EKS-RAN-00310

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00310

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IKK	440.4	3.3E-132	9	293	285

Status

Unreviewed

Ensembl Protein

ENSRNOP00000030127

UniProt Accession

D4A5E7;

Protein Name

Protein Synonyms/Alias

Inhibitor of kappaB kinase epsilon (Predicted); Protein Ikbke;

Gene Name

Ikbke

Gene Synonyms/Alias

Ikbke; Ikbke_predicted; rCG_45931;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000025100	ENSRNOP00000030127	ENSRNOT00000038151

Organism

Rattus norvegicus

Functional Description

Protein Length

717

Protein Sequence
(FASTA)

MQSTTNYLWH TDDLLGQGAT ANVYKARNKK SGEVVAVKVF NSASYRRPPE VQVREFEVLR 60

RLDHENIVKL FAVEETGGSR QKVLVMEYCS SGSLLSVLED PENTFGLPEE EFLVVLRCVV 120

AGMNHLRENG IVHRDIKPGN IMRLVGKEGQ SIYKLSDFGA ARKLDDDEKF VSVYGTEEYL 180

HPDMYERAVL RKPQQKAFGV TVDLWSIGVT LYHAATGSLP FIPFGGPRRN KEIMYRITTE 240

KPAGAISGTQ KQENGPLEWS YSLPITCRLS VGLQSQLVPI LANILEAEQA KCWGFDQFFA 300

ETSDILQRTV IHVFSLPQAV LHHIYIHAHN TIAIFLEAVY EQTNVAPKHQ EYFFEGHPCV 360

LEPSLSAQHI AHTAASSPLT LFSMASDTPK GLAFRDPALD VPKFVPKVDL QADYSTAKGV 420

LGAGYQALWL ARVLLDGQAL MLRGLHWVLV VLQNTCQQTL EITRTALLFL SSSLGTERLS 480

SGAGMLDIQE LKEATELRSR LQTFSEVLSK CSHNVTETQR SLSCLVGELL KSRDQIHEDN 540

RSIQKIQCCL DKMHFIYKQF KKSRMRPGLS YNEEQIHKLD KVNFSHLAKR LLQVFQEECA 600

QTYQVSLVTH GKRMRQVQKA QNHLHLIGHS VATCNSEARG AQESLAKMFD QLLLDRASKQ 660

GAEVSPQPMA THPGPDPKDL VFHMQELCND MKLLAFDLQD NNRLIERLHR VPPTPEV 717

Nucleotide Sequence
(FASTA)

ATGCAGAGTA CCACTAACTA CCTGTGGCAT ACTGATGACC TGCTAGGGCA GGGGGCCACT 60

GCCAATGTGT ACAAGGCCCG GAATAAGAAA TCCGGGGAGG TGGTTGCTGT AAAGGTCTTC 120

AACTCAGCCA GCTACCGGCG GCCCCCTGAG GTACAAGTGA GGGAGTTCGA GGTCTTGCGG 180

AGGCTGGATC ATGAGAACAT CGTGAAGCTA TTCGCAGTGG AGGAAACGGG AGGCAGCCGG 240

CAGAAGGTGC TAGTGATGGA GTACTGCTCC AGTGGGAGCC TGCTGAGCGT GCTGGAAGAC 300

CCTGAGAACA CATTCGGCCT TCCTGAGGAG GAGTTCCTGG TGGTACTGCG CTGTGTGGTG 360

GCTGGCATGA ACCACCTGCG GGAGAATGGC ATTGTCCACC GTGACATCAA GCCCGGGAAT 420

ATCATGCGCC TGGTAGGCAA GGAGGGGCAG AGCATCTACA AGCTGTCTGA CTTCGGGGCT 480

GCCCGGAAGC TGGACGACGA TGAGAAGTTT GTTTCTGTCT ATGGTACAGA GGAGTACCTG 540

CACCCTGACA TGTATGAGCG GGCAGTGCTT CGCAAACCCC AGCAAAAGGC GTTCGGGGTG 600

ACAGTGGATC TCTGGAGTAT TGGGGTGACC TTGTACCACG CAGCCACCGG TAGTCTGCCC 660

TTCATCCCCT TTGGTGGGCC CCGGCGCAAC AAGGAGATCA TGTATAGGAT CACCACAGAG 720

AAGCCAGCTG GGGCCATTTC CGGGACTCAG AAGCAGGAAA ATGGTCCCCT GGAATGGAGC 780

TACAGCCTCC CCATCACCTG TAGACTGTCT GTGGGGCTGC AGAGTCAGCT AGTGCCCATC 840

CTGGCCAACA TCCTGGAGGC CGAACAGGCT AAATGCTGGG GCTTCGATCA GTTCTTTGCA 900

GAGACCAGTG ACATCCTGCA GCGAACTGTC ATCCATGTCT TCTCCCTGCC CCAGGCGGTT 960

TTGCATCACA TCTACATCCA TGCCCACAAC ACGATTGCCA TCTTTTTGGA GGCTGTATAT 1020

GAACAGACCA ACGTGGCCCC CAAACACCAA GAATACTTCT TCGAGGGTCA CCCTTGTGTC 1080

CTCGAGCCAA GCCTCTCAGC CCAGCACATC GCCCACACAG CTGCCAGCAG CCCTCTAACT 1140

CTGTTCAGCA TGGCCAGCGA CACACCCAAG GGGCTGGCCT TCAGGGACCC TGCTCTGGAT 1200

GTCCCAAAGT TCGTCCCTAA GGTTGACCTA CAGGCCGATT ACAGCACCGC TAAGGGCGTG 1260

CTGGGCGCTG GTTACCAGGC CTTGTGGCTG GCGCGGGTCC TGCTGGATGG ACAGGCGTTG 1320

ATGCTTCGAG GGTTACACTG GGTCCTGGTG GTGCTTCAGA ACACGTGCCA ACAGACACTG 1380

GAGATCACAC GGACAGCCCT CCTCTTCCTC AGTAGCAGCC TGGGCACTGA AAGGCTCAGC 1440

AGTGGAGCTG GGATGCTTGA CATCCAGGAA CTAAAGGAAG CCACGGAGCT GAGGTCCAGG 1500

CTGCAGACTT TCTCAGAGGT CCTGTCTAAG TGTTCCCACA ATGTCACAGA AACCCAAAGG 1560

AGCCTGAGTT GTCTGGTTGG AGAGCTTTTG AAGAGCCGGG ATCAGATTCA TGAGGATAAC 1620

AGAAGTATCC AGAAGATTCA GTGTTGTTTG GACAAGATGC ACTTCATCTA CAAACAGTTC 1680

AAGAAGTCTA GGATGAGGCC AGGCCTCAGC TACAATGAGG AGCAGATCCA CAAGCTGGAT 1740

AAGGTAAATT TTAGTCACCT AGCCAAGAGG CTGCTGCAGG TGTTCCAGGA GGAGTGTGCA 1800

CAGACGTATC AGGTGTCACT GGTCACACAT GGCAAGCGGA TGAGGCAGGT GCAGAAGGCC 1860

CAGAACCACC TGCACCTCAT TGGCCACTCC GTGGCTACCT GTAACTCAGA AGCCCGGGGA 1920

GCCCAGGAGA GCCTGGCCAA GATGTTTGAT CAGCTCCTCC TGGACAGAGC TTCCAAACAG 1980

GGAGCTGAGG TCTCACCACA ACCTATGGCA ACTCATCCCG GCCCCGATCC GAAGGACCTG 2040

GTCTTCCACA TGCAGGAACT TTGTAATGAT ATGAAGCTAT TGGCCTTTGA TCTCCAGGAC 2100

AACAACAGAC TCATCGAACG GCTACATAGA GTTCCACCAA CACCAGAAGT CTGA 2154

Domain Profile

S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60

         W++++lLG+Ga++nv+karnkk+ge +avkv++++s++rp evqvre+evlr+l+h+niv

Q: 9     WHTDDLLGQGATANVYKARNKKSGEVVAVKVFNSASYRRPPEVQVREFEVLRRLDHENIV  68

         ************************************************************

S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvvaglry  120

         kl++vee+     +r+kvlv+eyCs+G+l++vLe+pen++GL+e+e+lvvL++vvag+++

Q: 69    KLFAVEET---GGSRQKVLVMEYCSSGSLLSVLEDPENTFGLPEEEFLVVLRCVVAGMNH  125

         ********...*************************************************

S: 121   LrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPely  180

         Lren+ivhRD+kP+ni++l+g++g+siykl+D+Gaar+ldddek+vs++GteeYl+P++y

Q: 126   LRENGIVHRDIKPGNIMRLVGKEGQSIYKLSDFGAARKLDDDEKFVSVYGTEEYLHPDMY  185

         ************************************************************

S: 181   e........qkkytatvDlWsiGvllyeaitGslPflpfegprr....lykkitkkpaka  228

         e        qk++++tvDlWsiGv+ly+a+tGslPf+pf+gprr    +y+++t+kpa+a

Q: 186   EravlrkpqQKAFGVTVDLWSIGVTLYHAATGSLPFIPFGGPRRnkeiMYRITTEKPAGA  245

         ************************************************************

S: 229   iagteka.ngevefssslPlsaslssglqeklekllanllevdeekrw  275

         i+gt+k+ ng++e+s+slP++++ls glq++l+++lan+le++++k+w

Q: 246   ISGTQKQeNGPLEWSYSLPITCRLSVGLQSQLVPILANILEAEQAKCW  293

         *******9***************************************9

Domain Sequence
(FASTA)

WHTDDLLGQG ATANVYKARN KKSGEVVAVK VFNSASYRRP PEVQVREFEV LRRLDHENIV 60

KLFAVEETGG SRQKVLVMEY CSSGSLLSVL EDPENTFGLP EEEFLVVLRC VVAGMNHLRE 120

NGIVHRDIKP GNIMRLVGKE GQSIYKLSDF GAARKLDDDE KFVSVYGTEE YLHPDMYERA 180

VLRKPQQKAF GVTVDLWSIG VTLYHAATGS LPFIPFGGPR RNKEIMYRIT TEKPAGAISG 240

TQKQENGPLE WSYSLPITCR LSVGLQSQLV PILANILEAE QAKCW 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0008384	; F:IkappaB kinase activity
GO:0004704	; F:NF-kappaB-inducing kinase activity
GO:0008630	; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade

KEGG

rno:363984

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013