| Tag | Content |
|---|
| EKPD ID | EKS-RAN-00143 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| TK/Csk | 471.5 | 5.8E-142 | 195 | 440 | 246 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000026358 |
| UniProt Accession | P32577; Q4G003; |
| Protein Name | Tyrosine-protein kinase CSK |
| Protein Synonyms/Alias | C-Src kinase; |
| Gene Name | Csk |
| Gene Synonyms/Alias | Csk; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Non-receptor tyrosine-protein kinase that plays animportant role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). |
| Protein Length | 450 |
Protein Sequence
(FASTA) | | MSAIQASWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60 | | PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120 | | SCEGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTTDA DGLCTRLIKP KVMEGTVAAQ 180 | | DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240 | | TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300 | | AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360 | | KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYDVMK 420 | | NCWHLDAATR PTFLQLREQL EHIRTHELHL 450 |
|
Nucleotide Sequence
(FASTA) | | ATGTCGGCTA TACAGGCCTC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 60 | | CATGGCACTG CCGAGCAAGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 120 | | GTCACCAAGG ACCCCAACTG GTACAAAGCC AAAAACAAAG TGGGCCGTGA GGGCATCATC 180 | | CCAGCCAACT ATGTCCAGAA GCGTGAGGGT GTGAAGGCAG GCACCAAGCT CAGCCTTATG 240 | | CCCTGGTTCC ACGGCAAGAT CACACGGGAG CAGGCGGAGC GGCTTCTCTA CCCACCAGAG 300 | | ACAGGCCTGT TCCTGGTGCG GGAAAGCACC AACTACCCTG GGGACTACAC ACTGTGTGTG 360 | | AGCTGTGAAG GCAAGGTGGA GCACTACCGC ATCATGTATC ACGCGAGCAA GCTGAGCATT 420 | | GATGAGGAGG TGTACTTCGA GAACCTCATG CAGCTGGTGG AGCACTACAC CACAGATGCC 480 | | GACGGACTCT GCACTCGCCT CATCAAACCA AAGGTCATGG AGGGCACAGT GGCGGCCCAA 540 | | GATGAATTCT ACCGCAGTGG CTGGGCCCTG AACATGAAGG AACTGAAGCT GCTACAGACG 600 | | ATAGGAAAGG GGGAGTTTGG AGATGTGATG CTGGGGGATT ACCGAGGCAA CAAAGTTGCA 660 | | GTCAAGTGCA TTAAGAATGA TGCTACAGCC CAGGCCTTCC TGGCTGAAGC CTCTGTCATG 720 | | ACGCAGCTTC GGCACAGCAA CCTAGTCCAG CTACTGGGTG TGATTGTGGA GGAGAAGGGT 780 | | GGGCTCTACA TCGTCACAGA GTACATGGCC AAGGGGAGTT TGGTGGACTA TCTTCGATCA 840 | | CGTGGTCGTT CGGTGCTAGG CGGAGACTGT CTCCTCAAAT TCTCACTAGA CGTCTGTGAA 900 | | GCCATGGAGT ACCTGGAGGG TAACAATTTT GTGCACCGGG ACTTGGCTGC CCGGAATGTG 960 | | CTGGTGTCTG AGGACAACGT GGCCAAAGTC AGTGACTTTG GCCTCACTAA GGAAGCTTCC 1020 | | AGCACTCAGG ACACAGGCAA ACTGCCAGTC AAGTGGACAG CTCCTGAAGC CTTGAGAGAG 1080 | | AAGAAATTTT CCACCAAGTC TGATGTGTGG AGTTTCGGAA TCCTTCTCTG GGAAATCTAT 1140 | | TCCTTCGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTCGTCCC TCGGGTGGAA 1200 | | AAGGGCTATA AGATGGACGC TCCGGATGGC TGCCCACCCG CAGTCTATGA TGTTATGAAG 1260 | | AACTGCTGGC ACCTGGATGC TGCCACGCGG CCCACCTTTC TGCAGCTTCG AGAGCAGCTC 1320 | | GAGCACATCA GAACCCATGA GCTGCACCTG TGA 1353 |
|
| Domain Profile | S: 1 lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv 60 | lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv | Q: 195 LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV 254 | 6899******************************************************** |
| S: 61 ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd 119 | i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd | Q: 255 IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD 314 | *****99***************************************************** |
| S: 120 laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi 179 | laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi | Q: 315 LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI 374 | ************************************************************ |
| S: 180 llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa 239 | llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vy++mk++w+l+aa+rp+f | Q: 375 LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFL 434 | ************************************************************ |
| S: 240 klkekl 245 | +l+e+l | Q: 435 QLREQL 440 | ***997 |
|
Domain Sequence
(FASTA) | | LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60 | | IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120 | | LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180 | | LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYDVMKNCWH LDAATRPTFL 240 | | QLREQL 246 |
|
| Keyword | 3D-structure; Adaptive immunity; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Immunity; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |