EKS-RAN-00391
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00391
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK347.55.8E-104120377258
StatusReviewed
Ensembl ProteinENSRNOP00000028185
UniProt AccessionQ66HA1; Q80YF1;
Protein NameMitogen-activated protein kinase kinase kinase 11
Protein Synonyms/Alias Mixed lineage kinase 3;
Gene NameMap3k11
Gene Synonyms/Alias Map3k11; Mlk3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000020773ENSRNOP00000028185ENSRNOT00000028185
OrganismRattus norvegicus
Functional DescriptionActivates the JUN N-terminal pathway. Required forserum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity).
Protein Length850
Protein Sequence
(FASTA)
MEPLKNLFLK SPLGSWNGSG SGGGGGSGGV RPEGSPKATA AYANPVWTAL FDYEPNGQDE 60
LALRKGDRVE VLSRDAAISG DEGWWAGQVG GQVGIFPSNY VSRGGGPPPC EVASFQELRL 120
EEVIGIGGFG KVYRGSWRGE LVAVKAARQD PDEDISVTAE SVRQEARLFA MLAHPNIIAL 180
KAVCLEEPNL CLVMEYAAGG PLSRALAGRR VPPHVLVNWA VQIARGMHYL HCEALVPVIH 240
RDLKSNNILL LQPIEGDDME HKTLKITDFG LAREWHKTTQ MSAAGTYAWM APEVIKASTF 300
SKGSDVWSFG VLLWELLTGE VPYRGIDCLA VAYGVAVNKL TLPIPSTCPE PFAQLMADCW 360
AQDPHRRPDF ASILQQLEAL EAQVLREMPR DSFHSMQEGW KREIQGLFDE LRAKEKELLS 420
REEELTRAAR EQRSQAEQLR RREHLLAQWE LEVFERELTL LLQQVDRERP HVRRRRGTFK 480
RSKLRARDGG ERISMPLDFK HRITVQASPG LDRRRNVFEV GAGDSPTFPR FRAIQLEPAE 540
SGQTWGRQSP RRLDDSSNGE RRACWAWGPS SPKPGEAQNG RRRSRMDEAT WYLDSDDSSP 600
LGSPSTPPAL NGNPPRPSPE PEEPRRSGPT ERGNSSGTPK LIQRALLRGT ALLASLGLGR 660
DLQPPGGLSR ERGESPTAPP PAQMASPCPP DLPSTPLIHL SQATPDARGP LTPAPLLLDL 720
GVSSGQPSAK SPRREETRGR TVSPPPGISR SAPGTPGTPR SPPLGLISRP RPSPLRNRID 780
PWSFVSAGPR PSPLPSPQPA PRRAPWTLFP DSDPFWDSPP ANPFRGGSQD CRTQTKDVGA 840
QAPWAPEAGP 850
Nucleotide Sequence
(FASTA)
ATGGAGCCCT TGAAGAACCT CTTCCTCAAG AGCCCGCTGG GGTCATGGAA CGGCAGTGGC 60
AGTGGGGGCG GTGGGGGTTC TGGTGGAGTC CGGCCAGAGG GGTCCCCGAA GGCAACAGCA 120
GCTTATGCCA ACCCTGTCTG GACAGCCCTG TTCGACTATG AGCCCAATGG GCAGGACGAA 180
CTAGCCCTGA GGAAGGGCGA CCGTGTGGAG GTGCTGTCCA GGGATGCAGC CATCTCAGGA 240
GATGAAGGCT GGTGGGCGGG CCAGGTGGGT GGCCAGGTGG GCATTTTTCC ATCCAACTAT 300
GTATCTCGGG GTGGAGGCCC ACCCCCCTGT GAGGTGGCCA GCTTCCAGGA GCTGCGACTG 360
GAGGAGGTGA TCGGCATCGG TGGCTTCGGC AAGGTCTACC GTGGCAGCTG GCGAGGGGAG 420
CTGGTGGCTG TGAAAGCAGC TCGACAGGAT CCTGATGAGG ACATCAGTGT AACAGCTGAG 480
AGTGTTCGAC AGGAGGCCCG GCTTTTTGCC ATGCTGGCAC ATCCCAACAT CATTGCCCTC 540
AAAGCTGTGT GCCTGGAGGA GCCAAACCTA TGCCTGGTGA TGGAGTATGC AGCTGGTGGA 600
CCTCTTAGCC GTGCCCTGGC TGGTCGGCGG GTGCCCCCCC ATGTGCTGGT CAACTGGGCT 660
GTGCAGATTG CCCGAGGGAT GCACTACCTG CACTGTGAGG CTCTAGTGCC TGTGATACAC 720
CGAGACCTGA AGTCCAACAA CATTCTGCTG CTGCAGCCCA TTGAAGGTGA CGACATGGAG 780
CACAAGACCC TAAAGATTAC TGACTTTGGC CTCGCCCGAG AGTGGCACAA AACCACACAG 840
ATGAGTGCTG CGGGGACCTA TGCGTGGATG GCTCCTGAGG TTATCAAGGC ATCTACCTTC 900
TCCAAGGGCA GCGATGTCTG GAGCTTTGGG GTGCTGCTGT GGGAACTGCT GACTGGGGAG 960
GTACCCTACC GTGGTATCGA CTGTCTTGCG GTAGCCTATG GTGTGGCTGT AAACAAGTTA 1020
ACATTACCCA TCCCATCCAC TTGCCCTGAG CCCTTCGCAC AACTCATGGC TGACTGCTGG 1080
GCACAGGACC CCCACCGCAG GCCCGACTTC GCCTCCATCC TGCAGCAGTT GGAAGCTCTA 1140
GAGGCTCAGG TGCTGAGGGA GATGCCACGG GACTCCTTCC ATTCCATGCA GGAGGGCTGG 1200
AAACGCGAGA TCCAGGGCCT TTTTGATGAG CTGCGGGCCA AGGAAAAGGA ACTACTGAGC 1260
CGCGAGGAGG AACTGACGCG CGCAGCACGC GAGCAGCGGT CCCAGGCAGA GCAGCTGCGA 1320
CGGCGCGAGC ACCTGCTGGC GCAGTGGGAG CTGGAGGTGT TCGAGCGCGA GCTGACACTG 1380
CTGCTACAGC AGGTGGACCG AGAACGGCCA CACGTGCGCC GCCGACGCGG CACCTTCAAG 1440
CGGAGCAAGC TCCGAGCGAG GGATGGCGGA GAACGCATCA GCATGCCCCT GGACTTCAAA 1500
CATCGCATCA CTGTGCAGGC CTCTCCAGGA CTTGACCGGA GGAGAAATGT GTTCGAGGTT 1560
GGGGCTGGGG ACTCGCCCAC CTTCCCTCGG TTCCGAGCTA TCCAGTTGGA ACCTGCAGAA 1620
TCAGGCCAGA CTTGGGGTCG CCAGTCCCCT AGACGTCTTG ACGATTCAAG CAATGGAGAG 1680
AGGCGTGCTT GCTGGGCCTG GGGTCCCAGT TCCCCCAAGC CTGGGGAGGC CCAGAATGGG 1740
AGGAGAAGGT CCCGCATGGA TGAAGCCACG TGGTACCTAG ATTCAGATGA CTCATCCCCA 1800
TTAGGGTCTC CTTCTACTCC CCCAGCACTC AACGGTAATC CTCCAAGGCC TAGCCCTGAG 1860
CCAGAGGAGC CACGGCGGTC TGGGCCCACA GAACGGGGCA ATAGCTCTGG GACGCCTAAA 1920
CTGATCCAAC GTGCATTGCT CCGGGGGACC GCTCTGCTGG CTTCCCTAGG CCTTGGCCGA 1980
GACCTGCAGC CTCCAGGAGG CCTGAGCCGT GAACGTGGAG AGTCCCCGAC AGCACCACCC 2040
CCTGCACAGA TGGCTTCACC CTGTCCACCT GACCTGCCCT CCACCCCGCT CATCCACCTC 2100
TCACAAGCAA CACCTGATGC CCGTGGACCA CTCACCCCTG CACCCTTATT GCTGGACCTA 2160
GGTGTTTCCT CTGGCCAGCC ATCAGCCAAG AGCCCTCGGC GGGAAGAGAC ACGTGGAAGA 2220
ACTGTTTCAC CTCCACCAGG AATATCACGC TCTGCTCCTG GCACCCCTGG AACCCCTCGC 2280
TCACCACCTT TGGGCCTCAT CAGCCGACCT CGGCCATCAC CACTCCGTAA CCGTATTGAC 2340
CCATGGAGCT TCGTGTCAGC TGGGCCACGG CCTTCACCCC TGCCCTCTCC ACAGCCTGCA 2400
CCCCGACGGG CACCATGGAC CTTATTCCCA GACTCAGATC CCTTCTGGGA CTCCCCACCT 2460
GCCAACCCCT TCCGGGGAGG CTCCCAGGAC TGCAGGACGC AGACCAAAGA TGTGGGTGCT 2520
CAGGCGCCAT GGGCACCAGA AGCAGGGCCC TGA 2553
Domain Profile
S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60
         lee+ig g fgkvy+++wr++ vavK++r++  e  + ++e++++ea+l+++l+hpnii+
Q: 120   LEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEdiSVTAESVRQEARLFAMLAHPNIIA  179
         789****************************99988999*********************
S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120
         l++vcleepnl+lvmey++gg Ls++l++   r+++++vlv+wa+qiArGm+YLh ea +
Q: 180   LKAVCLEEPNLCLVMEYAAGGPLSRALAG---RRVPPHVLVNWAVQIARGMHYLHCEALV  236
         *****************************...9***************************
S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173
         ++ihrdLks+n+Ll       ++e+ktlki+dFG are++k+t+msaagt+awmaPEv+k
Q: 237   PVIHRDLKSNNILLlqpiegdDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIK  296
         *********************9**************************************
S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233
         ++++s+ sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++Lm
Q: 297   ASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLM  356
         ************************************************************
S: 234   kecwnedpekRpsfseivksl  254
          +cw++dp++Rp+f++i+++l
Q: 357   ADCWAQDPHRRPDFASILQQL  377
         *****************9986
Domain Sequence
(FASTA)
LEEVIGIGGF GKVYRGSWRG ELVAVKAARQ DPDEDISVTA ESVRQEARLF AMLAHPNIIA 60
LKAVCLEEPN LCLVMEYAAG GPLSRALAGR RVPPHVLVNW AVQIARGMHY LHCEALVPVI 120
HRDLKSNNIL LLQPIEGDDM EHKTLKITDF GLAREWHKTT QMSAAGTYAW MAPEVIKAST 180
FSKGSDVWSF GVLLWELLTG EVPYRGIDCL AVAYGVAVNK LTLPIPSTCP EPFAQLMADC 240
WAQDPHRRPD FASILQQL 258
KeywordATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; SH3 domain; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00376
EKS-CAJ-00383
EKS-CAF-00376
EKS-CAP-00409
EKS-DIO-00059
EKS-EQC-00374
EKS-FEC-00364
EKS-GAA-00460
EKS-GOG-00367
EKS-HOS-00383
EKS-ICT-00356
EKS-LAC-00397
EKS-LOA-00385
EKS-MAM-00375
EKS-MOD-00366
EKS-MUM-00408
EKS-MUP-00370
EKS-MYL-00374
EKS-NOL-00344
EKS-ORN-00483
EKS-ORC-00352
EKS-ORL-00446
EKS-OTG-00378
EKS-PAT-00356
EKS-PES-00335
EKS-POA-00366
EKS-PTV-00099
EKS-SAH-00352
EKS-TAR-00479
EKS-TEN-00477
EKS-XIM-00473
Gene Ontology
GO:0005813; C:centrosome
GO:0005874; C:microtubule
GO:0005524; F:ATP binding
GO:0004706; F:JUN kinase kinase kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0007257; P:activation of JUN kinase activity
GO:0008219; P:cell death
GO:0008283; P:cell proliferation
GO:0000080; P:G1 phase of mitotic cell cycle
GO:0007017; P:microtubule-based process
GO:0046330; P:positive regulation of JNK cascade
GO:0043525; P:positive regulation of neuron apoptotic process
GO:0046777; P:protein autophosphorylation
KEGG
rno:309168;
InterPros
IPR011009; Kinase-like_dom.
IPR016231; MAPKKK9/10/11.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR011511; SH3_2.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF07653; SH3_2; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013