EKS-RAN-00144
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00144
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Csk440.81.4E-132194438245
StatusReviewed
Ensembl ProteinENSRNOP00000027730
UniProt AccessionP41243;
Protein NameMegakaryocyte-associated tyrosine-protein kinase
Protein Synonyms/Alias Protein kinase BATK; Tyrosine-protein kinase CTK;
Gene NameMatk
Gene Synonyms/Alias Matk; Batk, Ctk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000020431ENSRNOP00000027730ENSRNOT00000027730
OrganismRattus norvegicus
Functional DescriptionCould play a significant role in the signal transductionof hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain.
Protein Length467
Protein Sequence
(FASTA)
MPTQRWAPGT QCMTKCENSR PKPGELAFRK GDMVTILEAC EDKSWYRAKH HSSGQEGLLA 60
AAALRQREAL STDPKLSLMP WFHGKISGQE AIQQLQPPED GLFLVRESAR HPGDYVLCVS 120
FGRDVIHYRV LHRDGHLTID EAVCFCNLMD MVEHYTRDKG AICTKLVKPK RKQGAKSAEE 180
ELAKAGWLLD LQHLTLGAQI GEGEFGAVLQ GEYLGQKVAV KNIKCDVTAQ AFLDETAVMT 240
KLQHRNLVRL LGVILHHGLY IVMEHVSKGN LVNFLRTRGR ALVSTSQLLQ FALHVAEGME 300
YLESKKLVHR DLAARNILVS EDLVAKVSDF GLAKAELRKG LDSSRLPVKW TAPEALKNGR 360
FSSKSDVWSF GVLLWEVFSY GRAPYPKMSL KEVSEAVEKG YRMEPPDSCP GPVHTLMGSC 420
WEAEPSRRPP FRKIVEKLGR ELRSVGVAAP AGGQEAEGSA PTRSQDP 467
Nucleotide Sequence
(FASTA)
ATGCCAACGC AACGCTGGGC CCCTGGGACT CAATGTATGA CCAAGTGCGA GAACTCACGC 60
CCCAAGCCCG GTGAGCTAGC CTTTCGAAAG GGTGACATGG TGACCATCTT GGAGGCCTGT 120
GAGGACAAGA GCTGGTACCG AGCCAAGCAC CACAGCAGTG GGCAGGAAGG GCTGCTGGCG 180
GCTGCTGCTC TGCGACAGAG GGAGGCCCTT TCCACAGACC CCAAGCTCAG CCTCATGCCA 240
TGGTTCCATG GCAAGATTTC CGGTCAGGAA GCCATACAGC AGCTGCAGCC ACCCGAGGAT 300
GGGCTGTTCC TCGTGAGGGA ATCGGCCCGT CACCCTGGTG ACTATGTCCT GTGTGTCAGT 360
TTCGGCCGTG ATGTCATCCA CTACCGTGTC TTGCATCGAG ATGGGCACCT CACCATTGAT 420
GAGGCCGTGT GTTTCTGTAA TCTGATGGAC ATGGTAGAGC ACTACACCAG GGACAAGGGC 480
GCCATCTGCA CCAAGCTGGT GAAGCCCAAG AGGAAACAGG GCGCAAAGTC CGCAGAGGAA 540
GAGCTCGCCA AGGCTGGCTG GCTGCTAGAC CTGCAGCATC TGACTCTGGG AGCACAGATT 600
GGAGAGGGAG AGTTTGGAGC CGTCCTGCAG GGCGAGTACT TGGGACAGAA GGTGGCCGTG 660
AAGAATATAA AGTGTGATGT GACAGCCCAG GCCTTCCTGG ATGAGACGGC TGTGATGACA 720
AAGCTGCAGC ACAGGAACCT AGTGCGACTC CTGGGTGTGA TCCTGCACCA CGGCCTGTAC 780
ATTGTCATGG AACACGTGAG CAAGGGCAAC CTGGTGAACT TCCTGCGCAC GCGGGGCCGT 840
GCGCTTGTGA GCACCTCTCA GCTCCTGCAG TTTGCTCTTC ACGTTGCTGA AGGCATGGAG 900
TACCTGGAGA GCAAGAAGCT GGTACACAGG GACCTGGCTG CTCGAAACAT CCTGGTCTCT 960
GAGGACTTAG TGGCCAAGGT CAGTGACTTT GGCCTAGCAA AGGCAGAGCT TAGGAAGGGG 1020
CTGGACTCAA GTCGGCTGCC AGTCAAGTGG ACAGCACCCG AGGCTCTCAA AAATGGGAGG 1080
TTCTCCAGCA AGTCGGATGT CTGGAGTTTT GGGGTGCTAC TGTGGGAAGT CTTCTCATAT 1140
GGAAGAGCCC CATACCCCAA GATGTCGCTA AAGGAGGTTT CAGAGGCTGT GGAGAAGGGT 1200
TACCGCATGG AGCCCCCCGA CAGCTGCCCA GGCCCTGTGC ATACCCTCAT GGGCAGCTGC 1260
TGGGAGGCTG AGCCCTCGCG CAGACCACCG TTCCGCAAAA TAGTGGAGAA GCTGGGTCGT 1320
GAGCTCCGCA GTGTGGGCGT CGCAGCCCCC GCCGGGGGAC AGGAGGCTGA GGGCTCAGCT 1380
CCCACACGGA GCCAGGACCC CTGA 1404
Domain Profile
S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60
         l+lg++ig+gefg+vl+gey g+kvavk+ik+d+taqaflde++vmtkl+h+nlv+llgv
Q: 194   LTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKLQHRNLVRLLGV  253
         6899********************************************************
S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120
         il++ gly+v+e+v+kg+lv++lr+rgral++++qll+fal+vaegmeyleskklvhrdl
Q: 254   ILHH-GLYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLESKKLVHRDL  312
         ***9.*******************************************************
S: 121   aarnvlvsedlvakvsdfglakee.skdldsgklpvkwtapealkekkfstksdvwsfgi  179
         aarn+lvsedlvakvsdfglak+e +k+lds++lpvkwtapealk+++fs+ksdvwsfg+
Q: 313   AARNILVSEDLVAKVSDFGLAKAElRKGLDSSRLPVKWTAPEALKNGRFSSKSDVWSFGV  372
         **********************963789********************************
S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239
         llwe+fs+gr+pyp+++lk+v++avekgy+me+p+ cp+ v++lm ++we+e+++rp+f+
Q: 373   LLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPDSCPGPVHTLMGSCWEAEPSRRPPFR  432
         ************************************************************
S: 240   klkekl  245
         k++ekl
Q: 433   KIVEKL  438
         ***997
Domain Sequence
(FASTA)
LTLGAQIGEG EFGAVLQGEY LGQKVAVKNI KCDVTAQAFL DETAVMTKLQ HRNLVRLLGV 60
ILHHGLYIVM EHVSKGNLVN FLRTRGRALV STSQLLQFAL HVAEGMEYLE SKKLVHRDLA 120
ARNILVSEDL VAKVSDFGLA KAELRKGLDS SRLPVKWTAP EALKNGRFSS KSDVWSFGVL 180
LWEVFSYGRA PYPKMSLKEV SEAVEKGYRM EPPDSCPGPV HTLMGSCWEA EPSRRPPFRK 240
IVEKL 245
KeywordATP-binding; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00138
EKS-CAJ-00151
EKS-CAF-00153
EKS-CAP-00146
EKS-DIO-00081
EKS-EQC-00144
EKS-FEC-00137
EKS-GAG-00122
EKS-GAA-00172
EKS-GOG-00146
EKS-HOS-00151
EKS-ICT-00140
EKS-LAC-00155
EKS-LOA-00145
EKS-MEG-00112
EKS-MOD-00145
EKS-MUM-00150
EKS-MUP-00150
EKS-MYL-00156
EKS-NOL-00139
EKS-ORN-00180
EKS-OTG-00151
EKS-PAT-00136
EKS-PES-00129
EKS-POA-00142
EKS-PRC-00024
EKS-PTV-00138
EKS-SAH-00140
EKS-SUS-00128
EKS-TAG-00173
EKS-TAR-00189
EKS-TEN-00182
EKS-XET-00134
EKS-XIM-00174
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016020; C:membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
KEGG
rno:60450;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013