EPS-RAN-00062

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00062

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	274.0	9.3E-82	351	526	176

Status

Unreviewed

Ensembl Protein

ENSRNOP00000029743

UniProt Accession

D4ADC8;

Protein Name

Protein Synonyms/Alias

Protein Tpte;

Gene Name

Tpte2

Gene Synonyms/Alias

Tpte2; Tpte;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000024837	ENSRNOP00000029743	ENSRNOT00000034670

Organism

Rattus norvegicus

Functional Description

Protein Length

673

Protein Sequence
(FASTA)

MQGVKKSHLY LWMEHYGYDG PASSRVYSQL SRRRRNANKK VLSSTSKSTK LNGSIGYDGN 60

EETTTFTNGS SIDSMSYQDD MKSSNCMDPT SEKRYGNDSS LYTIDGTLNN GTTLYEMNSL 120

SELSKEVYLN DSALLRGKEA ASELQVSSTM KTQSSVSTSI LSTSDLISEE IQEEQINKCK 180

LNQISKLYDE DEHVDIRESY WSTVKKFVHF LVSSVAFRIF GILLIFLDVF LVAIDLHATE 240

KNIYIPLEYR AISLAIALFF LVDVLLRVYV EGRQRYFSDV LNTLDAVVIG VTVLVAVIYT 300

LYDKQFLRNI PRLAVLLRPL RLLILVRILQ LAHQKRQLEK LTRQLVSGNK RRYKKDGFDL 360

DLTYVTERII AMSFPSSGRE SFYRNPIKEV VRFLDTKHPN HYQVYNLCSE RSYDPKRFHY 420

RVRRIMIDDH NVPTLEEMLL FSKEVNDWMA QDPENVVAIH CKGGKGRTGT MVCACLIASE 480

IVLNAKASLY FFGERRTDKS NSSKFQGVET PSQNRYVKYF EKLKTSYQLT LPPKKVLVIK 540

RFTVYSIHGV GKGNGSDLEI QIMMWQETIF SCFNSKNCMI FHDVETDKVI INVFNCPALY 600

DDVKVKFLCP NLPKYYDDCP FFFWFHTSFI RNNRLYLPRS ELDNTHKQKT WKIYGPKFAV 660

EVYFEEISST VMY 673

Nucleotide Sequence
(FASTA)

ATGCAGGGAG TCAAAAAGAG CCATTTGTAT CTCTGGATGG AGCACTACGG ATACGATGGG 60

CCTGCAAGTT CCAGGGTGTA TTCTCAGCTC TCCAGAAGAA GACGCAATGC AAACAAAAAG 120

GTGTTATCGA GCACGTCGAA GTCCACTAAA CTAAACGGCA GCATTGGCTA TGACGGAAAT 180

GAAGAGACAA CCACGTTCAC TAACGGAAGT AGCATTGACA GTATGTCGTA TCAAGATGAC 240

ATGAAATCGT CAAATTGCAT GGACCCCACC AGTGAAAAAA GATATGGAAA TGATTCGTCA 300

TTATACACCA TTGACGGAAC TTTGAACAAC GGCACAACCC TGTATGAAAT GAATTCCTTG 360

AGTGAATTAT CGAAAGAAGT ATACCTGAAC GATTCTGCTT TGCTACGTGG TAAAGAAGCT 420

GCCAGCGAAC TCCAAGTCTC AAGTACAATG AAAACACAAT CATCTGTGTC GACCAGCATT 480

CTCAGCACAT CTGATTTAAT ATCAGAAGAA ATCCAGGAAG AGCAAATCAA CAAATGCAAG 540

TTAAACCAGA TCTCCAAGCT GTACGACGAG GACGAGCATG TTGACATCCG AGAGTCATAC 600

TGGAGCACAG TTAAGAAATT TGTGCATTTC CTTGTGTCCT CAGTTGCCTT CAGAATATTT 660

GGAATACTCC TGATCTTTCT GGATGTATTT CTTGTGGCTA TCGATCTACA TGCCACTGAA 720

AAGAATATTT ATATTCCTTT GGAATATCGG GCCATTTCTT TAGCTATTGC TTTATTTTTC 780

CTTGTGGATG TTCTTCTCCG AGTGTATGTA GAAGGGAGAC AGCGTTATTT CTCTGACGTG 840

CTGAACACCC TAGATGCTGT TGTCATCGGC GTGACTGTGC TCGTGGCTGT CATTTATACA 900

CTTTATGACA AACAGTTTCT CAGAAATATT CCAAGACTGG CAGTCTTACT TCGGCCTCTG 960

CGACTGCTCA TCCTGGTAAG AATTTTGCAG CTGGCCCATC AGAAGCGACA ACTGGAAAAG 1020

CTGACTCGGC AGCTGGTTTC GGGTAACAAG CGACGCTACA AGAAGGATGG CTTCGACCTG 1080

GACCTCACTT ACGTCACTGA GCGCATTATT GCCATGTCAT TTCCATCATC TGGAAGGGAG 1140

TCCTTCTATA GAAATCCAAT TAAGGAAGTT GTCAGGTTCC TCGACACCAA GCATCCAAAC 1200

CACTATCAAG TCTACAATCT ATGCAGTGAG AGATCTTATG ACCCTAAGCG CTTCCACTAC 1260

AGGGTCCGCA GAATCATGAT TGATGATCAT AACGTACCTA CCCTCGAGGA AATGTTGTTG 1320

TTCTCCAAGG AAGTAAATGA TTGGATGGCC CAAGATCCTG AAAATGTTGT AGCAATTCAC 1380

TGTAAGGGAG GAAAAGGGAG AACTGGAACC ATGGTGTGTG CCTGCCTCAT TGCCAGTGAA 1440

ATAGTCCTAA ACGCAAAGGC AAGTCTGTAC TTTTTTGGAG AGCGACGGAC AGATAAAAGT 1500

AACAGCTCTA AGTTTCAAGG AGTAGAGACC CCTTCTCAGA ATAGATATGT TAAATATTTT 1560

GAAAAACTGA AAACTAGCTA CCAATTGACT CTTCCTCCAA AAAAAGTACT TGTGATAAAA 1620

AGATTCACTG TTTACTCCAT TCATGGTGTT GGAAAAGGCA ATGGAAGTGA TCTAGAAATA 1680

CAAATAATGA TGTGGCAGGA GACGATTTTT TCCTGTTTTA ATTCCAAAAA TTGTATGATA 1740

TTTCATGATG TTGAAACAGA CAAAGTAATA ATTAATGTGT TCAACTGTCC GGCTCTATAT 1800

GATGATGTAA AAGTGAAATT TCTCTGTCCG AATCTTCCTA AATACTATGA TGACTGCCCC 1860

TTTTTCTTTT GGTTTCATAC ATCTTTTATT CGAAATAACA GGCTTTATCT ACCAAGAAGC 1920

GAATTGGATA ATACCCATAA ACAAAAAACA TGGAAAATTT ATGGTCCAAA GTTTGCAGTC 1980

GAGGTGTATT TTGAGGAGAT AAGCTCCACG GTTATGTACT AG 2022

Domain Profile

S: 1     rrltedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcse  60

         rr+++dgfdldltyvteriia+sfP+++re++yrn+++evvr+ld kh n+y++ynlcse

Q: 351   RRYKKDGFDLDLTYVTERIIAMSFPSSGRESFYRNPIKEVVRFLDTKHPNHYQVYNLCSE  410

         79**********************************************************

S: 61    rrydltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGv  120

         r yd+++++ +v +++i+d+n+P+le++  ++ke+++W+++d+envv++hckggkgr+G+

Q: 411   RSYDPKRFHYRVRRIMIDDHNVPTLEEMLLFSKEVNDWMAQDPENVVAIHCKGGKGRTGT  470

         ************************************************************

S: 121   ivcayllaseisakadealdtfgerr...tredkvagvkqPsqrryvsyfsqllkg  173

         +vca l+asei+++a+ +l++fgerr     + k++gv++Psq+ryv+yf +l+ +

Q: 471   MVCACLIASEIVLNAKASLYFFGERRtdkSNSSKFQGVETPSQNRYVKYFEKLKTS  526

         **************************5555789*******************9975

Domain Sequence
(FASTA)

RRYKKDGFDL DLTYVTERII AMSFPSSGRE SFYRNPIKEV VRFLDTKHPN HYQVYNLCSE 60

RSYDPKRFHY RVRRIMIDDH NVPTLEEMLL FSKEVNDWMA QDPENVVAIH CKGGKGRTGT 120

MVCACLIASE IVLNAKASLY FFGERRTDKS NSSKFQGVET PSQNRYVKYF EKLKTS 176

Keyword

Complete proteome; Ion transport; Ionic channel; Membrane; Reference proteome; Transmembrane; Transport.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005216	; F:ion channel activity
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0035335	; P:peptidyl-tyrosine dephosphorylation

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR005821	; Ion_trans_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR014020	; Tensin_phosphatase_C2-dom.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00782	; DSPc; 1.
PF00520	; Ion_trans; 1.
PF10409	; PTEN_C2; 1.

SMARTs

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS00383	; TYR_PHOSPHATASE_1; 1.

Prints

Created Date

20-Feb-2013