPLF  770
         **********************9
Domain Sequence
(FASTA)
FNPKDVLGRG AGGTFVFRGQ FEGRAVAVKR LLRECFSLVQ REVQLLQESD RHPNVLRYFC 60
TEQGPQFHYI ALELCQASLQ EYVESPDLDR WGLGPTMVLQ QMMSGLAHLH SLHIVHRDLK 120
PGNILMAGPD SQGQGRVVIS DFGLCKKLPA GRCSFSLHSG IPGTEGWMAP ELLQLPPDSP 180
TSAVDIFSAG CVFYYVLSGG SHPFGESLYR QANILSGDHC LAQLQEETHD KVVALDLVKA 240
MLSLLPQDRP SAGWVLAHPL F 261
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>
EKS-AIM-00270
EKS-ANC-00278
EKS-BOT-00288
EKS-CAJ-00293
EKS-CAF-00294
EKS-CAP-00323
EKS-CII-00169
EKS-DAR-00633
EKS-ECT-00032
EKS-FEC-00274
EKS-GOG-00287
EKS-HOS-00294
EKS-ICT-00273
EKS-LOA-00298
EKS-MAM-00291
EKS-MEG-00230
EKS-MIM-00023
EKS-MOD-00283
EKS-MUM-00319
EKS-MUP-00284
EKS-MYL-00290
EKS-OCP-00029
EKS-ORA-00254
EKS-ORC-00270
EKS-OTG-00294
EKS-PAT-00273
EKS-POA-00280
EKS-SAH-00270
EKS-TAR-00377
EKS-TEN-00371
EKS-TUB-00026
Gene Ontology
GO:0005524; F:ATP binding
GO:0016891; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007050; P:cell cycle arrest
GO:0006917; P:induction of apoptosis
GO:0006397; P:mRNA processing
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0006950; P:response to stress
GO:0016075; P:rRNA catabolic process
KEGG
rno:365363;
InterPros
IPR010513; KEN_RNase_activator.
IPR011009; Kinase-like_dom.
IPR018391; PQQ_beta_propeller_repeat.
IPR002372; PQQ_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR006567; PUG-dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF01011; PQQ; 1.
PF06479; Ribonuc_2-5A; 1.
SMARTs
SM00564; PQQ; 4.
SM00580; PUG; 1.
Prosites
PS51392; KEN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013