EKS-RAN-00288
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00288
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK399.71.2E-119111361251
StatusUnreviewed
Ensembl ProteinENSRNOP00000026107
UniProt AccessionD4A382;
Protein Name
Protein Synonyms/Alias
Gene NameDyrk1b
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000019254ENSRNOP00000026107ENSRNOT00000026107
OrganismRattus norvegicus
Functional Description
Protein Length589
Protein Sequence
(FASTA)
MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV DLIKTYKHIN 60
EVYYAKKKRR AQQAPPQDSS TKKEKKVLNH GYDDDNHDYI VRSGERWLER YEIDSLIGKG 120
SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK YYIVHLKRHF 180
MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL 240
KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG 300
CILVEMHTGE PLFSGSNEVD QMSRIVEVLG IPPAPMLEQA PKARKYFERL PGGGWTLRRT 360
KELRKDLVLR MLEYEPAARI SPLGALQHGF FRRTADEATN TGPAGSSAST SPAPLDTCPS 420
SSTASSISSS GGSSGSSSDN RAYRYSNRYC GGPGPPITDC EMNSPQVLPS QPLRPWAGGD 480
VPHKTHQAPT SGSTLLGTGA QLPPQPRCLG RPPSPTSPPP PELMDVSLVG SPPDCSPPHP 540
APAPQHPAAS ALRTRMTGGR PPLPPPDDPA TLGPRLGLHG VPQSTAASS 589
Nucleotide Sequence
(FASTA)
ATGGCCGTCC CACCAGGCCA TGGTCCCTTC TCTGGCTTTC CGGGGCCCCA GGAACACACA 60
CAGGTATTGC CTGATGTGCG GCTACTGCCA CGGAGACTGC CCCTGGCCTT CCGGGATGCG 120
ACCTCGGCCC CGCTGCGCAA GCTCTCAGTG GACCTCATCA AGACCTACAA GCACATCAAT 180
GAGGTATACT ATGCGAAGAA GAAGCGGCGG GCCCAACAGG CGCCACCCCA GGACTCGAGC 240
ACCAAAAAGG AGAAGAAGGT CCTGAATCAC GGCTATGACG ATGACAACCA CGACTACATT 300
GTGCGCAGCG GCGAGCGCTG GCTAGAGCGC TATGAAATTG ACTCTCTTAT TGGCAAAGGC 360
TCTTTTGGCC AGGTGGTGAA AGCCTATGAT CACCAGACTC AGGAGCTGGT GGCCATCAAG 420
ATCATCAAGA ACAAAAAGGC CTTCCTGAAC CAGGCACAGA TTGAGCTGAG GCTGCTGGAG 480
CTGATGAATC AGCATGATAC AGAGATGAAG TACTACATAG TACACCTGAA GCGGCACTTC 540
ATGTTCCGGA ATCACCTGTG CCTGGTGTTT GAGCTGCTGT CCTACAACCT GTACGACCTC 600
CTCCGCAACA CACACTTTCG CGGTGTCTCA CTGAACCTGA CGAGGAAGCT GGCACAGCAG 660
CTCTGCACAG CCCTGCTCTT TCTGGCCACG CCTGAGCTCA GCATCATCCA CTGCGACCTC 720
AAGCCTGAGA ACATCCTGCT CTGCAATCCT AAGCGCAGCG CCATCAAGAT TGTGGACTTC 780
GGCAGCTCCT GCCAGCTTGG CCAGCGGATC TACCAGTATA TCCAGAGCCG CTTCTACCGC 840
TCACCAGAGG TGCTCCTGGG TACACCCTAT GACCTGGCCA TCGACATGTG GTCCCTGGGC 900
TGCATCCTTG TGGAGATGCA CACCGGAGAA CCCCTCTTCA GTGGCTCTAA TGAGGTGGAC 960
CAGATGAGCC GGATTGTGGA GGTGTTGGGC ATCCCTCCCG CACCTATGCT GGAACAGGCA 1020
CCCAAAGCTC GCAAGTACTT TGAGCGGCTG CCTGGGGGTG GCTGGACCCT ACGAAGGACA 1080
AAGGAACTCA GGAAGGACCT GGTGCTGCGC ATGCTGGAGT ATGAGCCCGC CGCCCGCATC 1140
AGCCCTCTGG GCGCTCTGCA GCATGGCTTC TTCCGCCGCA CGGCCGACGA GGCCACCAAC 1200
ACGGGCCCGG CAGGCAGCAG TGCCTCCACC TCGCCGGCGC CCCTTGATAC CTGCCCCTCC 1260
TCTAGCACCG CCAGCTCCAT CTCCAGCTCT GGAGGCTCCA GTGGCTCCTC CAGTGACAAC 1320
AGGGCCTACC GCTACAGCAA CCGATATTGT GGGGGCCCAG GGCCCCCCAT CACTGACTGT 1380
GAGATGAACA GCCCCCAGGT CCTACCCTCC CAGCCTCTGC GCCCCTGGGC AGGGGGTGAT 1440
GTGCCCCACA AGACACATCA AGCCCCTACC TCTGGCTCAA CATTGCTGGG GACTGGGGCC 1500
CAGTTACCCC CACAACCCCG TTGCCTTGGA CGACCCCCAT CACCCACCTC ACCACCCCCC 1560
CCAGAGCTGA TGGATGTGAG CCTGGTGGGC AGCCCTCCAG ACTGCTCTCC ACCTCATCCA 1620
GCACCTGCTC CCCAGCACCC GGCTGCCTCA GCCCTCCGGA CTCGGATGAC GGGAGGTCGA 1680
CCACCTCTCC CGCCCCCTGA TGACCCTGCC ACTCTGGGGC CTCGTCTGGG CCTCCATGGT 1740
GTACCCCAGA GCACAGCAGC CAGCTCATGA 1770
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         ye++++igkGsfgqVvka+d++t+e vaikiiknkk+f++qaq+E+++Le +n++d+e+k
Q: 111   YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK  170
         9***********************************************************
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119
         y++v+l+++f+frnhlclvfells+nLy+ll++++f+g+sl+l+rklaqq+++aL +L+ 
Q: 171   YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAt  230
         **********************************************************99
S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++
Q: 231   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGTP  289
         99*************************************.********************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238
         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq++ ivevlg+pp+ +le+a ka+k+f++
Q: 290   YDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQAPKARKYFER  349
         ************************************************************
S: 239   keapkyilktkk  250
              ++l+++k
Q: 350   LPGGGWTLRRTK  361
         **9999998775
Domain Sequence
(FASTA)
YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK 60
YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT 120
PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY 180
DLAIDMWSLG CILVEMHTGE PLFSGSNEVD QMSRIVEVLG IPPAPMLEQA PKARKYFERL 240
PGGGWTLRRT K 251
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sus scrofa"; ?>
EKS-AIM-00254
EKS-BOT-00271
EKS-CAJ-00277
EKS-CAF-00279
EKS-CAP-00306
EKS-DIO-00022
EKS-EQC-00266
EKS-FEC-00257
EKS-HOS-00277
EKS-ICT-00254
EKS-LOA-00282
EKS-MAM-00273
EKS-MOD-00268
EKS-MUM-00302
EKS-MUP-00270
EKS-MYL-00273
EKS-NOL-00251
EKS-ORA-00239
EKS-OTG-00277
EKS-PAT-00257
EKS-POA-00262
EKS-PRC-00022
EKS-SUS-00233
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0003713; F:transcription coactivator activity
GO:0007520; P:myoblast fusion
GO:0045893; P:positive regulation of transcription, DNA-dependent
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013