EKS-RAN-00153

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00153

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	356.1	1.7E-106	67	328	262

Status

Unreviewed

Ensembl Protein

ENSRNOP00000029993

UniProt Accession

D4AE24;

Protein Name

Protein Synonyms/Alias

Protein Rps6kb2; Ribosomal protein S6 kinase, polypeptide 2;

Gene Name

Rps6kb2

Gene Synonyms/Alias

Rps6kb2; rCG_47735;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000021689	ENSRNOP00000029993	ENSRNOT00000029580

Organism

Rattus norvegicus

Functional Description

Protein Length

485

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE PEFNPADVCP LGELRAAGLE TVGHYEEVEL TESSVNLGPE 60

RIGPHCFELL SVLGKGGYGK VFQVRKVQGT NLGKIYAMKV LRKAKIVCSA KDTAHTRAER 120

NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL 180

ALGHLHSQGI IYRDLKPENI MLNSQGHIKL TDFGLCKESI HEGAITHTFC GTIEYMAPEI 240

LVRIGHNRAV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLVLPP YLTPDARDLA 300

KKFLKRNPTH RIGGGPGDAA DVQRHPFFRH INWDDLLAHR VDPPFRPSLQ SEEDVSQFDV 360

RFTRQTPVDS PDDTALSESA NQAFLGFTYV APSVLDSIKE GFSFQPKLRS PRRLNSSPRT 420

PISPLKFSPF EGFRPSPGPP EPMEPSLPPL LPPPSSPPPT STAPLPIRPP SGTKKSKKGR 480

GRPGR 485

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTTGATTT AGACTTGGAG ACCGAGGAAG GAAGTGAGGG CGAGGGCGAG 60

CCGGAGTTCA ACCCTGCGGA CGTGTGTCCC CTTGGCGAGT TAAGGGCTGC TGGCCTGGAG 120

ACAGTGGGAC ACTATGAGGA GGTGGAACTG ACAGAGAGCA GCGTCAACCT GGGTCCTGAG 180

CGCATCGGAC CCCACTGCTT TGAGCTACTG AGTGTTCTGG GCAAGGGGGG TTATGGCAAG 240

GTGTTCCAGG TGAGAAAAGT GCAAGGCACC AACTTGGGCA AAATATATGC CATGAAAGTC 300

TTGAGAAAGG CCAAGATTGT ATGCAGTGCC AAGGACACAG CACATACCCG GGCTGAGCGG 360

AACATTCTAG AATCGGTGAA GCACCCCTTC ATTGTAGAAC TGGCCTATGC TTTCCAGACA 420

GGTGGCAAAC TCTACCTCAT CCTGGAGTGC CTCAGTGGTG GTGAGCTCTT CACACATCTT 480

GAGCGAGAAG GCATCTTCCT GGAAGACACA GCCTGCTTCT ACCTGGCAGA GATCACACTA 540

GCCCTGGGCC ATCTCCATTC CCAAGGCATC ATCTACCGGG ATCTCAAGCC CGAGAACATC 600

ATGCTCAACA GCCAGGGCCA TATCAAACTG ACAGACTTTG GACTCTGCAA AGAGTCCATT 660

CATGAGGGTG CTATCACTCA CACCTTCTGT GGCACCATTG AGTACATGGC CCCAGAGATT 720

CTAGTGCGCA TCGGTCACAA CCGGGCAGTG GACTGGTGGA GCCTGGGAGC CCTGATGTAC 780

GACATGCTCA CTGGATCGCC GCCCTTCACC GCAGAGAACC GGAAGAAAAC TATGGATAAA 840

ATCATTAAAG GGAAGCTGGT GCTGCCCCCC TACCTCACCC CGGATGCCCG GGACCTTGCC 900

AAAAAGTTTC TGAAGCGGAA TCCCACTCAT CGAATTGGGG GTGGCCCAGG AGATGCTGCT 960

GATGTGCAGA GGCACCCGTT TTTCCGGCAC ATCAATTGGG ATGACCTCTT GGCCCATCGT 1020

GTAGACCCTC CCTTCAGACC GAGTCTGCAA TCAGAAGAGG ACGTGAGCCA GTTTGATGTG 1080

CGATTCACAC GGCAGACGCC AGTAGATAGT CCAGATGACA CAGCCCTCAG TGAGAGTGCC 1140

AACCAAGCCT TCCTGGGCTT CACGTATGTG GCACCTTCTG TACTGGACAG CATCAAAGAG 1200

GGCTTCTCCT TCCAGCCTAA GCTGCGCTCC CCCAGACGCC TTAACAGCAG TCCCCGCACC 1260

CCTATCAGCC CCCTCAAGTT CTCTCCCTTT GAGGGGTTCC GGCCCAGTCC TGGCCCACCA 1320

GAGCCCATGG AGCCATCTCT ACCTCCACTC CTGCCACCAC CATCATCACC ACCACCCACA 1380

AGTACTGCCC CACTTCCCAT CCGTCCCCCC TCAGGAACCA AGAAGTCCAA GAAGGGACGG 1440

GGCCGCCCTG GGCGCTAG 1458

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v   k++++t++er+iLe+v

Q: 67    FELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVCsaKDTAHTRAERNILESV  126

         899*************************************9999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 127   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r g

Q: 187   SQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESI-HEGAITHTFCGTIEYMAPEILVRIG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dl k

Q: 246   HNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LVLPPY--LTPDARDLAK  301

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 302   KFLKRNPTHRIGGgpgDAADVQRHPFF  328

         ***********99999*********97

Domain Sequence
(FASTA)

FELLSVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VCSAKDTAHT RAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLNSQG HIKLTDFGLC KESIHEGAIT HTFCGTIEYM APEILVRIGH 180

NRAVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL VLPPYLTPDA RDLAKKFLKR 240

NPTHRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005840	; C:ribosome
GO:0005524	; F:ATP binding
GO:0042277	; F:peptide binding
GO:0004711	; F:ribosomal protein S6 kinase activity
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade

KEGG

rno:361696

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013