Tag | Content |
---|
EKPD ID | EKS-RAN-00227 |
Classification | Group/Family | Score | E-Value | Start | End | Domain Length |
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STE/STE7 | 382.3 | 1.5E-114 | 73 | 369 | 297 |
|
Status | Reviewed |
Ensembl Protein | ENSRNOP00000027272 |
UniProt Accession | P36506; A0JN15; |
Protein Name | Dual specificity mitogen-activated protein kinase kinase 2 |
Protein Synonyms/Alias | MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2; |
Gene Name | Map2k2 |
Gene Synonyms/Alias | Map2k2; Mek2, Mkk2, Prkmk2; |
Ensembl Information | |
Organism | Rattus norvegicus |
Functional Description | Catalyzes the concomitant phosphorylation of a threonineand a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). |
Protein Length | 400 |
Protein Sequence (FASTA) | MLARRKPVLP ALTINPTIAE GPSPTSEGAS EAHLVDLQKK LEELDLDEQQ RKRLEAFLTQ 60 | KAKVGELKDD DFERISELGA GNGGVVTKAR HRPSGLIMAR KLIHLEIKPA VRNQIIRELQ 120 | VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEDIL GKVSIAVLRG 180 | LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ 240 | GTHYSVQSDI WSMGLSLVEL AIGRYPIPPP DAKELEASFG RPVVDGADGE PHSVSPRPRP 300 | PGRPISGHGM DSRPAMAIFE LLDYIVNEPP PKLPSGVFSS DFQEFVNKCL IKNPAERADL 360 | KLLTNHAFIK RSEGEDVDFA GWLCRTLRLK QPSTPTRTAV 400 |
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Nucleotide Sequence (FASTA) | ATGCTGGCCC GGAGGAAGCC GGTGTTACCG GCGCTCACCA TCAACCCTAC CATCGCTGAG 60 | GGCCCGTCCC CCACCAGCGA GGGCGCCTCC GAGGCACACC TGGTGGACCT CCAGAAGAAG 120 | TTGGAAGAGC TGGACCTGGA TGAACAGCAG AGGAAGCGGC TGGAGGCCTT CCTTACCCAG 180 | AAGGCCAAGG TTGGTGAGCT CAAGGACGAC GACTTTGAGA GAATCTCAGA ACTGGGTGCA 240 | GGCAATGGCG GCGTGGTCAC AAAGGCCCGG CATAGGCCCT CTGGCCTCAT CATGGCCAGA 300 | AAGCTGATCC ACCTGGAGAT CAAGCCAGCT GTCCGCAACC AGATCATCCG GGAGCTGCAG 360 | GTGCTGCATG AGTGCAACTC ACCGTACATC GTGGGCTTTT ATGGGGCCTT CTACAGCGAC 420 | GGCGAGATCA GCATCTGCAT GGAGCACATG GACGGTGGCT CACTGGACCA GGTACTGAAG 480 | GAGGCCAAGC GCATTCCCGA GGACATCTTA GGGAAGGTCA GCATTGCGGT GCTCCGGGGC 540 | CTGGCGTACC TCCGCGAGAA GCACCAGATC ATGCATAGAG ATGTGAAGCC CTCCAACATT 600 | CTGGTGAACT CTCGTGGAGA GATTAAGCTG TGCGACTTCG GAGTGAGCGG CCAGTTGATT 660 | GACTCCATGG CCAACTCATT TGTAGGGACA CGCTCCTACA TGTCCCCAGA ACGGCTGCAG 720 | GGCACCCACT ACTCTGTGCA GTCGGACATC TGGAGCATGG GGCTGTCGCT GGTGGAGCTG 780 | GCCATCGGGA GGTACCCCAT CCCCCCACCT GATGCCAAGG AACTAGAGGC CAGCTTTGGC 840 | CGGCCTGTGG TGGACGGGGC AGATGGAGAG CCCCATAGTG TCTCACCGCG GCCCCGGCCC 900 | CCTGGACGCC CCATCAGTGG TCATGGGATG GACAGCCGAC CAGCCATGGC CATCTTTGAG 960 | CTGCTGGACT ACATAGTGAA TGAGCCACCT CCCAAGCTGC CCAGTGGTGT GTTCAGCTCA 1020 | GACTTCCAGG AGTTTGTGAA TAAATGTCTC ATTAAGAACC CAGCAGAGCG TGCAGACCTC 1080 | AAGCTGCTGA CGAACCATGC CTTCATCAAA CGCTCTGAGG GGGAGGACGT GGACTTCGCT 1140 | GGCTGGCTAT GCAGAACCCT GCGGCTGAAG CAGCCCAGCA CACCCACGCG TACTGCAGTG 1200 | TGA 1203 |
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Domain Profile | S: 2 ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv 61 | e+++elGaGnggvV+k++h++sg i+a+K i+leik++ ++qi+rel+vl+++ nspyiv | Q: 73 ERISELGAGNGGVVTKARHRPSGLIMARKLIHLEIKPAVRNQIIRELQVLHEC-NSPYIV 131 | 789**************************************************.****** |
| S: 62 kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek 121 | +fyGaf+s+g++sicme+mdg+sld+vlk+ +kripe++lgk+++av+++l+yl+ek | Q: 132 GFYGAFYSDGEISICMEHMDGGSLDQVLKE----AKRIPEDILGKVSIAVLRGLAYLREK 187 | *****************************9....79************************ |
| S: 122 lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv 181 | ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv | Q: 188 HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV 246 | ******************************************************.***** |
| S: 182 ksdvWslGltlvelatgrypyeklke.................................. 207 | +sd+Ws+Gl+lvela+gryp++++++ | Q: 247 QSDIWSMGLSLVELAIGRYPIPPPDAkeleasfgrpvvdgadgephsvsprprppgrpis 306 | ************************999********************************* |
| S: 208 ...........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkh 256 | i+ell++ivne+ppklp+ fs++fqefv+kCl+k+++eR++lk l++h | Q: 307 ghgmdsrpamaIFELLDYIVNEPPPKLPSGVFSSDFQEFVNKCLIKNPAERADLKLLTNH 366 | ************************************************************ |
| S: 257 afi 259 | afi | Q: 367 AFI 369 | *97 |
|
Domain Sequence (FASTA) | ERISELGAGN GGVVTKARHR PSGLIMARKL IHLEIKPAVR NQIIRELQVL HECNSPYIVG 60 | FYGAFYSDGE ISICMEHMDG GSLDQVLKEA KRIPEDILGK VSIAVLRGLA YLREKHQIMH 120 | RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180 | MGLSLVELAI GRYPIPPPDA KELEASFGRP VVDGADGEPH SVSPRPRPPG RPISGHGMDS 240 | RPAMAIFELL DYIVNEPPPK LPSGVFSSDF QEFVNKCLIK NPAERADLKL LTNHAFI 297 |
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Keyword | Acetylation; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. |
Sequence Source | Ensembl |
Orthology | |
Gene Ontology | |
KEGG | |
InterPros | |
Pfam | |
SMARTs | |
Prosites | |
Prints | |
Created Date | 20-Feb-2013 |