EPS-RAN-00159

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00159

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PSP-Other/RPAP2	N/A	N/A	N/A	N/A	N/A

Status

Reviewed

Ensembl Protein

ENSRNOP00000002815

UniProt Accession

Q5I0E6; D4A5J9; D4A672;

Protein Name

RNA polymerase II subunit B1 CTD phosphatase Rpap2

Protein Synonyms/Alias

Putative RNA polymerase II-associated protein 2;

Gene Name

Rpap2

Gene Synonyms/Alias

Rpap2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000023484	ENSRNOP00000002815	ENSRNOT00000002815
ENSRNOG00000023484	ENSRNOP00000059546	ENSRNOT00000063778

Organism

Rattus norvegicus

Functional Description

Protein phosphatase that displays CTD phosphataseactivity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).

Protein Length

609

Protein Sequence
(FASTA)

MADSAVPYSL GPSARASSTH RVATGTKQTS ALKRRDASKR QAELEAALQR KVESERRAVR 60

LVEQLLEENI TEEFLKECGM FITPAHYSDV VDERAIIKLC GYPLCQKKLG VIPKQKYRIS 120

TKTNKVYDIT ERKSFCSNFC YKASKFFEAQ IPKTPVWVRE EERPPEFQLL KKGQSGCSGE 180

VVQFFRDAVT AADVDAYGAF DAQCEPASSS TWSERASDER ASDEEGPGFV SSLLPGNRPK 240

AVGTKPQPHR QSSTVKKKAA QKMTSKHGEQ TVSEVTEQLS NCRLDSQEKV ATCKLPAKKE 300

NTQISSPGPL CDRLNTSTVS ENKHSVSQVT LVGISKKSAE HFRSKFAKSN PGSGSASGLV 360

QVRPEVAKAN LLRVLKDTLT EWKTDETLKF LYGQDHGSVC LQPSAASGPD EELDEDDISC 420

QAQNTLDETL PFRGSDTAIK PLPSYESLKK ETEMLNLRVR EFYRGRCVLN EDSTKSQDSK 480

ENELQRDPSF PLIDSSSQNQ IRRRIVLEKL SKVLPGLLGP LQITMGDIYT ELKNLVQTFR 540

LSNRNIIHKP VEWTLIAVVL LSLLTPILGI QKHSPKNVVF TQFIATLLTE LHLKCEDLEN 600

LAMIFRTSC 609

Nucleotide Sequence
(FASTA)

ATGGCGGACT CTGCTGTTCC TTACTCTCTG GGCCCAAGTG CCCGGGCTTC CAGCACCCAC 60

CGAGTCGCTA CCGGTACTAA ACAGACCAGT GCCCTGAAAC GAAGAGATGC GTCTAAAAGA 120

CAAGCGGAAC TGGAAGCTGC CCTGCAAAGG AAGGTGGAGT CTGAGAGGAG AGCTGTACGC 180

CTCGTAGAGC AGCTCCTGGA GGAGAACATC ACAGAAGAAT TCCTGAAGGA GTGTGGGATG 240

TTCATCACAC CGGCTCACTA CAGCGACGTT GTGGATGAGC GGGCCATCAT TAAACTCTGT 300

GGCTATCCTT TATGTCAGAA GAAGCTAGGG GTTATACCAA AACAGAAATA CCGGATTTCT 360

ACTAAAACCA ATAAAGTCTA TGATATTACT GAAAGAAAGT CTTTCTGCAG CAATTTTTGT 420

TACAAAGCAT CTAAATTTTT TGAAGCACAG ATTCCCAAAA CTCCAGTATG GGTTCGAGAG 480

GAAGAGAGGC CTCCTGAATT TCAGCTGCTG AAGAAAGGAC AAAGTGGCTG TTCTGGAGAG 540

GTCGTACAGT TCTTCAGAGA CGCCGTTACA GCAGCAGATG TCGATGCTTA TGGTGCCTTT 600

GATGCACAGT GTGAACCTGC TTCCTCCAGC ACTTGGAGCG AGCGTGCCAG CGACGAGCGT 660

GCCAGCGATG AGGAGGGGCC AGGCTTTGTT TCTTCTCTTC TCCCAGGAAA CAGACCGAAG 720

GCCGTGGGCA CAAAACCACA GCCACACAGA CAAAGCAGCA CCGTGAAGAA GAAGGCTGCT 780

CAGAAAATGA CCTCCAAGCA CGGAGAACAG ACCGTGTCAG AGGTCACGGA GCAGTTGTCT 840

AATTGTAGAT TAGATAGTCA GGAGAAAGTA GCTACTTGTA AACTTCCTGC AAAGAAAGAA 900

AACACTCAGA TTTCTTCACC TGGCCCTTTG TGTGACAGAT TAAATACTTC AACAGTTTCT 960

GAAAATAAAC ACAGTGTATC ACAAGTTACT CTTGTGGGGA TAAGCAAGAA GAGTGCTGAG 1020

CATTTCAGGA GCAAATTTGC CAAATCTAAC CCAGGGTCTG GGTCAGCCTC TGGTTTGGTG 1080

CAGGTGCGTC CTGAGGTCGC AAAGGCAAAT TTACTCCGAG TTCTAAAGGA CACCCTGACT 1140

GAATGGAAGA CAGACGAAAC ACTGAAGTTT TTATATGGCC AAGACCATGG TTCTGTGTGC 1200

CTGCAACCCT CTGCAGCCTC TGGGCCTGAT GAAGAACTTG ATGAAGATGA CATAAGCTGT 1260

CAAGCTCAGA ACACCTTGGA TGAGACACTC CCCTTCAGAG GCTCAGATAC AGCCATTAAG 1320

CCACTGCCAA GTTATGAGAG CCTGAAAAAG GAAACAGAGA TGTTGAACCT GAGGGTCAGG 1380

GAGTTCTACA GAGGACGCTG TGTTTTAAAT GAAGACAGTA CCAAGTCTCA GGACTCAAAA 1440

GAGAATGAGC TTCAGCGTGA TCCCAGCTTC CCCCTGATTG ATTCGAGTTC CCAGAACCAG 1500

ATTAGAAGAC GGATTGTTCT TGAAAAATTG AGCAAAGTAT TGCCCGGCCT TTTGGGTCCT 1560

CTTCAGATTA CAATGGGAGA TATTTACACT GAACTTAAAA ACCTTGTTCA GACTTTCAGA 1620

TTATCAAATA GAAACATTAT CCACAAACCT GTGGAGTGGA CTTTAATCGC CGTGGTCTTG 1680

CTGTCACTGT TGACACCAAT TCTCGGCATT CAGAAGCATT CTCCAAAAAA TGTGGTATTT 1740

ACACAGTTTA TAGCCACCCT GCTGACAGAA TTGCATCTAA AATGTGAAGA TCTGGAAAAC 1800

TTAGCCATGA TATTTAGAAC CAGCTGCTAA 1830

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016591	; C:DNA-directed RNA polymerase II, holoenzyme
GO:0008420	; F:CTD phosphatase activity
GO:0046872	; F:metal ion binding
GO:0070940	; P:dephosphorylation of RNA polymerase II C-terminal domain
GO:0009301	; P:snRNA transcription

KEGG

rno:305120

;

InterPros

IPR007308

; DUF408.

Pfam

PF04181

; RPAP2_Rtr1; 1.

SMARTs

Prosites

PS51479

; ZF_RTR1; 1.

Prints

Created Date

20-Feb-2013