EKS-RAN-00393
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00393
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK343.01.4E-10299357259
StatusUnreviewed
Ensembl ProteinENSRNOP00000031328
UniProt AccessionD3ZKP3;
Protein Name
Protein Synonyms/Alias Protein Map3k10;
Gene NameMap3k10
Gene Synonyms/Alias Map3k10;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000023521ENSRNOP00000031328ENSRNOT00000034609
OrganismRattus norvegicus
Functional Description
Protein Length942
Protein Sequence
(FASTA)
MEEEEGAAAR EWGATPAGPV WTAVFDYEAV GDEELTLRRG DRVQVLSQDC AVSGDEGWWT 60
GQLPSGRVGV FPSNYVAPAA PAAPTDLQLP QEIPFHELQL EEIIGVGGFG KVYRALWRGE 120
EVAVKAARLD PERDPAVTAE QVRQEARLFG ALQHPNIIAL RGACLSPPNL CLVMEYARGG 180
ALSRVLAGRR VPPHVLVNWA VQVARGMNYL HNDAPVPIIH RDLKSINILI LEAIENHNLA 240
DTVLKITDFG LAREWHKTTK MSAAGTYAWM APEVIRLSLF SKSSDVWSFG VLLWELLTGE 300
VPYREIDALA VAYGVAMNKL TLPIPSTCPE PFARLLEECW DPDPHGRPDF GSILKQLEVI 360
EQSALFQMPL ESFHSLQEDW KLEIQHMFDD LRTKEKELRS REEELLRAAQ EQRFQEEQLR 420
RREQELAERE MDIVERELHL LMSQLSQEKP RVRKRKGNFK RSRLLKLREG SSHISLPSGF 480
EHKITVQASP TLDKRKGSDG ASPPASPSII PRLRAIRLTP VDCGSSGGSG TWSRSGPPKK 540
EELVGGKKKG RTWGPSSTLQ KERAGGEERL KALGEGSKQW SSSAPNLGKS PKHTPMAPGF 600
ASLNEMEEFA EADEGNNVPP SPYSTPSYLK VPLPAEASPC AQPPWEPPAA TPSRPGHGAR 660
RRCDLALLGC ATLLSAVGLG ADVAEARAGD GEEQRGWLDG LFFPRPGRFP RGLSPTGRPG 720
GRREETAPGF GLAPSATLVS LSSVSDCNST RSLLRSDSDE AAPTAPSPPP SLLPPSPSTN 780
PLVDVELESF KKDPRQSLTP THVTAAHAVS RGHRRTPSDG ALRQREPPEL TNHGPSPRDP 840
LDFPRLPDPQ ALFPTRRRPL EFPGRPTTLT FAPRPRPAAS RPRLDPWKLV SFGRTLSISP 900
PSRPDTPESP GPLSVQPTLL DMDMEGQSQD NTVPLCGAYG SH 942
Nucleotide Sequence
(FASTA)
ATGGAGGAGG AGGAGGGGGC GGCGGCCAGA GAGTGGGGCG CGACCCCCGC GGGGCCAGTG 60
TGGACCGCCG TGTTCGACTA CGAGGCGGTG GGCGACGAGG AGCTGACCCT GCGGAGAGGC 120
GATCGCGTCC AGGTGCTTTC CCAGGACTGT GCGGTGTCTG GAGATGAGGG CTGGTGGACA 180
GGGCAGCTGC CCAGCGGCCG AGTGGGCGTC TTCCCCAGCA ACTACGTGGC CCCCGCTGCA 240
CCCGCTGCAC CCACAGACCT CCAGCTGCCA CAGGAGATCC CCTTTCACGA GCTGCAGCTG 300
GAGGAGATCA TCGGTGTGGG GGGCTTTGGC AAGGTCTACC GCGCCTTATG GCGTGGAGAG 360
GAAGTAGCGG TCAAGGCCGC CCGGCTGGAC CCTGAACGGG ACCCAGCAGT GACAGCGGAG 420
CAGGTGCGCC AGGAGGCCCG GCTCTTTGGA GCCCTTCAGC ACCCCAACAT CATTGCCCTG 480
AGGGGCGCCT GCCTCAGCCC CCCAAACCTC TGCCTGGTGA TGGAATATGC TCGGGGAGGT 540
GCATTGAGCA GGGTACTGGC AGGTCGCCGG GTCCCCCCTC ATGTGCTGGT CAACTGGGCT 600
GTGCAGGTGG CACGGGGCAT GAACTATCTG CACAATGATG CCCCTGTACC CATCATTCAC 660
CGGGACCTCA AGTCCATCAA CATCCTAATT CTGGAGGCCA TTGAGAACCA CAACCTCGCT 720
GACACGGTGC TCAAGATCAC AGACTTCGGC CTTGCCCGAG AGTGGCACAA GACGACCAAA 780
ATGAGTGCGG CGGGGACCTA CGCCTGGATG GCTCCTGAGG TTATCCGCCT CTCCCTCTTC 840
TCCAAAAGCA GCGATGTCTG GAGCTTCGGG GTTCTTCTTT GGGAGCTGCT GACCGGGGAG 900
GTCCCCTACC GAGAAATCGA CGCCTTGGCC GTGGCTTACG GTGTGGCTAT GAACAAGCTG 960
ACGCTACCCA TCCCCTCCAC GTGCCCCGAG CCCTTTGCCC GCCTACTGGA GGAATGCTGG 1020
GACCCAGACC CTCATGGGCG ACCAGATTTT GGCAGCATCT TGAAGCAGCT GGAGGTCATC 1080
GAGCAGTCAG CCCTGTTCCA GATGCCACTG GAGTCCTTCC ACTCACTGCA GGAAGACTGG 1140
AAGCTGGAGA TTCAGCATAT GTTCGATGAC CTTCGGACCA AGGAGAAGGA ATTGCGCAGC 1200
CGTGAAGAAG AGCTGTTGCG GGCCGCACAG GAGCAGCGTT TTCAGGAAGA GCAGCTGCGG 1260
CGGCGGGAGC AGGAGCTGGC CGAGCGAGAG ATGGACATTG TAGAACGTGA ACTGCACCTG 1320
CTCATGAGCC AGCTGAGCCA GGAGAAGCCC AGGGTCCGCA AACGCAAGGG CAACTTCAAA 1380
CGCAGCCGCT TGCTCAAGCT ACGGGAAGGC AGCAGCCACA TCAGCCTGCC CTCCGGATTT 1440
GAACACAAGA TCACTGTCCA GGCCTCCCCC ACCCTGGACA AGAGGAAAGG ATCTGATGGG 1500
GCCAGCCCTC CTGCCAGCCC CAGCATCATT CCCCGGCTGA GGGCCATTCG CTTGACCCCC 1560
GTAGACTGTG GCAGCAGCGG TGGCAGTGGA ACATGGAGCC GCAGTGGGCC ACCAAAAAAG 1620
GAAGAACTGG TTGGGGGCAA GAAGAAAGGC AGGACGTGGG GTCCCAGTTC TACTTTACAA 1680
AAGGAGCGGG CCGGAGGAGA GGAGAGGCTC AAGGCCCTGG GGGAAGGAAG CAAGCAGTGG 1740
TCCTCGAGCG CCCCCAACCT GGGCAAATCC CCTAAGCACA CCCCCATGGC CCCAGGCTTC 1800
GCCAGCCTCA ATGAGATGGA AGAATTTGCG GAGGCAGATG AAGGCAACAA CGTGCCCCCT 1860
TCCCCCTACT CCACCCCGTC CTACCTCAAG GTGCCTCTGC CCGCCGAGGC CTCTCCTTGT 1920
GCTCAGCCGC CTTGGGAGCC GCCGGCTGCG ACCCCCTCCC GGCCGGGACA CGGAGCTCGG 1980
AGGCGCTGTG ATCTGGCTCT GCTGGGCTGC GCCACGCTGC TGAGTGCGGT GGGCCTGGGC 2040
GCCGACGTTG CCGAGGCACG GGCCGGGGAT GGTGAGGAGC AGCGGGGCTG GCTGGACGGT 2100
CTCTTCTTCC CACGGCCCGG CCGCTTCCCT CGGGGTCTCA GCCCGACAGG GCGCCCAGGA 2160
GGTCGCCGCG AAGAGACAGC CCCAGGCTTT GGCCTGGCAC CCTCGGCCAC CCTGGTGTCT 2220
TTATCTTCTG TATCTGATTG CAACTCTACG CGCTCATTGC TGCGCTCTGA CAGTGATGAG 2280
GCTGCCCCCA CTGCGCCCTC CCCGCCGCCT TCTCTGCTCC CGCCCTCACC TAGCACCAAT 2340
CCTCTTGTGG ACGTAGAGCT GGAGAGCTTC AAGAAGGACC CCCGGCAGTC GCTCACGCCC 2400
ACCCACGTCA CTGCGGCCCA CGCTGTGAGC CGTGGACACA GACGGACACC ATCGGATGGG 2460
GCTCTGAGAC AGCGGGAGCC TCCAGAGCTC ACCAACCACG GTCCAAGTCC TCGAGATCCC 2520
TTGGACTTCC CTCGACTGCC CGACCCCCAG GCCCTGTTCC CTACCCGACG CCGGCCCCTG 2580
GAGTTCCCTG GCCGTCCCAC CACCCTCACC TTTGCCCCAA GACCCCGGCC AGCTGCCAGC 2640
CGCCCCCGTC TGGACCCCTG GAAACTGGTC TCCTTTGGCC GGACACTCAG CATCTCGCCT 2700
CCAAGCAGGC CAGACACTCC AGAGAGCCCT GGGCCCCTCA GCGTGCAGCC CACGCTGCTG 2760
GACATGGACA TGGAGGGTCA GAGCCAGGAC AATACAGTGC CCCTGTGTGG GGCCTATGGC 2820
TCTCACTGA 2829
Domain Profile
S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59
         +lee+ig g fgkvy+a wr++evavK++r + e+  + ++e++++ea+l+ +l+hpnii
Q: 99    QLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERdpAVTAEQVRQEARLFGALQHPNII  158
         789*******************************988999********************
S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119
         +l+G+cl++pnl+lvmey++gg+Ls+vl++   r+++++vlv+wa+q+ArGm+YLh++ap
Q: 159   ALRGACLSPPNLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHNDAP  215
         ******************************...9**************************
S: 120   kkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172
         ++iihrdLks n+L+       + ++++lki+dFG are++k+tkmsaagt+awmaPEv+
Q: 216   VPIIHRDLKSINILIleaienhNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVI  275
         ********************99999***********************************
S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232
         + + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++L
Q: 276   RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARL  335
         ************************************************************
S: 233   mkecwnedpekRpsfseivksl  254
         ++ecw+ dp+ Rp+f +i+k+l
Q: 336   LEECWDPDPHGRPDFGSILKQL  357
         ******************9986
Domain Sequence
(FASTA)
QLEEIIGVGG FGKVYRALWR GEEVAVKAAR LDPERDPAVT AEQVRQEARL FGALQHPNII 60
ALRGACLSPP NLCLVMEYAR GGALSRVLAG RRVPPHVLVN WAVQVARGMN YLHNDAPVPI 120
IHRDLKSINI LILEAIENHN LADTVLKITD FGLAREWHKT TKMSAAGTYA WMAPEVIRLS 180
LFSKSSDVWS FGVLLWELLT GEVPYREIDA LAVAYGVAMN KLTLPIPSTC PEPFARLLEE 240
CWDPDPHGRP DFGSILKQL 259
KeywordComplete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; SH3 domain; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00351
EKS-ANC-00366
EKS-BOT-00379
EKS-CAJ-00382
EKS-CAF-00385
EKS-CAP-00410
EKS-DAR-00758
EKS-FEC-00366
EKS-GAA-00461
EKS-GOG-00369
EKS-HOS-00385
EKS-ICT-00357
EKS-LOA-00388
EKS-MOD-00368
EKS-MUM-00411
EKS-MUP-00371
EKS-MYL-00376
EKS-NOL-00352
EKS-ORN-00485
EKS-ORC-00355
EKS-OTG-00380
EKS-PAT-00359
EKS-POA-00368
EKS-SUS-00331
EKS-TEN-00479
EKS-TUT-00103
EKS-XET-00491
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0003714; F:transcription corepressor activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046330; P:positive regulation of JNK cascade
GO:0043507; P:positive regulation of JUN kinase activity
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR016231; MAPKKK9/10/11.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00018; SH3_1; 1.
SMARTs
SM00326; SH3; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013