EKS-RAN-00318
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00318
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk516.71.5E-155195464270
StatusUnreviewed
Ensembl ProteinENSRNOP00000030962
UniProt AccessionF1M856;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameLtk
Gene Synonyms/Alias Ltk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000025130ENSRNOP00000030962ENSRNOT00000030532
OrganismRattus norvegicus
Functional Description
Protein Length577
Protein Sequence
(FASTA)
LETRAAAQGS GRRGGAAGGD TSESDLLWAD GEDGISFVHP SGELYLQPLA VTEGDVEVEI 60
RRHPNCSHCS FKDCQWQAEL WRAECICPEG MELAVDNITC TGLPTTTSPL IMMGAVVTAL 120
TLSLLMMCGV LILVNQKKCQ SLRGTRLPGP ELELSKLRTS AIRTAPNPYY CQVGLSPAQA 180
WPLPQGLTEV SPANVTLLRA LGHGAFGEVY EGLVIGLPGD SSPLPVAIKT LPELCSPQDE 240
LDFLMEALII SKFSHQNIVR CVGLSFQAAP RLILLELMSG GDMKSFLRHS RPHPGQLSPL 300
TMQDLLQLAQ DIAQGCHYLE ENHFIHRDIA ARNCLLSCSG DSRVAKIGDF GMARDIYQAS 360
YYRKGGRTLL PVKWMPPEAL LEGLFTSKTD SWSFGVLLWE IFSLGYMPYP GHTNQEVLDF 420
IATGNRMDPP RNCPGPVYRI MTQCWQLQPE LRPDFASILE RIQYCIQDPD VLNSPLPMEP 480
GPIVEEEGAS GPGNRSLEGL RSPKTLELSS QNLKSRGGDL LGSQLPSGLK TLTSRCLQPQ 540
NIWNPTYGSW TPRSPQGEDS DIDLSNGPSS DSFPGEQ 577
Nucleotide Sequence
(FASTA)
CTGGAGACCC GCGCGGCGGC GCAGGGCAGC GGCAGGAGAG GAGGCGCGGC CGGCGGTGAT 60
ACTTCTGAGT CTGACCTCCT CTGGGCTGAT GGGGAAGATG GCATATCCTT CGTCCACCCT 120
AGTGGCGAGC TTTACCTACA ACCTCTGGCA GTCACAGAGG GCGATGTTGA GGTGGAGATC 180
CGAAGGCACC CCAATTGCAG TCACTGCTCT TTCAAAGACT GCCAGTGGCA GGCAGAGCTC 240
TGGAGGGCTG AATGCATATG CCCAGAGGGC ATGGAGCTAG CTGTGGATAA TATCACATGC 300
ACGGGCCTGC CAACCACCAC AAGCCCTCTG ATAATGATGG GAGCTGTTGT GACAGCCTTG 360
ACGCTGAGTC TCCTTATGAT GTGTGGAGTC CTAATTCTAG TGAACCAGAA GAAATGTCAG 420
AGCCTGCGGG GAACCAGGCT GCCAGGCCCT GAGCTTGAGC TGAGTAAGCT GAGAACCTCT 480
GCCATCAGGA CAGCACCCAA CCCATATTAC TGTCAGGTGG GGCTCAGCCC TGCCCAGGCC 540
TGGCCTCTGC CCCAAGGGCT CACTGAGGTT TCCCCAGCCA ATGTCACTCT ACTCAGAGCC 600
CTTGGCCATG GTGCCTTTGG GGAAGTGTAT GAGGGACTAG TGATTGGTCT TCCTGGGGAT 660
TCCAGCCCTC TTCCGGTGGC TATCAAGACT CTGCCGGAGC TCTGCTCCCC TCAGGATGAG 720
CTGGACTTTC TCATGGAGGC TCTCATCATC AGCAAGTTCA GCCATCAGAA TATTGTACGC 780
TGTGTGGGGC TCAGCTTCCA GGCTGCCCCT CGCCTCATTC TGCTGGAGCT GATGTCTGGT 840
GGGGACATGA AGAGCTTTCT GAGGCATAGC AGACCACACC CGGGACAACT GTCACCTCTG 900
ACCATGCAGG ACCTATTACA GTTGGCCCAG GATATAGCTC AGGGCTGCCA CTACTTGGAG 960
GAAAATCACT TTATCCACAG AGACATTGCC GCCCGAAACT GTCTGCTTAG CTGCAGTGGA 1020
GACAGCCGAG TGGCCAAGAT TGGAGACTTT GGAATGGCAA GAGATATCTA CCAGGCCAGT 1080
TATTATCGCA AAGGGGGCCG GACCTTGCTC CCAGTGAAGT GGATGCCCCC AGAAGCTCTC 1140
CTGGAGGGCC TTTTCACATC CAAGACGGAC TCCTGGTCTT TTGGGGTCCT GCTCTGGGAG 1200
ATCTTCTCAC TAGGTTATAT GCCCTACCCT GGACACACCA ACCAGGAGGT TCTAGACTTC 1260
ATTGCCACAG GGAACAGGAT GGACCCTCCT AGGAACTGTC CTGGGCCAGT GTACCGAATC 1320
ATGACCCAGT GCTGGCAGCT TCAACCTGAG CTCCGCCCTG ACTTTGCCAG CATCTTGGAG 1380
CGCATTCAAT ACTGCATTCA GGACCCTGAT GTGCTGAACT CGCCCTTGCC CATGGAACCA 1440
GGGCCCATTG TGGAGGAGGA AGGGGCCTCT GGGCCGGGGA ACAGGTCACT GGAAGGTCTT 1500
AGATCCCCAA AGACCCTGGA ACTGAGTTCC CAGAACTTGA AAAGCCGGGG AGGAGACCTT 1560
CTTGGCTCTC AGCTGCCCTC TGGCCTCAAG ACCCTCACAT CCAGATGCCT TCAACCTCAG 1620
AACATTTGGA ACCCCACCTA TGGCTCCTGG ACCCCAAGGA GCCCCCAGGG TGAAGATTCA 1680
GACATTGACC TTAGCAATGG CCCCTCCTCG GATTCCTTTC CAGGCGAGCA GTAG 1734
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         ++l+ralG+GafGevyeglv+glpgd+s+l va+ktlpe +s qdeldfl+ealiiskf+
Q: 195   VTLLRALGHGAFGEVYEGLVIGLPGDSSPLPVAIKTLPELCSPQDELDFLMEALIISKFS  254
         689*********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+nivr++G+s++++prlillel++GGd+ksflr+srp+p qls+l+m+dll++a+d+a+
Q: 255   HQNIVRCVGLSFQAAPRLILLELMSGGDMKSFLRHSRPHPGQLSPLTMQDLLQLAQDIAQ  314
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gc+yleen+fihrdiaarn+lls++G srvaki+dfGmardiy+a+yyrkggr+llpvkw
Q: 315   GCHYLEENHFIHRDIAARNCLLSCSGDSRVAKIGDFGMARDIYQASYYRKGGRTLLPVKW  374
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppea+leG+ftsktd+wsfGvllwe+fslG++pypg++nqevl+++++G+r+d+p+++p
Q: 375   MPPEALLEGLFTSKTDSWSFGVLLWEIFSLGYMPYPGHTNQEVLDFIATGNRMDPPRNCP  434
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+cw+ +pe rp+f+siler+q+
Q: 435   GPVYRIMTQCWQLQPELRPDFASILERIQY  464
         ****************************97
Domain Sequence
(FASTA)
VTLLRALGHG AFGEVYEGLV IGLPGDSSPL PVAIKTLPEL CSPQDELDFL MEALIISKFS 60
HQNIVRCVGL SFQAAPRLIL LELMSGGDMK SFLRHSRPHP GQLSPLTMQD LLQLAQDIAQ 120
GCHYLEENHF IHRDIAARNC LLSCSGDSRV AKIGDFGMAR DIYQASYYRK GGRTLLPVKW 180
MPPEALLEGL FTSKTDSWSF GVLLWEIFSL GYMPYPGHTN QEVLDFIATG NRMDPPRNCP 240
GPVYRIMTQC WQLQPELRPD FASILERIQY 270
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>
EKS-CAJ-00313
EKS-CAP-00342
EKS-EQC-00293
EKS-FEC-00288
EKS-GOG-00303
EKS-HOS-00308
EKS-ICT-00291
EKS-LOA-00318
EKS-MUM-00339
EKS-NOL-00277
EKS-ORC-00283
EKS-OTG-00309
EKS-PAT-00291
EKS-POA-00293
EKS-PTV-00067
EKS-SAH-00288
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0008283; P:cell proliferation
GO:0071300; P:cellular response to retinoic acid
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0010976; P:positive regulation of neuron projection development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR026984; LTK.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013