EKS-RAN-00052

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00052

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	404.3	3.5E-121	348	609	262

Status

Unreviewed

Ensembl Protein

ENSRNOP00000041584

UniProt Accession

F1LY04;

Protein Name

Protein Synonyms/Alias

Protein RGD1562674;

Gene Name

Ksr2

Gene Synonyms/Alias

Ksr2; RGD1562674;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000028630	ENSRNOP00000041584	ENSRNOT00000046190

Organism

Rattus norvegicus

Functional Description

Protein Length

631

Protein Sequence
(FASTA)

RAKKKSKPLN LKIHSGVGSC ENIPAQQRSP LLSERSLRSF FVGHGPFLPS TPPVHTEANF 60

SANTLSVPRW SPQIPRRDLG NSIKHRFSTK YWMSQTCTVC GKGMLFGLKC KNCKLKCHNK 120

CTKEAPPCHL LIIHRGDSLC CFHPTDPARL VRTESVPCDI NNPVRKPARY SDLHISQTLP 180

KTNKINKDHI PVPYQPDSSS NPSSTTSSTP SSPAPPLPPS ATPPSPLHPS PQCPRQKKNF 240

NLPASHYYKY KQQFIFPDVV PVPETPTRAP QVILHPVTSN TILEGNPLLQ IEVEPTSENE 300

EGHDEAEESE DEFEEMNLSL LSARSFPRKA SQTSIFLQEW DIPFEQLEIG ELIGKGRFGQ 360

VYHGRWHGEV AIRLIDIERD NEDQLKAFKR EVMAYRQTRH ENVVLFMGAC MSPPHLAIIT 420

SLCKGRTLYS VVRDAKIVLD VNKTRQIAQE IVKGMGYLHA KGILHKDLKS KNVFYDNGKV 480

VITDFGLFSI SGVLQAGRRD DKLRIQNGWL CHLAPEIIRQ LSPDTEEDKL PFSKHSDVFA 540

LGTIWYELHA REWPFKTQPA EAIIWQMGAG MKPNLSQIGM GKEISDILLF CWAFEQEERP 600

TFTKLMDMLE KLPKRNRRLS HPGHFWKSAE Y 631

Nucleotide Sequence
(FASTA)

AGAGCCAAGA AGAAGAGCAA ACCCTTGAAC CTCAAGATCC ACAGTGGCGT GGGCAGCTGT 60

GAGAACATCC CTGCCCAGCA GCGGTCTCCG CTCCTGTCCG AGCGCTCCCT GCGGTCCTTC 120

TTTGTGGGCC ACGGGCCCTT CCTGCCCTCC ACCCCGCCCG TCCACACTGA AGCCAATTTC 180

TCTGCAAACA CACTCTCTGT ACCTCGATGG TCGCCACAGA TCCCACGCAG AGACCTTGGC 240

AATTCCATCA AACACAGGTT TTCCACCAAG TACTGGATGT CTCAGACGTG CACGGTCTGC 300

GGGAAAGGGA TGCTCTTTGG CCTCAAGTGT AAAAACTGCA AGTTAAAGTG CCACAATAAA 360

TGCACCAAAG AAGCCCCACC CTGTCACCTC TTGATCATCC ACCGAGGAGA CTCTCTCTGC 420

TGTTTTCACC CTACGGACCC AGCAAGGTTA GTGCGAACGG AGTCCGTCCC CTGTGACATC 480

AACAACCCTG TCCGGAAGCC TGCCCGATAT TCCGATCTCC ACATCAGCCA GACGCTCCCT 540

AAAACCAACA AAATCAACAA GGACCACATC CCTGTCCCCT ACCAGCCAGA CTCCAGCAGC 600

AATCCCTCCT CCACGACGTC CTCCACGCCC TCCTCACCGG CACCCCCCCT CCCTCCCAGT 660

GCCACGCCGC CTTCTCCCCT GCACCCCTCC CCGCAGTGCC CGAGACAGAA AAAGAACTTC 720

AACCTGCCAG CTTCCCACTA TTACAAATAC AAGCAGCAGT TCATCTTCCC AGATGTGGTA 780

CCTGTACCAG AGACGCCCAC CCGAGCACCC CAAGTCATCC TGCATCCTGT CACCTCGAAT 840

ACAATCTTGG AAGGGAATCC GTTACTTCAA ATTGAAGTGG AACCAACCTC CGAGAATGAA 900

GAGGGCCACG ACGAAGCAGA GGAGTCTGAG GATGAATTTG AAGAAATGAA TCTGTCCCTC 960

CTCTCAGCCC GAAGCTTCCC ACGCAAGGCC AGCCAGACCA GCATCTTCCT TCAGGAGTGG 1020

GACATCCCGT TTGAACAGCT AGAGATCGGC GAACTCATCG GGAAGGGCCG CTTCGGGCAG 1080

GTTTACCATG GACGCTGGCA TGGCGAGGTG GCCATCCGGT TGATTGACAT AGAGAGGGAC 1140

AATGAGGACC AACTCAAGGC CTTCAAGCGG GAAGTGATGG CCTACAGGCA GACGAGGCAC 1200

GAGAACGTGG TGCTCTTCAT GGGAGCCTGC ATGAGCCCAC CCCACTTGGC TATCATCACC 1260

AGCCTCTGTA AGGGACGGAC ACTCTACTCC GTGGTGAGGG ACGCCAAGAT TGTCTTGGAT 1320

GTCAACAAAA CCAGGCAGAT TGCACAAGAG ATTGTTAAGG GCATGGGCTA TCTCCATGCC 1380

AAGGGCATCC TTCACAAGGA CCTCAAATCG AAGAATGTCT TCTACGACAA CGGTAAAGTG 1440

GTCATCACAG ACTTCGGGCT CTTCAGCATT TCTGGGGTGC TGCAGGCTGG CAGGCGGGAT 1500

GACAAGTTGC GGATCCAGAA CGGTTGGCTG TGCCACCTAG CCCCAGAGAT CATCCGCCAG 1560

CTGTCCCCTG ACACAGAAGA GGACAAGCTC CCGTTCTCCA AGCACTCGGA TGTCTTTGCA 1620

CTTGGCACCA TCTGGTATGA GCTCCACGCC AGGGAGTGGC CATTCAAGAC CCAACCAGCA 1680

GAGGCAATAA TTTGGCAGAT GGGCGCAGGA ATGAAACCCA ACCTCAGCCA GATTGGCATG 1740

GGAAAAGAAA TCTCGGACAT ACTGCTCTTC TGCTGGGCCT TCGAGCAGGA AGAGCGGCCC 1800

ACCTTCACCA AGCTCATGGA TATGCTAGAG AAACTGCCAA AGCGGAACCG CCGTCTGTCG 1860

CACCCCGGAC ACTTCTGGAA GTCTGCAGAG TAC 1893

Domain Profile

S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61

         e++e iG+GrfG+vy+g+whG+va++l+++e+++e+ql+aFk+ev+ay++tRhen+vLFm

Q: 348   EIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFM  407

         7899********************************************************

S: 62    G.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120

         G ++s+p+lai+tslckg++Ly+++++++  ld++k+++ia++i++gm+YLhak+ilhkD

Q: 408   GaCMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKD  467

         ************************************************************

S: 121   lksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidle  179

         lkskn+++++g kvvitDFgl+s++ +l++ rr+++l+i++gw+++lape+ir+ls+d+e

Q: 468   LKSKNVFYDNG-KVVITDFGLFSISGVLQAgRRDDKLRIQNGWLCHLAPEIIRQLSPDTE  526

         ***********.***************9977*****************************

S: 180   qdelpfskesDvyafGivlyellarelpykeesadqilfavgrGlkpdlskvksklpkel  239

         +d+lpfsk+sDv+a+G+++yel+are+p+k+++a++i++++g G+kp+ls++   ++ke+

Q: 527   EDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGAGMKPNLSQI--GMGKEI  584

         ****************************************************..******

S: 240   kellleClkfekeeRPlftqilkkl  264

         +++ll C++fe+eeRP+ft+++++l

Q: 585   SDILLFCWAFEQEERPTFTKLMDML  609

         **********************986

Domain Sequence
(FASTA)

EIGELIGKGR FGQVYHGRWH GEVAIRLIDI ERDNEDQLKA FKREVMAYRQ TRHENVVLFM 60

GACMSPPHLA IITSLCKGRT LYSVVRDAKI VLDVNKTRQI AQEIVKGMGY LHAKGILHKD 120

LKSKNVFYDN GKVVITDFGL FSISGVLQAG RRDDKLRIQN GWLCHLAPEI IRQLSPDTEE 180

DKLPFSKHSD VFALGTIWYE LHAREWPFKT QPAEAIIWQM GAGMKPNLSQ IGMGKEISDI 240

LLFCWAFEQE ERPTFTKLMD ML 262

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR025561	; KSR_SAM-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13543	; KSR1-SAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013