| Tag | Content |
|---|
| EKPD ID | EKS-RAN-00498 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CAMK/CAMK1 | 381.0 | 3.5E-114 | 42 | 296 | 255 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000027771 |
| UniProt Accession | P13234; A1A5L5; Q63892; |
| Protein Name | Calcium/calmodulin-dependent protein kinase type IV |
| Protein Synonyms/Alias | CaMK IV; CaM kinase-GR; Calspermin; |
| Gene Name | Camk4 |
| Gene Synonyms/Alias | Camk4; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Isoform 1: Calcium/calmodulin-dependent protein kinasethat operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consodilation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteolclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphrylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity). Isoform 2: Heat-stable, acidic, calmodulin-bindingprotein. |
| Protein Length | 474 |
Protein Sequence
(FASTA) | | MLKVTVPSCP SSPCSSVTSS TENLVPDYWI DGSKRDPLSD FFEVESELGR GATSIVYRCK 60 | | QKGTQKPYAL KVLKKTVDKK IVRTEIGVLL RLSHPNIIKL KEIFETPTEI SLVLELVTGG 120 | | ELFDRIVEKG YYSERDAADA VKQILEAVAY LHENGIVHRD LKPENLLYAT PAPDAPLKIA 180 | | DFGLSKIVEH QVLMKTVCGT PGYCAPEILR GCAYGPEVDM WSVGIITYIL LCGFEPFYDE 240 | | RGDQFMFRRI LNCEYYFISP WWDEVSLNAK DLVKKLIVLD PKKRLTTFQA LQHPWVTGKA 300 | | ANFVHMDTAQ KKLQEFNARR KLKAAVKAVV ASSRLGSASS SHTNIQESNK ASSEAQPAQD 360 | | GKDKTDPLEN KMQAGDHEAA KAAADETMKL QSEEVEEEEG VKEEEEEEEE EEETSRMVPQ 420 | | EPEDRLETDD QEMKRNSEET LKSVEEEMDP KAEEEAAAVG LGVPPQQDAI LPEY 474 |
|
Nucleotide Sequence
(FASTA) | | ATGCTCAAAG TCACGGTGCC CTCCTGTCCC TCCTCGCCCT GCTCCTCGGT CACCTCCAGT 60 | | ACTGAGAACC TCGTCCCGGA TTACTGGATC GACGGCTCTA AACGGGATCC TCTGAGCGAT 120 | | TTCTTCGAGG TGGAGTCAGA GCTGGGACGG GGTGCTACAT CCATTGTGTA CAGATGCAAA 180 | | CAGAAGGGGA CCCAGAAGCC CTATGCTCTC AAAGTGTTAA AGAAAACAGT GGACAAGAAG 240 | | ATCGTGAGAA CTGAAATAGG AGTTCTCCTG AGACTCTCAC ACCCGAACAT CATAAAACTC 300 | | AAGGAAATAT TTGAAACCCC CACAGAAATC AGCCTGGTTC TTGAGCTAGT CACAGGAGGA 360 | | GAACTGTTTG ACAGGATTGT GGAGAAAGGC TATTACAGTG AACGCGACGC GGCCGATGCT 420 | | GTGAAGCAGA TCCTGGAGGC AGTTGCTTAC CTGCACGAAA ATGGAATCGT CCATCGCGAC 480 | | CTCAAACCAG AGAATCTTCT TTATGCAACG CCAGCCCCTG ATGCACCACT CAAAATTGCT 540 | | GATTTTGGAC TTTCTAAAAT CGTGGAACAT CAAGTGCTCA TGAAGACGGT GTGTGGAACC 600 | | CCGGGGTACT GTGCACCTGA GATTCTCCGA GGCTGTGCCT ATGGCCCCGA GGTGGACATG 660 | | TGGTCTGTAG GAATAATTAC CTACATCCTA CTTTGTGGAT TTGAACCATT CTATGATGAG 720 | | AGAGGTGATC AGTTCATGTT CAGGAGAATT CTGAATTGTG AATATTACTT TATCTCCCCC 780 | | TGGTGGGATG AAGTTTCTTT AAATGCCAAG GACTTGGTCA AGAAACTCAT TGTTTTGGAC 840 | | CCTAAGAAGC GGCTGACTAC ATTCCAAGCC CTCCAACACC CGTGGGTCAC AGGAAAAGCA 900 | | GCCAACTTTG TCCACATGGA TACCGCTCAG AAAAAGCTTC AAGAATTCAA TGCTAGGCGC 960 | | AAGCTTAAGG CGGCAGTGAA GGCTGTGGTG GCCTCTTCTC GGCTGGGAAG TGCCAGCAGC 1020 | | AGTCACACCA ACATCCAAGA AAGCAACAAA GCCAGCTCGG AGGCACAGCC CGCCCAAGAC 1080 | | GGCAAGGACA AGACAGATCC TCTGGAAAAC AAAATGCAAG CGGGGGACCA CGAGGCAGCC 1140 | | AAGGCTGCAG CCGATGAGAC GATGAAGCTA CAGTCCGAGG AGGTGGAGGA AGAGGAAGGT 1200 | | GTAAAAGAAG AGGAGGAAGA GGAAGAAGAG GAAGAGGAGA CCTCCAGGAT GGTACCTCAG 1260 | | GAGCCAGAGG ACAGGCTGGA GACAGATGAC CAGGAAATGA AGAGAAATTC AGAGGAGACG 1320 | | TTGAAGAGTG TGGAGGAAGA AATGGACCCG AAAGCTGAGG AGGAAGCCGC TGCCGTGGGA 1380 | | CTTGGGGTCC CTCCACAGCA GGATGCTATT CTGCCAGAGT ACTAA 1425 |
|
| Domain Profile | S: 1 yklkeklGeGafsevlkakekktqkavaikvikkkalkgkeesveneiavlkklkhpniv 60 | ++++++lG+Ga+s v+++k+k tqk++a+kv+kk+ +++ v++ei vl +l+hpni+ | Q: 42 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRLSHPNII 98 | 7899******************************98...89******************* |
| S: 61 alkdiyesksklylvlelvtGGelfdrivekgvytekdasevikqvleavkylhelgivh 120 | +lk+i+e++++++lvlelvtGGelfdrivekg+y+e+da++ +kq+leav+ylhe+givh | Q: 99 KLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVH 158 | ************************************************************ |
| S: 121 rdlkPenllylskeedskikiadfGlskleeke.llktacGtvgyvapevlkqkkyskkv 179 | rdlkPenlly++++ d+++kiadfGlsk+ e++ l+kt+cGt+gy+ape+l+ ++y+ +v | Q: 159 RDLKPENLLYATPAPDAPLKIADFGLSKIVEHQvLMKTVCGTPGYCAPEILRGCAYGPEV 218 | ****************************9999989************************* |
| S: 180 dvWsiGvityillcGyppfydekeekl.lekilkgeyefesPyWdeisesakdfikklle 238 | d+Ws+G+ityillcG++pfyde+ +++ +++il++ey+f sP+Wde+s +akd++kkl+ | Q: 219 DMWSVGIITYILLCGFEPFYDERGDQFmFRRILNCEYYFISPWWDEVSLNAKDLVKKLIV 278 | ***********************9998789****************************** |
| S: 239 ldpekrytieqaledpWi 256 | ldp+kr+t+ qal++pW+ | Q: 279 LDPKKRLTTFQALQHPWV 296 | *****************7 |
|
Domain Sequence
(FASTA) | | FEVESELGRG ATSIVYRCKQ KGTQKPYALK VLKKTVDKKI VRTEIGVLLR LSHPNIIKLK 60 | | EIFETPTEIS LVLELVTGGE LFDRIVEKGY YSERDAADAV KQILEAVAYL HENGIVHRDL 120 | | KPENLLYATP APDAPLKIAD FGLSKIVEHQ VLMKTVCGTP GYCAPEILRG CAYGPEVDMW 180 | | SVGIITYILL CGFEPFYDER GDQFMFRRIL NCEYYFISPW WDEVSLNAKD LVKKLIVLDP 240 | | KKRLTTFQAL QHPWV 255 |
|
| Keyword | Acetylation; Adaptive immunity; Alternative promoter usage; Alternative splicing; ATP-binding; Calcium; Calmodulin-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Immunity; Inflammatory response; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
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| Created Date | 20-Feb-2013 |