EKS-RAN-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	434.8	1.9E-130	204	490	287

Status

Reviewed

Ensembl Protein

ENSRNOP00000008673

UniProt Accession

P80203; Q63559;

Protein Name

Serine/threonine-protein kinase receptor R3

Protein Synonyms/Alias

SKR3; TGF-B superfamily receptor type I; TSR-I;

Gene Name

Acvrl1

Gene Synonyms/Alias

Acvrl1; Acvrlk1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000028713	ENSRNOP00000008673	ENSRNOT00000008673

Organism

Rattus norvegicus

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.

Protein Length

504

Protein Sequence
(FASTA)

MTLGIFRRVF LMLSVALGLT KGDLVKPSRG QLVNCTCENP HCKRPICQGA WCTVVLVREQ 60

GRHPQVYRGC GSLNQELCLG RPTEFVNHHC CYRSFCNHNV SLMLEATQTP SEEPEVDAHL 120

PLILGPVLAL LVLVALGTLG LWRVRRRQEK QRGLHSDLGE SSLILKASEQ GDSMLGDFLV 180

SDCTTGSGSG LPFLVQRTVA RQVALVECVG KGRYGEVWRG SWHGESVAVK IFSSRDEQSW 240

FRETEIYNTV LLRHDNILGF IASDMTSRNS STQLWLITHY HEHGSLYDFL QRQTLEPQLA 300

LRLAVSAACG LAHLHVEIFG TQGKPAIAHR DLKSRNVLVK SNLQCCIADL GLAVMHSQSS 360

DYLDIGNNPR VGTKRYMAPE VLDEQIRTDC FESYKWTDIW AFGLVLWEIA RRTIINGIVE 420

DYRPPFYDMV PNDPSFEDMK KVVCVDQQTP TIPNRLAADP VLSGLAQMMR ECWYPNPSAR 480

LTALRIKKTL QKLSQNPEKP KVIH 504

Nucleotide Sequence
(FASTA)

ATGACCCTGG GGATTTTCCG AAGGGTCTTT TTGATGCTGT CGGTGGCCTT GGGCCTAACT 60

AAGGGAGACT TGGTGAAGCC CTCCAGGGGT CAGCTGGTAA ACTGCACTTG TGAGAACCCA 120

CACTGCAAGA GGCCAATCTG CCAGGGGGCA TGGTGCACAG TGGTGCTAGT TCGAGAGCAG 180

GGCAGGCACC CCCAGGTCTA TCGGGGCTGC GGGAGCCTGA ACCAGGAGCT CTGCCTGGGA 240

CGTCCCACGG AGTTTGTGAA CCATCACTGC TGCTATAGAT CCTTCTGCAA CCACAATGTG 300

TCCCTGATGC TGGAGGCCAC CCAAACTCCT TCGGAGGAGC CAGAAGTAGA TGCCCATCTG 360

CCTCTGATCC TGGGTCCCGT GCTGGCCTTG CTGGTCCTGG TGGCCCTGGG CACTCTGGGC 420

TTGTGGCGTG TCCGGAGAAG GCAGGAGAAG CAGCGGGGTC TGCACAGTGA CCTGGGCGAG 480

TCCAGTCTCA TCCTGAAGGC ATCGGAACAG GGAGACAGCA TGTTGGGGGA CTTCCTGGTC 540

AGCGACTGTA CCACAGGCAG CGGCTCAGGG CTACCCTTCT TGGTGCAGAG GACAGTAGCG 600

CGACAGGTTG CACTGGTGGA GTGTGTGGGA AAGGGCCGAT ATGGCGAGGT GTGGCGCGGT 660

TCGTGGCATG GCGAGAGTGT GGCGGTCAAG ATTTTCTCCT CACGAGATGA GCAGTCCTGG 720

TTCCGGGAGA CAGAGATCTA CAACACAGTT CTGCTTAGAC ACGACAACAT CCTAGGCTTC 780

ATCGCCTCCG ACATGACCTC GCGGAACTCC AGCACGCAGC TGTGGCTTAT CACCCACTAC 840

CACGAGCATG GCTCCCTCTA TGACTTTCTG CAGAGGCAGA CGCTGGAGCC CCAGTTGGCC 900

CTGAGGCTGG CTGTGTCCGC GGCCTGCGGC CTGGCGCACC TGCATGTAGA GATCTTTGGC 960

ACTCAAGGCA AACCAGCCAT CGCCCATCGT GACCTCAAGA GCCGCAACGT GCTGGTCAAG 1020

AGCAACTTGC AGTGTTGCAT TGCAGACCTG GGATTGGCTG TGATGCACTC GCAAAGCAGC 1080

GATTACCTGG ACATTGGTAA CAACCCCCGA GTGGGTACCA AGAGATACAT GGCACCCGAG 1140

GTGCTGGATG AGCAGATCCG CACAGACTGT TTTGAGTCGT ACAAGTGGAC AGACATCTGG 1200

GCCTTCGGCT TAGTGCTATG GGAGATTGCC CGGCGGACCA TCATCAATGG CATTGTGGAG 1260

GACTACAGGC CACCCTTCTA TGACATGGTA CCCAATGACC CCAGTTTTGA GGACATGAAA 1320

AAGGTGGTGT GTGTTGACCA GCAGACCCCC ACCATCCCTA ACCGACTGGC AGCAGATCCG 1380

GTCCTCTCCG GGCTGGCCCA GATGATGCGA GAGTGCTGGT ACCCCAACCC CTCCGCTCGC 1440

CTCACCGCAC TGCGCATAAA GAAGACATTA CAGAAGCTCA GCCAGAATCC AGAGAAACCC 1500

AAAGTGATTC ACTAG 1515

Domain Profile

S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61

          l+e++gkGrygeVw+++++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+

Q: 204   ALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  263

         689*********************************************************

S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121

         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +lrla s+a+GlahLH ei+gt+g

Q: 264   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQG  323

         ************************************************************

S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181

           KpaiaHRDlks+N+lvk++l+cciaDlGLa++++++++ ld+ +n +vGtkRYmaPEv

Q: 324   --KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEV  381

         ..**********************************************************

S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241

         l+e++ +++fe++k++D++++gLvlWE+a+R+   +++ve+y++pf+++v++dPs+e+mk

Q: 382   LDEQIRTDCFESYKWTDIWAFGLVLWEIARRTII-NGIVEDYRPPFYDMVPNDPSFEDMK  440

         *********************************9.*************************

S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalr+kk+l

Q: 441   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  490

         ************************************************97

Domain Sequence
(FASTA)

ALVECVGKGR YGEVWRGSWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60

DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPQLALRL AVSAACGLAH LHVEIFGTQG 120

KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQSSDYL DIGNNPRVGT KRYMAPEVLD 180

EQIRTDCFES YKWTDIWAFG LVLWEIARRT IINGIVEDYR PPFYDMVPND PSFEDMKKVV 240

CVDQQTPTIP NRLAADPVLS GLAQMMRECW YPNPSARLTA LRIKKTL 287

Keyword

ATP-binding; Complete proteome; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0030425	; C:dendrite
GO:0016021	; C:integral to membrane
GO:0043025	; C:neuronal cell body
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0046332	; F:SMAD binding
GO:0050431	; F:transforming growth factor beta binding
GO:0005025	; F:transforming growth factor beta receptor activity, type I
GO:0051291	; P:protein heterooligomerization
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

rno:25237

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013