EKS-RAN-00135

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00135

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	504.8	6.5E-152	148	405	258

Status

Unreviewed

Ensembl Protein

ENSRNOP00000054688

UniProt Accession

F1M6A8;

Protein Name

Protein Synonyms/Alias

Gene Name

Akt3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000021497	ENSRNOP00000054688	ENSRNOT00000057879

Organism

Rattus norvegicus

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 60

LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 120

PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 180

KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 240

RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 300

ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 360

EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP 420

PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDDDGMDCM DNERRPHFPQ FSYSASGRE 479

Nucleotide Sequence
(FASTA)

ATGAGCGATG TTACCATCGT TAAAGAAGGC TGGGTTCAGA AGAGGGGAGA ATATATAAAA 60

AATTGGAGGC CAAGATACTT CCTTTTGAAG ACAGACGGCT CATTCATAGG CTATAAAGAG 120

AAACCTCAAG ATGTGGACTT ACCTTATCCC CTCAACAACT TCTCAGTGGC AAAATGTCAA 180

TTAATGAAAA CAGAACGACC AAAGCCAAAT ACATTTATTA TCAGATGTCT TCAGTGGACC 240

ACTGTTATAG AGAGAACATT TCATGTAGAT ACTCCAGAGG AAAGAGAAGA ATGGACAGAA 300

GCTATCCAAG CTGTAGCCGA TCGACTGCAG AGGCAAGAAG AGGAGAGGAT GAATTGTAGT 360

CCAACGTCAC AGATTGATAA TATTGGAGAG GAAGAGATGG ATGCATCTAC AACCCATCAT 420

AAAAGAAAGA CAATGAATGA TTTTGACTAT TTGAAACTGC TAGGTAAAGG CACTTTTGGG 480

AAGGTTATTT TGGTTCGAGA GAAGGCAAGT GGAAAATACT ACGCTATGAA GATTCTGAAG 540

AAAGAAGTCA TTATCGCAAA GGATGAAGTG GCACATACTC TGACTGAGAG CAGAGTTCTA 600

AAGAACACCA GACATCCATT TCTAACATCC TTGAAATATT CCTTCCAGAC AAAAGACCGT 660

TTGTGTTTTG TGATGGAATA TGTTAATGGG GGAGAGCTGT TTTTCCATTT GTCGAGAGAG 720

CGGGTGTTCT CTGAGGACCG CACACGTTTC TATGGTGCAG AAATTGTCTC TGCTTTGGAC 780

TATCTACATT CTGGAAAGAT TGTGTACCGA GATCTCAAGT TGGAGAATTT GATGCTAGAT 840

AAGGATGGCC ATATAAAAAT TACGGATTTT GGACTTTGCA AAGAAGGGAT CACAGATGCA 900

GCTACCATGA AGACATTCTG TGGTACACCA GAGTATCTGG CACCAGAGGT ATTAGAAGAT 960

AATGACTATG GCCGAGCTGT GGACTGGTGG GGCCTAGGTG TTGTCATGTA TGAAATGATG 1020

TGTGGGAGGT TGCCTTTCTA CAACCAGGAT CATGAGAAAC TCTTTGAACT AATACTCATG 1080

GAAGACATCA AATTCCCCCG AACACTCTCT TCAGATGCAA AGTCATTGCT TTCAGGGCTC 1140

TTGATAAAGG ATCCAAATAA ACGCCTTGGT GGAGGGCCAG ATGATGCAAA AGAGATAATG 1200

AGGCACAGTT TCTTTTCTGG AGTAAACTGG CAGGACGTAT ATGACAAAAA GCTTGTACCT 1260

CCTTTTAAGC CTCAAGTAAC ATCTGAGACA GACACCAGAT ATTTCGATGA AGAATTTACA 1320

GCTCAGACTA TTACAATAAC ACCACCTGAA AAGTATGACG ACGACGGCAT GGACTGCATG 1380

GATAATGAGC GGCGGCCACA CTTCCCTCAG TTCTCCTACT CTGCAAGCGG ACGGGAATAA 1440

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 148   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  207

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++

Q: 208   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKI  267

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 268   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  327

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls++aksllsGll kdp+k

Q: 328   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNK  387

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 388   RLGGGPDDAKEIMRHSFF  405

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSGKI 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSSDAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000002	; P:mitochondrial genome maintenance
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013