EKS-RAN-00106
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00106
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec480.31.4E-144270520251
StatusUnreviewed
Ensembl ProteinENSRNOP00000030643
UniProt AccessionQ501W1;
Protein Name
Protein Synonyms/Alias Protein Txk; TXK tyrosine kinase;
Gene NameTxk
Gene Synonyms/Alias Txk;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000025925ENSRNOP00000030643ENSRNOT00000035623
OrganismRattus norvegicus
Functional Description
Protein Length526
Protein Sequence
(FASTA)
MISFSDSTFQ SILCCCCCCS VQGRRVTTRI SLSREEELSE KHSQRQRQWF SKLMGKSQSS 60
RGGVQPSKRR PLPPLPQEFT EERIRVKALY DFLPREPCNL ALKRAEEYLI LERCDPHWWR 120
ARDRLGNEGL IPSNYVTENR LTNLETYEWY HKNITRDQTE RLLRQEAKEG AFIVRDSRHL 180
GSYTISVFTR ARRHTQSSIK HYQIKKNDSG QWYVTERHLF PSVPELIQYH QYNAAGLMSR 240
LRYPVGLLGS CLPATSGFSY EKWEIDPSEL TFVKEIGSGQ FGVVYLGEWR ARIRVAIKAI 300
NEGSMSEEDF IEEAKVMMKL SHSRLVQLYG VCIQQKPLYI VTEFMENGCL LDYLRERKGK 360
LPKALLLSMC QDICEGMAYL EKSCYIHRDL AARNCLVSSA CVVKISDFGM ARYVLDDEYI 420
SSSGAKFPVK WSPPEVFHFN KYSSKSDVWS FGVLMWEVFT EGKMPFENKS NLQVVEAISK 480
GFRLYRPHLA PMSIYGVMYS CWHESPKGRP TFAELLQVLA EIAETW 526
Nucleotide Sequence
(FASTA)
ATGATCTCCT TTTCAGACAG CACCTTCCAG TCTATCCTCT GTTGCTGCTG TTGCTGCTCA 60
GTGCAGGGGA GACGAGTGAC AACACGGATC AGCCTAAGCA GAGAGGAAGA ACTCTCAGAA 120
AAGCATTCCC AGCGTCAGAG GCAGTGGTTC TCCAAACTGA TGGGCAAAAG TCAATCCAGC 180
AGAGGTGGGG TGCAACCCTC AAAGCGTAGG CCACTGCCTC CCCTCCCGCA GGAGTTTACA 240
GAAGAGAGAA TCCGGGTCAA GGCTCTTTAT GACTTCCTGC CTCGGGAGCC CTGTAATTTG 300
GCACTGAAGA GAGCAGAGGA ATATCTGATA TTGGAGAGGT GTGACCCTCA CTGGTGGAGG 360
GCCAGAGACC GCCTCGGGAA TGAAGGCTTA ATCCCAAGCA ACTATGTGAC AGAAAACAGA 420
CTCACCAATT TAGAAACATA TGAATGGTAT CATAAGAACA TCACTAGAGA CCAGACGGAA 480
CGCCTGTTGA GGCAGGAGGC TAAAGAAGGT GCATTTATCG TGAGAGATTC GAGACATTTG 540
GGGTCTTACA CAATCTCTGT GTTTACAAGA GCTAGAAGGC ATACACAGTC TTCAATAAAA 600
CATTATCAGA TTAAAAAGAA TGACTCAGGA CAATGGTACG TCACCGAAAG ACACCTCTTT 660
CCCTCGGTTC CCGAGTTGAT CCAGTATCAC CAGTACAATG CAGCTGGTCT CATGTCCCGT 720
CTCCGCTATC CTGTTGGGCT CCTGGGCAGC TGTTTACCAG CCACATCTGG TTTTAGCTAT 780
GAAAAGTGGG AAATAGATCC GTCTGAGTTG ACTTTTGTCA AGGAGATCGG AAGTGGTCAG 840
TTTGGGGTAG TCTACTTAGG AGAGTGGAGA GCACGTATCC GGGTCGCCAT CAAGGCCATC 900
AATGAAGGCT CCATGTCTGA AGAAGATTTC ATTGAGGAAG CCAAGGTGAT GATGAAGCTG 960
TCACACTCGA GGTTAGTTCA ACTTTATGGG GTGTGCATAC AGCAGAAGCC CCTCTACATA 1020
GTGACGGAGT TCATGGAAAA TGGCTGCCTG CTCGACTATC TCAGGGAGAG AAAAGGCAAG 1080
CTTCCGAAGG CATTGCTTTT GAGCATGTGC CAGGACATAT GTGAAGGGAT GGCGTACCTG 1140
GAGAAGAGCT GCTATATCCA CAGGGATCTG GCTGCCAGGA ACTGTTTGGT CAGTTCTGCC 1200
TGCGTAGTAA AGATCTCGGA CTTTGGGATG GCGAGGTACG TTTTGGACGA TGAATATATC 1260
AGTTCTTCTG GAGCTAAGTT CCCAGTCAAG TGGTCCCCAC CTGAAGTTTT TCATTTCAAC 1320
AAGTACAGTA GCAAGTCTGA CGTCTGGTCA TTCGGAGTTT TAATGTGGGA AGTTTTTACA 1380
GAAGGAAAAA TGCCCTTTGA GAATAAGTCC AATTTGCAAG TGGTGGAAGC CATTTCTAAA 1440
GGTTTCCGGC TCTATCGTCC TCACCTGGCC CCCATGTCCA TATACGGAGT TATGTACAGT 1500
TGCTGGCATG AGAGCCCTAA AGGCCGTCCG ACATTTGCTG AGTTGCTTCA GGTTCTCGCA 1560
GAGATCGCGG AAACCTGGTG A 1581
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt++ke+gsgqfgvv lg+wra+i+vaikai+eg+mseedfieeakvmmklsh++lvqly
Q: 270   LTFVKEIGSGQFGVVYLGEWRARIRVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLY  329
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++qkp+yivte++engcll+ylre+k+kl k+lll+mc+d+cegm+yle++++ihrd
Q: 330   GVCIQQKPLYIVTEFMENGCLLDYLRERKGKLPKALLLSMCQDICEGMAYLEKSCYIHRD  389
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv++++vvk+sdfg+aryvldd+y+ss+gakfpvkwsppev++++kyssksdvw
Q: 390   LAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWSPPEVFHFNKYSSKSDVW  449
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+p+e+ksn +vve++s+g+rlyrp+la++++y vm+scw+e+p++r
Q: 450   SFGVLMWEVFTEGKMPFENKSNLQVVEAISKGFRLYRPHLAPMSIYGVMYSCWHESPKGR  509
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ell+ l+
Q: 510   PTFAELLQVLA  520
         *******9885
Domain Sequence
(FASTA)
LTFVKEIGSG QFGVVYLGEW RARIRVAIKA INEGSMSEED FIEEAKVMMK LSHSRLVQLY 60
GVCIQQKPLY IVTEFMENGC LLDYLRERKG KLPKALLLSM CQDICEGMAY LEKSCYIHRD 120
LAARNCLVSS ACVVKISDFG MARYVLDDEY ISSSGAKFPV KWSPPEVFHF NKYSSKSDVW 180
SFGVLMWEVF TEGKMPFENK SNLQVVEAIS KGFRLYRPHL APMSIYGVMY SCWHESPKGR 240
PTFAELLQVL A 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00100
EKS-BOT-00109
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-EQC-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GAG-00089
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MAM-00104
EKS-MEG-00084
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MUP-00112
EKS-MYL-00122
EKS-NOL-00101
EKS-ORC-00100
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-POA-00101
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0001865; P:NK T cell differentiation
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
rno:305311;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013