EKS-RAN-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	532.1	2.7E-160	889	1156	268

Status

Unreviewed

Ensembl Protein

ENSRNOP00000060141

UniProt Accession

F1LQ13;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

Insr

Gene Synonyms/Alias

Insr;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000029986	ENSRNOP00000049655	ENSRNOT00000041155
ENSRNOG00000029986	ENSRNOP00000060141	ENSRNOT00000067448

Organism

Rattus norvegicus

Functional Description

Protein Length

1248

Protein Sequence
(FASTA)

MNITRGSVRI EKNNELCYLA TIDWSRILDS VEDNYIVLNK DDNEECGDVC PGTAKGKTNC 60

PATVINGQFV ERCWTHSHCQ KVCPTICKSH GCTAEGLCCH KECLGNCSEP DDPTKCVACR 120

NFYLDGQCVE TCPPPYYHFQ DWRCVNFSFC QDLHYKCRNS RKPGCHQYVI HNNKCIPECP 180

SGYTMNSSNL MCTPCLGPCP KVCQILEGEK TIDSVTSAQE LRGCTVINGS LIINIRGGNN 240

LAAELEANLG LIEEISGFLK IRRSYALVSL SFFRKLHLIR GETLEIGNYS FYALDNQNLR 300

QLWDWNKHNL TITQGKLFFH YNPKLCLSEI HKMEEVSGTK GRQERNDIAL KTNGDQASCE 360

NELLKFSFIR TSFDKILLRW EPYWPPDFRD LLGFMLFYKE APYQNVTEFD GQDACGSNSW 420

TVVDIDPPQR SNDPKSQTPS HPGWLMRGLK PWTQYAIFVK TLVTFSDERR TYGAKSDIIY 480

VQTDATNPSV PLDPISVSNS SSQIILKWKP PSDPNGNITH YLVYWERQAE DSELFELDYC 540

LKGLKLPSRT WSPPFESDDS QKHNQSEYDD SASECCSCPK TDSQILKELE ESSFRKTFED 600

YLHNVVFVPR KTSSGNGAED TRPSRKRRSL EEVGNVTATT PTLPDFPNIS STIAPTSHEE 660

HRPFEKVVNK ESLVISGLRH FTGYRIELQA CNQDSPEERC SVAAYVSART MPEAKADDIV 720

GPVTHEIFEN NVVHLMWQEP KEPNGLIVLY EVSYRRYGDE ELHLCVSRKH FALERGCRLR 780

GLSPGNYSVR VRATSLAGNG SWTEPTYFYV TDYLDVPSNI AKIIIGPLIF VFLFSVVIGS 840

IYLFLRKRQP DGPMGPLYAS SNPEYLSASD VFPSSVYVPD EWEVPREKIT LLRELGQGSF 900

GMVYEGNAKD IIKGEVETRV AVKTVNESAS LRERIEFLNE ASVMKGFTCH HVVRLLGVVS 960

KGQPTLVVME LMAHGDLKSH LRSLRPDAEN NPGRPPPTLQ EMIQMTAEIA DGMAYLNAKK 1020

FVHRDLAARN CMVAHDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT 1080

ASSDMWSFGV VLWEITSLAE QPYQGLSNEQ VLKFVMDGGY LDPPDNCPER LTDLMRMCWQ 1140

FNPKMRPTFL EIVNLLKDDL HPSFPEVSFF YSEENKAPES EELEMEFEDM ENVPLDRSSH 1200

CQREEAGCRE GGSSLSIKRT YDEHIPYTHM NGGKKNGRVL TLPRSNPS 1248

Nucleotide Sequence
(FASTA)

ATGAACATCA CCCGGGGCTC TGTCCGCATC GAGAAGAATA ATGAACTCTG CTACCTGGCC 60

ACTATCGACT GGTCCCGCAT CCTGGATTCC GTGGAGGACA ACTACATTGT ACTGAACAAA 120

GATGACAATG AGGAATGTGG GGACGTCTGT CCAGGCACAG CCAAGGGCAA GACCAACTGC 180

CCTGCCACCG TCATCAATGG GCAGTTTGTG GAACGGTGCT GGACACACAG TCATTGTCAG 240

AAAGTTTGCC CAACCATCTG TAAGTCACAT GGCTGCACAG CTGAAGGCCT GTGCTGTCAC 300

AAGGAGTGCC TGGGCAACTG TTCAGAACCC GATGACCCTA CCAAGTGTGT GGCCTGTCGA 360

AACTTCTACC TGGATGGTCA GTGTGTGGAG ACCTGCCCAC CACCCTACTA TCACTTCCAG 420

GATTGGCGCT GTGTAAACTT CAGCTTCTGC CAAGACCTTC ACTACAAATG CAGGAACTCT 480

CGGAAGCCTG GCTGTCACCA ATACGTCATT CACAACAACA AGTGCATCCC CGAGTGCCCG 540

TCTGGCTATA CCATGAATTC CAGCAACTTG ATGTGCACCC CGTGTCTGGG ACCCTGTCCT 600

AAGGTCTGCC AAATCCTCGA AGGCGAGAAG ACCATTGATT CCGTGACATC TGCCCAGGAG 660

CTCCGAGGCT GCACTGTGAT CAATGGCAGC CTGATTATCA ACATCCGAGG GGGCAACAAC 720

CTGGCAGCTG AACTAGAGGC TAACCTTGGC CTCATTGAAG AAATCTCAGG GTTCCTAAAG 780

ATCCGTCGCT CCTATGCTCT GGTGTCACTT TCTTTCTTCA GGAAGCTACA TCTGATTCGA 840

GGAGAGACCT TGGAAATTGG GAACTATTCT TTCTACGCCT TGGACAACCA GAACCTGAGG 900

CAGCTGTGGG ACTGGAACAA GCACAACCTC ACGATCACTC AGGGCAAGCT CTTCTTCCAC 960

TACAACCCCA AACTCTGCCT GTCTGAGATC CACAAGATGG AGGAAGTGTC CGGAACCAAG 1020

GGCCGCCAGG AGAGGAACGA CATTGCCCTG AAGACCAACG GGGACCAGGC ATCCTGTGAA 1080

AATGAATTAC TTAAATTCTC TTTCATCCGG ACGTCTTTTG ACAAGATCTT GCTGAGGTGG 1140

GAGCCCTACT GGCCCCCCGA CTTCCGAGAT CTCCTGGGAT TCATGCTGTT CTACAAAGAG 1200

GCCCCTTATC AGAACGTGAC AGAGTTTGAC GGGCAGGATG CGTGTGGCTC CAACAGCTGG 1260

ACTGTGGTGG ATATTGACCC GCCCCAGAGG TCCAACGACC CTAAGTCTCA GACCCCAAGC 1320

CACCCTGGGT GGCTGATGCG GGGCCTCAAA CCCTGGACCC AGTATGCCAT CTTTGTCAAG 1380

ACCTTGGTTA CCTTCTCTGA TGAACGCCGG ACCTATGGAG CCAAAAGTGA TATCATCTAT 1440

GTGCAAACAG ATGCCACCAA TCCTTCCGTT CCCCTGGATC CCATATCAGT TTCCAACTCC 1500

TCATCTCAGA TTATCTTAAA GTGGAAGCCC CCCTCGGACC CCAATGGCAA CATCACACAC 1560

TACCTGGTCT ACTGGGAGAG GCAGGCGGAG GACAGCGAGC TGTTCGAGTT GGATTATTGT 1620

CTCAAAGGGC TGAAGCTCCC CTCACGCACC TGGTCCCCAC CTTTTGAGTC TGACGATTCT 1680

CAAAAGCACA ATCAGAGTGA GTATGACGAC TCGGCCAGCG AGTGCTGCTC ATGTCCTAAG 1740

ACTGACTCTC AGATCCTGAA GGAGCTGGAG GAGTCTTCAT TCAGGAAGAC CTTCGAGGAT 1800

TACCTGCACA ACGTGGTTTT TGTTCCCAGA AAAACCTCTT CAGGCAATGG TGCTGAGGAC 1860

ACTAGGCCAT CCCGAAAGCG AAGATCCCTT GAAGAGGTGG GCAATGTGAC AGCCACTACA 1920

CCCACACTTC CAGATTTTCC CAACATCTCC TCCACCATCG CGCCCACAAG CCACGAAGAG 1980

CACAGACCAT TTGAGAAAGT AGTAAACAAG GAGTCACTTG TCATCTCTGG CCTGAGACAC 2040

TTCACTGGGT ACCGCATTGA GCTGCAGGCA TGCAATCAGG ACTCCCCAGA AGAGAGGTGC 2100

AGCGTGGCTG CCTACGTCAG TGCCCGGACC ATGCCTGAAG CTAAGGCAGA TGACATCGTT 2160

GGCCCTGTGA CCCATGAAAT CTTTGAGAAC AATGTTGTAC ACTTAATGTG GCAAGAGCCA 2220

AAGGAACCTA ATGGTCTGAT TGTGCTATAT GAAGTGAGCT ATCGGCGATA TGGTGATGAG 2280

GAGCTGCACC TCTGTGTCTC CCGGAAGCAT TTTGCCCTGG AGCGGGGCTG CAGGCTTCGA 2340

GGGCTCTCTC CAGGAAACTA CAGTGTTCGA GTCCGGGCTA CCTCTCTGGC AGGAAATGGC 2400

TCCTGGACAG AACCCACCTA TTTTTATGTG ACTGATTATT TAGATGTCCC ATCAAATATT 2460

GCCAAAATTA TCATCGGGCC CCTCATCTTC GTCTTCCTCT TCAGTGTCGT GATCGGAAGT 2520

ATTTATCTAT TCTTGAGGAA GAGGCAGCCA GATGGGCCAA TGGGACCACT GTACGCTTCT 2580

TCAAACCCAG AGTACCTCAG TGCCAGTGAT GTCTTTCCAT CTTCCGTATA CGTTCCGGAT 2640

GAGTGGGAGG TACCTCGAGA GAAGATCACC CTCCTCCGAG AGCTGGGGCA GGGATCCTTC 2700

GGTATGGTGT ACGAAGGCAA TGCCAAGGAT ATCATCAAGG GTGAGGTAGA GACCCGTGTT 2760

GCGGTGAAGA CGGTCAATGA GTCAGCCAGT CTTCGAGAAC GGATCGAGTT CCTCAATGAG 2820

GCATCAGTCA TGAAGGGCTT CACCTGTCAT CACGTGGTCC GCCTTCTTGG GGTGGTGTCC 2880

AAAGGCCAGC CCACATTGGT AGTGATGGAA CTGATGGCTC ATGGAGACCT GAAAAGTCAC 2940

CTCCGTTCTC TGCGGCCCGA TGCTGAGAAC AACCCAGGCC GTCCTCCCCC TACCTTGCAA 3000

GAAATGATTC AGATGACAGC AGAAATTGCC GATGGCATGG CATACTTGAA CGCCAAGAAG 3060

TTTGTGCACC GGGACCTGGC AGCTCGGAAC TGCATGGTTG CCCATGATTT TACTGTCAAA 3120

ATCGGAGACT TTGGAATGAC GAGAGACATC TACGAGACAG ATTACTATCG GAAAGGGGGC 3180

AAGGGGTTGC TGCCCGTGAG GTGGATGTCA CCCGAGTCCC TGAAGGACGG AGTCTTCACT 3240

GCTTCTTCCG ACATGTGGTC CTTTGGGGTG GTCCTTTGGG AAATCACCAG CCTGGCTGAG 3300

CAACCTTACC AAGGCCTGTC TAATGAACAG GTGTTGAAAT TTGTCATGGA TGGAGGCTAT 3360

CTGGATCCCC CTGATAACTG TCCAGAGAGA CTCACTGACC TGATGCGCAT GTGCTGGCAG 3420

TTCAACCCCA AGATGAGGCC GACCTTCCTG GAAATCGTCA ACCTGCTCAA GGACGACCTC 3480

CACCCCAGCT TTCCGGAAGT TTCCTTCTTC TACAGCGAGG AGAACAAGGC TCCCGAGAGT 3540

GAAGAGCTGG AGATGGAGTT CGAGGACATG GAGAATGTCC CCTTGGATCG TTCCTCTCAC 3600

TGTCAGAGAG AAGAGGCTGG ATGCCGGGAG GGAGGGTCCT CTCTGAGCAT CAAACGGACC 3660

TATGATGAAC ACATCCCCTA CACCCACATG AACGGGGGCA AGAAGAATGG GCGGGTCCTC 3720

ACCCTGCCGA GGTCGAACCC TTCCTAA 3747

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+llrelGqGsfGmvyeG+akd++kge etrva+ktvne+as reriefl+easvmk f+

Q: 889   ITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEASVMKGFT  948

         789*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvskgqp+lvvmelm++Gdlks+lrslrp++en+++++pp+l+++iqm+ae

Q: 949   CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAE  1008

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+akkfvhrdlaarncmva+d+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1009  IADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1068

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft++sd+wsfGvvlwei++laeqpyqGlsneqvlkfv+dgg+l+ p+ncp

Q: 1069  MSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCP  1128

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         e+lt+lmr+cwq+npk+rp+fleiv+ll

Q: 1129  ERLTDLMRMCWQFNPKMRPTFLEIVNLL  1156

         *************************976

Domain Sequence
(FASTA)

ITLLRELGQG SFGMVYEGNA KDIIKGEVET RVAVKTVNES ASLRERIEFL NEASVMKGFT 60

CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SHLRSLRPDA ENNPGRPPPT LQEMIQMTAE 120

IADGMAYLNA KKFVHRDLAA RNCMVAHDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTASSDMWSF GVVLWEITSL AEQPYQGLSN EQVLKFVMDG GYLDPPDNCP 240

ERLTDLMRMC WQFNPKMRPT FLEIVNLL 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0005899	; C:insulin receptor complex
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0032148	; P:activation of protein kinase B activity
GO:0071363	; P:cellular response to growth factor stimulus
GO:0031017	; P:exocrine pancreas development
GO:0007186	; P:G-protein coupled receptor signaling pathway
GO:0003007	; P:heart morphogenesis
GO:0008286	; P:insulin receptor signaling pathway
GO:0030238	; P:male sex determination
GO:0030335	; P:positive regulation of cell migration
GO:0048639	; P:positive regulation of developmental growth
GO:0045740	; P:positive regulation of DNA replication
GO:0045725	; P:positive regulation of glycogen biosynthetic process
GO:0045821	; P:positive regulation of glycolysis
GO:0043410	; P:positive regulation of MAPK cascade
GO:0045840	; P:positive regulation of mitosis
GO:0045429	; P:positive regulation of nitric oxide biosynthetic process
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060267	; P:positive regulation of respiratory burst
GO:0046777	; P:protein autophosphorylation
GO:0045995	; P:regulation of embryonic development
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0019087	; P:transformation of host cell by virus

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 2.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013