EKS-RAN-00161
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00161
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb425.68.5E-128415674260
StatusUnreviewed
Ensembl ProteinENSRNOP00000028678
UniProt AccessionD3ZSB7;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameCcdc88b
Gene Synonyms/Alias Ccdc88b;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000021117ENSRNOP00000028678ENSRNOT00000028678
OrganismRattus norvegicus
Functional Description
Protein Length773
Protein Sequence
(FASTA)
MGDEDEDEGC AVELQITEAN LTGHEEKVSV ENFALLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVSG 120
GEMFTHLYQR QYFKEAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKAGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLQRLLCKD PKKRLGAGPQ GAQEVKSHLF 300
FQGLDWVALA ARKIPAPFRP QIRSELDVGN FAEEFTRLEP VYSPAGSPPP GDPRIFQGYS 360
FVAPSILFDH NNAVMADVLA APGAGYRPGR AAVARSAMMQ DSPFFQQYEL DLREPALGQG 420
SFSVCRRCRQ RQSGQEFAVK ILSRRLEENT QREVAALRLC QSHPNVVNLH EVLHDQLHTY 480
LVLELLRGGE LLEHIRKKRL FSESEASQIL RSLVSAVSFM HEEAGVVHRD LKPENILYAD 540
DTPGAPVKII DFGFARLRPQ SPAGPMQTPC FTLQYAAPEL LAQQGYDESC DLWSLGVILY 600
MMLSGQVPFQ GASGQGGQSQ AAEIMCKIRE GRFSLDGEAW QGVSEEAKEL VRGLLTVDPA 660
KRLKLEGLRS SSWLQDGSAR SSPPLRTPDV LESSGPAVRS GLNATFMAFN RGKREGFFLK 720
SVENAPLAKR RKQKLRSAAA SRRGSPVPAS SGRLPASASK GTTRRANGPL SPS 773
Nucleotide Sequence
(FASTA)
ATGGGAGACG AGGATGAGGA TGAGGGCTGC GCCGTGGAGC TGCAGATCAC CGAAGCCAAC 60
CTGACCGGGC ATGAGGAGAA GGTGAGCGTG GAGAACTTCG CGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGGAAGGCGG GTGGGCACGA TGCGGGCAAG 180
CTCTATGCCA TGAAGGTGCT TCGCAAGGCG GCGTTGGTGC AGCGCGCCAA GACGCAGGAG 240
CATACCCGCA CCGAACGCTC AGTGCTGGAG CTGGTACGCC AGGCACCCTT CCTGGTCACA 300
CTGCACTACG CCTTCCAGAC GGACGCCAAA CTGCACCTCA TCCTGGACTA TGTGAGCGGT 360
GGTGAGATGT TCACTCACCT GTACCAGCGC CAGTACTTCA AGGAGGCTGA GGTGCGAGTG 420
TACGGGGGAG AGATTGTGCT GGCCCTAGAG CACCTGCACA AGTTGGGCAT CATCTACAGG 480
GACCTGAAGC TGGAGAACGT CTTACTTGAC TCTGAAGGTC ACATTGTCCT CACAGACTTT 540
GGTTTGAGCA AGGAGTTCCT GACTGAGGAG AAAGAGCGAA CCTTCTCCTT CTGTGGCACC 600
ATCGAGTACA TGGCTCCCGA AATCATCCGA AGCAAGGCTG GACATGGCAA GGCTGTGGAC 660
TGGTGGAGCC TGGGTATCCT GCTCTTCGAG CTGCTGACAG GAGCCTCACC CTTCACACTG 720
GAGGGAGAAA GGAACACTCA GGCTGAGGTG TCTCGACGGA TCTTGAAGTG CTCCCCTCCC 780
TTCCCTCCCC GGATTGGGCC TGTGGCACAG GACCTGCTAC AGCGCCTGCT GTGCAAGGAC 840
CCTAAGAAGA GGTTGGGCGC AGGTCCCCAG GGTGCACAGG AAGTCAAGAG TCACCTCTTT 900
TTCCAGGGTC TGGATTGGGT TGCTCTGGCT GCCAGAAAGA TCCCAGCCCC ATTCCGGCCC 960
CAGATCCGCT CAGAGCTGGA TGTGGGGAAT TTTGCAGAGG AATTCACTCG GCTGGAGCCT 1020
GTCTACTCCC CTGCTGGCAG CCCTCCACCT GGGGACCCTA GGATCTTTCA GGGATACTCC 1080
TTCGTGGCTC CTTCCATACT CTTTGACCAC AACAACGCAG TGATGGCTGA TGTGCTGGCG 1140
GCACCTGGTG CTGGATACAG GCCTGGCAGG GCAGCAGTTG CCAGGAGTGC CATGATGCAG 1200
GACTCGCCTT TCTTCCAGCA GTATGAGCTG GACCTTCGGG AGCCAGCGCT GGGGCAGGGC 1260
AGCTTCTCTG TGTGTAGGCG ATGTCGCCAG CGCCAGAGTG GTCAGGAATT TGCCGTCAAG 1320
ATCCTCAGCC GCAGGCTGGA GGAGAACACT CAGCGCGAGG TAGCTGCCCT TCGCTTGTGC 1380
CAGTCACACC CCAACGTGGT GAACCTGCAT GAGGTGCTTC ACGACCAGTT ACACACTTAT 1440
CTGGTCCTGG AGTTGCTGCG GGGCGGGGAG CTGCTGGAGC ACATCCGCAA GAAGCGACTC 1500
TTCAGCGAGT CCGAGGCTAG CCAGATCCTT CGGAGCTTGG TGTCAGCCGT GAGCTTCATG 1560
CATGAGGAGG CGGGCGTGGT GCACCGTGAC CTGAAACCCG AGAACATCTT GTACGCAGAC 1620
GACACTCCTG GGGCCCCGGT GAAGATCATC GACTTTGGGT TCGCGAGACT GCGGCCCCAG 1680
AGCCCGGCGG GGCCCATGCA GACGCCTTGC TTCACCCTGC AGTACGCTGC ACCCGAGCTG 1740
CTGGCACAGC AGGGGTACGA CGAGTCCTGT GATCTTTGGA GCCTGGGTGT CATTCTGTAC 1800
ATGATGCTGT CTGGACAGGT TCCCTTCCAA GGGGCCTCTG GCCAGGGTGG ACAGAGCCAG 1860
GCAGCTGAGA TCATGTGCAA GATCCGTGAA GGGCGCTTCT CTCTGGACGG GGAAGCCTGG 1920
CAAGGTGTTT CGGAGGAAGC CAAGGAGCTG GTCCGAGGGC TACTGACAGT GGACCCCGCC 1980
AAGCGGCTGA AGCTGGAGGG GCTGCGTAGC AGCTCGTGGC TTCAGGACGG CAGTGCGCGC 2040
TCCTCGCCCC CGCTCCGCAC GCCGGATGTG CTGGAGTCCT CTGGGCCAGC AGTGCGCTCC 2100
GGGCTCAATG CCACTTTCAT GGCGTTTAAC CGAGGAAAGC GCGAGGGCTT CTTTTTGAAG 2160
AGTGTGGAGA ACGCGCCGCT GGCCAAAAGG CGCAAGCAGA AGCTCCGGAG CGCGGCCGCC 2220
TCCCGCCGCG GCTCCCCGGT GCCTGCCTCC TCGGGTCGCC TACCAGCCTC TGCCTCCAAG 2280
GGGACAACTC GCCGAGCCAA CGGCCCCTTG TCCCCTTCTT AG 2322
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ + +t++e+++l+++++hpn+v+l++v +
Q: 415   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEENTQREVAALRLCQSHPNVVNLHEVLH  474
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk+ fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 475   DQLHTYLVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  534
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++qGyde+cdlw
Q: 535   NILYADDTPGAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLAQQGYDESCDLW  593
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 594   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  653
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkle+l+++swl
Q: 654   LLTVDPAKRLKLEGLRSSSWL  674
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEENTQREV AALRLCQSHP NVVNLHEVLH 60
DQLHTYLVLE LLRGGELLEH IRKKRLFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK LEGLRSSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAE-00125
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00453
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00155
EKS-FEC-00154
EKS-GAG-00140
EKS-GAA-00194
EKS-GOG-00163
EKS-HOS-00170
EKS-ICT-00159
EKS-LAC-00173
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MEG-00130
EKS-MOD-00162
EKS-MUM-00169
EKS-MUP-00168
EKS-MYL-00173
EKS-NOL-00157
EKS-ORN-00204
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-PEM-00087
EKS-POA-00160
EKS-SAH-00158
EKS-SUS-00141
EKS-TAG-00191
EKS-TAR-00211
EKS-TEN-00204
EKS-XET-00152
EKS-XIM-00199
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013