EKS-RAN-00233
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00233
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/MAPKAPK403.45.1E-12185368284
StatusReviewed
Ensembl ProteinENSRNOP00000039672
UniProt AccessionQ5U2N4;
Protein NameMAP kinase-interacting serine/threonine-protein kinase 2
Protein Synonyms/Alias MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2;
Gene NameMknk2
Gene Synonyms/Alias Mknk2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000029028ENSRNOP00000039672ENSRNOT00000041106
OrganismRattus norvegicus
Functional DescriptionSerine/threonine-protein kinase that phosphorylatesSFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal (By similarity).
Protein Length459
Protein Sequence
(FASTA)
MVQKRTAELQ GFHRSFKGQN PFELAFTLDP AQHGDSDFSP QCEARPDMPS SQPIDIPDAK 60
KRGRKKKRCR ATDSFSGRFE DVYQLQEDVL GEGAHARVQT CVNLITNQEY AVKIIEKQLG 120
HIRSRVFREV EMLYQCQGHR NVLELIEFFE EEDRFYLVFE KMRGGSILSH IHRRRHFNEL 180
EASVVVQDVA SALDFLHNKG IAHRDLKPEN ILCEHPNQVS PVKICDFDLG SGIKLNGDCS 240
PISTPELLTP CGSAEYMAPE VVEAFSEEAS IYDKRCDLWS LGVILYILLS GYPPFVGHCG 300
SDCGWDRGEA CPACQNMLFE SIQEGKYEFP DKDWSHISFA AKDLISKLLV RDAKQRLSAA 360
QVLQHPWVQG CAPENTLPTP LVLQRNSCAK DLTSFAAEAI AMNRQLAQCE EDAGQDQPVL 420
IRATSRCLQL SPPSQSKLAQ RRQRASLSAT PVVLVGDRV 459
Nucleotide Sequence
(FASTA)
ATGGTGCAGA AGAGAACAGC CGAACTTCAG GGCTTCCACC GTTCGTTCAA GGGGCAGAAT 60
CCTTTCGAGT TGGCCTTCAC CTTAGACCCC GCCCAGCACG GGGACTCTGA CTTCAGCCCG 120
CAGTGTGAAG CCCGACCTGA CATGCCTTCC AGTCAGCCCA TCGACATCCC AGACGCCAAG 180
AAGAGAGGCC GCAAAAAGAA GCGCTGTCGG GCTACTGACA GCTTCTCAGG CAGATTTGAA 240
GATGTCTACC AGCTGCAGGA GGATGTGCTG GGGGAAGGGG CCCATGCCCG TGTGCAGACC 300
TGTGTCAATC TCATCACCAA CCAGGAATAT GCTGTCAAGA TCATTGAGAA GCAGCTGGGC 360
CATATCCGCA GCAGGGTGTT CCGGGAGGTG GAGATGCTGT ACCAGTGCCA GGGACATAGG 420
AATGTTCTAG AACTGATTGA GTTCTTTGAG GAGGAGGACC GCTTCTACCT GGTGTTTGAA 480
AAGATGCGTG GTGGATCCAT CCTGAGCCAC ATCCACAGAA GGCGCCACTT TAATGAACTG 540
GAGGCCAGCG TGGTGGTACA GGATGTGGCC AGTGCCCTGG ACTTCCTGCA TAACAAAGGC 600
ATCGCCCACA GGGACCTAAA GCCAGAGAAC ATCCTGTGTG AGCACCCCAA CCAGGTCTCG 660
CCAGTGAAGA TCTGTGACTT CGATCTTGGC AGTGGCATTA AACTCAACGG AGACTGCTCC 720
CCCATCTCCA CGCCAGAGCT GCTCACCCCG TGTGGGTCTG CGGAGTACAT GGCACCCGAG 780
GTGGTGGAAG CCTTTAGTGA GGAGGCCAGC ATCTATGACA AGCGCTGCGA CCTGTGGAGC 840
CTGGGTGTCA TCCTGTACAT CCTGCTCAGT GGCTACCCGC CCTTCGTAGG CCACTGTGGC 900
AGCGACTGTG GCTGGGACCG CGGGGAGGCC TGCCCTGCCT GCCAGAACAT GCTGTTTGAG 960
AGCATCCAGG AAGGGAAGTA CGAGTTCCCC GACAAGGACT GGTCCCACAT CTCCTTCGCT 1020
GCCAAAGACC TCATCTCCAA GCTGCTGGTG CGAGATGCCA AGCAGAGGCT GAGCGCTGCC 1080
CAAGTTCTGC AGCACCCCTG GGTGCAGGGG TGTGCTCCAG AGAACACCTT ACCAACACCC 1140
TTGGTTCTGC AGAGGAACAG CTGTGCCAAA GACCTCACGT CCTTTGCAGC TGAGGCCATC 1200
GCCATGAACC GGCAGCTGGC CCAGTGTGAG GAGGACGCTG GGCAGGACCA GCCTGTGCTC 1260
ATCCGAGCTA CCTCACGCTG CCTGCAGTTG TCCCCGCCCT CCCAGTCCAA GCTGGCCCAG 1320
AGGCGCCAGA GGGCCAGCCT GTCGGCCACC CCTGTGGTCC TCGTAGGGGA TCGCGTGTGA 1380
Domain Profile
S: 2     lteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghknive  56
         l+e+vlGeG++++v++cv+  t+++ya+ki+     + r++v+reve+++q++gh+n++e
Q: 85    LQEDVLGEGAHARVQTCVNLITNQEYAVKIIekqlgHIRSRVFREVEMLYQCQGHRNVLE  144
         789*********************************************************
S: 57    lidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhskn  116
         li++fe    +e+r++lv+ek++GG++ls+i++r++f+e eas vv+d+asal+flh+k+
Q: 145   LIEFFE----EEDRFYLVFEKMRGGSILSHIHRRRHFNELEASVVVQDVASALDFLHNKG  200
         ******....9*************************************************
S: 117   iahrDlkpenlLyeskeknapvklcDfglaketeee........eelktpcltaeyvaPe  168
         iahrDlkpen+L+e++++++pvk+cDf+l+++++ +        +el tpc++aey+aPe
Q: 201   IAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNgdcspistPELLTPCGSAEYMAPE  260
         ********************************955556899999****************
S: 169   vleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskklke  217
         v+ea++eea++ydk+CDlWslGvilyill+GypPf++++g            a++++l+e
Q: 261   VVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGHCGsdcgwdrgeacPACQNMLFE  320
         ***************************************99**********9********
S: 218   riqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265
         +iqegkyefP+++Ws++s +akdli+klL+rd+k+rl++++vl+hpwv
Q: 321   SIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWV  368
         ***********************************************8
Domain Sequence
(FASTA)
LQEDVLGEGA HARVQTCVNL ITNQEYAVKI IEKQLGHIRS RVFREVEMLY QCQGHRNVLE 60
LIEFFEEEDR FYLVFEKMRG GSILSHIHRR RHFNELEASV VVQDVASALD FLHNKGIAHR 120
DLKPENILCE HPNQVSPVKI CDFDLGSGIK LNGDCSPIST PELLTPCGSA EYMAPEVVEA 180
FSEEASIYDK RCDLWSLGVI LYILLSGYPP FVGHCGSDCG WDRGEACPAC QNMLFESIQE 240
GKYEFPDKDW SHISFAAKDL ISKLLVRDAK QRLSAAQVLQ HPWV 284
KeywordApoptosis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Translation regulation; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00224
EKS-BOT-00235
EKS-CAJ-00240
EKS-CAP-00261
EKS-DAR-00550
EKS-EQC-00228
EKS-FEC-00221
EKS-GAM-00139
EKS-GAA-00287
EKS-GOG-00234
EKS-HOS-00243
EKS-ICT-00222
EKS-MAM-00238
EKS-MIM-00007
EKS-MOD-00234
EKS-MUM-00241
EKS-MUP-00234
EKS-MYL-00234
EKS-ORN-00303
EKS-ORA-00207
EKS-ORL-00282
EKS-OTG-00241
EKS-PAT-00225
EKS-PES-00211
EKS-POA-00228
EKS-PRC-00010
EKS-SAH-00220
EKS-SUS-00206
EKS-TAG-00252
EKS-TAR-00300
EKS-TEN-00294
EKS-XET-00309
EKS-XIM-00295
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006915; P:apoptotic process
GO:0071243; P:cellular response to arsenic-containing substance
GO:0030097; P:hemopoiesis
GO:0007243; P:intracellular protein kinase cascade
GO:0006417; P:regulation of translation
KEGG
rno:299618;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013