EKS-RAN-00092

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00092

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	399.4	1.7E-119	2703	3022	320

Status

Unreviewed

Ensembl Protein

ENSRNOP00000045529

UniProt Accession

D4ACL8;

Protein Name

Protein Synonyms/Alias

Ataxia telangiectasia mutated homolog (Human) (Mapped), isoform CRA_a; Protein Atm;

Gene Name

Atm

Gene Synonyms/Alias

Atm; Atm_mapped; rCG_58300;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000029773	ENSRNOP00000045529	ENSRNOT00000050555

Organism

Rattus norvegicus

Functional Description

Protein Length

3064

Protein Sequence
(FASTA)

MSLALNDLLI CCRQLEHDRA TERRKEVDKF KRLIQDPETV QHLDRHSDSK QGKYLNWDAV 60

FRFLQKYIQK ETESLRTAKS NVSASTQTSR QKKMQEISSL VRFFIKCANK RAPRLKCQDL 120

LNYVMDTVKD SSNGATYGAD CSNILLKDIL SVRKYWCEVS QQQWLELFSL YIRLYLKPSQ 180

DINRVLVARI IHAVTRGCCS QTDGLPSKFL DLFSKAIQYA RQEKSSPGLS HILAALNIFL 240

KTLAVNFRKR VCEIGDEILP TLLYIWTQHR LNDSLKEVII ELIHLQIYIH HPQGAKAPEE 300

GAYESMKWKR ILYNLYDLLV NEISHIGSRG KYSSGSRNIA VKENLIDLMA DVCYQLFNAD 360

TRSVEISQSY ATQRESTDYS VPCKRRKIDI GWEVIKDYLQ KSQNDFDLVP WLQITTRLIS 420

KYPSSLPNCE LSPLILILYQ LLPQQRRGER IPHVLRCLTE VALCQGKKSN LESSQKSDLL 480

KLWIKIWSIT FRGISSEQTQ TENFGLLGAI IQGSLVELDR EFWKLFTGSA CKPSSPSVRC 540

LTLALSMCVV PDAIKMGTEQ SVCDANRSFS VKESIMRWLL FYQLEGDLED SAEPPPILQS 600

NFPHLILEKI LVSLTMKNSK AAMKFFQSAP ECEQHCEDTE EPSFSEAEEL FLQTTFDKMD 660

FLTPVKEDTV EKFQSRVGFS VHQNLKESLD HYLLGLSEQL LSNYSSEITS SETLVRCSSL 720

LVGVLGCYCY MGVITEDEAY KSELFQKAKS LMQCAGESIS LFKNKTNEES RVGSLRSVIH 780

LCTSCLCRHT KHTLNKIASG FFLRLLTSKL MNDIADICKS LASCTKKPFD YGEEHSLRDD 840

DDDGDGGDGG ESLMETQGSS STDLFSDYSA STVSDANDYG ENQNAVGAAN PLTADWLSRQ 900

DHLLLDMLRF LCLSVTACQS RTASFRGADI RRKLLMLLDP STLDLTKSLH LHMYLVLLKD 960

LPGKEHLLPM EDVVELLQPL SLVCSLYRRD QDVCKTILSN VLHIVTNLGQ GSVDTESTRN 1020

AQGQFLTVMG AFWHLTKEKK CIFSVRMALV KCLQTLLEAD PYSKWAILNV KGQDFPVREA 1080

FPQFLADGHH HVRMLAAGSI SRLFQDMRQG DSSRSLKALP LKFQQTSFNS AYMIAEAGIR 1140

ELLCDSQNPD LLDEIYNRKS VLLTVIAVVL HCSPICEKQA LFALCKSVKE NGLEPHLVKK 1200

VLEKVSESFG CRCLEDFMAS HLDYLVLEWL NLQDAKYSLS SFPFTLLNYM SVEDFYRSCY 1260

KILIPHLVIR KHFDEVKSIA NQIQRCWKSL LIDCFPKMLV HILPYFACEG TGDSSSAQKR 1320

ETATEVYDTL KGEDFLGKQI DQVFISNLPE IVVELLMTLH ETADSDSGQS PDLCDFSGDL 1380

DPAPNPPYFP SHVIKATFAY ISSCHKTKFK SILEILSKIP DSYQKILLAI CEQAAETNNV 1440

FKKHRILKIY HLFVSLLLKD IQSGLGGAWA FVLRDVIYTL IHYINKRSSH FTDVSLRSFS 1500

LCCDLLSRVC RTAVTHCKDA LENHLHVIVG TLIPLVDYQE VQEQVLDLLK YLVIDNKDNK 1560

NLFVTIKLLD PFPDHVVFKD LRLTQQKIKY SGGPFTLLEE INHFLSVSAY NPLPLTRLEG 1620

LKDLRRQLEQ HKDQMLDLVR ASQDNPQDGI VVKLVVSLLQ LSKMAVNQTG EREVLEAVGR 1680

CLGEIGPLDF STIAVQHSKD TPYTKAYGLP EDRELQWTLI MLTALNNTLV EDSVKIRSAA 1740

ATCLKNILAT KTGHIFWENH KTSADPMLTY LQPFRASRKK FLELPQFVKE DALEGLDDVN 1800

LWVPQSESHD IWIKTLTCAF LDSGGIKSEI LQLLKPMCEV KTDFCQMVLP YLIHDVLLQD 1860

THESWRTLLS THVRGFFTNC FKHSSQASRS ATPANSDSES ENFLRCCLDK KSQRTMLAVV 1920

DYLRRQKRPS SGTAFEDAFW LDLNYLEVAK VAQSCAAHFT ALLYAEIYSD KKNMDEQEKR 1980

SPTFEEGSQG TTISSLSEKS KEETGISLQD LLLEIYRSIG EPDSLYGCGG GKVLQPLTRI 2040

RTYEHEATWE KALVTYDLET TISSSTRQSG IIQALQNLGL SHILSIYLKG LDHERREWCG 2100

ELQELHYQAA WRNMQWDLCT SANQELEGTS YHESLYNALQ CLRNREFSTF YDSLRHARVK 2160

EVEELSKGSL ESVYSLYPTL SRLQAVGELE NSGELFSRSV TDRERSEVYL KWQKHSQLLK 2220

DSDFSFQEPL MALRTVILEI LVQKEMENSQ GGCSKDILTK HLVEFSVLAR TFKNTQLPER 2280

AIFKIKQYNP AICGISEWHL EEAQVFWAKK EQSLALSILK QMIKKLDSSF REVCNEAGLK 2340

GLHAECLRVC GNWLAETCLE NPAVIMQTYL EKAVKVAGSY DGDSRELRNG QMKAFLSLAR 2400

FSDTQYQRIE NYMKSSEFEN KQALLKRAKE EVGLIREHKI QTNRYTIKVQ RELELDECAL 2460

RALKEDRKRF LCKAVENYIS CLLSGEEHDL WVFRLCSLWL ENSGVSEVNG MMKRDGMKIS 2520

SYKFLPLMYQ LAARMGTKMT GGLGFHEVLN NLISRISMDH PHHTLFIILA LANANKDEFL 2580

SKPETARRGR ITKNAPKESS QLDEDRAEAA SRIIHTIRSA RRTMVKDMEA LCDAYIILAN 2640

LDASQWRNQR KGISIPANQP ITKLKNLEDV VVPTMEIKVD PTGEYEKLVT IKSFKTEFRL 2700

AGGLNLPKII DCVGSDGKER RQLVKGRDDL RQDAVMQQVF QMCNMLLQRN TETRKRKLTI 2760

CTYKVVPLSQ RSGVLEWCTG TIPIGEYLVN NEEGAHKRYR PNDLSANQCQ KKMMEVQKKS 2820

FEEKYETFMT ICQNFEPVFR YFCMEKFLDP AVWFEKRLAY TRSVATSSIV GYILGLGDRH 2880

VQNILINEQS AELVHIDLGV AFEQGKILPT PETVPFRLSR DIVDGMGITG VEGVFRRCCE 2940

KTMEVMRSSQ EALLTIVEVL LYDPLFDWTM NPLKALYLQQ RPEDETDLQS TPSADDQECK 3000

RSLSDTDQSF NKVAERVLMR LQEKLKGVEE GTVLSVGGQV NLLIQQAMDP KNLSRLFPGW 3060

KAWV 3064

Nucleotide Sequence
(FASTA)

ATGAGTCTAG CGCTGAATGA CCTGCTCATC TGCTGCCGGC AGTTAGAACA TGACAGGGCT 60

ACAGAACGAA GGAAAGAAGT GGATAAATTT AAGCGCCTGA TTCAGGATCC TGAAACAGTT 120

CAACATTTGG ATAGGCATTC TGACTCCAAA CAAGGGAAAT ATCTGAATTG GGATGCTGTT 180

TTCAGGTTTT TGCAGAAGTA CATTCAAAAG GAAACAGAAA GTCTTAGAAC AGCAAAATCA 240

AATGTCTCAG CCTCTACACA AACCTCCAGA CAGAAGAAGA TGCAAGAGAT TAGCAGTCTG 300

GTCAGATTCT TCATCAAATG TGCAAATAAA AGAGCACCCA GGCTAAAATG TCAGGACCTC 360

TTGAATTACG TCATGGATAC AGTGAAAGAC TCATCTAATG GCGCAACTTA CGGAGCTGAC 420

TGCAGCAACA TTCTTCTCAA AGACATCCTG TCTGTGAGGA AATACTGGTG TGAAGTGTCT 480

CAGCAGCAGT GGCTAGAATT GTTTTCCCTG TACATCAGGC TGTATCTCAA ACCATCACAG 540

GACATTAATA GAGTTTTAGT GGCTAGAATA ATTCATGCTG TCACCAGAGG ATGCTGCTCA 600

CAGACTGATG GATTACCTTC AAAGTTCTTA GATCTTTTTT CCAAGGCTAT TCAGTATGCC 660

AGACAGGAAA AGAGCTCTCC TGGCTTAAGT CACATCTTAG CAGCCCTTAA CATTTTCCTC 720

AAGACTTTGG CTGTCAACTT CCGAAAGCGG GTGTGTGAAA TAGGAGATGA AATTCTTCCT 780

ACCTTACTGT ATATTTGGAC TCAACATCGA CTTAATGACT CCTTAAAAGA AGTAATTATT 840

GAACTAATTC ACCTGCAGAT TTACATCCAT CATCCACAGG GAGCCAAAGC GCCTGAGGAA 900

GGTGCTTATG AATCCATGAA ATGGAAAAGG ATCTTGTACA ACTTATACGA CCTGCTGGTG 960

AATGAGATAA GTCACATAGG AAGCAGAGGG AAATACTCCT CAGGATCTCG TAATATTGCT 1020

GTCAAGGAAA ATTTGATTGA CTTGATGGCA GATGTCTGTT ACCAGCTTTT TAATGCAGAT 1080

ACCAGATCCG TGGAGATTTC TCAGTCTTAT GCGACACAAA GGGAATCCAC TGACTACAGT 1140

GTACCTTGCA AAAGAAGGAA AATAGACATA GGCTGGGAAG TGATAAAAGA TTATCTTCAG 1200

AAGTCACAGA ATGATTTTGA TCTTGTGCCA TGGCTACAGA TTACAACCCG ATTAATATCA 1260

AAATATCCTT CCAGTTTGCC TAACTGTGAG CTGTCTCCAT TAATACTGAT CCTGTACCAG 1320

CTTCTGCCTC AACAGCGGCG TGGAGAACGC ATCCCACATG TGTTACGATG CCTTACCGAA 1380

GTTGCCTTAT GTCAAGGCAA GAAATCAAAC CTAGAAAGCT CTCAAAAGTC AGATTTATTG 1440

AAACTATGGA TTAAAATTTG GTCTATTACC TTTCGTGGTA TAAGTTCTGA ACAAACACAA 1500

ACTGAAAACT TTGGTTTACT TGGGGCCATT ATTCAAGGTA GTTTAGTTGA ACTTGACAGA 1560

GAATTCTGGA AGTTATTTAC TGGCTCAGCC TGTAAACCTT CAAGTCCTTC AGTTCGCTGC 1620

TTGACTTTGG CGCTTAGCAT GTGTGTAGTT CCAGATGCAA TAAAAATGGG AACAGAACAA 1680

AGTGTGTGTG ACGCAAATAG AAGTTTTTCT GTGAAGGAGT CGATAATGAG GTGGCTCTTA 1740

TTCTACCAGT TAGAGGGCGA CTTGGAAGAC AGCGCAGAGC CGCCTCCCAT TCTCCAGAGT 1800

AATTTCCCTC ATCTCATACT GGAAAAAATT CTTGTAAGTC TCACTATGAA AAACTCAAAA 1860

GCTGCAATGA AGTTTTTTCA AAGTGCCCCA GAATGTGAGC AGCACTGTGA AGATACAGAA 1920

GAGCCTTCGT TCTCAGAAGC GGAAGAACTG TTTCTCCAGA CAACTTTTGA CAAGATGGAT 1980

TTTTTAACTC CTGTCAAAGA AGATACTGTA GAAAAATTTC AATCTCGTGT TGGCTTCTCT 2040

GTCCACCAAA ATCTCAAGGA ATCACTGGAT CATTATCTTC TGGGATTATC AGAACAGCTT 2100

TTAAGTAATT ACTCTTCTGA GATTACAAGT TCAGAAACCC TTGTCCGGTG TTCGAGTCTT 2160

CTGGTGGGTG TTCTTGGCTG CTATTGTTAC ATGGGTGTAA TAACTGAAGA CGAAGCATAT 2220

AAATCAGAAT TATTCCAGAA AGCCAAGTCT CTGATGCAGT GTGCAGGGGA AAGTATCTCT 2280

TTGTTTAAAA ATAAGACAAA TGAGGAGTCC AGAGTTGGTT CACTGAGAAG TGTGATACAT 2340

CTGTGTACAA GTTGCTTGTG TAGACATACC AAGCACACTC TAAACAAGAT AGCCTCTGGC 2400

TTTTTCCTGC GATTATTAAC GTCCAAGCTC ATGAATGACA TTGCAGATAT TTGTAAAAGC 2460

TTGGCATCCT GTACGAAAAA GCCATTTGAC TATGGAGAGG AGCATTCGTT GAGAGATGAT 2520

GATGATGATG GTGATGGTGG TGATGGTGGT GAAAGTCTGA TGGAGACACA GGGTTCATCA 2580

TCCACAGATC TATTTAGCGA TTACTCTGCT AGTACTGTGA GCGATGCAAA CGATTATGGA 2640

GAGAACCAGA ATGCTGTTGG TGCCGCGAAT CCTCTAACTG CTGACTGGCT GTCCAGACAA 2700

GATCATCTTC TTTTAGACAT GCTCAGGTTC TTGTGCCTCT CTGTAACTGC ATGTCAGAGC 2760

CGGACTGCGT CTTTCAGAGG AGCTGATATT AGAAGAAAGT TGTTAATGTT ACTCGATCCT 2820

AGCACACTCG ATCTCACTAA ATCCCTACAC CTACACATGT ACTTGGTGCT TTTGAAGGAT 2880

CTCCCTGGAA AAGAGCATTT GTTGCCAATG GAAGATGTTG TTGAACTTCT GCAGCCATTA 2940

TCCCTTGTAT GTTCTCTGTA TCGGCGTGAC CAAGATGTCT GCAAGACGAT TTTAAGCAAT 3000

GTCCTCCATA TAGTGACAAA CCTAGGTCAG GGCAGCGTGG ACACAGAGAG CACAAGGAAT 3060

GCTCAAGGAC AGTTCCTGAC AGTGATGGGA GCATTTTGGC ATTTAACAAA GGAAAAGAAA 3120

TGTATATTCT CTGTCAGAAT GGCGTTAGTA AAGTGTCTTC AAACACTGCT TGAGGCTGAT 3180

CCATATTCCA AGTGGGCGAT TCTTAATGTA AAGGGACAGG ACTTTCCTGT ACGTGAAGCA 3240

TTTCCACAGT TTCTTGCTGA CGGTCACCAT CACGTTCGGA TGTTGGCTGC GGGGTCGATC 3300

AGCAGATTAT TCCAGGATAT GAGACAAGGT GATTCCTCCA GAAGCTTGAA AGCACTTCCT 3360

CTGAAGTTTC AGCAGACATC TTTCAACAGT GCATACATGA TAGCAGAGGC AGGAATCAGA 3420

GAACTGTTAT GTGATTCTCA GAACCCTGAT CTTCTGGATG AGATTTATAA TAGAAAATCC 3480

GTATTGCTGA CGGTGATAGC TGTGGTCTTG CACTGTAGCC CAATCTGTGA AAAGCAGGCT 3540

TTGTTTGCCT TATGCAAATC TGTGAAGGAA AATGGACTAG AACCCCATCT TGTGAAAAAG 3600

GTTTTGGAGA AAGTCTCCGA GTCGTTTGGA TGTAGGTGCT TAGAGGACTT CATGGCTTCT 3660

CATCTAGATT ACTTGGTTTT GGAATGGCTG AACCTTCAAG ATGCTAAATA CAGCTTATCT 3720

TCCTTTCCTT TTACGTTATT AAACTACATG AGCGTGGAGG ATTTCTATAG ATCTTGTTAC 3780

AAGATTCTGA TTCCACACTT GGTAATTAGA AAGCACTTTG ATGAGGTGAA GTCCATTGCT 3840

AATCAGATTC AGAGGTGCTG GAAAAGCCTG CTGATCGACT GCTTTCCAAA GATGCTTGTG 3900

CACATCCTTC CGTACTTTGC CTGTGAGGGC ACGGGGGACA GCAGCTCGGC ACAGAAGAGG 3960

GAGACTGCTA CCGAGGTCTA CGATACTCTT AAAGGTGAAG ACTTCCTAGG AAAACAGATT 4020

GATCAAGTAT TCATTAGTAA TTTGCCAGAG ATCGTGGTGG AGCTGCTTAT GACGTTGCAT 4080

GAAACGGCTG ACTCGGATTC CGGTCAAAGC CCCGACCTCT GCGATTTTTC AGGGGATTTG 4140

GATCCCGCTC CCAATCCACC ATATTTCCCG TCACATGTCA TTAAGGCAAC ATTTGCCTAC 4200

ATCAGCAGCT GTCATAAAAC CAAGTTTAAA AGCATTCTAG AAATCCTTTC TAAAATCCCT 4260

GATTCCTATC AGAAAATACT CCTGGCCATT TGTGAACAAG CAGCTGAGAC AAATAATGTC 4320

TTTAAAAAGC ACAGAATTCT TAAAATATAC CACCTGTTTG TTAGTTTATT ACTGAAAGAC 4380

ATACAGAGTG GCTTGGGAGG AGCTTGGGCC TTTGTTCTCC GAGATGTTAT TTATACTTTG 4440

ATTCACTATA TCAACAAAAG GTCTTCCCAT TTCACTGACG TGTCATTACG TAGCTTCTCC 4500

CTGTGCTGTG ACCTATTAAG TCGAGTTTGC CGTACAGCGG TAACTCACTG TAAGGACGCC 4560

CTAGAAAACC ATCTTCATGT TATTGTGGGC ACACTTATAC CCCTTGTGGA TTATCAGGAG 4620

GTTCAAGAAC AGGTATTGGA CCTGTTGAAG TACTTGGTGA TAGATAACAA AGACAATAAA 4680

AACCTCTTTG TCACAATTAA GCTTCTGGAT CCGTTTCCTG ACCATGTTGT TTTTAAGGAT 4740

TTGCGTCTTA CTCAACAGAA GATAAAATAT AGTGGAGGAC CCTTTACACT CTTAGAGGAA 4800

ATAAACCATT TTCTCTCAGT AAGTGCTTAT AATCCACTTC CACTGACCAG ACTCGAAGGA 4860

CTGAAGGATC TTCGGAGACA ACTGGAACAG CATAAAGATC AGATGCTAGA TCTTGTGAGA 4920

GCATCTCAGG ATAACCCACA AGATGGCATT GTGGTGAAGC TGGTTGTCAG CTTGTTGCAG 4980

CTATCCAAGA TGGCAGTGAA CCAGACTGGT GAAAGAGAAG TTTTAGAGGC TGTCGGCAGG 5040

TGTTTGGGAG AAATCGGTCC TCTGGATTTC TCTACTATAG CTGTACAGCA TAGCAAAGAT 5100

ACGCCGTACA CCAAAGCCTA CGGGTTACCT GAAGACAGAG AACTTCAGTG GACCTTGATA 5160

ATGCTGACTG CCCTGAACAA CACCCTGGTG GAGGACAGTG TCAAAATTCG ATCAGCTGCT 5220

GCTACCTGTT TGAAAAACAT TTTGGCTACC AAGACCGGAC ATATTTTCTG GGAGAATCAT 5280

AAGACATCAG CGGATCCAAT GCTGACCTAT CTGCAGCCTT TCAGAGCGTC GAGGAAAAAG 5340

TTTTTAGAAT TACCCCAGTT TGTTAAAGAA GATGCTTTAG AAGGCCTGGA TGATGTAAAT 5400

CTGTGGGTTC CTCAAAGTGA AAGCCATGAC ATTTGGATAA AGACTCTGAC TTGTGCCTTT 5460

TTGGACAGTG GAGGCATAAA AAGCGAAATT CTTCAGTTAC TAAAGCCAAT GTGTGAAGTG 5520

AAAACTGACT TTTGTCAGAT GGTGCTGCCA TACTTGATCC ATGATGTTTT ACTCCAAGAT 5580

ACACATGAGT CGTGGAGAAC TCTGCTATCT ACACACGTCC GAGGATTTTT CACTAACTGT 5640

TTTAAACATT CCTCCCAAGC AAGCCGCTCA GCGACTCCCG CAAATTCGGA TTCAGAGTCA 5700

GAGAACTTTC TCCGATGCTG TTTGGATAAA AAATCACAAA GAACCATGCT CGCTGTTGTC 5760

GACTACCTGA GAAGGCAAAA GAGGCCTTCC TCAGGAACAG CTTTCGAGGA TGCCTTCTGG 5820

CTAGATTTGA ATTATCTTGA GGTTGCAAAG GTGGCTCAAT CCTGTGCAGC TCACTTCACA 5880

GCACTGCTCT ATGCAGAGAT CTATTCAGAT AAGAAAAACA TGGATGAGCA AGAGAAAAGA 5940

AGTCCAACAT TTGAAGAAGG AAGTCAAGGT ACAACTATTT CTAGTTTGAG TGAAAAAAGT 6000

AAAGAAGAAA CTGGAATAAG CTTACAGGAT CTTCTCTTGG AGATCTACAG AAGTATAGGA 6060

GAGCCAGACA GCCTGTATGG CTGCGGGGGA GGGAAAGTGT TACAACCCCT TACCCGAATA 6120

AGGACGTACG AGCATGAAGC AACGTGGGAG AAAGCCTTAG TGACATACGA CCTTGAGACC 6180

ACCATCTCCT CCTCCACCCG CCAGTCGGGA ATCATCCAGG CCTTGCAGAA CTTGGGGCTC 6240

TCCCATATTC TTTCTATCTA CTTGAAAGGA TTGGACCATG AAAGGAGAGA GTGGTGTGGG 6300

GAACTGCAGG AGCTTCATTA CCAGGCGGCG TGGAGGAACA TGCAGTGGGA CCTCTGCACT 6360

TCTGCCAACC AAGAACTAGA AGGAACCAGT TACCACGAAT CGTTGTATAA TGCTCTGCAG 6420

TGCCTAAGAA ACAGAGAATT CTCCACATTT TATGACAGTC TCCGACATGC CAGGGTGAAG 6480

GAAGTTGAAG AGTTGAGCAA AGGCAGCCTT GAATCGGTAT ATTCGCTGTA CCCCACACTT 6540

AGCAGATTGC AGGCAGTCGG AGAACTGGAA AACAGTGGAG AGCTCTTCTC AAGGTCAGTC 6600

ACAGACAGAG AGCGCTCTGA GGTATACCTG AAGTGGCAGA AGCACTCCCA GCTTCTGAAG 6660

GACAGTGACT TCAGCTTTCA GGAGCCTCTC ATGGCTCTCC GCACAGTCAT TCTGGAGATC 6720

CTGGTACAAA AGGAAATGGA GAACTCTCAA GGAGGATGCT CTAAGGACAT TCTCACCAAA 6780

CACCTTGTTG AATTCTCTGT TCTGGCCCGA ACCTTCAAGA ATACACAGCT CCCTGAAAGA 6840

GCAATATTTA AAATTAAGCA ATATAATCCA GCTATTTGCG GAATCTCTGA ATGGCATTTG 6900

GAAGAAGCAC AAGTATTTTG GGCAAAGAAG GAGCAGAGTC TTGCCCTGAG TATCCTCAAG 6960

CAAATGATCA AGAAGTTGGA CTCCAGCTTT AGAGAGGTGT GTAATGAAGC AGGTCTAAAA 7020

GGCCTACACG CAGAGTGTCT GAGGGTTTGT GGCAACTGGC TGGCAGAGAC TTGCCTAGAA 7080

AATCCTGCAG TCATCATGCA GACCTATCTA GAAAAGGCAG TGAAGGTTGC TGGCAGTTAT 7140

GATGGCGACA GCCGAGAGCT CAGAAATGGA CAGATGAAGG CCTTCCTCTC ATTAGCGCGG 7200

TTCTCTGATA CGCAGTACCA GAGGATTGAG AACTACATGA AGTCGTCCGA ATTCGAAAAC 7260

AAGCAAGCTC TCTTAAAAAG AGCCAAGGAA GAAGTGGGTC TTATAAGGGA GCATAAAATT 7320

CAGACGAACA GATACACAAT AAAGGTTCAG AGAGAACTGG AGCTAGATGA ATGTGCTCTC 7380

CGTGCACTGA AAGAGGACCG TAAACGCTTC CTGTGTAAAG CAGTTGAGAA CTACATCAGC 7440

TGCTTACTAA GCGGAGAAGA ACATGATCTG TGGGTGTTCC GACTCTGCTC CCTCTGGCTG 7500

GAAAATTCTG GAGTCTCTGA AGTCAATGGC ATGATGAAGA GAGATGGAAT GAAGATTTCC 7560

TCCTATAAGT TTTTGCCTCT CATGTACCAA TTGGCTGCTA GAATGGGGAC CAAAATGACA 7620

GGAGGCCTAG GATTTCATGA AGTCCTCAAT AATCTCATCT CTAGGATTTC AATGGATCAC 7680

CCCCATCACA CCTTGTTCAT CATCCTGGCC TTAGCAAATG CAAACAAAGA TGAGTTTTTG 7740

AGCAAACCAG AGACAGCAAG AAGGGGCAGA ATAACCAAGA ATGCACCCAA AGAAAGCTCT 7800

CAGCTTGATG AGGATCGAGC AGAGGCTGCA AGCAGAATAA TCCATACAAT CAGAAGTGCG 7860

AGGCGTACAA TGGTGAAGGA CATGGAGGCG CTCTGCGATG CCTACATCAT CCTGGCGAAC 7920

CTGGATGCCT CTCAGTGGAG GAACCAGAGA AAAGGCATCA GCATTCCAGC CAACCAGCCA 7980

ATCACTAAAC TGAAGAATTT AGAAGACGTT GTTGTTCCCA CTATGGAAAT TAAGGTTGAC 8040

CCCACAGGAG AGTATGAAAA GCTGGTGACT ATAAAGTCAT TTAAAACAGA ATTTCGCTTA 8100

GCCGGAGGCT TAAATTTACC AAAAATAATA GACTGTGTGG GTTCTGATGG CAAGGAAAGG 8160

AGACAGCTTG TGAAGGGCCG CGATGACCTG AGGCAAGATG CTGTCATGCA GCAGGTTTTC 8220

CAGATGTGCA ATATGCTACT GCAGAGGAAC ACCGAGACTA GAAAGAGGAA ACTGACCATC 8280

TGCACATACA AGGTGGTTCC CCTCTCCCAG CGAAGCGGTG TTCTTGAGTG GTGCACAGGA 8340

ACCATCCCTA TTGGTGAATA TCTTGTTAAC AACGAAGAAG GTGCTCATAA AAGATACAGG 8400

CCAAATGATC TCAGCGCCAA TCAGTGCCAA AAGAAAATGA TGGAAGTGCA GAAGAAGTCT 8460

TTTGAAGAGA AGTATGAGAC CTTCATGACT ATTTGCCAAA ACTTTGAGCC AGTTTTCCGT 8520

TACTTCTGCA TGGAAAAATT CTTGGATCCA GCTGTTTGGT TTGAGAAACG GTTGGCGTAT 8580

ACGCGTAGTG TGGCCACGTC GTCTATCGTT GGTTACATCC TTGGACTTGG TGATAGGCAT 8640

GTCCAGAATA TCCTGATAAA CGAGCAGTCA GCAGAACTTG TGCACATAGA TTTGGGAGTG 8700

GCTTTTGAAC AGGGGAAGAT CCTTCCCACT CCAGAGACAG TTCCTTTTAG ACTCAGCAGA 8760

GATATCGTGG ACGGGATGGG TATCACTGGT GTGGAAGGTG TCTTCAGAAG GTGCTGTGAA 8820

AAAACAATGG AAGTTATGCG TAGTTCCCAG GAAGCTCTGC TCACCATTGT AGAGGTTCTT 8880

TTGTACGACC CGCTCTTTGA TTGGACTATG AACCCTTTAA AAGCTTTGTA CTTACAGCAG 8940

AGGCCAGAAG ACGAGACTGA CCTCCAGTCC ACCCCCAGTG CAGACGATCA GGAGTGCAAA 9000

CGAAGTCTTA GTGATACTGA CCAGAGTTTC AACAAAGTAG CTGAGCGCGT CCTGATGAGA 9060

TTGCAAGAGA AGCTGAAAGG CGTGGAGGAG GGCACCGTGC TCAGTGTGGG CGGACAGGTG 9120

AACCTGCTTA TCCAGCAGGC CATGGACCCC AAAAACCTCA GCCGACTCTT CCCAGGGTGG 9180

AAAGCGTGGG TGTGA 9195

Domain Profile

S: 13    skqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdketsrrkLkirt  72

          ++ pk +   Gsdgke+++Lvkg++Dlrqd++++q+f+++N lL++++et++rkL+i+t

Q: 2703  GLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNMLLQRNTETRKRKLTICT  2762

         5677999999**************************************************

S: 73    ykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdlstvqarkpklkh  132

         ykVvpls+rsg++ew+++t++++e+l   v++++++++   +yr++dls++q++k+++++

Q: 2763  YKVVPLSQRSGVLEWCTGTIPIGEYL---VNNEEGAHK---RYRPNDLSANQCQKKMMEV  2816

         **************************...799999998...9******************

S: 133   lkls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvislvgyiL  188

         +k+s    +e f+ +++n+ p  +++++++ekf++p++wfe+r aytrs+A++s+vgyiL

Q: 2817  QKKSfeekYETFMTICQNFEP--VFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYIL  2874

         *********************..9************************************

S: 189   gLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnalgvtgveG  248

         gLgdrh++n+li+++++e+vhid+gvafe++k+ l++pe+vPFRL r+iv+++g+tgveG

Q: 2875  GLGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLSRDIVDGMGITGVEG  2933

         *********************************.**************************

S: 249   vfrasceavlrvlreskeklltiLevflydplvdwkk......kkktsketeeelaekak  302

         vfr++ce++++v+r+s+e llti+ev+lydpl+dw++      + ++++e+e++l+++ +

Q: 2934  VFRRCCEKTMEVMRSSQEALLTIVEVLLYDPLFDWTMnplkalYLQQRPEDETDLQSTPS  2993

         *******************************************9****************

S: 303   aealkikkllskvekaenavatrdlllle  331

         a+++++k+ ls+ ++++n+va+r+l++l+

Q: 2994  ADDQECKRSLSDTDQSFNKVAERVLMRLQ  3022

         ************************99987

Domain Sequence
(FASTA)

GLNLPKIIDC VGSDGKERRQ LVKGRDDLRQ DAVMQQVFQM CNMLLQRNTE TRKRKLTICT 60

YKVVPLSQRS GVLEWCTGTI PIGEYLVNNE EGAHKRYRPN DLSANQCQKK MMEVQKKSFE 120

EKYETFMTIC QNFEPVFRYF CMEKFLDPAV WFEKRLAYTR SVATSSIVGY ILGLGDRHVQ 180

NILINEQSAE LVHIDLGVAF EQGKILPTPE TVPFRLSRDI VDGMGITGVE GVFRRCCEKT 240

MEVMRSSQEA LLTIVEVLLY DPLFDWTMNP LKALYLQQRP EDETDLQSTP SADDQECKRS 300

LSDTDQSFNK VAERVLMRLQ 320

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005819	; C:spindle
GO:0016303	; F:1-phosphatidylinositol-3-kinase activity
GO:0005524	; F:ATP binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0035174	; F:histone serine kinase activity
GO:0006915	; P:apoptotic process
GO:0007420	; P:brain development
GO:0007050	; P:cell cycle arrest
GO:0071480	; P:cellular response to gamma radiation
GO:0006975	; P:DNA damage induced protein phosphorylation
GO:0006281	; P:DNA repair
GO:0007292	; P:female gamete generation
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0007507	; P:heart development
GO:0071044	; P:histone mRNA catabolic process
GO:0008630	; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0042159	; P:lipoprotein catabolic process
GO:0007094	; P:mitotic cell cycle spindle assembly checkpoint
GO:0043066	; P:negative regulation of apoptotic process
GO:0030889	; P:negative regulation of B cell proliferation
GO:0051402	; P:neuron apoptotic process
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525	; P:positive regulation of neuron apoptotic process
GO:0002331	; P:pre-B cell allelic exclusion
GO:0046777	; P:protein autophosphorylation
GO:0051726	; P:regulation of cell cycle
GO:0090399	; P:replicative senescence
GO:0006974	; P:response to DNA damage stimulus
GO:0001666	; P:response to hypoxia
GO:0001756	; P:somitogenesis
GO:0000723	; P:telomere maintenance

KEGG

rno:300711

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013