EKS-RAN-00394

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00394

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	320.2	1.2E-95	170	407	238

Status

Unreviewed

Ensembl Protein

ENSRNOP00000038786

UniProt Accession

Q66H82;

Protein Name

Protein Synonyms/Alias

Protein Map3k13; Similar to mitogen-activated protein kinase kinase kinase 13;

Gene Name

LOC303823

Gene Synonyms/Alias

LOC303823; Map3k13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000025423	ENSRNOP00000038786	ENSRNOT00000035945

Organism

Rattus norvegicus

Functional Description

Protein Length

958

Protein Sequence
(FASTA)

MANPQEHLSC SSLPHLPLTE NKISGGRNEL AAMGNHPSPK FPEDSQERVV AIQSELTEIT 60

GSPVSTTVLT SVSEDSRSQF ENSVLQLREQ DESEVTVSPG NSNTVDGENT NGPEDIKIQF 120

SRSGSGSGGF LEGLFGCLRP VWNIIGKAYS TDYKLQQQDT WEVPFEEISE LQWLGSGAQG 180

AVFLGKFRAE EVAIKKVREQ NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ 240

LYEVLRAGRK ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT 300

SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA 360

IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKPRNRPSF RQTLMHLDIA SADVLATPQE 420

TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL DEELIRRRRE ELRHALDIRE HYERKLERAN 480

NLYMELSAIM LQLEMREKEL LKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKVVSH 540

KAGVQTKRPD LLRSEGIPST EAVPTASPLS GSPKMSTGSS RSRYRSKPRH RRGNSRGSHS 600

DFAAILKTQP AQENSPHPTY LQHTQAQCPS AYQHNLPQQQ VPPPLPQSRH PRLNAHGQDI 660

ATCANNLRYF GPAAALRSPL SNHAQRQMPG SSPDLISTAM AADCWRNSEL DQDQVGPWGC 720

CQAEPYDPCF QCRPEHSGSL DVPTTEPVGR SPDPSSSPAH NPLSGNAQGS ERTEANGFNG 780

CQSGISHQFT PPLLPQKPRP LQKSGDDSSE EEGEVDSEVE FPRRQRPHRC ISSYQSYSTF 840

SSENFSVSDG EEGNTSDHSN SPDESANRRQ DRLAETLDDL LSQTPEAPIE ISSHSDGLSD 900

KECAVRRVKT QMSLGKLCAE ERGYENPVQF ADSDRDSSEG DCSDATVRTS KNYSSATW 958

Nucleotide Sequence
(FASTA)

ATGGCCAACC CTCAGGAGCA CCTGAGCTGC TCCTCTTTGC CACACTTGCC CTTGACTGAG 60

AACAAAATCT CTGGTGGACG AAATGAGCTT GCGGCTATGG GGAACCACCC TTCCCCCAAG 120

TTCCCTGAGG ACTCGCAGGA GAGGGTGGTG GCTATACAGT CAGAGCTGAC GGAGATCACG 180

GGCAGCCCGG TCTCCACAAC AGTGCTGACC AGTGTAAGCG AAGATTCCAG GAGCCAGTTT 240

GAGAACAGTG TCCTTCAGCT AAGGGAACAG GACGAATCAG AGGTGACCGT ATCTCCAGGG 300

AACAGCAACA CCGTGGATGG AGAGAACACG AACGGACCTG AAGACATCAA GATCCAGTTC 360

AGCAGGTCAG GCAGCGGCAG CGGTGGGTTT CTCGAAGGAC TCTTTGGTTG CCTCAGGCCC 420

GTGTGGAACA TCATCGGGAA GGCGTACTCC ACGGATTACA AACTGCAGCA GCAAGACACT 480

TGGGAAGTGC CGTTTGAGGA AATCTCAGAG CTGCAGTGGC TGGGTAGTGG AGCCCAGGGA 540

GCCGTCTTCC TGGGCAAATT CCGAGCAGAG GAGGTGGCCA TCAAGAAGGT GAGAGAGCAG 600

AATGAGACGG ACATCAAGCA TCTGAGGAAG CTGAAGCACC CTAACATCAT CGCCTTCAAG 660

GGCGTTTGCA CTCAGGCCCC GTGCTACTGC ATCATCATGG AGTACTGTGC CCACGGACAG 720

CTGTACGAGG TCCTGAGGGC CGGCAGGAAG ATCACGCCCC GGCTGCTCGT GGACTGGTCC 780

ACGGGGATCG CCAGTGGAAT GAATTACCTC CATCTCCATA AGATTATACA TCGAGATCTC 840

AAGTCGCCCA ATGTTTTAGT GACTCACACA GATGCAGTGA AAATTTCAGA CTTTGGCACA 900

TCTAAGGAAC TCAGTGATAA AAGCACCAAG ATGTCCTTTG CTGGCACCGT TGCGTGGATG 960

GCACCTGAGG TGATCCGGAA TGAGCCTGTC TCTGAGAAGG TTGACATATG GTCGTTTGGA 1020

GTCGTGCTTT GGGAGCTGCT GACAGGGGAG ATCCCCTACA AGGACGTGGA CTCATCAGCC 1080

ATCATTTGGG GTGTTGGCAG CAATAGCTTG CACCTCCCGG TTCCTTCCAC TTGCCCAGAC 1140

GGATTCAAAA TCCTTATGAA ACAGACGTGG CAGAGTAAGC CTCGAAACCG GCCTTCTTTC 1200

CGGCAGACAC TCATGCATCT GGACATTGCC TCTGCAGATG TGCTTGCCAC CCCTCAAGAA 1260

ACGTACTTCA AGTCTCAGGC TGAATGGAGA GAAGAAGTGA AAAAACATTT CGAGAAAATC 1320

AAAAGTGAAG GGACCTGTAT TCATCGATTA GATGAAGAAC TGATTCGTCG CCGCAGGGAG 1380

GAGCTCAGGC ATGCCCTGGA TATTCGAGAG CACTATGAGA GGAAGCTCGA GCGGGCTAAC 1440

AATCTGTACA TGGAGCTGAG CGCCATCATG CTGCAGCTGG AGATGCGGGA GAAGGAGCTC 1500

CTCAAGCGAG AGCAAGCAGT GGAAAAGAAG TATCCTGGGA CCTACAAGCG ACACCCTGTC 1560

CGTCCAATCA TCCACCCCAA TGCCATGGAG AAGCTCATGA AAAGGAAGGT TGTGTCTCAC 1620

AAGGCTGGTG TACAGACTAA GCGGCCAGAC CTGTTGCGAT CCGAAGGCAT CCCTAGTACA 1680

GAAGCAGTTC CCACTGCATC CCCTCTGTCT GGAAGTCCCA AAATGTCCAC CGGAAGCAGC 1740

AGGAGCCGGT ACCGAAGCAA ACCACGTCAC CGCCGAGGGA ACAGTAGAGG CAGCCATAGT 1800

GACTTCGCAG CAATCTTGAA AACCCAGCCT GCCCAGGAAA ATTCACCCCA CCCCACCTAC 1860

CTACAGCACA CTCAGGCTCA GTGCCCTTCT GCCTATCAAC ATAATCTTCC CCAGCAGCAA 1920

GTCCCTCCTC CCCTGCCTCA GAGCCGCCAT CCCAGACTCA ATGCGCATGG GCAGGACATT 1980

GCGACCTGCG CCAATAACCT GAGGTACTTC GGCCCAGCAG CAGCCCTGCG GAGTCCACTC 2040

AGCAACCACG CTCAAAGACA GATGCCTGGC TCTAGTCCCG ACCTCATCTC CACAGCCATG 2100

GCAGCAGATT GCTGGAGAAA TTCTGAACTT GACCAAGACC AAGTCGGACC CTGGGGCTGT 2160

TGTCAGGCTG AACCCTATGA TCCCTGTTTC CAGTGCAGGC CAGAACATTC TGGGTCCTTA 2220

GATGTTCCCA CCACTGAGCC AGTGGGGAGG AGCCCAGACC CTTCCAGTTC ACCAGCACAC 2280

AATCCTCTTT CAGGAAATGC CCAAGGCTCT GAGAGAACGG AGGCAAATGG ATTCAATGGC 2340

TGTCAGTCTG GTATTTCTCA TCAATTCACA CCCCCATTGC TACCTCAAAA GCCACGGCCC 2400

CTTCAGAAGA GTGGAGATGA CTCCTCAGAA GAGGAAGGAG AAGTGGACAG TGAAGTAGAA 2460

TTTCCTCGAC GACAGAGGCC TCACCGTTGC ATTAGTAGTT ACCAGTCGTA CTCAACCTTT 2520

AGCTCCGAGA ACTTCTCTGT GTCTGATGGA GAGGAGGGTA ACACTAGCGA CCACTCCAAC 2580

AGTCCGGATG AGTCGGCCAA CAGACGGCAG GACCGCCTGG CAGAGACGCT GGACGACCTG 2640

CTGTCCCAGA CACCAGAGGC CCCCATCGAG ATCTCCTCCC ACTCGGATGG GCTGTCTGAC 2700

AAGGAGTGTG CCGTACGGCG TGTGAAGACA CAGATGTCCC TTGGCAAGCT GTGTGCTGAG 2760

GAGCGCGGCT ACGAGAACCC CGTGCAGTTT GCAGACTCGG ACCGCGACTC TTCAGAGGGG 2820

GACTGCTCTG ATGCCACAGT TAGGACCAGC AAGAACTACA GCTCTGCCAC CTGGTGA 2877

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + +++gsga+g+v+ +k+r++eva+Kk+re++e+         ++k+l+kl+hpnii+++

Q: 170   ELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNET---------DIKHLRKLKHPNIIAFK  220

         6789**************************9999.........*****************

S: 63    GvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkki  122

         Gvc++ p+++++mey+++g+L++vl++   r+i+++ lv+w++ iA+Gm+YLh +   ki

Q: 221   GVCTQAPCYCIIMEYCAHGQLYEVLRA--GRKITPRLLVDWSTGIASGMNYLHLH---KI  275

         ***************************..99************************...9*

S: 123   ihrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseks  181

         ihrdLks+nvL+ ++++ +ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+

Q: 276   IHRDLKSPNVLV-THTDAVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKV  334

         ************.999***************99***************************

S: 182   DvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedp  241

         D+wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+ps+cp+ +k Lmk++w+++p

Q: 335   DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKP  394

         ************************************************************

S: 242   ekRpsfseivksl  254

         ++Rpsf++ +++l

Q: 395   RNRPSFRQTLMHL  407

         *******998775

Domain Sequence
(FASTA)

ELQWLGSGAQ GAVFLGKFRA EEVAIKKVRE QNETDIKHLR KLKHPNIIAF KGVCTQAPCY 60

CIIMEYCAHG QLYEVLRAGR KITPRLLVDW STGIASGMNY LHLHKIIHRD LKSPNVLVTH 120

TDAVKISDFG TSKELSDKST KMSFAGTVAW MAPEVIRNEP VSEKVDIWSF GVVLWELLTG 180

EIPYKDVDSS AIIWGVGSNS LHLPVPSTCP DGFKILMKQT WQSKPRNRPS FRQTLMHL 238

Keyword

Complete proteome; Kinase; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008385	; C:IkappaB kinase complex
GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007254	; P:JNK cascade
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013