EKS-RAN-00022

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00022

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/Trio	367.1	5.9E-110	1606	1859	254

Status

Reviewed

Ensembl Protein

ENSRNOP00000026941

UniProt Accession

Q63638;

Protein Name

Striated muscle-specific serine/threonine-protein kinase

Protein Synonyms/Alias

Aortic preferentially expressed protein 1; APEG-1;

Gene Name

Speg

Gene Synonyms/Alias

Speg; Apeg1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000019850	ENSRNOP00000063082	ENSRNOT00000065076
ENSRNOG00000019850	ENSRNOP00000026941	ENSRNOT00000026941

Organism

Rattus norvegicus

Functional Description

Isoform 2 may have a role in regulating the growth anddifferentiation of arterial smooth muscle cells.

Protein Length

3259

Protein Sequence
(FASTA)

MQKARGTRGE DAGTRAPPSP GVPPKRAKVG AGRGVLVTGA GAGAPVFLRP LKNAAVCAGS 60

DVRLRVVVSG TPEPSLSWFR DGQLLPTPVP EPSCLWLRNC GAQDAGVYSC SAQNERGKAS 120

CEAVLTVLEV RDSETAEDDI SDVPGTQRLE LRDDRAFSTP TGGSDTLVGT SLDTPPTSVT 180

GTSEEQVSWW GSGQTVLEQE AGSGGGTRPL PGSPRQAQTT GAGPRHLGVE PLVRASRANL 240

VGASWGSEDS LSVASDLYGS AFSLYRGRAL SIHVSIPPSG LRREEPDLQP QPASDALRPR 300

PALPPPSKSA LLPPPSPRVG KRALPGSSAQ PPATPTSPHR CTQEPSLPED ITTTEEKRGK 360

KPKSSGPSLA GTVESRPQTP LSEASGRLSA LGRSPRLVRA GSRILDKLQF FEERRRSLER 420

SDSPPAPLRP WVPLRKARSL EQPKSEGGAA WDTPGASQEE LRSPRGSVAE RRRLFQQKAA 480

SLDERTRQRS ATSDLELRFA QELGRIRRST SREELVRSHE SLRATLQRAP SPREPGEPPL 540

FSRPSIPKTS RAVSPAATQP PPPSGAGKSG DETGRPRSRG PVGRTEPGEG PQQEIKRRDQ 600

FPLTRSRAIQ ECRSPVPPFT ADPPESRTKA PSARKREPPA QAVRFLPWAT PGVEDSVLPQ 660

TLEKNRAGPE AEKRLRRGPE EDGPWGAWDR RGTRSQGKGR RARPTSPELE SSDDSYVSAG 720

EEPLEAPVFE IPLQNMVVAP GADVLLKCII TANPPPQVSW KKDGSVLHSE GRLLIRAEGE 780

RHTLLLREAQ AADAGSYTAT ATNELGQASC ASSLAVRPGA STSPFSSPIT SDEEYLSPPE 840

EFPEPGETWS RTPTMKPSPS QDRDSSDSSS KAPPTFKVSL MDQSVREGQD VIMSIRVQGE 900

PKPVVSWLRN RQPVRPDQRR FAEEAEGGLC RLRILAAERG DAGFYTCKAV NEYGARQCEA 960

RLEVRAHPES RSLAVLAPLQ DVDVGAGEMA LFECLVAGPA DVEVDWLCRG RLLQPALLKC 1020

KMHFDGRKCK LLLTSVHEDD SGVYTCKLST VKDELTCSAR LTVRPSLAPL FTRLLEDVEV 1080

LEGRAARLDC KISGTPPPSV TWTHFGHPVN ESENLRLRQD GGLHSLHIAR VGSEDEGLYE 1140

VSATNTHGQA HCSAQLYVEE PRTAASGPSS KLEKMPSIPE EPEHGDLERL SIPDFLRPLQ 1200

DLEVGLAKEA MLECQVTGLP YPTISWFHNG HRIQSSDDRR MTQYRDIHRL VFPAVGPQHA 1260

GVYKSVIANK LGKAACYAHL YVTDVVPGPP DGAPQVVAVT GRMVTLSWNP PRSLDMAIDP 1320

DSLTYTVQHQ VLGSDQWTAL VTGLREPEWA ATGLKKGLHH IFRVLSSSGK SSSKPSAPSE 1380

PVQLLEHGPP LEEAPAVLDK QDIVYVVEGQ PACVTVTFNH VEAQVVWRSC RGALLEPRTG 1440

VYELSQPDDD QYCLRICRVS RRDLGPLTCS ARNRHGTKAC SITLELAEAP RFESIMEDVE 1500

VGPGETARFA VVVEGKPLPD IMWYKDEVLL AESNHVSFVY EENECSLVVL SAGSQDGGVY 1560

TCTARNLAGE VSCKAELSVH SAQTAMEVEG VGEDEEHRGR RLSDYYDIHQ EIGRGAFSYL 1620

RRVVERSSGL EFAAKFIPSQ AKPKASARRE ARLLARLQHD CVLYFHEAFE RRRGLVIVTE 1680

LCTEELLERM ARKPTVCESE TRTYMRQVLE GIGYLHQSHV LHLDVKPENL LVWDGAGGEE 1740

QVRICDFGNA QELTPGEPQY CQFGTPEFVA PEIVNQSPVS GVTDIWPVGV VAFLCLTGIS 1800

PFVGENDRTT LMNIRNYNVA FEETTFLSLS REARGFLIKV LVQDRLRPTA EETLEHPWFK 1860

TEAKGAEVST DHLKLFLSRR RWQRSQISYK CHLVLRPIPE LLRAPPERVW VAMPRRQPPS 1920

GGLSSSSDSE EEELEELPSV PRPLQPEFSG SRVSLTDIPT EDEALGTPEA GAATPMDWQE 1980

QGRAPSKDQE APSPEALPSP GQESPDGPSP RRPELRRGSS AESALPRVGS REPGRSLHKA 2040

ASVELPQRRS PSPGATRLTR GGLGEGEYAQ RLQALRQRLL RGGPEDGKVS GLRGPLLESL 2100

GGRARDPRMA RAASSEAAPH HQPPPESRGL QKSSSFSQGE AEPRGRHRRA GAPLEIPVAR 2160

LGARRLQESP SLSALSETQP PSPALPSAPK PSITKSPEPS AATSRDSPQP PAPQPVPEKI 2220

PEPKPEPVRA AKPAQPPLAL QMPAQSLTPY AQIMQSLQLS SPTLSPQVPP SEPKPHAAVF 2280

ARVASPPPGA SEKRVPSARI PPVLAEKVRV PTVPPRPGSS LSGSIENLES EAVFEAKFKR 2340

SRESPLSRGL RLLSRSRSEE RGPFRGAEDD GIYRPSPAGT PLELVRRPER SRSVQDLRVA 2400

GEPGLVRRLS LSLSQKLRRT PPGQRHPAWE SRSGDGESSE GGSSARGSPV LAVRRRLSST 2460

LERLSSRLQR SGSSEDSGGA SGRSTPLFGR LRRATSEGES LRRLGVPHNQ LASQTGATTP 2520

SAESLGSEAS GTSGSSAPGE SRSRHRWGLS RLRKDKGLSQ PNLSASVQED LGHQYVPSES 2580

DFPPVFHIKL KDQVLLEGEA ATLLCLPAAC PTPRISWMKD KQSLRSEPSV VIVSCKDGRQ 2640

LLSIPRASKR HAGLYECSAT NVLGSITSSC TVAVARTPGK LAPPEVPQTY CDTALVLWKP 2700

GDSRAPCTYT LERRVDGESV WHPVSSGIPD CYYNVTQLPV GVTVRFRVAC SNRAGQGPFS 2760

NPSEKVFIRG TQDSPAQSAA APRDAPVTSG PTRAPPPDSP TSLVPTPPLA PQVSQASTLS 2820

PSTSSMSANQ ALSSLKAVGP PPATPPRKHR GLLATQQAEP SPPSILVTPS EHKSFVPDTG 2880

TLTPTSSPQG VKPAPSSSSL YMVTSFVSAP PDPQPPAPEP PPEPTKVTVR SLSPAKEVVS 2940

SPTPESTTLR QGPPQKPYTF LEEKARGRFG VVRSCRENAT GRTFVAKIVP YAAEGKRRVL 3000

QEYEVLRTLH HERLMSLHEA YITPRYLVLI AESCGNRELL CGLSDRFRYS EDDVATYVVQ 3060

LLQGLDYLHG RHVLHLDIKP DNLLLAADNA LKIVDFGSAQ PYNPQALKPL GHRTGTLEFM 3120

APEMVRGDPI GSATDIWGAG VLTYIMLSGY SPFYEPDPQE TEARIVGGRF DAFQLYPNTS 3180

QSATLFLRKV LSVHPWSRPS LQDCLAHPWL QDAYLMKLRR QTLTFTTNRL KEFLGEQRRR 3240

RAEAATRHKV LLRSYPGSP 3259

Nucleotide Sequence
(FASTA)

ATGCAAAAAG CCCGGGGTAC GCGAGGCGAG GACGCCGGCA CGAGGGCACC TCCTAGCCCC 60

GGGGTGCCCC CGAAGAGAGC CAAGGTGGGG GCCGGCAGAG GGGTCCTCGT CACCGGGGCA 120

GGGGCCGGGG CGCCGGTCTT CCTGCGGCCC CTGAAGAACG CGGCGGTGTG TGCGGGCAGT 180

GATGTGCGGC TGCGGGTGGT TGTGAGCGGG ACACCCGAGC CTAGCCTCAG TTGGTTCCGG 240

GATGGGCAGC TCCTGCCTAC ACCGGTCCCA GAGCCCAGCT GCCTATGGCT GCGGAACTGC 300

GGGGCACAGG ACGCCGGCGT GTACAGCTGC AGCGCCCAGA ATGAGCGGGG CAAGGCCTCC 360

TGTGAGGCTG TGCTCACAGT GCTGGAGGTC AGAGACTCGG AGACTGCTGA GGATGACATC 420

AGCGATGTGC CGGGGACCCA GCGCCTGGAG CTTCGGGATG ACAGGGCCTT CAGCACCCCC 480

ACGGGGGGCT CTGACACCCT GGTGGGCACC TCCCTGGACA CACCCCCGAC CTCCGTGACA 540

GGCACCTCAG AGGAGCAAGT GAGCTGGTGG GGCAGCGGGC AGACGGTCCT GGAGCAGGAA 600

GCGGGCAGCG GGGGTGGCAC CCGCCCCCTC CCAGGCAGCC CAAGGCAAGC ACAGACAACC 660

GGGGCCGGGC CACGGCACCT GGGGGTGGAG CCGCTGGTGC GGGCATCGCG AGCTAATCTG 720

GTGGGCGCAA GCTGGGGGTC AGAGGATAGC CTTTCGGTGG CCAGTGACCT GTATGGCAGC 780

GCGTTCAGTC TGTACAGAGG ACGGGCGCTC TCGATCCACG TCAGCATTCC TCCGAGTGGA 840

TTGCGCAGAG AGGAGCCTGA CCTTCAGCCT CAACCGGCCA GTGATGCCCT TCGTCCACGT 900

CCTGCCCTTC CACCTCCCTC CAAGTCCGCT CTGCTTCCGC CACCATCTCC TCGGGTGGGT 960

AAGAGGGCTC TGCCAGGATC TAGTGCCCAG CCCCCAGCTA CTCCCACTTC GCCCCATCGG 1020

TGTACTCAGG AGCCCTCGCT GCCTGAGGAC ATCACCACCA CCGAAGAGAA GCGAGGGAAA 1080

AAGCCTAAGT CATCGGGGCC GTCGCTGGCG GGCACAGTGG AGTCCCGGCC CCAGACGCCA 1140

TTGAGCGAAG CTTCAGGTCG CCTGTCAGCA CTGGGCCGTT CGCCCCGGCT GGTGCGCGCC 1200

GGCTCCCGCA TCCTGGACAA GCTGCAGTTC TTCGAGGAGC GGCGCCGCAG CCTGGAGCGC 1260

AGCGACTCGC CGCCAGCGCC CCTGCGGCCC TGGGTGCCCC TGCGCAAGGC TCGCTCGCTG 1320

GAGCAGCCGA AGTCCGAGGG TGGCGCGGCG TGGGACACAC CCGGGGCCTC TCAGGAGGAG 1380

CTGCGGTCAC CTAGGGGCAG TGTGGCAGAG CGGCGTCGCC TGTTCCAACA AAAGGCGGCC 1440

TCTCTGGACG AGCGCACGCG ACAACGCAGT GCAACCTCGG ACCTCGAGCT CCGCTTCGCC 1500

CAGGAGCTGG GTCGCATCCG CCGATCTACG TCCCGGGAGG AGCTGGTGCG TTCGCACGAG 1560

TCCCTGCGTG CCACGCTGCA GCGCGCCCCA TCCCCTCGAG AGCCCGGCGA GCCCCCACTC 1620

TTCTCCCGGC CCTCCATACC CAAGACCTCA CGGGCTGTGA GCCCGGCTGC CACCCAGCCG 1680

CCTCCTCCCA GTGGCGCGGG CAAATCTGGG GACGAGACTG GGAGACCCCG AAGCAGAGGG 1740

CCGGTGGGCA GGACTGAACC GGGGGAAGGC CCACAGCAGG AGATCAAGCG TCGGGACCAA 1800

TTCCCACTCA CCCGGAGCAG AGCCATCCAG GAGTGCAGGA GCCCTGTGCC GCCCTTCACC 1860

GCGGATCCTC CAGAGAGCAG GACAAAAGCC CCCTCTGCTC GCAAGCGGGA ACCCCCTGCC 1920

CAAGCCGTGC GCTTTCTGCC CTGGGCCACT CCGGGAGTGG AGGACTCTGT TCTGCCCCAA 1980

ACCTTGGAGA AGAACAGAGC GGGACCTGAG GCTGAGAAAA GGCTTCGTAG AGGACCTGAG 2040

GAGGATGGTC CCTGGGGGGC CTGGGACCGT AGAGGGACCC GCAGCCAAGG CAAAGGTCGC 2100

CGTGCTCGGC CTACTTCCCC TGAGCTCGAG TCCTCGGACG ACTCCTATGT GTCCGCTGGG 2160

GAAGAGCCCC TGGAGGCACC AGTGTTTGAG ATACCCCTGC AGAACATGGT GGTGGCGCCA 2220

GGAGCTGATG TACTACTTAA GTGTATCATC ACCGCCAACC CCCCACCCCA AGTGTCCTGG 2280

AAAAAGGATG GGTCCGTGTT ACACAGTGAG GGTCGTCTTC TCATCCGGGC TGAAGGTGAA 2340

CGGCACACAC TGCTACTTAG AGAGGCCCAG GCTGCTGATG CTGGGAGCTA CACAGCCACT 2400

GCCACCAACG AACTGGGCCA GGCTAGCTGT GCTTCTTCTC TGGCCGTGAG ACCTGGCGCG 2460

TCCACATCCC CCTTCAGCAG CCCAATCACC TCTGATGAGG AGTACCTGAG CCCCCCAGAG 2520

GAGTTCCCAG AACCTGGGGA GACCTGGTCC CGAACCCCTA CCATGAAGCC CAGTCCCAGC 2580

CAGGATCGAG ATTCCTCTGA CTCTTCCTCC AAGGCACCCC CAACCTTCAA GGTCTCACTC 2640

ATGGACCAAT CAGTGAGAGA AGGTCAAGAT GTCATTATGA GCATCCGCGT GCAGGGGGAG 2700

CCCAAGCCTG TGGTCTCCTG GCTGAGGAAT CGGCAGCCTG TGCGCCCAGA CCAGCGGCGC 2760

TTTGCAGAGG AGGCCGAGGG TGGGCTCTGC CGGTTGAGGA TCCTGGCTGC TGAGAGGGGA 2820

GATGCTGGTT TCTACACTTG CAAGGCGGTC AACGAATATG GCGCTCGGCA GTGTGAGGCC 2880

CGCCTGGAGG TCCGAGCACA CCCTGAAAGC CGGTCCCTGG CCGTGCTGGC CCCCCTGCAG 2940

GACGTGGACG TGGGGGCCGG GGAGATGGCG CTGTTTGAGT GCCTGGTGGC AGGTCCAGCT 3000

GACGTCGAGG TGGACTGGCT GTGCCGTGGC CGCCTGCTGC AGCCTGCGCT GCTCAAATGC 3060

AAGATGCATT TTGATGGCCG CAAGTGCAAG CTGCTGCTGA CCTCTGTGCA TGAGGACGAC 3120

AGCGGTGTCT ACACTTGCAA GCTGAGCACA GTCAAAGATG AACTGACCTG CAGTGCCCGG 3180

CTGACGGTCC GGCCATCGCT GGCGCCTCTG TTCACCCGGT TACTGGAAGA TGTGGAGGTG 3240

CTAGAAGGCC GTGCTGCCCG CCTGGATTGC AAGATCAGCG GCACCCCGCC TCCCTCTGTT 3300

ACCTGGACTC ATTTTGGCCA CCCTGTAAAT GAGAGTGAAA ACTTGCGGCT GCGGCAGGAT 3360

GGGGGGCTAC ACTCACTGCA CATTGCCCGG GTGGGCAGCG AGGACGAGGG ACTCTATGAA 3420

GTCAGTGCCA CCAACACTCA TGGCCAGGCC CACTGCTCTG CCCAGCTGTA TGTGGAGGAG 3480

CCTCGGACAG CGGCCTCTGG CCCCAGCTCG AAGCTGGAGA AGATGCCATC TATCCCTGAG 3540

GAGCCGGAGC ATGGAGATCT AGAGAGGCTG TCTATTCCTG ACTTCCTGCG GCCACTGCAA 3600

GATCTGGAAG TGGGACTAGC TAAGGAAGCC ATGCTGGAGT GCCAAGTGAC CGGCCTGCCC 3660

TATCCCACCA TCAGCTGGTT CCACAATGGC CACCGCATTC AAAGCAGTGA CGACCGACGC 3720

ATGACACAGT ACAGGGATAT ACATCGCCTG GTGTTCCCAG CTGTGGGGCC TCAGCACGCT 3780

GGTGTCTACA AGAGTGTCAT CGCCAACAAG CTGGGCAAAG CAGCCTGCTA TGCCCATCTC 3840

TATGTCACAG ATGTGGTTCC AGGCCCTCCA GATGGCGCTC CGCAAGTAGT GGCTGTGACC 3900

GGAAGGATGG TCACACTCTC ATGGAACCCA CCCAGGAGTC TGGACATGGC TATTGACCCA 3960

GATTCCCTGA CATACACAGT GCAGCACCAG GTGTTGGGCT CGGACCAGTG GACAGCACTG 4020

GTCACGGGCC TGCGGGAGCC TGAGTGGGCA GCCACGGGGC TGAAGAAGGG GCTCCATCAC 4080

ATCTTCCGGG TCCTCAGCTC CAGCGGCAAG AGCAGCAGCA AACCCTCAGC ACCATCGGAA 4140

CCTGTACAGC TGTTAGAGCA CGGCCCACCC CTGGAAGAGG CACCTGCCGT GCTGGACAAG 4200

CAGGACATTG TGTATGTGGT AGAGGGCCAG CCTGCCTGTG TCACCGTCAC TTTTAACCAT 4260

GTGGAGGCCC AGGTTGTCTG GAGGAGCTGC CGGGGAGCCC TCCTGGAGCC GCGCACGGGT 4320

GTGTATGAAC TGAGTCAGCC AGATGACGAC CAATATTGCC TTCGGATCTG CCGGGTGAGC 4380

CGACGAGACC TGGGACCCCT TACTTGCAGT GCCCGAAACC GCCATGGCAC AAAGGCCTGC 4440

TCGATCACCC TAGAGCTGGC AGAGGCACCT CGGTTTGAGT CTATCATGGA AGATGTGGAG 4500

GTGGGGCCTG GAGAAACCGC TCGCTTTGCT GTGGTGGTTG AGGGGAAACC ACTGCCGGAC 4560

ATCATGTGGT ACAAGGATGA GGTGCTGCTG GCCGAGAGCA ATCATGTGAG CTTCGTGTAC 4620

GAAGAGAACG AGTGCTCCCT GGTGGTGCTC AGTGCAGGAA GCCAGGATGG AGGCGTCTAT 4680

ACCTGTACGG CCCGGAACCT GGCAGGCGAA GTCTCCTGCA AGGCAGAGCT GTCTGTGCAC 4740

TCAGCTCAGA CAGCCATGGA GGTCGAAGGG GTCGGAGAGG ATGAGGAGCA CCGAGGAAGA 4800

AGACTTAGCG ACTACTATGA CATCCACCAA GAGATCGGCA GAGGTGCCTT CTCCTACCTG 4860

CGGCGGGTAG TGGAGCGGAG CTCTGGCCTG GAGTTTGCAG CCAAGTTCAT CCCTAGTCAG 4920

GCCAAGCCTA AAGCATCAGC GAGACGCGAG GCCCGGTTGC TGGCCCGACT CCAGCATGAC 4980

TGTGTGCTCT ACTTCCACGA AGCCTTCGAA AGGCGCAGGG GACTTGTCAT AGTCACCGAG 5040

CTCTGCACAG AAGAGCTTCT AGAGCGCATG GCCAGGAAGC CCACCGTGTG TGAGTCTGAG 5100

ACTCGGACTT ATATGCGCCA AGTGCTAGAG GGGATAGGCT ATCTGCATCA GAGCCATGTG 5160

CTGCACCTGG ATGTCAAGCC GGAGAACCTG CTGGTGTGGG ATGGTGCCGG GGGTGAGGAG 5220

CAGGTGCGCA TCTGTGACTT CGGGAACGCC CAGGAACTCA CTCCGGGAGA ACCCCAGTAC 5280

TGCCAGTTTG GCACGCCAGA GTTTGTTGCG CCTGAGATTG TCAACCAGAG CCCTGTGTCT 5340

GGAGTCACTG ACATCTGGCC CGTGGGCGTC GTTGCCTTCC TCTGTTTGAC GGGTATCTCC 5400

CCATTTGTTG GAGAGAACGA CCGGACAACA CTCATGAATA TCCGAAATTA CAACGTGGCA 5460

TTTGAAGAGA CTACGTTCCT GAGTCTGAGC AGGGAGGCCC GGGGCTTCCT TATCAAAGTG 5520

CTGGTGCAGG ATCGACTGAG ACCTACTGCA GAAGAGACTC TGGAACATCC TTGGTTCAAA 5580

ACAGAAGCAA AGGGTGCAGA GGTGAGCACA GACCACCTGA AGCTCTTTCT GTCACGGAGG 5640

AGGTGGCAGC GCTCTCAAAT CAGCTACAAG TGCCACCTGG TGCTGCGACC CATTCCGGAA 5700

CTGCTACGGG CACCCCCGGA GCGGGTGTGG GTGGCCATGC CTAGAAGACA ACCCCCGAGT 5760

GGGGGACTTT CATCCTCTTC AGACTCAGAA GAGGAAGAAT TGGAGGAACT TCCCTCAGTA 5820

CCCCGCCCCC TGCAGCCTGA GTTCTCAGGT TCTCGGGTAT CCCTCACCGA CATCCCCACC 5880

GAAGATGAGG CTCTGGGGAC CCCGGAAGCT GGGGCTGCCA CCCCCATGGA CTGGCAAGAG 5940

CAGGGAAGGG CTCCCTCTAA GGACCAGGAG GCCCCCAGCC CTGAGGCACT CCCCTCTCCA 6000

GGCCAGGAGT CCCCTGATGG GCCTAGCCCC AGGCGGCCAG AACTCCGTAG GGGCAGCTCT 6060

GCTGAGAGCG CCCTGCCCCG GGTCGGGTCG CGGGAGCCGG GCCGGAGCCT GCACAAAGCA 6120

GCATCGGTGG AGCTGCCGCA GCGCAGGAGC CCCAGCCCGG GTGCCACTCG CCTGACTCGG 6180

GGAGGCCTGG GTGAGGGCGA GTATGCCCAG AGGCTGCAGG CCCTGCGTCA GCGGCTGCTG 6240

AGGGGAGGCC CGGAGGATGG CAAGGTCAGC GGTCTCAGGG GACCCCTGCT GGAGAGCCTG 6300

GGGGGCCGAG CACGGGATCC CAGGATGGCG CGGGCTGCCT CCAGTGAGGC TGCACCCCAC 6360

CACCAGCCCC CTCCCGAGTC CCGCGGCCTG CAAAAGAGCA GCAGCTTCTC TCAGGGTGAG 6420

GCAGAGCCCC GGGGTCGGCA CCGCCGAGCG GGGGCACCCC TCGAAATCCC CGTAGCTAGG 6480

CTTGGGGCCC GTAGGCTGCA GGAGTCTCCC TCCTTATCTG CCCTTAGTGA GACCCAGCCA 6540

CCGAGTCCTG CGTTGCCCAG CGCCCCCAAA CCCAGTATCA CCAAGTCTCC GGAACCTTCC 6600

GCTGCCACAT CCAGAGACTC TCCCCAGCCC CCAGCACCTC AGCCTGTCCC AGAAAAGATC 6660

CCAGAGCCCA AACCAGAACC AGTCCGAGCT GCCAAACCAG CACAACCCCC TTTGGCTCTG 6720

CAAATGCCAG CGCAGTCTCT CACCCCCTAT GCCCAGATCA TGCAGTCGCT CCAGCTGTCC 6780

AGTCCCACCC TGTCCCCACA GGTGCCTCCA TCAGAGCCCA AGCCCCACGC GGCTGTGTTT 6840

GCCAGGGTGG CTTCTCCGCC GCCCGGAGCC TCTGAGAAGC GCGTGCCTTC GGCCAGAATT 6900

CCCCCAGTGC TAGCCGAGAA AGTCCGAGTC CCCACGGTGC CCCCCAGGCC AGGCAGCAGC 6960

CTCAGCGGTA GCATCGAGAA CCTCGAGTCA GAGGCCGTGT TCGAGGCTAA GTTTAAGCGT 7020

AGCCGCGAAT CGCCACTGTC GCGGGGCCTG AGGCTACTAA GCCGCTCGCG CTCAGAGGAG 7080

CGCGGTCCCT TCCGTGGGGC GGAGGACGAT GGCATATACC GGCCCAGCCC GGCGGGAACG 7140

CCGCTAGAGC TGGTGCGACG GCCGGAGCGC TCGCGCTCGG TGCAGGACCT CAGGGTAGCC 7200

GGAGAGCCAG GCCTTGTGCG TCGCCTTTCG CTGTCCCTGT CGCAGAAGCT GCGGCGGACA 7260

CCGCCCGGGC AGCGACACCC TGCGTGGGAG TCCCGCAGTG GAGATGGAGA GAGCTCCGAG 7320

GGCGGCAGCT CAGCTCGGGG TTCCCCGGTG CTGGCGGTGC GCAGGAGACT CAGCTCCACG 7380

CTGGAGCGTC TGTCCAGCCG TTTGCAGCGC AGCGGCAGCA GCGAGGACTC CGGGGGCGCC 7440

TCGGGTCGCA GCACGCCGCT GTTTGGACGG CTACGCAGGG CTACTTCCGA AGGGGAGAGC 7500

CTGCGACGCC TCGGTGTTCC GCACAATCAG CTGGCTTCGC AGACTGGTGC CACCACACCG 7560

TCCGCTGAGT CTCTGGGCTC AGAGGCCAGC GGCACATCGG GTTCCTCAGC TCCAGGGGAA 7620

AGCCGAAGCC GGCACCGGTG GGGCCTTTCC AGGCTGCGCA AGGACAAGGG CTTATCGCAG 7680

CCAAACCTCT CCGCCAGTGT CCAAGAGGAC TTGGGTCACC AGTATGTGCC CAGTGAGTCA 7740

GATTTCCCCC CAGTCTTCCA CATCAAACTC AAGGACCAGG TGCTGTTGGA GGGGGAAGCA 7800

GCTACCCTGC TCTGCCTACC AGCAGCCTGC CCAACACCCC GCATCTCCTG GATGAAAGAT 7860

AAGCAGTCCC TGCGGTCAGA GCCCTCGGTG GTCATTGTGT CCTGCAAAGA TGGTCGGCAG 7920

CTGCTGAGCA TACCCCGGGC TAGCAAGCGG CATGCTGGGC TCTATGAGTG CTCAGCGACC 7980

AACGTCCTAG GCAGCATTAC CAGCTCCTGT ACTGTGGCAG TGGCCCGCAC CCCAGGAAAG 8040

CTGGCTCCTC CAGAGGTGCC CCAGACCTAC TGTGACACGG CGCTGGTGCT GTGGAAGCCG 8100

GGAGACAGTC GGGCACCTTG CACGTATACT CTGGAGCGGC GGGTAGATGG GGAATCCGTC 8160

TGGCACCCTG TGAGCTCAGG CATCCCCGAC TGTTACTACA ATGTGACTCA GCTGCCTGTT 8220

GGTGTGACTG TGAGGTTCCG GGTGGCCTGT TCCAATCGTG CTGGGCAGGG GCCCTTCAGC 8280

AACCCTTCTG AGAAGGTCTT CATCCGAGGC ACTCAAGATT CTCCAGCTCA GTCAGCTGCT 8340

GCTCCCCGAG ATGCCCCTGT TACCTCAGGG CCAACTAGGG CCCCACCGCC TGACTCTCCT 8400

ACCTCACTGG TCCCTACCCC GCCTCTTGCT CCCCAAGTCT CCCAGGCATC CACACTCAGC 8460

CCTTCAACCT CCTCCATGTC TGCCAACCAG GCCTTGTCCT CTCTCAAGGC TGTGGGTCCA 8520

CCACCCGCAA CCCCTCCACG AAAGCACAGG GGGCTTCTGG CCACCCAGCA AGCAGAGCCA 8580

TCCCCACCCA GTATCCTGGT CACCCCAAGT GAACACAAGT CTTTTGTCCC TGACACTGGA 8640

ACCCTGACCC CAACCTCTAG TCCTCAAGGG GTCAAACCAG CACCTTCCTC AAGTTCCTTG 8700

TATATGGTGA CTTCCTTCGT GTCTGCACCT CCAGACCCCC AGCCCCCAGC CCCTGAGCCC 8760

CCTCCCGAGC CCACCAAGGT GACTGTTCGA AGCCTCAGCC CAGCCAAGGA GGTGGTCAGC 8820

TCCCCAACAC CTGAGAGCAC CACTCTTCGA CAGGGCCCTC CTCAGAAACC CTACACCTTC 8880

CTTGAGGAGA AGGCCAGGGG CCGCTTTGGC GTTGTGCGGT CATGCCGGGA GAATGCTACA 8940

GGCCGAACGT TCGTTGCTAA GATCGTGCCG TATGCTGCCG AGGGCAAGCG ACGAGTGCTG 9000

CAGGAATATG AGGTGCTTCG GACACTGCAC CACGAGAGGC TCATGTCCCT GCACGAGGCC 9060

TACATCACCC CTCGGTACCT TGTGCTTATC GCCGAGAGCT GTGGCAACCG GGAACTTCTC 9120

TGTGGGCTCA GCGACAGATT CCGGTATTCA GAAGATGATG TGGCCACCTA TGTGGTGCAG 9180

CTGCTACAAG GCCTGGACTA CCTCCATGGC CGCCATGTGC TGCACCTGGA CATCAAGCCG 9240

GACAATCTAC TCTTGGCCGC TGATAATGCC CTTAAGATTG TGGACTTCGG CAGTGCTCAG 9300

CCCTATAACC CTCAGGCCCT GAAGCCGCTT GGCCACCGCA CAGGCACTCT AGAGTTCATG 9360

GCTCCTGAGA TGGTAAGGGG AGACCCCATC GGCTCTGCCA CGGATATCTG GGGAGCGGGT 9420

GTGCTCACCT ACATCATGCT TAGTGGGTAC TCCCCATTCT ATGAGCCAGA TCCCCAGGAA 9480

ACAGAGGCTC GGATTGTTGG GGGTCGCTTT GATGCCTTCC AGCTGTACCC TAACACCTCC 9540

CAGAGTGCCA CCCTCTTCTT GAGAAAGGTC CTCTCAGTAC ATCCCTGGAG CCGGCCCTCC 9600

CTGCAGGACT GCTTGGCCCA CCCATGGCTG CAGGATGCCT ACTTGATGAA GCTGCGCCGC 9660

CAGACACTCA CCTTCACCAC CAACCGGCTC AAGGAATTCC TGGGCGAGCA GCGTCGACGT 9720

CGGGCTGAGG CTGCTACCCG TCACAAGGTG CTGCTCCGCT CCTACCCTGG CAGCCCCTAG 9780

Domain Profile

S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60

         y++++eigRG+Fs++++v+e++++ ++aakf+p++ak ka+++rEa++L+rLqH++++++

Q: 1606  YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYF  1665

         99**********************************************************

S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120

         h+a+e++r lv+++Elc+ eeLL+r+a+k +++Ese+++y+rq+le++ YLH+s+vlHLD

Q: 1666  HEAFERRRGLVIVTELCT-EELLERMARKPTVCESETRTYMRQVLEGIGYLHQSHVLHLD  1724

         ******************.9****************************************

S: 121   ikpenllv..laaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatD  178

         +kpenllv   a  ee+v+i+D+gnAqeltp epq+++ gtpEfvaPEi++++pvs +tD

Q: 1725  VKPENLLVwdGAGGEEQVRICDFGNAQELTPGEPQYCQFGTPEFVAPEIVNQSPVSGVTD  1784

         ********988999**********************************************

S: 179   iWavGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqed  238

         iW+vGv+a+++L+g+sPf++e++r+tl+ni++++v+f+e++f +ls+eA+ Fl+kvL++d

Q: 1785  IWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQD  1844

         ************************************************************

S: 239   prkRPsaaecLqhpWl  254

          r RP+a+e+L+hpW+

Q: 1845  -RLRPTAEETLEHPWF  1859

         .**************8

Domain Sequence
(FASTA)

YDIHQEIGRG AFSYLRRVVE RSSGLEFAAK FIPSQAKPKA SARREARLLA RLQHDCVLYF 60

HEAFERRRGL VIVTELCTEE LLERMARKPT VCESETRTYM RQVLEGIGYL HQSHVLHLDV 120

KPENLLVWDG AGGEEQVRIC DFGNAQELTP GEPQYCQFGT PEFVAPEIVN QSPVSGVTDI 180

WPVGVVAFLC LTGISPFVGE NDRTTLMNIR NYNVAFEETT FLSLSREARG FLIKVLVQDR 240

LRPTAEETLE HPWF 254

Keyword

Alternative promoter usage; Alternative splicing; ATP-binding; Complete proteome; Differentiation; Disulfide bond; Immunoglobulin domain; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0042692	; P:muscle cell differentiation

KEGG

rno:363256

;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR015726	; Ser/Thr_kin_striated_muscle-sp.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07679	; I-set; 8.
PF00069	; Pkinase; 2.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 4.
SM00408	; IGc2; 5.
SM00220	; S_TKc; 2.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 8.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013