| Tag | Content |
|---|
| EKPD ID | EKS-RAN-00066 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/CDK | 337.0 | 1.0E-100 | 6 | 295 | 290 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000034754 |
| UniProt Accession | P35426; |
| Protein Name | Cyclin-dependent kinase 4 |
| Protein Synonyms/Alias | Cell division protein kinase 4; PSK-J3; |
| Gene Name | Cdk4 |
| Gene Synonyms/Alias | Cdk4; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexesthat phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). |
| Protein Length | 303 |
Protein Sequence
(FASTA) | | MATTRYEPVA EIGVGAYGTV YKARDPHSGH FVALKSVRVP NGGAAGGGLP VSTVREVALL 60 | | RRLEAFEHPN VVRLMDVCAT SRTDRDIKVT LVFEHIDQDL RTYLDKAPPP GLPVETIKDL 120 | | MRQFLSGLDF LHANCIVHRD LKPENILVTS NGTVKLADFG LARIYSYQMA LTPVVVTLWY 180 | | RAPEVLLQST YATPVDMWSV GCIFAEMFRR KPLFCGNSEA DQLGKIFDLI GLPPEDDWPR 240 | | EVSLPRGAFS PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP LKRISAFRAL QHSYLHKEES 300 | | DPE 303 |
|
Nucleotide Sequence
(FASTA) | | ATGGCTACCA CTCGATATGA ACCCGTGGCT GAAATTGGTG TCGGTGCCTA TGGGACGGTG 60 | | TACAAAGCCC GAGATCCCCA CAGTGGCCAC TTTGTGGCTC TCAAGAGTGT GAGAGTTCCT 120 | | AATGGAGGAG CAGCTGGAGG GGGCCTTCCC GTCAGCACAG TTCGTGAGGT GGCCTTGTTA 180 | | AGAAGGCTGG AGGCCTTTGA ACATCCCAAT GTTGTACGGC TGATGGATGT CTGTGCTACT 240 | | TCCCGAACTG ATCGGGACAT CAAGGTCACC TTAGTGTTTG AGCATATAGA CCAGGACCTA 300 | | CGGACATACC TGGACAAAGC ACCTCCGCCG GGCTTGCCTG TTGAGACCAT TAAGGATCTG 360 | | ATGCGCCAGT TTCTAAGCGG CCTAGATTTC CTTCATGCAA ACTGCATTGT TCACCGGGAC 420 | | CTGAAGCCAG AGAACATTCT AGTGACAAGT AATGGGACAG TTAAGCTGGC CGACTTTGGC 480 | | CTAGCCAGAA TCTACAGCTA CCAGATGGCC CTCACGCCTG TGGTTGTTAC GCTCTGGTAC 540 | | CGGGCTCCTG AAGTTCTTCT GCAGTCTACA TATGCAACGC CTGTGGATAT GTGGAGTGTT 600 | | GGCTGTATCT TCGCAGAGAT GTTTCGCCGG AAGCCTCTCT TCTGTGGGAA CTCTGAGGCT 660 | | GACCAGCTGG GCAAAATCTT TGATCTCATT GGATTGCCTC CAGAAGACGA CTGGCCTCGA 720 | | GAGGTCTCTC TTCCTCGAGG AGCCTTTTCC CCCAGAGGAC CTCGGCCAGT GCAGTCAGTG 780 | | GTGCCGGAGA TGGAGGAATC TGGAGCGCAG TTGCTGCTGG AAATGCTGAC CTTTAATCCA 840 | | CTTAAGCGAA TCTCTGCCTT CCGAGCCCTG CAGCACTCTT ACCTGCACAA GGAGGAAAGT 900 | | GACCCGGAGT GA 912 |
|
| Domain Profile | S: 1 yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkel.. 55 | ye +++ig G+yg+vyka+d ++g++vAlK++r+ + g+p++++rE++ll++l | Q: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGAaggGLPVSTVREVALLRRLea 65 | 88899*****************************99874455***************988 |
| S: 56 .khknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqll 110 | +h+n+v+L++v+a ++ k++Lvfe+++qdL ++l+k + +l+ e++k l++q+l | Q: 66 fEHPNVVRLMDVCAtsrtDRDIKVTLVFEHIDQDLRTYLDKAPPPGLPVETIKDLMRQFL 125 | 89************887444489************************************* |
| S: 111 eglaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPe 170 | +gl++lH+n i+HRDlKp+N+L++++g++klaDfGlar +s ++ +t++vvTlwYraPe | Q: 126 SGLDFLHANCIVHRDLKPENILVTSNGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPE 184 | ******************************************999.************** |
| S: 171 lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk 230 | +Ll+++ Y t vD+Wsvgci+ae+++rkplf g+se dql +if+l+g p e++wp+ + | Q: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPREVS 243 | ***985.***************************************************** |
| S: 231 lpeykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf 284 | lp+ f+++ ++ ++++v++++e++ +ll ++l+++p kRisa +alqh+y+ | Q: 244 LPRGA--FSPRGPRPVQSVVPEMEESGAQLLLEMLTFNPLKRISAFRALQHSYL 295 | ***65..9999*****************************************96 |
|
Domain Sequence
(FASTA) | | YEPVAEIGVG AYGTVYKARD PHSGHFVALK SVRVPNGGAA GGGLPVSTVR EVALLRRLEA 60 | | FEHPNVVRLM DVCATSRTDR DIKVTLVFEH IDQDLRTYLD KAPPPGLPVE TIKDLMRQFL 120 | | SGLDFLHANC IVHRDLKPEN ILVTSNGTVK LADFGLARIY SYQMALTPVV VTLWYRAPEV 180 | | LLQSTYATPV DMWSVGCIFA EMFRRKPLFC GNSEADQLGK IFDLIGLPPE DDWPREVSLP 240 | | RGAFSPRGPR PVQSVVPEME ESGAQLLLEM LTFNPLKRIS AFRALQHSYL 290 |
|
| Keyword | Acetylation; ATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |