| Tag | Content |
|---|
| EKPD ID | EKS-RAN-00117 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/NAK | 332.9 | 1.8E-99 | 22 | 290 | 269 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000026194 |
| UniProt Accession | P57760; |
| Protein Name | Serine/threonine-protein kinase 16 |
| Protein Synonyms/Alias | Myristoylated and palmitoylated serine/threonine-protein kinase; MPSK; Protein kinase PKL12; TGF-beta-stimulated factor 1; TSF-1; Tyrosine-protein kinase STK16; |
| Gene Name | Stk16 |
| Gene Synonyms/Alias | Stk16; Mpsk1, Tsf1; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Membrane-associated protein kinase that phosphorylateson serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins. |
| Protein Length | 305 |
Protein Sequence
(FASTA) | | MGHALCVCSR GTVIIDNKRY LFVQKLGEGG FSYVDLVEGL HDGHFYALKR ILCHEQQDQE 60 | | EAQREADMHR LFQHPNILRL MAYSLKERGA KHEAWLLLPF FKRGTLWNEI ERLKDQGNFL 120 | | TEDQILPLLL GICRGLEAIH AKGYAHRDLK PTNILLGDEG QPVLMDLGSM NQACIQVEGS 180 | | RQALALQDWA AQRCTISYRA PELFSVQSHC VIDERTDVWS LGCVLYAMMF GEGPYDMVFQ 240 | | KGDSVALAVQ NDLSIPQSPR HSSALRQLLA SMMTVDPQQR PHIPVLLSQL EALQPPAPGQ 300 | | HTTQI 305 |
|
Nucleotide Sequence
(FASTA) | | ATGGGCCATG CACTGTGTGT CTGTTCCCGG GGAACTGTCA TCATTGACAA TAAGCGTTAC 60 | | CTCTTCGTCC AGAAATTGGG GGAGGGTGGG TTCAGCTACG TGGACCTAGT GGAGGGCTTA 120 | | CATGATGGAC ACTTCTACGC CCTGAAGCGA ATCCTGTGTC ATGAGCAGCA GGACCAGGAA 180 | | GAGGCCCAAC GAGAGGCAGA CATGCATCGC CTCTTCCAGC ATCCAAACAT CCTTCGCCTC 240 | | ATGGCTTACT CTTTGAAAGA ACGAGGTGCT AAGCATGAAG CCTGGCTGCT GCTACCCTTC 300 | | TTCAAGAGAG GTACACTGTG GAATGAGATA GAAAGGCTGA AGGACCAAGG CAACTTCCTG 360 | | ACTGAAGACC AAATCCTTCC GTTGTTGCTG GGTATCTGCA GAGGCCTTGA GGCCATTCAT 420 | | GCCAAAGGTT ATGCACACAG GGACCTGAAG CCCACCAATA TTTTGCTTGG TGATGAGGGG 480 | | CAGCCGGTTT TAATGGACTT GGGTTCTATG AATCAAGCAT GCATCCAAGT GGAGGGATCT 540 | | CGCCAGGCCC TAGCTCTACA GGACTGGGCA GCCCAGCGGT GCACCATCTC CTACCGGGCA 600 | | CCTGAACTTT TTTCTGTGCA AAGCCACTGT GTCATCGATG AGCGGACTGA TGTCTGGTCC 660 | | CTAGGCTGTG TGCTTTATGC AATGATGTTT GGGGAAGGCC CTTATGATAT GGTGTTCCAG 720 | | AAAGGTGACA GTGTGGCCCT TGCTGTGCAG AATGACCTCA GCATCCCACA AAGCCCCAGG 780 | | CATTCTTCAG CATTGCGACA GCTGTTGGCC TCTATGATGA CTGTGGACCC CCAGCAACGC 840 | | CCTCACATCC CTGTCCTCCT CAGTCAATTG GAGGCATTGC AGCCACCAGC TCCTGGCCAG 900 | | CACACCACCC AAATCTGA 918 |
|
| Domain Profile | S: 3 iekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivkl 62 | + ++l+eGGf++v+l+e++++g+ yalKril++e++d+ee++rE+++++ ++ h+ni++l | Q: 22 FVQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDQEEAQREADMHRLFQ-HPNILRL 80 | 6799************************************************.******* |
| S: 63 vdssvkeekdngskevlllleyckkgslvdllnkrlekge.lseaeilkilldvtravaa 121 | +++s+ke+ + ++e++lll+++k+g+l++ +++ +++g+ l+e++il +ll+++r+++a | Q: 81 MAYSLKERGA--KHEAWLLLPFFKRGTLWNEIERLKDQGNfLTEDQILPLLLGICRGLEA 138 | ********99..9*********************************************** |
| S: 122 lHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeieknttl 181 | +H +++++HRDlk++Nill deg++vl+DlGS+++a+++ve+++++ alq+++++++t+ | Q: 139 IH--AKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIQVEGSRQALALQDWAAQRCTI 196 | **..99****************************************************** |
| S: 182 syrsPElidlysnlvideksDiWaLGcllYklcffesPf......eesvklailngkysi 235 | syr+PEl++++s++vide++D+W+LGc+lY+++f+e P+ ++sv+la++n +si | Q: 197 SYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYdmvfqkGDSVALAVQN-DLSI 255 | *******************************************************.9*** |
| S: 236 PensryseklkslikkmlevdpeeRptiaqvlell 270 | P+++r+s++l++l+++m++vdp++Rp+i +l++l | Q: 256 PQSPRHSSALRQLLASMMTVDPQQRPHIPVLLSQL 290 | *****************************999875 |
|
Domain Sequence
(FASTA) | | FVQKLGEGGF SYVDLVEGLH DGHFYALKRI LCHEQQDQEE AQREADMHRL FQHPNILRLM 60 | | AYSLKERGAK HEAWLLLPFF KRGTLWNEIE RLKDQGNFLT EDQILPLLLG ICRGLEAIHA 120 | | KGYAHRDLKP TNILLGDEGQ PVLMDLGSMN QACIQVEGSR QALALQDWAA QRCTISYRAP 180 | | ELFSVQSHCV IDERTDVWSL GCVLYAMMFG EGPYDMVFQK GDSVALAVQN DLSIPQSPRH 240 | | SSALRQLLAS MMTVDPQQRP HIPVLLSQL 269 |
|
| Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | | GO:0005798 | ; C:Golgi-associated vesicle | | GO:0016020 | ; C:membrane | | GO:0048471 | ; C:perinuclear region of cytoplasm | | GO:0005524 | ; F:ATP binding | | GO:0004715 | ; F:non-membrane spanning protein tyrosine kinase activity | | GO:0004672 | ; F:protein kinase activity | | GO:0004674 | ; F:protein serine/threonine kinase activity | | GO:0001077 | ; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | | GO:0071560 | ; P:cellular response to transforming growth factor beta stimulus | | GO:0046777 | ; P:protein autophosphorylation |
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| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
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| Prints | |
| Created Date | 20-Feb-2013 |