EPS-RAN-00022

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-RAN-00022

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	290.6	1.6E-86	23	293	271

Status

Reviewed

Ensembl Protein

ENSRNOP00000048342

UniProt Accession

P35815; Q546R0; Q64046;

Protein Name

Protein phosphatase 1B

Protein Synonyms/Alias

Protein phosphatase 2C isoform beta; PP2C-beta;

Gene Name

Ppm1b

Gene Synonyms/Alias

Ppm1b; Pp2c2, Pppm1b;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000030667	ENSRNOP00000048342	ENSRNOT00000048656
ENSRNOG00000030667	ENSRNOP00000041472	ENSRNOT00000040509

Organism

Rattus norvegicus

Functional Description

Enzyme with a broad specificity.

Protein Length

390

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT TNEDFRAADK SGFALEPSVE NVKTGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PTHIYFINCG DSRAVLCRNG QVCFSTQDHK PCNPMEKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVYEIL RAEEDEFVVL 240

ACDGIWDVMS NEELCEFVNS RLEVSDDLEN VCNWVVDTCL HKGSRDNMSI VLVCFANAPK 300

VSDEAVKRDL ELDKHLESRV EEIMQKSGEE GMPDLAHVMR ILSAENIPNL PPGGGLAGKR 360

NVIEAVYSRL NPNKDNDGGA GDLEDSLVAL 390

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA ACCCAAAACT GAAAAGCACA ATGCTCACGG TGCAGGGAAC 60

GGTCTGCGTT ACGGTCTGAG CAGTATGCAA GGATGGAGAG TAGAAATGGA AGACGCACAC 120

ACTGCTGTTG TGGGAATTCC TCACGGCTTG GAGGACTGGT CGTTTTTTGC AGTCTATGAT 180

GGTCATGCTG GATCCCGAGT GGCAAATTAC TGTTCAACAC ATCTATTAGA ACACATCACT 240

ACCAATGAAG ACTTTAGGGC AGCTGACAAA TCAGGCTTTG CTCTTGAGCC GTCAGTGGAA 300

AATGTTAAGA CTGGTATCCG AACTGGCTTT TTGAAAATTG ATGAATATAT GCGTAACTTT 360

TCAGACCTGA GGAACGGGAT GGACAGGAGC GGCTCTACCG CAGTGGGCGT GATGATTTCA 420

CCGACACACA TCTACTTTAT CAACTGCGGT GACTCGAGAG CTGTTCTGTG TAGGAATGGA 480

CAAGTCTGCT TTTCTACCCA GGATCACAAA CCTTGTAATC CAATGGAAAA GGAGCGCATC 540

CAAAATGCAG GAGGCAGTGT AATGATACAG CGTGTGAATG GGTCGTTAGC AGTGTCTCGT 600

GCTCTGGGGG ACTATGATTA CAAGTGTGTT GATGGCAAGG GCCCCACAGA GCAGCTTGTT 660

TCTCCAGAGC CTGAGGTTTA TGAGATTCTA AGAGCAGAAG AGGATGAATT TGTCGTCCTG 720

GCTTGTGATG GGATCTGGGA TGTGATGAGC AATGAGGAGC TCTGTGAGTT TGTTAACTCT 780

AGGCTTGAGG TGTCAGACGA CCTGGAGAAT GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CATAAGGGAA GTCGAGATAA CATGAGTATT GTGTTAGTTT GCTTTGCAAA TGCCCCCAAG 900

GTCTCAGATG AAGCCGTGAA AAGAGATTTA GAGTTGGACA AGCACTTGGA ATCACGGGTG 960

GAAGAAATCA TGCAGAAGTC TGGAGAGGAA GGAATGCCTG ATCTTGCCCA TGTGATGCGC 1020

ATTTTGTCTG CAGAAAATAT CCCAAATTTA CCTCCCGGGG GAGGCCTCGC TGGCAAGCGC 1080

AATGTTATTG AAGCTGTTTA TAGTAGACTT AATCCAAACA AAGACAATGA TGGGGGCGCT 1140

GGCGATCTAG AAGACTCATT GGTAGCCTTA TAA 1173

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +d ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPH--GLED-WSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************98555444..4434.***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e++ ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TTNEDfraadksgfALEPSVENVKTGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99*********99********************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravLcrng+++  ++dHkp ++ E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPTHIYFINCGDSRAVLCRNGQVCFSTQDHKPCNPMEKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev+++ + +edef++La+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVYEILRAEEDEFVVLACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVNSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLED WSFFAVYDGH AGSRVANYCS THLLEHITTN 60

EDFRAADKSG FALEPSVENV KTGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPT 120

HIYFINCGDS RAVLCRNGQV CFSTQDHKPC NPMEKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVYEILRA EEDEFVVLAC DGIWDVMSNE ELCEFVNSRL 240

EVSDDLENVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

rno:24667

;

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013