EKS-RAN-00211

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00211

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NKF1	411.3	1.9E-123	53	313	261

Status

Reviewed

Ensembl Protein

ENSRNOP00000025808

UniProt Accession

Q9Z335; A2RRT7;

Protein Name

Serine/threonine-protein kinase SBK1

Protein Synonyms/Alias

SH3-binding kinase 1;

Gene Name

Sbk1

Gene Synonyms/Alias

Sbk1; Sbk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000019082	ENSRNOP00000025808	ENSRNOT00000025808

Organism

Rattus norvegicus

Functional Description

May be involved in signal-transduction pathways relatedto the control of brain development.

Protein Length

417

Protein Sequence
(FASTA)

MSVGCPEPEP LHSLPCCGPG AAPVPGAGVP LLTEDMQALT LRTLAASDVT KHYELVRELG 60

KGTYGKVDLV AYKGTGTKMA LKFVNKSKTK LKNFLREVSI TNSLSSSPFI IKVFDVVFET 120

EECYVFAQEY APAGDLFDII PPQVGLPEDT VKRCVQQLGL ALDFMHSRQL VHRDIKPENV 180

LLFDRECRRV KLADFGMTRR VGCRVKRVSG TIPYTAPEVC QAGRADGFAV DTGVDVWAFG 240

VLIFCVLTGN FPWEAASGAD AFFEEFVRWQ RGRLPGLPSQ WRRFTEPALR MFQRLLALEP 300

ERRGPAKEVF RFLKHELTSE LRRRPSHRAR KPPGDRLPGP LRLEAPGPLK RTVLTESGSG 360

SRPSPPSVGP VVPVPVPVPV PVPEAGLAPP APPGRTDGRA DKSKGQVVLA TAIEICV 417

Nucleotide Sequence
(FASTA)

ATGAGCGTGG GCTGCCCTGA GCCTGAACCG CTCCACTCCC TGCCTTGCTG TGGGCCGGGG 60

GCCGCCCCTG TACCTGGTGC AGGTGTGCCC CTCCTCACAG AAGACATGCA AGCCCTGACC 120

CTGCGCACAC TGGCTGCCAG CGACGTCACC AAGCACTACG AGCTCGTGCG GGAGCTGGGT 180

AAAGGGACCT ACGGGAAGGT CGACCTGGTG GCTTACAAGG GCACAGGCAC TAAAATGGCC 240

CTGAAATTTG TGAATAAGAG TAAGACCAAG CTGAAGAACT TCCTGCGTGA GGTGAGCATC 300

ACCAACAGCC TGTCGTCTAG CCCCTTCATC ATCAAGGTCT TCGACGTGGT CTTCGAGACG 360

GAGGAGTGCT ATGTCTTTGC TCAGGAGTAT GCACCTGCTG GGGACCTGTT TGACATCATC 420

CCTCCTCAGG TGGGGCTCCC GGAGGACACG GTGAAGCGCT GTGTGCAGCA GCTGGGGCTG 480

GCACTGGACT TCATGCATAG CAGGCAGCTG GTGCACCGCG ACATCAAGCC CGAGAATGTG 540

CTGCTGTTTG ACCGTGAGTG CCGCCGCGTG AAGCTGGCTG ACTTCGGCAT GACGCGGCGC 600

GTAGGCTGCC GTGTGAAGCG AGTAAGCGGC ACTATACCCT ACACGGCGCC CGAGGTGTGC 660

CAGGCTGGCC GCGCCGATGG CTTCGCGGTG GACACGGGCG TGGATGTGTG GGCATTCGGC 720

GTGCTCATCT TCTGCGTGCT CACTGGCAAC TTCCCGTGGG AGGCTGCGTC AGGTGCCGAT 780

GCCTTCTTCG AGGAATTTGT GCGCTGGCAG CGGGGTCGCC TGCCCGGGCT GCCATCCCAG 840

TGGCGACGCT TTACGGAGCC TGCTCTACGC ATGTTCCAGC GGCTTCTGGC GCTGGAGCCT 900

GAGCGGCGTG GGCCCGCCAA GGAGGTCTTT CGCTTCCTCA AGCATGAGCT CACATCTGAG 960

CTGCGGCGGC GGCCATCGCA CCGCGCACGA AAGCCACCTG GGGACCGCCT GCCTGGGCCC 1020

CTGCGCCTTG AGGCTCCAGG GCCACTCAAG CGCACTGTGC TCACCGAGAG TGGCAGCGGC 1080

TCGCGGCCTT CCCCACCCAG CGTAGGGCCC GTGGTACCCG TGCCAGTGCC AGTGCCAGTA 1140

CCCGTACCTG AGGCTGGTCT GGCTCCGCCC GCACCCCCGG GCAGGACCGA CGGCCGTGCG 1200

GACAAGAGCA AAGGGCAGGT GGTATTGGCC ACAGCCATCG AGATCTGCGT CTGA 1254

Domain Profile

S: 1     yelvrklgeGsfgkvlLvehrqsgtkvalKllpkektklkdFlrEfsvglslsshsaivk  60

         yelvr+lg+G++gkv+Lv+++++gtk+alK+++k+ktklk+FlrE+s+++slss+++i+k

Q: 53    YELVRELGKGTYGKVDLVAYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIK  112

         9***********************************************************

S: 61    tydvaletadayvFaqEyaplgdLaeaiqekvGlpeaavkrvvaqlasAldflHsrnlvh  120

         ++dv++et+++yvFaqEyap+gdL+++i+++vGlpe++vkr+v+ql+ Aldf+Hsr+lvh

Q: 113   VFDVVFETEECYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHSRQLVH  172

         ************************************************************

S: 121   rdlKpenvLvfdpdcsrvkltDfGltrkkgslvkkkeevipytapelcelvkeeklkvdp  180

         rd+KpenvL+fd++c+rvkl+DfG+tr++g++vk+++ +ipytape+c++ ++++++vd+

Q: 173   RDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGFAVDT  232

         ************************************************************

S: 181   svDvWalGvllfvvltgkfPWdkasleadpfyeeflkwqkrklrklPkkfkrlsekalrl  240

         +vDvWa+Gvl+f+vltg+fPW++a + ad+f+eef++wq+++l+ lP++++r++e+alr+

Q: 233   GVDVWAFGVLIFCVLTGNFPWEAA-SGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRM  291

         ************************.9**********************************

S: 241   lkklldlepedrskakevakfl  262

         +++ll+lepe+r +akev++fl

Q: 292   FQRLLALEPERRGPAKEVFRFL  313

         *******************997

Domain Sequence
(FASTA)

YELVRELGKG TYGKVDLVAY KGTGTKMALK FVNKSKTKLK NFLREVSITN SLSSSPFIIK 60

VFDVVFETEE CYVFAQEYAP AGDLFDIIPP QVGLPEDTVK RCVQQLGLAL DFMHSRQLVH 120

RDIKPENVLL FDRECRRVKL ADFGMTRRVG CRVKRVSGTI PYTAPEVCQA GRADGFAVDT 180

GVDVWAFGVL IFCVLTGNFP WEAASGADAF FEEFVRWQRG RLPGLPSQWR RFTEPALRMF 240

QRLLALEPER RGPAKEVFRF L 261

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007420	; P:brain development
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation

KEGG

rno:113907

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR016234	; Ser/Thr_kinase_Sbk1.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013