EPS-RAN-00059
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-RAN-00059
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/PTEN300.85.5E-9014185172
StatusUnreviewed
Ensembl ProteinENSRNOP00000028143
UniProt AccessionO54857;
Protein Name
Protein Synonyms/Alias Phosphatase and tensin homolog, isoform CRA_a; Protein Pten; Protein tyrosine phosphatase and tensin homolog/mutated in multiple advanced cancers protein; Protein tyrosine phosphatase and tensin-like protein;
Gene NamePten
Gene Synonyms/Alias Pten; PTEN/MMAC1; rCG_47874;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000020723ENSRNOP00000028143ENSRNOT00000028143
OrganismRattus norvegicus
Functional Description
Protein Length403
Protein Sequence
(FASTA)
MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK 60
HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA 120
AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY 180
LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKLMY 240
FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI 300
DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS 360
SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHSQI TKV 403
Nucleotide Sequence
(FASTA)
ATGACAGCCA TCATCAAAGA GATCGTTAGC AGAAACAAAA GGAGATATCA AGAGGATGGA 60
TTCGACTTAG ACTTGACCTA TATTTATCCA AATATTATTG CTATGGGATT TCCTGCAGAA 120
AGACTTGAAG GTGTATACAG GAACAATATT GATGATGTAG TAAGGTTTTT GGATTCAAAG 180
CATAAAAACC ATTACAAGAT ATACAATCTA TGTGCTGAGA GACATTATGA CACCGCCAAA 240
TTTAACTGCA GAGTTGCACA GTATCCTTTT GAAGACCATA ACCCACCACA GCTAGAACTT 300
ATCAAACCCT TTTGTGAAGA TCTTGACCAA TGGCTAAGTG AAGACGACAA TCATGTTGCA 360
GCAATTCACT GTAAAGCTGG GAAAGGACGG ACTGGTGTAA TGATTTGTGC ATATTTATTG 420
CATCGGGGCA AGTTTTTAAA GGCACAAGAG GCCCTGGATT TTTATGGGGA AGTAAGGACC 480
AGAGATAAAA AGGGAGTAAC TATTCCCAGT CAGAGGCGCT ATGTATATTA TTATAGCTAC 540
CTGTTAAAGA ATCACCTGGA TTACAGACCA GTGGCACTGT TGTTTCACAA GATGATGTTT 600
GAAACTATTC CAATGTTCAG TGGCGGAACT TGCAATCCCC AGTTTGTGGT CTGCCAGCTA 660
AAGGTGAAGA TCTACTCCTC CAACTCAGGA CCCACGCGGC GGGAGGACAA GCTCATGTAC 720
TTTGAGTTCC CTCAGCCATT GCCTGTGTGT GGTGACATCA AAGTAGAGTT CTTCCACAAA 780
CAGAACAAGA TGCTCAAAAA GGACAAAATG TTTCACTTTT GGGTAAATAC GTTCTTCATA 840
CCAGGACCAG AGGAAACCTC AGAAAAAGTG GAAAATGGAA GTCTTTGTGA TCAGGAAATC 900
GATAGCATTT GTAGTATAGA GCGTGCGGAT AATGACAAGG AGTATCTTGT GCTCACCCTG 960
ACAAAAAATG ATCTTGACAA AGCAAACAAA GACAAGGCCA ACCGATACTT CTCTCCAAAT 1020
TTTAAGGTGA AATTATACTT TACAAAAACA GTAGAGGAAC CATCAAATCC AGAGGCTAGC 1080
AGTTCAACTT CTGTGACTCC AGACGTTAGT GACAATGAAC CTGATCATTA TAGATATTCT 1140
GACACCACTG ACTCTGATCC AGAGAATGAA CCTTTTGATG AAGATCAGCA TTCACAAATT 1200
ACAAAAGTCT GA 1212
Domain Profile
S: 1     rrltedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcse  60
         rr++edgfdldlty++++iia++fPae+ e+vyrnn+++vvr+ldskh+n+yk+ynlc+e
Q: 14    RRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAE  73
         79**********************************************************
S: 61    rrydltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGv  120
         r+yd++k+n++va++++ed+n+P+le ++++c++ld+Wlsedd++v+++hck+gkgr+Gv
Q: 74    RHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGV  133
         ************************************************************
S: 121   ivcayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkgs  174
         ++cayll++++++ka+eald++ge+rtr++k  gv++Psqrryv+y+s+llk++
Q: 134   MICAYLLHRGKFLKAQEALDFYGEVRTRDKK--GVTIPSQRRYVYYYSYLLKNH  185
         *******************************..******************986
Domain Sequence
(FASTA)
RRYQEDGFDL DLTYIYPNII AMGFPAERLE GVYRNNIDDV VRFLDSKHKN HYKIYNLCAE 60
RHYDTAKFNC RVAQYPFEDH NPPQLELIKP FCEDLDQWLS EDDNHVAAIH CKAGKGRTGV 120
MICAYLLHRG KFLKAQEALD FYGEVRTRDK KGVTIPSQRR YVYYYSYLLK NH 172
Keyword3D-structure; Complete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EPS-AIM-00070
EPS-ANC-00070
EPS-BOT-00060
EPS-CAE-00090
EPS-CAJ-00060
EPS-CAF-00075
EPS-CAP-00056
EPS-CHH-00018
EPS-CII-00031
EPS-CIS-00020
EPS-DAR-00103
EPS-DIO-00023
EPS-DRM-00027
EPS-EQC-00058
EPS-ERE-00015
EPS-FEC-00070
EPS-GAM-00057
EPS-GAG-00064
EPS-GAA-00095
EPS-GOG-00071
EPS-HOS-00056
EPS-ICT-00059
EPS-LAC-00074
EPS-LOA-00054
EPS-MAM-00059
EPS-MEG-00066
EPS-MOD-00058
EPS-MUM-00056
EPS-MYL-00058
EPS-NOL-00066
EPS-ORN-00073
EPS-ORA-00063
EPS-ORC-00054
EPS-ORL-00083
EPS-OTG-00058
EPS-PAT-00053
EPS-PES-00071
EPS-POA-00072
EPS-SAH-00057
EPS-SUS-00058
EPS-TAG-00068
EPS-TAR-00092
EPS-TAS-00020
EPS-TEN-00069
EPS-VIP-00021
EPS-XET-00068
EPS-XIM-00102
EPS-SCP-00017
Gene Ontology
GO:0042995; C:cell projection
GO:0005737; C:cytoplasm
GO:0009898; C:internal side of plasma membrane
GO:0035749; C:myelin sheath adaxonal region
GO:0005634; C:nucleus
GO:0043220; C:Schmidt-Lanterman incisure
GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287; F:magnesium ion binding
GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438; F:phosphatidylinositol-3-phosphatase activity
GO:0004722; F:protein serine/threonine phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0007092; P:activation of mitotic anaphase-promoting complex activity
GO:0001525; P:angiogenesis
GO:0060070; P:canonical Wnt receptor signaling pathway
GO:0048738; P:cardiac muscle tissue development
GO:0032286; P:central nervous system myelin maintenance
GO:0021955; P:central nervous system neuron axonogenesis
GO:0060997; P:dendritic spine morphogenesis
GO:0021542; P:dentate gyrus development
GO:0043542; P:endothelial cell migration
GO:0048853; P:forebrain morphogenesis
GO:0006917; P:induction of apoptosis
GO:0046855; P:inositol phosphate dephosphorylation
GO:0007611; P:learning or memory
GO:0045475; P:locomotor rhythm
GO:0060291; P:long-term synaptic potentiation
GO:0060179; P:male mating behavior
GO:0042711; P:maternal behavior
GO:0033555; P:multicellular organismal response to stress
GO:0043066; P:negative regulation of apoptotic process
GO:0050771; P:negative regulation of axonogenesis
GO:0090344; P:negative regulation of cell aging
GO:0030336; P:negative regulation of cell migration
GO:0045792; P:negative regulation of cell size
GO:0031658; P:negative regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0061002; P:negative regulation of dendritic spine morphogenesis
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential
GO:0051895; P:negative regulation of focal adhesion assembly
GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle
GO:0031642; P:negative regulation of myelination
GO:0046621; P:negative regulation of organ growth
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0090071; P:negative regulation of ribosome biogenesis
GO:2000808; P:negative regulation of synaptic vesicle clustering
GO:0007270; P:neuron-neuron synaptic transmission
GO:0046856; P:phosphatidylinositol dephosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:2000463; P:positive regulation of excitatory postsynaptic membrane potential
GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0097107; P:postsynaptic density assembly
GO:0060134; P:prepulse inhibition
GO:0097105; P:presynaptic membrane assembly
GO:0060736; P:prostate gland growth
GO:0043491; P:protein kinase B signaling cascade
GO:0050821; P:protein stabilization
GO:0002902; P:regulation of B cell apoptotic process
GO:0033032; P:regulation of myeloid cell apoptotic process
GO:0060024; P:rhythmic synaptic transmission
GO:0035176; P:social behavior
GO:0060074; P:synapse maturation
KEGG
rno:50557;
InterPros
IPR017361; Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR014019; Phosphatase_tensin-typ.
IPR014020; Tensin_phosphatase_C2-dom.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
PF10409; PTEN_C2; 1.
SMARTs
Prosites
PS51182; C2_TENSIN; 1.
PS51181; PPASE_TENSIN; 1.
PS00383; TYR_PHOSPHATASE_1; 1.
Prints
Created Date20-Feb-2013