EKS-RAN-00093

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00093

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	383.9	8.9E-115	3215	3564	350

Status

Unreviewed

Ensembl Protein

ENSRNOP00000037412

UniProt Accession

D3ZTN0;

Protein Name

Protein Synonyms/Alias

Gene Name

Prkdc

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000025028	ENSRNOP00000037412	ENSRNOT00000035247
ENSRNOG00000025028	ENSRNOP00000059458	ENSRNOT00000065799

Organism

Rattus norvegicus

Functional Description

Protein Length

3624

Protein Sequence
(FASTA)

DVESRSENRW ASEEVRMGRW KVPTYKDYVD LFQNLLGCDQ MADFILGDET FLFVNSSLKS 60

LNHLLYDEFI RSVLKIVEKL DLTLEKQTTG EQEDERTADV WVIPTSDPAA NLHPIKPNDF 120

SAFINLVEFC REILPKKQVS FFEPWVYSFA YELILQSTRL PLISGFYKLL SIAVKNARKI 180

KYFEGVSPKC LKHSPENTEK HSCFALFAKF GKEVSVKMKQ YKDELLASCL TFVLSLPPDI 240

IKLDVRAYVP ALQMAFKLGL SHLPLAEIGL HALKEWSVHI DKSIMQPYYK DIVPCLDGYL 300

NTSTLSDETK SHWEVSALSR AARKGFNRDV VKLLKRTRNV TSDEALSLEE IRIRVVQILG 360

SLGGQINKNL ITATSGERMK KYVAWDREKR LSFAVPFREM KPVIYLDVFL PRVTELALSA 420

SDRQTKVAAC ELLHSMVMFM LGRATQMPEG QGLPPMYQLY KHMFPVLLKL ACDVDQVTRQ 480

LYEPLVMQLI HWFTNNKKFE SQDTVALLEA ILDGIVDPVD STLRDFCGQC VQEFLKWSIK 540

QTTPQQQEKS PVNSKSLFKR LYSLALHPNA FKRLGAALAF NHIYKEFREE GSLVEQFVFE 600

ALVTYMESLA LAHADEKSLG TIQQCCDAID HLRRIIEKKY ISLNKAKKRR LPRGFPPLTS 660

LCLLDLVKWL FAHCGRPQTE CRHKSIELFY KFVPLLPGNK SPSLWLRDLI KAEGISFLIN 720

TFEGGASSSG QPSGILAQPT LLHLQGPVSL RGMLQWLDHL LAALECYNTF IEEKTVQVQE 780

VLGTEVQSSL LKSVAFFLES IATCDARTVE QRFGTGLTGP PSVQEEEKYN YSKCTVLVRI 840

MEFTTTLLVT FPEDCKLLEK DLCNTKLMKV LVKMLCEPLS IGFNIGDVQV MNHLPSICVN 900

LLKALRKSPY RDKLETHLKE KVTAQSVEEL CAINLCSSAA CQERTKLLSL LSACKQLHKA 960

GFSHIISASQ STALNHSIGM RLLSLVYNGI APAQEKQYLQ SLDPSCKSLA SGLLELAFAF 1020

GGLCEHLVSL LLNSSMLSTQ YLGSSQRNIS FSHGEYFYSL FPEVINTELL KSLDVTVSRL 1080

LESSSDNPKM VSTILNGMLD MSFRDRAVQK HQGLKLATAI LQNWRKCDSW WAPDSAPESK 1140

TTVLSLLAKM LQIDSTLSFD TNHSSFSEIF TTYANLLADT KLGLHLKGQA VILLPFFTRV 1200

TEDRLGDLKH ILEKFIVLNF PMKSDEFPPD SLKYNNYVDC MKKFLDALEL SQSPMLLQLM 1260

TDILCREQQH IMEELFQTTF KRIARRSPCV TQLNLLESVY TMFRKGGLLS DVTQAFVDRS 1320

LLTLLWHCDL DTLKEFFSRI VVEAIDVLKS RFTKLNDTFD TQITKKMCYY KMLAVMYSRL 1380

LKDDVHSKES KINQAFQGSC VAEGNELTKT LLKLCHDAFT ENMAGESQLL EKRRLYHCAA 1440

YNCAISLISR VFNELKFYQG FLFSEKPEKN LFIFENLIDL KRCYTFPIEV EVPMERKKKY 1500

VEIRKEARDA ANGASGNPRY MSSLSYLTES SLSEEMSQFD FSTGVQSYSY SSQDRKPTTG 1560

HFQRREHQDS MAQDDIIELE MDELNQHECM APMTSLIKHM QRNVIAPKGQ EGSISKDLPP 1620

WMKFLHDKLE NASVSLNIRL FLAKLVINTE EVFRPYAKHW LGPLLQLAVC ENIGEGIHYM 1680

IVEIVATILS WTGLATPTGV PKYEVLANRL LYFLMKYVFH PKRAVFRHNL EIIKTLVECW 1740

KECLSIPYRL IFEKFSNKDP NSKDNSVGIQ LLGIVVANNL PPYDLKGDIT SAMYFEALVN 1800

NMSFVKYKEV YAAAAEVLGL ILQHVTERKH VIAESVYELV VKQLKQHQNT MEDKFIVCLN 1860

KIVKGFPPLA DRFLNALFFL LPKFHGVMKT LCLEVVLCRA EAITGLYLQL KSKDFLQVMR 1920

HRDDERQKVC LDIIYKMVAK LKPTELRELL NPVVEFVSHP SPTCREQMYN ILMWIHDNYR 1980

DPESQMDEDS QEIFKLAKDV LIQGLIDENL GLQLIIRNFW SHETRLPSNT LDRLLALNSL 2040

YSPKIEVHFL SLATNFLLEM TRMSPDYLNP IFEHPLSECE FQEYTIDPDW RFRSTVLTPM 2100

FIETQAFPST LNTQTQEGSP SDRRQKPGQV RATQQQYDFT PTQTSVERSS FDWLTGSSID 2160

LMADHTVFSS ESLSSSLLFS HKKSEKSQRV SWKSVGPDFG TKKLGLPGDE VDNQVKSGTH 2220

SQTEILRLRR RFLKDQEKLS LLYAKRGLME QKLEKDIKSE LKMKQDAQVV LYRSYRHGDL 2280

PDIQIQHSSL ITPLQAVAQK DPIIAKQLFS SLFSGILKEM HKFRTTSEKN IIIQNLLQDF 2340

NRFLNTTFLF FPPFVSCIQE ISCQHVDLLT LDPAAVRVGC LASLQQPGGI RLLEEALLHL 2400

LPKEPPTKRI RGKTCLPPDV LRWMELAKLY RSIGEYDVLH GIFSSELGTK QDTQNALLAE 2460

ARSDYFQAAN LYKEALNKLE WLDGEPTEAE KEFWEMASLD CYNNLSQWKE LEYRSTVNIG 2520

SENSLDLSKM WSKPFYQETY LPYVIRSKLK LLLQGEDNQS LLTFVDEAMH KELQQMVLEL 2580

QYSQELSLLY ILQDDIDRAT YYIKNAIQIF MQNYSSIDVL LYRSRLAKLQ SVQTLAEIEE 2640

FLNFIRKHGD LSSLGPLRRL LKTWTSRYPD TVTDPMHIWD DIITNRCFFL SKIEERLTVS 2700

PGDHSMSVDE DEDSFAREGS EPKEDAHHIL QSCRFTMKMK MIESSWKQNN FSLSMKLLKE 2760

MHKESKIRES WRMQWIHSFC QLNHCRSHTQ SPQEQVLTML KTITLLDESD ISNYLNKNIQ 2820

AFCDQNILLG TSCRIMADAL SREPACLSGL EKSKTESIFA LSGSNTENTE RVISGLYQRA 2880

FHHLSMAVQS AEEETQLSCW GHEAAAERAH AYMTLVGFCD QQLRKVEESA SSKNSTELEG 2940

YPALVVEKML RALKLNSSEA RLKFPRLLQI IEQYPEETVN IIIKEISSIP CWQFIGWIGH 3000

MVALLDKEEA IAVQHTVEEI ADNYPQAIIY PFIISSESYS FQNTSSGHNN KAFVERIKSK 3060

LDQGGVIQGF INALDQLSNP DMLFKDWVND TKDELGKNPV NKKNIEKLYE RMYAALGDFR 3120

APGLGPFRRK FIQTFGKEFV KSFGNGGSKL LTMKLDEFRN ITDSLFVRMR KDSKLPGNLK 3180

EYSPWMSEFT VKSELEIPGQ YDGKSKPLPE YHVRISGFDE RVKVMVSLRK PKRIVIRGHD 3240

EKEYPFLVKG GEDLRQDQRI EQLFEVMNAI LSQDAACSQR NMQLRTYRVV PMTSRLGLIE 3300

WIENTMTLKD LLLSNMSQEE KVAYDSDSKA PIYDYRDWLI KVSGRSDVKG YTLMYSRANR 3360

TETVTAFRRR ENKVPADLLK RAFVKMSTSP EAFLALRSHF ASSHALLCIS HWLLGIGDRH 3420

LNNFMVAMET GSVIGIDFGH AFGSATQFLP IPELMPFRLT RQFISLMLPM KETGLVCTVM 3480

VHALRAFRSC AGLLTDTMEV FVKEPSFDWK GFEQTMLRKG GSWIQEINVT EKNWYPQHKI 3540

RYAKRKLAGA NPAVITCDEL RLGHEASPAF RSYVAVARGN KDYNIRAQEP ESRLSEETQV 3600

KCLVDQATDP NILGRTWEGW EPWM 3624

Nucleotide Sequence
(FASTA)

GATGTTGAGT CAAGGTCTGA AAACCGTTGG GCCTCGGAGG AAGTCAGAAT GGGCAGGTGG 60

AAAGTACCCA CATACAAAGA CTACGTGGAT CTTTTTCAGA ATCTTTTAGG CTGTGACCAG 120

ATGGCGGATT TTATCTTAGG AGATGAAACA TTTCTTTTTG TAAATTCCTC CCTTAAAAGT 180

CTGAATCATT TACTCTATGA TGAATTTATA AGATCAGTTT TGAAGATTGT GGAAAAGTTG 240

GATCTTACAC TGGAAAAACA GACTACTGGA GAGCAGGAGG ACGAACGCAC TGCTGATGTC 300

TGGGTGATCC CAACTTCAGA TCCAGCCGCT AACTTGCACC CTATAAAACC AAATGATTTT 360

TCAGCATTCA TTAACCTGGT GGAGTTTTGC AGGGAGATTC TTCCTAAGAA ACAAGTAAGC 420

TTTTTTGAGC CATGGGTGTA CTCATTTGCA TATGAGTTAA TTTTACAGTC TACACGCTTA 480

CCACTCATCA GTGGTTTCTA CAAATTGCTT TCTATTGCAG TGAAAAATGC CAGGAAAATA 540

AAATATTTTG AGGGAGTTAG CCCAAAGTGT CTGAAACATT CTCCTGAAAA TACAGAAAAG 600

CATTCTTGCT TTGCTTTATT TGCAAAATTT GGCAAAGAGG TGTCAGTTAA AATGAAGCAG 660

TACAAGGATG AACTTTTGGC TTCTTGTTTA ACATTTGTTC TGTCCTTGCC ACCTGACATC 720

ATTAAACTTG ATGTTCGAGC CTATGTTCCT GCATTGCAGA TGGCTTTCAA GCTGGGCCTG 780

AGCCATCTGC CATTGGCAGA AATAGGTCTG CATGCCCTTA AAGAATGGTC AGTTCACATT 840

GACAAGTCTA TAATGCAGCC TTACTACAAA GACATCGTCC CCTGCCTTGA TGGATACCTG 900

AATACGTCAA CCTTATCAGA TGAAACCAAG AGCCACTGGG AAGTGTCAGC ACTTTCTCGG 960

GCTGCTCGGA AGGGATTTAA TAGAGATGTA GTGAAGCTTC TGAAAAGGAC AAGAAATGTT 1020

ACATCTGACG AAGCACTGTC CTTAGAAGAA ATAAGAATTA GAGTAGTACA AATACTTGGA 1080

TCTCTGGGAG GACAAATAAA CAAAAATCTT ATAACAGCTA CATCAGGAGA AAGGATGAAG 1140

AAGTATGTGG CGTGGGACAG GGAGAAAAGA CTCAGCTTTG CAGTACCCTT CAGAGAGATG 1200

AAGCCTGTCA TCTATCTGGA TGTCTTTCTG CCTCGGGTCA CTGAATTGGC TCTTTCTGCT 1260

AGTGATCGAC AAACTAAAGT AGCAGCTTGT GAACTGTTAC ACAGCATGGT TATGTTCATG 1320

TTGGGAAGAG CCACTCAGAT GCCTGAAGGT CAGGGGTTGC CTCCCATGTA CCAGCTTTAT 1380

AAGCACATGT TTCCTGTGCT GCTTAAACTT GCATGTGATG TGGATCAAGT GACAAGGCAA 1440

CTCTATGAAC CACTTGTTAT GCAGCTCATC CACTGGTTTA CTAACAATAA GAAATTCGAA 1500

AGTCAAGATA CTGTCGCCTT ATTAGAAGCC ATACTGGATG GCATTGTGGA TCCTGTTGAC 1560

AGTACTTTAA GAGATTTTTG TGGACAGTGT GTTCAAGAAT TCCTCAAATG GTCCATTAAG 1620

CAAACAACAC CTCAGCAGCA AGAGAAGAGC CCAGTAAACA GCAAGTCACT TTTCAAGCGG 1680

CTCTACAGCC TTGCACTACA TCCTAATGCG TTCAAGAGGC TAGGCGCAGC ACTTGCTTTT 1740

AATCACATCT ACAAGGAATT CAGGGAAGAA GGATCCCTGG TAGAACAGTT TGTTTTTGAA 1800

GCCTTAGTGA CATATATGGA AAGTCTGGCC TTGGCACATG CAGATGAGAA ATCCTTAGGT 1860

ACAATTCAGC AGTGCTGTGA TGCCATTGAT CACCTAAGAC GCATCATTGA AAAGAAGTAC 1920

ATTTCTTTAA ACAAAGCAAA AAAGCGGCGT TTGCCACGGG GATTTCCACC TTTGACATCA 1980

TTATGTTTAT TGGATCTGGT CAAGTGGCTT TTCGCTCACT GTGGAAGACC CCAGACAGAA 2040

TGTCGACACA AGTCCATAGA ACTCTTTTAT AAATTTGTTC CTTTATTACC AGGCAACAAA 2100

TCCCCTTCTT TATGGTTGAG AGATCTTATA AAAGCGGAAG GTATTTCTTT TCTCATAAAC 2160

ACATTTGAAG GAGGGGCAAG CAGCAGCGGT CAGCCATCAG GCATTCTTGC TCAGCCAACC 2220

CTCCTCCACT TGCAAGGGCC AGTCAGCCTG CGAGGAATGC TCCAGTGGCT GGACCACCTC 2280

CTTGCAGCAC TGGAGTGCTA CAACACATTT ATCGAGGAGA AGACTGTACA AGTGCAAGAG 2340

GTCCTGGGTA CTGAAGTACA GTCTTCACTT TTGAAGTCTG TGGCCTTCTT TTTGGAAAGC 2400

ATAGCAACAT GTGATGCTAG AACAGTAGAA CAACGCTTTG GCACTGGGCT GACCGGCCCT 2460

CCCAGTGTCC AAGAGGAAGA AAAATACAAT TACAGCAAAT GCACAGTCTT GGTCCGGATT 2520

ATGGAATTTA CCACAACCCT GCTCGTCACC TTTCCAGAAG ATTGCAAGCT CCTGGAGAAG 2580

GACTTGTGTA ACACAAAGCT TATGAAGGTC TTAGTGAAAA TGCTCTGTGA GCCCCTGAGC 2640

ATAGGTTTCA ATATTGGCGA CGTCCAGGTT ATGAACCATC TTCCCAGCAT TTGTGTGAAC 2700

CTGCTGAAAG CATTGAGGAA GTCCCCATAC AGAGACAAGC TGGAGACTCA CCTGAAGGAG 2760

AAAGTGACAG CACAGAGTGT TGAAGAGCTC TGTGCTATTA ACTTGTGTAG CTCTGCAGCT 2820

TGCCAAGAAA GGACCAAGTT GCTGTCTCTC TTATCAGCTT GTAAACAGCT TCACAAAGCT 2880

GGTTTCTCTC ATATTATATC TGCATCTCAG TCTACAGCAT TAAACCATTC CATTGGCATG 2940

AGACTGCTGT CCTTGGTTTA TAATGGCATT GCGCCTGCAC AGGAAAAGCA GTACCTGCAG 3000

TCTTTGGATC CCAGCTGTAA GAGCCTGGCC AGTGGACTCC TGGAATTAGC CTTTGCTTTT 3060

GGAGGACTGT GTGAGCATCT TGTGAGTTTG CTCCTGAATT CATCAATGTT GTCTACACAA 3120

TATCTGGGCA GTTCACAGAG AAACATTAGC TTCTCCCATG GGGAGTATTT CTACAGTTTG 3180

TTTCCAGAAG TAATCAACAC TGAACTGTTG AAAAGTCTTG ATGTTACTGT ATCAAGGCTT 3240

CTGGAGTCAT CTTCAGATAA TCCCAAAATG GTGAGTACTA TTTTAAATGG TATGTTAGAT 3300

ATGAGCTTCA GGGATCGAGC TGTTCAGAAA CACCAAGGAC TGAAGCTTGC GACTGCAATT 3360

CTGCAAAACT GGAGGAAGTG TGATTCATGG TGGGCCCCAG ATTCTGCTCC AGAGAGCAAA 3420

ACGACTGTGC TGTCCTTACT GGCAAAAATG TTGCAGATTG ATTCAACTTT ATCTTTTGAT 3480

ACAAATCACA GCTCATTTTC TGAAATCTTC ACAACGTATG CTAATCTACT TGCAGATACA 3540

AAGTTGGGTC TACACTTAAA GGGCCAAGCC GTCATCCTTC TTCCATTCTT CACCAGAGTG 3600

ACAGAAGACA GGCTAGGAGA CCTAAAGCAC ATTCTGGAAA AGTTCATTGT TCTTAATTTC 3660

CCCATGAAGT CTGACGAATT TCCTCCTGAT TCCCTGAAGT ACAATAATTA TGTGGACTGC 3720

ATGAAAAAGT TCCTAGATGC TTTGGAATTA TCTCAGAGTC CTATGTTGCT TCAGTTGATG 3780

ACAGACATTC TTTGTAGGGA ACAGCAACAT ATTATGGAAG AATTGTTCCA AACCACCTTC 3840

AAAAGGATCG CTAGGCGGAG TCCATGTGTC ACACAATTAA ATCTTTTGGA AAGTGTATAC 3900

ACAATGTTCC GGAAGGGTGG CCTCCTTTCA GATGTCACTC AGGCATTCGT GGATCGCTCT 3960

CTCCTCACCT TGTTGTGGCA CTGTGACTTG GACACACTGA AAGAGTTCTT TAGCAGAATT 4020

GTGGTGGAGG CCATTGATGT GTTGAAGTCC AGATTTACAA AGCTAAATGA CACTTTTGAC 4080

ACTCAAATCA CCAAGAAGAT GTGCTATTAC AAGATGCTAG CTGTGATGTA TTCTCGTCTT 4140

TTAAAAGATG ATGTTCACTC TAAAGAATCT AAAATTAATC AAGCTTTCCA AGGCTCCTGT 4200

GTTGCAGAAG GAAATGAACT TACAAAGACA CTTCTTAAGT TGTGCCACGA TGCATTTACA 4260

GAGAACATGG CAGGGGAAAG CCAGTTACTG GAAAAGAGAA GACTTTATCA TTGTGCTGCA 4320

TACAACTGTG CCATTTCTCT GATAAGCCGA GTCTTCAATG AGTTGAAATT TTACCAAGGG 4380

TTTTTGTTTA GTGAAAAACC AGAAAAGAAT TTGTTTATTT TTGAAAATTT GATAGACCTG 4440

AAACGTTGCT ATACATTTCC TATAGAAGTT GAGGTTCCTA TGGAAAGAAA GAAAAAGTAC 4500

GTTGAAATTA GGAAAGAGGC CAGGGATGCA GCAAATGGGG CTTCAGGCAA TCCTCGTTAT 4560

ATGTCTTCAT TGTCATATTT AACAGAGAGT AGCCTAAGTG AAGAAATGAG TCAATTTGAT 4620

TTCTCAACTG GAGTTCAGAG CTATTCATAC AGTTCTCAAG ATCGTAAACC TACGACGGGC 4680

CATTTTCAGA GAAGGGAGCA TCAAGATTCC ATGGCTCAGG ATGACATCAT AGAGTTAGAG 4740

ATGGATGAGC TCAATCAACA TGAATGTATG GCACCCATGA CATCCCTGAT TAAACACATG 4800

CAGAGAAATG TGATTGCACC CAAGGGACAA GAGGGTTCAA TATCAAAAGA TCTTCCACCT 4860

TGGATGAAAT TTCTCCATGA CAAACTAGAA AATGCGTCAG TATCTTTAAA TATCCGTCTC 4920

TTCTTAGCCA AGCTTGTTAT TAATACAGAA GAGGTCTTTC GCCCTTATGC AAAGCACTGG 4980

CTGGGCCCCC TGCTACAGCT AGCTGTTTGT GAGAACATTG GAGAAGGAAT TCACTACATG 5040

ATAGTAGAAA TAGTAGCTAC CATTCTCTCT TGGACAGGCT TGGCTACACC TACAGGAGTC 5100

CCTAAATATG AAGTCTTAGC AAATCGATTG CTTTATTTTC TAATGAAATA TGTCTTCCAT 5160

CCCAAAAGAG CTGTGTTTAG ACACAACCTT GAAATCATTA AAACCCTTGT TGAATGCTGG 5220

AAGGAGTGTC TGTCCATCCC TTACAGGTTA ATATTTGAAA AATTTTCCAA TAAGGACCCC 5280

AATTCTAAAG ACAATTCTGT AGGAATTCAA TTATTGGGCA TTGTAGTAGC TAATAACTTG 5340

CCTCCCTATG ACCTAAAGGG TGACATCACG AGTGCCATGT ATTTTGAAGC TTTAGTCAAT 5400

AACATGTCCT TTGTGAAGTA TAAAGAAGTA TATGCAGCTG CAGCAGAAGT TCTAGGACTC 5460

ATTCTTCAAC ATGTTACTGA GAGAAAACAC GTGATAGCAG AGTCGGTATA TGAACTGGTT 5520

GTAAAACAAC TAAAGCAACA TCAAAATACT ATGGAAGACA AATTTATCGT ATGCTTAAAC 5580

AAAATAGTGA AGGGCTTCCC TCCTCTTGCT GACAGGTTCT TGAATGCTTT GTTCTTTCTG 5640

CTGCCAAAAT TTCATGGAGT AATGAAGACG CTTTGTCTGG AAGTGGTACT TTGTCGAGCA 5700

GAGGCGATCA CAGGCCTATA CTTACAGTTA AAGAGTAAGG ACTTTCTTCA AGTCATGAGA 5760

CATAGAGATG ATGAAAGACA AAAGGTGTGT TTGGATATAA TTTATAAGAT GGTGGCAAAA 5820

TTAAAACCAA CGGAACTCCG AGAACTTCTG AATCCTGTTG TGGAATTTGT TTCCCATCCT 5880

TCTCCAACAT GTAGAGAACA AATGTATAAT ATTCTTATGT GGATTCATGA CAATTACAGA 5940

GATCCAGAGA GTCAAATGGA TGAAGACTCC CAGGAAATAT TTAAACTCGC AAAAGATGTG 6000

CTGATTCAAG GACTGATTGA TGAGAACCTT GGACTCCAAC TAATTATTCG GAATTTCTGG 6060

AGCCATGAAA CGAGATTGCC ATCCAATACA TTGGACCGAT TGTTGGCATT AAATTCTTTA 6120

TATTCTCCCA AGATAGAAGT CCACTTTTTA AGTTTAGCAA CAAATTTTCT GCTTGAAATG 6180

ACCAGGATGA GCCCAGATTA TCTAAACCCC ATTTTTGAGC ATCCTCTTTC AGAATGTGAA 6240

TTTCAGGAAT ATACTATAGA TCCTGACTGG CGTTTTCGTA GTACTGTTCT TACCCCGATG 6300

TTTATTGAGA CCCAGGCCTT TCCAAGTACT CTCAATACCC AAACCCAAGA AGGGTCCCCG 6360

TCAGACCGAA GGCAGAAGCC TGGACAAGTG CGGGCCACCC AACAGCAGTA TGATTTCACT 6420

CCAACACAAA CTTCAGTTGA AAGGAGCTCA TTTGATTGGC TAACTGGAAG CAGCATTGAC 6480

CTAATGGCAG ATCATACAGT CTTCTCTTCA GAGTCCTTGT CTTCTTCCTT GCTGTTTTCC 6540

CACAAGAAGA GTGAAAAGTC ACAAAGAGTA TCCTGGAAGT CAGTAGGACC TGACTTCGGG 6600

ACAAAAAAGC TGGGCCTGCC TGGTGATGAG GTGGATAACC AAGTAAAAAG TGGCACTCAC 6660

AGCCAGACAG AAATTCTGAG ATTACGCAGA CGATTTTTAA AGGACCAAGA AAAACTGAGT 6720

TTGCTGTATG CCAAAAGGGG TCTCATGGAG CAAAAACTAG AAAAGGATAT CAAGAGTGAG 6780

TTAAAAATGA AGCAGGATGC CCAGGTTGTT CTTTACAGAA GTTATCGTCA TGGCGACCTT 6840

CCTGATATCC AGATCCAGCA CAGCAGTCTG ATCACCCCCT TGCAGGCTGT GGCCCAGAAA 6900

GACCCAATAA TTGCAAAACA ACTCTTCAGC AGCTTGTTTT CTGGGATTTT GAAAGAAATG 6960

CATAAATTTA GGACCACATC TGAAAAGAAC ATCATCATCC AAAATTTGCT TCAAGACTTC 7020

AACCGCTTCC TCAATACAAC TTTCTTGTTC TTTCCACCCT TTGTCTCTTG CATCCAGGAA 7080

ATAAGTTGCC AACACGTAGA CTTGCTGACA CTTGACCCAG CCGCAGTTCG AGTGGGATGC 7140

CTGGCCAGTC TGCAACAGCC TGGAGGTATT CGTCTTCTGG AAGAGGCCCT ACTTCACCTG 7200

CTGCCCAAGG AACCACCCAC CAAACGAATC CGGGGCAAGA CTTGCTTGCC TCCCGATGTT 7260

CTCCGGTGGA TGGAACTTGC TAAACTCTAT CGATCAATTG GGGAATATGA TGTCCTCCAT 7320

GGCATTTTTA GCAGCGAGTT AGGAACAAAG CAGGACACTC AGAACGCACT GTTAGCAGAA 7380

GCCAGAAGTG ATTATTTTCA AGCTGCTAAC TTGTATAAGG AGGCTTTAAA TAAATTGGAG 7440

TGGTTAGATG GTGAACCCAC AGAAGCTGAG AAGGAGTTCT GGGAGATGGC ATCCCTTGAC 7500

TGTTACAACA ACCTCTCTCA ATGGAAAGAA CTTGAGTACA GGTCTACAGT CAATATAGGC 7560

AGTGAGAACT CTCTTGATCT AAGTAAAATG TGGAGCAAAC CATTTTACCA GGAGACGTAT 7620

CTTCCTTATG TGATCCGCAG CAAACTGAAG CTCTTGCTTC AAGGAGAAGA CAACCAGTCT 7680

CTGCTAACAT TTGTGGATGA AGCCATGCAC AAAGAGCTGC AGCAGATGGT CCTAGAACTT 7740

CAGTATAGTC AAGAGCTGAG TCTTCTTTAC ATCTTACAGG ATGATATTGA CAGAGCCACA 7800

TACTACATTA AAAATGCCAT TCAGATTTTC ATGCAAAATT ATTCTAGTAT TGATGTCCTC 7860

TTGTATAGAA GTAGACTCGC CAAATTACAG TCTGTACAGA CTTTAGCAGA AATTGAGGAG 7920

TTCCTCAATT TTATACGTAA ACATGGTGAT TTATCATCTC TGGGTCCCCT AAGGAGGCTT 7980

CTGAAAACCT GGACCAGCAG ATACCCAGAT ACTGTGACAG ACCCAATGCA CATCTGGGAT 8040

GACATCATCA CAAATCGCTG CTTTTTTCTC AGTAAAATAG AGGAGAGACT GACTGTTTCT 8100

CCAGGAGATC ACAGTATGAG TGTGGATGAG GATGAAGATT CCTTTGCCAG GGAAGGGTCC 8160

GAGCCAAAGG AAGATGCTCA TCACATCCTT CAGAGCTGCA GATTCACCAT GAAGATGAAG 8220

ATGATAGAAA GCTCCTGGAA GCAGAATAAT TTCTCACTTT CCATGAAACT CCTGAAAGAA 8280

ATGCATAAAG AATCAAAAAT AAGAGAGTCT TGGCGAATGC AGTGGATACA CAGTTTCTGC 8340

CAGCTGAACC ACTGCCGGAG CCACACTCAG AGCCCTCAGG AACAAGTCCT CACCATGCTC 8400

AAGACCATCA CACTGTTGGA TGAAAGTGAT ATTTCAAACT ACTTAAATAA AAACATTCAG 8460

GCCTTTTGTG ACCAGAACAT CCTCTTGGGC ACAAGTTGCA GGATCATGGC TGATGCTCTC 8520

AGCAGGGAGC CAGCCTGCCT GTCTGGCCTG GAGAAAAGTA AGACGGAATC CATCTTTGCA 8580

CTTTCCGGAT CTAATACGGA GAACACAGAG AGGGTAATCT CAGGTCTGTA CCAGAGAGCA 8640

TTCCATCACC TCTCCATGGC TGTGCAGTCA GCTGAAGAGG AGACCCAACT TTCCTGTTGG 8700

GGCCATGAGG CTGCAGCTGA GAGGGCCCAT GCTTATATGA CACTGGTAGG TTTCTGTGAC 8760

CAACAACTCC GAAAGGTAGA AGAGAGTGCA TCCAGCAAGA ACTCCACCGA ACTGGAAGGA 8820

TATCCAGCAC TTGTGGTGGA GAAAATGTTG AGAGCGTTAA AGTTGAACTC TTCTGAAGCC 8880

AGGCTGAAAT TTCCTAGATT ACTTCAGATT ATAGAACAAT ATCCAGAAGA GACCGTAAAC 8940

ATAATAATAA AAGAGATTTC ATCCATTCCT TGCTGGCAGT TCATTGGCTG GATCGGCCAC 9000

ATGGTTGCCT TACTGGACAA AGAGGAAGCT ATTGCGGTGC AGCATACCGT GGAAGAAATT 9060

GCTGATAACT ATCCACAGGC CATTATCTAC CCTTTTATAA TAAGCAGTGA AAGCTACTCC 9120

TTTCAAAATA CTTCTTCTGG CCATAATAAT AAAGCATTTG TTGAGAGGAT AAAAAGTAAA 9180

CTTGATCAAG GAGGAGTGAT TCAAGGTTTT ATTAATGCCT TAGACCAGCT CTCCAATCCT 9240

GATATGCTCT TTAAGGACTG GGTTAATGAT ACAAAAGATG AACTAGGAAA GAATCCTGTG 9300

AATAAGAAAA ATATTGAAAA ATTGTATGAA AGGATGTATG CTGCCTTGGG TGACTTTCGG 9360

GCTCCAGGCC TGGGGCCCTT TCGGAGGAAG TTCATACAGA CCTTTGGGAA AGAATTTGTC 9420

AAAAGCTTTG GGAATGGTGG TTCTAAGCTG CTTACAATGA AGCTCGATGA GTTTCGCAAT 9480

ATCACTGACT CACTATTTGT AAGGATGAGA AAAGACTCAA AGCTACCTGG GAACCTGAAA 9540

GAGTATTCCC CCTGGATGAG TGAGTTCACA GTGAAGAGTG AACTGGAGAT TCCTGGACAA 9600

TATGATGGGA AGAGCAAACC ATTGCCTGAG TATCATGTGC GGATCTCTGG ATTTGACGAG 9660

CGGGTAAAAG TAATGGTCTC CTTGAGGAAA CCAAAGCGCA TTGTTATTCG AGGCCATGAT 9720

GAAAAGGAAT ACCCATTCCT GGTAAAAGGT GGTGAGGACC TCCGACAAGA CCAGCGCATT 9780

GAGCAGCTCT TTGAGGTCAT GAATGCCATC CTCTCTCAGG ATGCTGCCTG CAGTCAGAGA 9840

AACATGCAGT TAAGGACTTA CCGTGTTGTG CCCATGACCT CTAGATTAGG ATTAATTGAA 9900

TGGATTGAAA ATACTATGAC CTTGAAGGAC CTTCTTTTGA GTAATATGTC ACAAGAGGAG 9960

AAAGTGGCTT ATGACAGTGA TTCCAAAGCA CCAATTTATG ACTACAGAGA CTGGCTGATA 10020

AAAGTGTCAG GGAGAAGTGA TGTTAAAGGC TACACACTAA TGTACAGCAG AGCTAACCGT 10080

ACAGAAACAG TTACGGCTTT TAGAAGAAGG GAAAATAAAG TACCTGCTGA TCTCTTAAAG 10140

CGGGCCTTTG TGAAGATGAG CACCAGCCCT GAGGCCTTCC TGGCACTTCG TTCCCACTTT 10200

GCCAGTTCTC ACGCACTGCT GTGCATCAGC CACTGGCTCC TTGGTATTGG AGACAGACAC 10260

CTGAACAATT TCATGGTGGC CATGGAAACA GGCAGTGTGA TTGGAATTGA CTTTGGACAT 10320

GCTTTTGGAT CAGCTACTCA GTTTCTTCCA ATCCCTGAGT TGATGCCTTT TCGTCTAACC 10380

CGCCAATTTA TCAGTCTCAT GTTGCCAATG AAAGAAACGG GTCTTGTGTG CACAGTCATG 10440

GTGCATGCAC TGAGGGCTTT CCGCTCGTGT GCAGGTCTGC TCACTGATAC CATGGAAGTT 10500

TTTGTGAAGG AACCCTCCTT TGATTGGAAG GGTTTTGAGC AGACGATGCT AAGAAAAGGA 10560

GGATCATGGA TTCAAGAAAT AAATGTAACT GAAAAGAATT GGTATCCACA ACACAAAATA 10620

CGCTATGCTA AGAGAAAGTT AGCAGGGGCC AACCCAGCAG TTATAACTTG TGATGAACTA 10680

CGTCTAGGCC ATGAAGCTTC ACCAGCCTTC AGAAGTTATG TAGCTGTAGC TCGAGGCAAC 10740

AAAGACTACA ACATTCGTGC ACAAGAGCCA GAGAGTAGAC TTTCAGAAGA GACTCAAGTG 10800

AAGTGCTTGG TGGATCAGGC GACAGACCCC AACATCCTTG GCAGGACTTG GGAAGGATGG 10860

GAGCCTTGGA TGTAA 10875

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i gfderv+++ s++kpk++++rG+d+keyp+Lvkg eDlrqd+r++qlf+++N +L +d

Q: 3215  ISGFDERVKVMVSLRKPKRIVIRGHDEKEYPFLVKGGEDLRQDQRIEQLFEVMNAILSQD  3274

         789*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkkl.vekkavlldqpi...syr  116

         +++s+r++++rty+Vvp+++r+gliew+ent++Lk+ll     ++++v++d+      y

Q: 3275  AACSQRNMQLRTYRVVPMTSRLGLIEWIENTMTLKDLLLSNmSQEEKVAYDSDSkapIYD  3334

         ************************************98654477777777655556889*

S: 117   ykdlstvqarkpklkhlkls.........levfkevlenlvpkdllkklllekfpspeew  167

         y d+ ++++   ++k ++l+         ++ f+ ++++ vp+dllk++++++++spe++

Q: 3335  YRDWLIKVSGRSDVKGYTLMysranrtetVTAFRRRENK-VPADLLKRAFVKMSTSPEAF  3393

         *************************************99.********************

S: 168   felrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpe  227

         ++lr+++++s+A+ +++++ Lg+gdrhl+n+++++etg v+ idfg+af++a+++l++pe

Q: 3394  LALRSHFASSHALLCISHWLLGIGDRHLNNFMVAMETGSVIGIDFGHAFGSATQFLPIPE  3453

         ************************************************************

S: 228   kvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk..  285

          +PFRLTr+++ ++ +++++G+    ++++lr++r+    l+ ++evf+++p++dwk

Q: 3454  LMPFRLTRQFISLMLPMKETGLVCTVMVHALRAFRSCAGLLTDTMEVFVKEPSFDWKGfe  3513

         *********************************************************999

S: 286   ....kkktsketeeelaekakaealkikkllskvekaenavatrdllllee  332

              k++s+++e++++ek+++++ ki ++++k+++a++av+t+d+l+l++

Q: 3514  qtmlRKGGSWIQEINVTEKNWYPQHKIRYAKRKLAGANPAVITCDELRLGH  3564

         999999****************************************99887

Domain Sequence
(FASTA)

ISGFDERVKV MVSLRKPKRI VIRGHDEKEY PFLVKGGEDL RQDQRIEQLF EVMNAILSQD 60

AACSQRNMQL RTYRVVPMTS RLGLIEWIEN TMTLKDLLLS NMSQEEKVAY DSDSKAPIYD 120

YRDWLIKVSG RSDVKGYTLM YSRANRTETV TAFRRRENKV PADLLKRAFV KMSTSPEAFL 180

ALRSHFASSH ALLCISHWLL GIGDRHLNNF MVAMETGSVI GIDFGHAFGS ATQFLPIPEL 240

MPFRLTRQFI SLMLPMKETG LVCTVMVHAL RAFRSCAGLL TDTMEVFVKE PSFDWKGFEQ 300

TMLRKGGSWI QEINVTEKNW YPQHKIRYAK RKLAGANPAV ITCDELRLGH 350

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005958	; C:DNA-dependent protein kinase-DNA ligase 4 complex
GO:0005667	; C:transcription factor complex
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0006915	; P:apoptotic process
GO:0002326	; P:B cell lineage commitment
GO:0007420	; P:brain development
GO:0032869	; P:cellular response to insulin stimulus
GO:0006303	; P:double-strand break repair via nonhomologous end joining
GO:0035234	; P:germ cell programmed cell death
GO:0007507	; P:heart development
GO:0033152	; P:immunoglobulin V(D)J recombination
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0002328	; P:pro-B cell differentiation
GO:0031648	; P:protein destabilization
GO:0010332	; P:response to gamma radiation
GO:0001756	; P:somitogenesis
GO:0033077	; P:T cell differentiation in thymus
GO:0002360	; P:T cell lineage commitment
GO:0033153	; P:T cell receptor V(D)J recombination
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR012582	; NUC194.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF08163	; NUC194; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013