EKS-RAN-00171
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00171
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC436.93.4E-131380634255
StatusUnreviewed
Ensembl ProteinENSRNOP00000025902
UniProt AccessionF1LM10;
Protein Name
Protein Synonyms/Alias Protein kinase C theta type;
Gene NamePrkcq
Gene Synonyms/Alias Prkcq;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000019057ENSRNOP00000025902ENSRNOT00000025901
OrganismRattus norvegicus
Functional Description
Protein Length707
Protein Sequence
(FASTA)
MSPFLRIGLS NFDCGTCQAC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF 60
DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GRTEIWLELK PQGRMLMNAR 120
YFLEMSDTKD MSEFENEGFF ALHHRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 180
WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 240
SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 300
ARTLRDSEHI FREGPIEISF PRSIKSETRP PCVPTPGKKE PQGICWESPL DGADKTAQPP 360
EPEVNLQRAS LQLKLKIDDF ILHKMLGKGS FGKVFLAEFK RTKQFFAIKA LKKDVVLMDD 420
DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLSR 480
ATFYAAEIIL GLQFLHSKGI VYRDLKLDNI LLDRDGHIKI ADFGMCKENM LGDAKTNTFC 540
GTPDYIAPEI LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 600
WLEREAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPYD 660
CSNFDKEFLS EKPRLSFADR ALINSMDQNM FSNFSFINPG METLICS 707
Nucleotide Sequence
(FASTA)
ATGTCACCGT TTCTTCGAAT TGGTTTATCC AACTTTGACT GTGGGACCTG TCAAGCTTGT 60
CAGGGAGAGG CGGTGAACCC CTACTGTGCC GTGCTTGTCA AAGAGTATGT GGAATCAGAA 120
AACGGGCAGA TGTACATCCA GAAAAAGCCG ACCATGTACC CGCCTTGGGA CAGCACCTTT 180
GATGCCCACA TTAACAAGGG AAGGGTGATG CAGATCATCG TGAAAGGCAA AAATGTAGAC 240
CTCATATCAG AAACCACCGT GGAGCTCTAC TCCCTGGCAG AGAGATGCCG CAAGAACAAT 300
GGGCGGACAG AAATATGGTT AGAGCTGAAA CCTCAAGGCC GAATGCTAAT GAATGCAAGA 360
TACTTTCTGG AAATGAGTGA CACAAAGGAC ATGAGTGAAT TTGAGAACGA AGGATTCTTT 420
GCACTGCATC ACCGCCGAGG CGCCATCAAA CAAGCCAAAG TCCACCACGT CAAGTGTCAC 480
GAGTTCACAG CCACCTTTTT CCCTCAACCC ACGTTCTGCT CTGTCTGCCA TGAATTTGTC 540
TGGGGGCTGA ACAAGCAGGG CTACCAGTGC CGACAATGTA ATGCAGCGAT TCACAAGAAG 600
TGCATCGATA AAGTGATAGC CAAGTGCACA GGATCGGCGA TCAATAGTCG AGAGACCATG 660
TTCCACAAGG AGAGATTCAA GATCGACATG CCACACAGAT TCAAAGTCTA CAACTACAAG 720
AGTCCAACCT TCTGTGAGCA CTGTGGTACC CTGCTATGGG GGCTGGCGAG GCAAGGTCTC 780
AAGTGTGATG CATGTGGCAT GAACGTCCAC CACCGATGCC AGACAAAGGT TGCCAACCTC 840
TGTGGTATAA ACCAGAAGCT AATGGCTGAA GCGCTAGCAA TGATTGAAAG CACTCAACAG 900
GCTCGCACCT TAAGAGATTC AGAACACATC TTCCGAGAAG GACCAATTGA AATCAGTTTC 960
CCGCGCTCCA TCAAAAGTGA AACCAGGCCA CCATGCGTAC CAACACCTGG GAAAAAAGAA 1020
CCCCAGGGAA TTTGCTGGGA GTCCCCTTTG GATGGGGCAG ATAAAACGGC CCAGCCTCCT 1080
GAACCTGAAG TGAACTTGCA AAGGGCTTCT CTGCAACTGA AACTGAAGAT CGATGACTTC 1140
ATCCTGCACA AGATGCTGGG GAAAGGAAGT TTTGGCAAGG TCTTCCTGGC AGAGTTCAAG 1200
AGAACCAAAC AGTTTTTCGC AATAAAAGCC TTAAAGAAAG ATGTGGTGTT GATGGACGAT 1260
GACGTCGAGT GCACGATGGT GGAGAAGAGA GTTCTGTCCT TGGCCTGGGA GCATCCGTTT 1320
CTTACACACA TGTTCTGCAC ATTCCAGACC AAGGAAAATC TCTTTTTCGT GATGGAGTAT 1380
CTCAATGGAG GAGACTTAAT GTACCACATC CAAAGTTGCC ACAAATTTGA TCTTTCCAGA 1440
GCCACGTTTT ATGCTGCTGA GATCATCCTT GGTCTACAGT TCCTTCATTC CAAAGGAATT 1500
GTCTACAGGG ACCTGAAGCT AGATAATATC CTGTTAGACA GAGATGGCCA TATCAAAATA 1560
GCAGACTTTG GGATGTGCAA AGAGAATATG CTGGGAGATG CGAAGACAAA TACTTTCTGT 1620
GGGACGCCTG ACTACATCGC TCCGGAGATC TTGCTGGGTC AGAAATACAA CCATTCCGTT 1680
GACTGGTGGT CCTTTGGGGT TCTTCTTTAC GAGATGCTGA TTGGCCAGTC GCCTTTCCAC 1740
GGGCAGGACG AAGAGGAGCT TTTCCACTCC ATCCGCATGG ACAATCCCTT TTACCCAAGG 1800
TGGCTAGAAA GGGAGGCCAA GGATCTTCTA GTGAAGCTTT TTGTGAGAGA GCCTGAAAAG 1860
AGGCTGGGAG TGAGAGGAGA CATCCGCCAG CATCCTTTGT TTCGAGAGAT CAACTGGGAA 1920
GAGCTTGAGA GAAAAGAGAT TGACCCACCC TTCAGACCAA AAGTGAAATC ACCATATGAC 1980
TGTAGCAATT TCGACAAGGA ATTCCTAAGT GAGAAACCCC GGCTATCGTT CGCTGACAGA 2040
GCACTCATCA ACAGCATGGA CCAGAACATG TTCAGCAACT TCTCCTTCAT TAACCCGGGG 2100
ATGGAGACTC TCATTTGCTC CTGA 2124
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f l+k+lGkGsfgkv+lae k+t++++aik lkkdvvl+dddve+t+vekrvl+la+++p
Q: 380   FILHKMLGKGSFGKVFLAEFKRTKQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHP  439
         7899********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+++f++fqt+++lffv+ey+nGGdlm+hiq+++k++ +ra+fyaaeiil+l+flh+kg
Q: 440   FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKG  499
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         i+yrdlkldn+lld++Ghik+adfG+cke++l +++t+tfcGtPdyiaPeil +++y++s
Q: 500   IVYRDLKLDNILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHS  559
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+de+elf+si++++++yP++l++ea+++l +l+ ++pe
Q: 560   VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPE  619
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlGv  +g  di++h++f
Q: 620   KRLGV--RG--DIRQHPLF  634
         *****..55..89999987
Domain Sequence
(FASTA)
FILHKMLGKG SFGKVFLAEF KRTKQFFAIK ALKKDVVLMD DDVECTMVEK RVLSLAWEHP 60
FLTHMFCTFQ TKENLFFVME YLNGGDLMYH IQSCHKFDLS RATFYAAEII LGLQFLHSKG 120
IVYRDLKLDN ILLDRDGHIK IADFGMCKEN MLGDAKTNTF CGTPDYIAPE ILLGQKYNHS 180
VDWWSFGVLL YEMLIGQSPF HGQDEEELFH SIRMDNPFYP RWLEREAKDL LVKLFVREPE 240
KRLGVRGDIR QHPLF 255
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-BOT-00175
EKS-CAF-00182
EKS-CAP-00174
EKS-DAR-00470
EKS-EQC-00171
EKS-FEC-00165
EKS-GAM-00093
EKS-GAA-00211
EKS-GOG-00174
EKS-HOS-00181
EKS-LAC-00186
EKS-LOA-00174
EKS-MOD-00173
EKS-MUM-00181
EKS-MUP-00179
EKS-MYL-00184
EKS-NOL-00167
EKS-ORN-00220
EKS-ORA-00152
EKS-ORC-00162
EKS-ORL-00206
EKS-OTG-00180
EKS-PAT-00165
EKS-PES-00155
EKS-PEM-00089
EKS-POA-00168
EKS-SUS-00153
EKS-TAG-00203
EKS-TEN-00220
EKS-XIM-00215
EKS-SCP-00081
Gene Ontology
GO:0005737; C:cytoplasm
GO:0001772; C:immunological synapse
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0035556; P:intracellular signal transduction
GO:0006509; P:membrane protein ectodomain proteolysis
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0070233; P:negative regulation of T cell apoptotic process
GO:0032740; P:positive regulation of interleukin-17 production
GO:0045086; P:positive regulation of interleukin-2 biosynthetic process
GO:0032753; P:positive regulation of interleukin-4 production
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0042102; P:positive regulation of T cell proliferation
GO:2000318; P:positive regulation of T-helper 17 type immune response
GO:2000570; P:positive regulation of T-helper 2 cell activation
GO:0090330; P:regulation of platelet aggregation
KEGG
rno:85420;
InterPros
IPR000961; AGC-kinase_C.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013