EKS-RAN-00410
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00410
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl550.38.2E-166521786266
StatusUnreviewed
Ensembl ProteinENSRNOP00000028132
UniProt AccessionE9PSY0;
Protein Name
Protein Synonyms/Alias Protein Axl;
Gene NameAxl
Gene Synonyms/Alias Axl;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000020716ENSRNOP00000028132ENSRNOT00000028132
ENSRNOG00000020716ENSRNOP00000028131ENSRNOT00000028131
OrganismRattus norvegicus
Functional Description
Protein Length879
Protein Sequence
(FASTA)
MGRVPLAWCV ALCCWGCAAP KDTQTEADSP FVGNPGNITG ARGLTGTLRC ELQVQGEPPE 60
VMWLRDGQIL ELADNTQTQV PLGEDWQDEW KVVSQLRISA LQLSDAGEYQ CMVHLEGRTF 120
VSQPGFVGLE GLPYFLEEPE DKAVPANTPF NLSCQAQGPP EPVTLLWLQD AVPLAPVAGY 180
SFQHSLQAPG LNKTSSFSCE AHNAKGVTTS RTATITVLPQ RPHNLHVVSR HPTELEVAWI 240
PSLSGIYPLT HCTLQAVLSD DGVGVWLGES DPPEEPLTVQ VSVPPHQLRL EKLLPHTPYH 300
IRVSCTSSQG PSPWTHWLPV ETTEGVPLGP PENVSAMRNG SQALVRWQEP REPLQGTLLG 360
YRLAYRGQDT PEVLMDIGLT REVTLELRGD RPVANLTVSV AAYTSAGDGP WSLPVPLEPW 420
RPVSEPPPPA FSWPWWYVLL GALVAAACVL ILTLFLVHRR KKETRYGEVF EPTVERGELV 480
VRYRARKSYS RRTTEATLNS LGISEELKEK LRDVMVDRHK VALGKTLGEG EFGAVMEGQL 540
NQDDSILKVA VKTMKIAICT RSELEDFLSE AVCMKEFDHP NVMRLIGVCF QGSDREGFPE 600
PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD IASGMEYLST KRFIHRDLAA 660
RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW IAIESLADRV YTSKSDVWSF 720
GVTMWEIATR GQTPYPGVEN SEIYDYLRQG NRLKQPLDCL DGLYALMSRC WELNPRDRPS 780
FAELREDLEN TLKALPPAQE PDEILYVNMD EGGSHLEPRG AAGGADPPTQ PDPKDSCSCL 840
TEADVHSAGR YVLCPSTAPG PTLSADRGCP APPGQEDGA 879
Nucleotide Sequence
(FASTA)
ATGGGCAGGG TCCCGCTGGC CTGGTGCGTG GCGCTGTGCT GCTGGGGGTG TGCAGCTCCT 60
AAGGACACAC AGACCGAGGC TGACAGCCCA TTCGTGGGGA ACCCAGGGAA TATCACGGGT 120
GCCAGAGGAC TCACAGGGAC CCTTCGGTGT GAGCTCCAGG TTCAGGGGGA GCCCCCTGAG 180
GTGATGTGGC TTCGAGATGG ACAGATCCTA GAACTGGCTG ATAACACCCA GACCCAGGTG 240
CCTCTGGGCG AAGACTGGCA AGATGAATGG AAAGTCGTCA GTCAGCTCAG AATCTCAGCC 300
CTGCAACTTT CAGATGCAGG AGAGTACCAG TGTATGGTGC ACCTGGAAGG ACGGACCTTT 360
GTGTCTCAGC CTGGCTTTGT AGGACTGGAA GGTCTCCCAT ACTTCCTGGA GGAACCTGAA 420
GACAAAGCTG TGCCTGCCAA CACCCCCTTC AACCTAAGCT GCCAGGCCCA GGGACCCCCG 480
GAACCCGTGA CCCTGCTCTG GCTTCAAGAT GCTGTCCCTC TGGCCCCAGT CGCAGGATAC 540
AGCTTTCAGC ACAGTTTGCA AGCTCCAGGC CTGAACAAGA CATCTTCTTT CTCATGTGAA 600
GCCCACAATG CCAAGGGAGT CACCACCTCC CGCACAGCTA CCATCACAGT GCTCCCACAG 660
AGACCTCACA ATCTCCACGT GGTTTCCAGA CATCCCACGG AGCTAGAGGT AGCTTGGATC 720
CCTAGCCTGA GTGGCATCTA CCCGCTCACC CACTGCACCC TGCAGGCTGT GCTGTCAGAC 780
GATGGGGTGG GCGTCTGGCT GGGAGAGTCA GATCCTCCAG AAGAGCCCCT CACGGTGCAA 840
GTATCAGTGC CCCCCCACCA GCTTCGGCTG GAAAAGCTCC TTCCTCACAC CCCATATCAC 900
ATCCGGGTAT CCTGCACTAG CAGCCAGGGC CCCTCACCTT GGACCCACTG GCTTCCTGTG 960
GAGACCACGG AGGGAGTGCC CTTGGGTCCC CCTGAGAACG TTAGCGCCAT GCGGAATGGG 1020
AGCCAGGCCC TCGTGCGTTG GCAGGAGCCA AGGGAGCCCT TGCAGGGCAC CCTGTTAGGG 1080
TACCGGCTGG CATATCGAGG CCAGGACACC CCCGAGGTAC TTATGGATAT AGGGCTAACT 1140
CGAGAGGTGA CCTTGGAACT TCGGGGGGAC AGGCCTGTGG CTAACCTGAC TGTGTCTGTG 1200
GCAGCCTATA CCTCAGCTGG GGATGGGCCC TGGAGCCTTC CTGTGCCCCT AGAGCCCTGG 1260
CGCCCAGTGA GTGAACCCCC ACCTCCCGCC TTCTCGTGGC CTTGGTGGTA TGTACTGCTG 1320
GGAGCACTTG TGGCCGCCGC CTGTGTCCTT ATCTTGACCC TGTTCCTTGT CCATCGGAGG 1380
AAGAAGGAGA CGAGATATGG GGAGGTGTTC GAGCCAACTG TGGAAAGGGG TGAACTGGTA 1440
GTCAGGTACC GTGCCCGAAA GTCCTACAGT CGCCGGACCA CGGAAGCCAC CTTGAACAGT 1500
CTGGGCATCA GCGAAGAGCT GAAGGAGAAA CTACGAGACG TCATGGTAGA TCGGCATAAG 1560
GTGGCCTTGG GGAAGACCCT GGGAGAAGGA GAATTTGGTG CTGTGATGGA GGGCCAGCTC 1620
AACCAGGATG ACTCCATCCT CAAGGTCGCT GTGAAGACCA TGAAAATTGC CATCTGCACA 1680
AGATCAGAGC TGGAGGATTT CCTGAGTGAA GCTGTCTGCA TGAAGGAATT TGACCACCCC 1740
AACGTCATGA GGCTCATTGG CGTCTGTTTC CAGGGTTCTG ACCGAGAGGG TTTCCCAGAA 1800
CCGGTGGTCA TCTTGCCTTT CATGAAACAT GGAGACCTCC ACAGTTTCCT CCTGTACTCG 1860
CGGCTCGGGG ACCAGCCAGT GTTCCTGCCC ACTCAGATGC TAGTGAAGTT TATGGCCGAC 1920
ATTGCCAGTG GCATGGAGTA CCTCAGTACC AAGAGATTCA TACACCGGGA CCTAGCTGCC 1980
AGGAACTGCA TGCTGAATGA GAACATGTCC GTGTGCGTGG CAGACTTCGG GCTCTCCAAG 2040
AAGATCTACA ATGGGGATTA CTACCGCCAA GGGCGCATTG CCAAGATGCC AGTCAAGTGG 2100
ATTGCTATCG AGAGTCTGGC AGATCGAGTC TACACCAGCA AGAGTGACGT GTGGTCCTTC 2160
GGTGTGACAA TGTGGGAGAT CGCCACCCGA GGCCAAACTC CCTATCCTGG GGTGGAGAAC 2220
AGTGAGATTT ACGACTACCT ACGTCAAGGA AATCGCCTGA AACAGCCTCT GGACTGTCTG 2280
GATGGCCTCT ATGCCCTGAT GTCCCGGTGC TGGGAGCTGA ACCCTCGAGA CCGGCCAAGT 2340
TTTGCAGAGC TCCGGGAAGA CTTGGAGAAC ACATTGAAGG CTCTACCCCC TGCTCAGGAG 2400
CCTGATGAAA TCCTCTACGT CAACATGGAT GAGGGCGGAA GTCACCTTGA ACCCCGTGGT 2460
GCTGCTGGAG GAGCTGACCC CCCAACTCAA CCCGATCCTA AGGATTCCTG TAGCTGTCTC 2520
ACTGAAGCTG ACGTCCATTC GGCTGGACGC TATGTCCTCT GTCCTTCTAC AGCCCCAGGA 2580
CCCACTCTGT CTGCTGACAG AGGCTGCCCA GCACCTCCAG GGCAGGAGGA CGGAGCCTGA 2640
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lgk+lgegefg+vmegql+q+d silkvavkt+k++i++rse+e+flsea+cmkefdh
Q: 521   VALGKTLGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDH  579
         68**********************.***********************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnv+rl+gv++++s+++ +p+pvvilpfmk+gdlh+fllysrlg++pv+lp+q+lvkfm+
Q: 580   PNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHSFLLYSRLGDQPVFLPTQMLVKFMA  639
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         diasgmeyls+++fihrdlaarncml+e+m+vcvadfglskkiy+gdyyrqgriak+pvk
Q: 640   DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK  699
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvw+fgvtmweiatrgqtpy+gven+eiydyl+qgnrlkqp dc
Q: 700   WIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPLDC  759
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlre  267
         ld+ly+lm+rcwe++p+drpsf++lre
Q: 760   LDGLYALMSRCWELNPRDRPSFAELRE  786
         *************************96
Domain Sequence
(FASTA)
VALGKTLGEG EFGAVMEGQL NQDDSILKVA VKTMKIAICT RSELEDFLSE AVCMKEFDHP 60
NVMRLIGVCF QGSDREGFPE PVVILPFMKH GDLHSFLLYS RLGDQPVFLP TQMLVKFMAD 120
IASGMEYLST KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWSF GVTMWEIATR GQTPYPGVEN SEIYDYLRQG NRLKQPLDCL 240
DGLYALMSRC WELNPRDRPS FAELRE 266
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00371
EKS-ANC-00385
EKS-BOT-00398
EKS-CAJ-00402
EKS-CAP-00425
EKS-CII-00235
EKS-EQC-00386
EKS-GAA-00486
EKS-GOG-00386
EKS-HOS-00402
EKS-ICT-00374
EKS-LAC-00413
EKS-LOA-00405
EKS-MAM-00398
EKS-MOD-00383
EKS-MUM-00431
EKS-MUP-00391
EKS-MYL-00394
EKS-ORN-00509
EKS-ORC-00373
EKS-ORL-00466
EKS-OTG-00401
EKS-PAT-00376
EKS-PEM-00218
EKS-POA-00389
EKS-SAH-00366
EKS-TAR-00500
EKS-TEN-00498
EKS-XET-00509
EKS-XIM-00501
Gene Ontology
GO:0009986; C:cell surface
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0001786; F:phosphatidylserine binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0001974; P:blood vessel remodeling
GO:0048469; P:cell maturation
GO:0031668; P:cellular response to extracellular stimulus
GO:0035457; P:cellular response to interferon-alpha
GO:0071222; P:cellular response to lipopolysaccharide
GO:0097028; P:dendritic cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0034101; P:erythrocyte homeostasis
GO:0021885; P:forebrain cell migration
GO:0006954; P:inflammatory response
GO:0001779; P:natural killer cell differentiation
GO:2000669; P:negative regulation of dendritic cell apoptotic process
GO:0032689; P:negative regulation of interferon-gamma production
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0001764; P:neuron migration
GO:0042698; P:ovulation cycle
GO:0030168; P:platelet activation
GO:0001961; P:positive regulation of cytokine-mediated signaling pathway
GO:0032825; P:positive regulation of natural killer cell differentiation
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013