EKS-RAN-00402

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00402

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	364.5	4.7E-109	689	945	257

Status

Unreviewed

Ensembl Protein

ENSRNOP00000051338

UniProt Accession

D3ZW27;

Protein Name

Protein Synonyms/Alias

Protein RGD1306565;

Gene Name

RGD1306565

Gene Synonyms/Alias

RGD1306565;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000031700	ENSRNOP00000051338	ENSRNOT00000051496
ENSRNOG00000031700	ENSRNOP00000063417	ENSRNOT00000067070

Organism

Rattus norvegicus

Functional Description

Protein Length

1380

Protein Sequence
(FASTA)

MGTEAGEGIT FSVPPILSAG FCPIPEGGSC RRGGGAATAA EGEPSLQPLL MPPPPPPPGS 60

FWNVESAAAP GTSCPTTAPG SSATRGRGNS GSGGGRRTTV AYVINEASQG QLVVAESEAL 120

QSLREACEAV GATLETLHFG KLDFGETTVL DRFYNADIAV VEMSDAFRQP SLFYHLGVRE 180

SFSMANNIIL YCDTNSDSLQ SLKEIICQKN TVCTGNYTFI PYMVTPHNKV YCCDSSFMKG 240

LTELMQPNFE LLLGPICLPL VDRFVQLLKV AQASSSQYFR ESILNDIRKA RNLYTGKELA 300

AELARIRQRV DNIEVLTADI VINLLLSYRD IQDYDSIVKL VETLEKLPTF DLASHHHVKF 360

HYAFALNRRN LPGDRAKALD IMIPMVQSEE QVASDMYCLV GRIYKDMFLD SNFTDTESRD 420

HGASWFKKAF ESEPTLQSGI NYAVLLLAAG HQFESSFELR KVGVKLSSLL GKKGNLEKLQ 480

SYWEVGFFLG ASVLANDHLR VIQASEKLFR LKTPAWYLKS IVETILIYKH FVKLTTEQPT 540

AKQELVDFWM DFLVEATKTD VTVVRFPVLI LEPTKIYQPS YLSINNEVEE KTISIWHVLP 600

DDKKGIHEWN FNASSVRGVR ISRYNDVGIL LFLNYNSNNK PLHFCSEVHL GRFFEMVNTI 660

TEEKGRGAEE GDCEGDSLEY DYEHDENGDR VVLGKGTYGI VYAGRDLSNQ VRIAIKEIPE 720

RDSRYSQPLH EEIALHKHLK HKNIVQYLGS FSENGFIKIF MEQVPGGSLS ALLRSKWGPL 780

KDNEQTIGFY TKQILEGLKY LHDNQIVHRD IKGDNVLINT YSGVLKISDF GTSKRLAGIN 840

PCTETFTGTL QYMAPEIIDK GPRGYGKAAD IWSLGCTIIE MATGKPPFYE LGEPQAAMFK 900

VGMFKVHPEI PESMSAEAKA FILKCFEPDP DKRACANDLL VDEFLKVSSK KKKTQPKLSV 960

LAARANKYLR SISLPVPVLV EDTSSSSEYG SVSPDTELKA DPFSFKTRAK SCGEKDGKGI 1020

RTLFLGIPDE NFEDHSAPPS PEEKDSGFFM LRKDSERRAT LHRILTEDQD KVVRNLMESL 1080

AQGPEEPKLK WEHITTLISS LREFVRSTDR KIIATTLSRL KLELDFDSHG ISQVQVVLFG 1140

FQDAVNKVLR NHNIKPHWMF ALDSIIRKAV QTAITILVPE LRPHFSLASE SDTADPEDLD 1200

VDDEHEESPS NQTARRPQPV AEDAVATSGV STLSSTVSHD SQNAHRSLNV QLGRMKMETN 1260

RLLEELVRKE KELQALLHQA IEEKDQEIKH LRLKSQPIDT PGFPVCHLNA PGTAIEDSEL 1320

TGWLRENGAD EDTISRFLAE DYTLVDVLYY VTRDDLKCLR LRGGMLCTLW KAIIDFRNKG 1380

Nucleotide Sequence
(FASTA)

ATGGGCACCG AAGCCGGCGA GGGCATCACT TTCTCCGTGC CGCCCATTTT GTCCGCGGGT 60

TTCTGCCCCA TCCCGGAGGG CGGCAGCTGC CGGAGGGGAG GAGGAGCGGC GACGGCGGCG 120

GAGGGCGAGC CGAGCCTGCA GCCCTTGCTT ATGCCGCCGC CGCCACCACC GCCGGGCAGT 180

TTCTGGAACG TGGAGAGCGC GGCGGCTCCT GGCACCAGCT GCCCTACCAC CGCCCCCGGG 240

AGCAGCGCCA CCCGAGGCCG GGGCAACTCT GGCAGCGGGG GCGGCCGGCG TACCACCGTG 300

GCGTATGTGA TCAACGAGGC GAGCCAGGGG CAGCTGGTGG TGGCGGAGAG CGAGGCCCTG 360

CAGAGCCTGC GGGAGGCGTG CGAGGCGGTG GGCGCCACCC TGGAGACCCT GCATTTCGGG 420

AAGCTGGACT TTGGGGAAAC CACCGTGCTG GACCGTTTTT ACAACGCTGA CATCGCCGTG 480

GTAGAGATGA GTGACGCCTT CCGGCAGCCT TCCCTGTTTT ATCATCTCGG AGTGAGAGAG 540

AGCTTCAGCA TGGCCAACAA CATCATCCTC TACTGCGATA CTAATTCAGA CTCGCTTCAG 600

TCCCTGAAGG AAATCATTTG CCAGAAGAAC ACAGTGTGCA CTGGGAACTA CACCTTCATC 660

CCCTACATGG TGACACCACA CAACAAGGTC TACTGCTGTG ACAGCAGCTT CATGAAGGGC 720

CTGACCGAGC TCATGCAGCC CAACTTCGAG CTCCTGCTGG GGCCGATCTG CTTACCTCTC 780

GTGGACCGTT TCGTTCAGCT CCTGAAGGTG GCGCAAGCCA GTTCCAGCCA GTACTTCCGG 840

GAATCTATAC TCAACGACAT CAGGAAAGCT CGGAATCTGT ACACTGGTAA AGAGTTGGCG 900

GCTGAGCTGG CGAGGATCCG GCAGCGGGTA GACAATATTG AAGTTCTGAC GGCAGACATT 960

GTTATCAACC TGTTGCTTTC CTACAGAGAT ATCCAGGACT ATGACTCCAT AGTGAAGCTG 1020

GTAGAGACCT TAGAAAAACT ACCGACCTTC GATCTGGCCT CGCACCACCA CGTGAAGTTT 1080

CATTATGCCT TTGCACTGAA CAGGAGAAAT CTCCCTGGAG ACAGAGCAAA AGCTCTTGAC 1140

ATCATGATCC CCATGGTGCA AAGTGAAGAG CAAGTTGCTT CGGATATGTA CTGTCTCGTT 1200

GGCCGAATCT ACAAAGACAT GTTTTTGGAT TCAAATTTCA CTGACACCGA AAGCAGGGAC 1260

CATGGAGCAT CTTGGTTCAA AAAGGCGTTT GAGTCTGAGC CAACACTACA GTCAGGAATT 1320

AATTACGCAG TCCTCTTGCT GGCGGCTGGG CACCAGTTTG AATCTTCTTT TGAGCTTCGG 1380

AAAGTTGGAG TTAAACTGAG CAGCCTTCTG GGTAAAAAGG GGAACTTGGA GAAACTCCAG 1440

AGCTACTGGG AAGTCGGATT TTTTCTGGGA GCCAGCGTCC TGGCCAACGA CCATCTGAGG 1500

GTCATTCAGG CATCTGAGAA ACTGTTCAGA CTGAAGACGC CAGCGTGGTA CCTCAAGTCT 1560

ATTGTGGAGA CCATTTTGAT ATATAAGCAT TTTGTGAAAC TGACCACAGA GCAGCCCACA 1620

GCCAAGCAGG AGCTCGTGGA CTTCTGGATG GATTTCCTGG TGGAGGCCAC AAAGACAGAT 1680

GTTACTGTCG TTAGATTTCC AGTGTTAATA TTAGAGCCAA CGAAAATCTA TCAGCCTTCT 1740

TACCTGTCGA TCAACAATGA AGTCGAGGAG AAGACGATCT CTATTTGGCA TGTCCTCCCT 1800

GACGACAAGA AGGGTATCCA TGAGTGGAAC TTTAACGCTT CCTCTGTCAG GGGGGTGAGG 1860

ATCTCTAGGT ATAATGACGT GGGTATTTTG TTGTTTCTGA ATTACAATAG TAACAACAAA 1920

CCTCTCCATT TTTGCTCCGA AGTCCATTTG GGTAGGTTTT TCGAAATGGT GAACACCATC 1980

ACCGAAGAGA AGGGGAGAGG CGCGGAGGAA GGAGACTGTG AAGGTGACTC CCTAGAGTAT 2040

GACTACGAAC ACGATGAAAA TGGAGACAGA GTTGTGCTAG GAAAGGGGAC TTACGGGATA 2100

GTCTACGCAG GCCGAGACCT GAGCAACCAG GTCAGAATTG CTATTAAGGA AATCCCAGAG 2160

AGAGACAGCA GATACTCTCA GCCCCTGCAT GAGGAAATTG CCTTACACAA GCATCTGAAG 2220

CACAAGAACA TTGTCCAGTA TCTGGGCTCC TTCAGTGAGA ACGGCTTCAT CAAAATCTTC 2280

ATGGAGCAAG TCCCAGGAGG AAGTCTCTCT GCTCTCCTCC GTTCAAAATG GGGCCCACTA 2340

AAAGACAATG AGCAGACGAT TGGCTTCTAT ACGAAGCAAA TATTGGAAGG ATTAAAATAT 2400

CTTCATGACA ATCAGATAGT CCACCGGGAT ATAAAGGGTG ACAATGTATT GATTAATACC 2460

TACAGTGGCG TGCTCAAGAT CTCTGACTTT GGGACATCCA AGAGGCTTGC TGGCATAAAC 2520

CCGTGCACCG AAACCTTTAC AGGTACCCTT CAGTATATGG CGCCAGAAAT CATCGATAAA 2580

GGACCACGAG GCTATGGAAA GGCCGCCGAC ATTTGGTCAC TGGGCTGTAC GATCATCGAA 2640

ATGGCTACTG GAAAACCACC GTTTTATGAA CTAGGAGAGC CCCAGGCAGC CATGTTCAAG 2700

GTGGGGATGT TTAAGGTCCA CCCCGAGATC CCAGAGTCCA TGTCTGCCGA GGCCAAGGCG 2760

TTCATACTGA AGTGTTTTGA ACCAGACCCT GACAAGAGAG CCTGTGCTAA TGACCTGCTT 2820

GTTGATGAGT TCCTAAAAGT TTCCAGCAAA AAGAAGAAGA CACAGCCCAA ACTCTCGGTC 2880

TTAGCTGCTC GTGCAAACAA GTATCTTAGA AGCATCTCGC TGCCGGTCCC TGTCCTGGTA 2940

GAAGACACCA GCAGCAGCAG CGAGTATGGC TCCGTTTCTC CGGACACAGA GCTGAAGGCC 3000

GACCCCTTCT CCTTCAAAAC CAGAGCTAAG TCCTGTGGAG AAAAGGACGG GAAAGGGATC 3060

CGGACGCTGT TCCTGGGCAT TCCGGATGAA AACTTTGAAG ATCACAGTGC GCCCCCGTCC 3120

CCTGAAGAGA AAGACTCCGG CTTTTTTATG CTGAGAAAGG ATAGCGAAAG GCGGGCGACC 3180

CTTCACAGGA TCCTGACAGA AGACCAGGAC AAGGTTGTGA GGAACCTAAT GGAGTCTCTG 3240

GCCCAGGGTC CTGAAGAGCC TAAACTCAAG TGGGAACACA TCACAACTCT CATCTCAAGC 3300

CTCAGAGAGT TTGTGAGGTC CACTGACCGG AAAATCATAG CCACTACACT GTCCAGGCTC 3360

AAGCTGGAGC TGGACTTCGA CAGCCATGGC ATCAGCCAGG TGCAGGTGGT CCTCTTTGGC 3420

TTCCAGGATG CGGTCAATAA AGTTCTCCGG AATCATAACA TCAAGCCACA CTGGATGTTT 3480

GCCTTGGACA GTATCATTCG GAAGGCTGTG CAGACAGCTA TCACCATCCT GGTTCCAGAG 3540

TTGAGGCCAC ATTTCAGCCT CGCGTCGGAG AGCGACACGG CGGATCCGGA AGACTTGGAT 3600

GTCGACGATG AACACGAGGA ATCGCCTTCG AATCAAACCG CGCGGAGGCC CCAACCCGTC 3660

GCGGAGGATG CCGTGGCTAC CTCAGGGGTG AGCACGCTCA GCTCCACCGT ATCCCATGAT 3720

TCCCAGAATG CACACCGCTC GCTGAATGTG CAGCTTGGGA GGATGAAGAT GGAAACTAAC 3780

AGATTACTTG AAGAGTTGGT TCGGAAAGAG AAAGAGTTGC AGGCACTCCT TCATCAAGCC 3840

ATTGAAGAAA AGGACCAAGA AATTAAGCAC CTGAGACTTA AGTCCCAACC CATAGATACC 3900

CCTGGGTTTC CCGTGTGCCA CCTGAACGCT CCTGGTACAG CCATTGAAGA CTCTGAACTT 3960

ACTGGCTGGC TGAGGGAAAA TGGAGCTGAC GAAGACACTA TAAGTCGGTT TCTGGCTGAG 4020

GATTACACGC TGGTGGATGT CCTTTACTAC GTCACGCGTG ACGACTTGAA GTGCCTCCGA 4080

CTAAGGGGAG GGATGCTGTG CACGCTGTGG AAGGCCATCA TTGACTTTCG GAACAAAGGG 4140

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k+lkH+n

Q: 689   DRVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKHLKHKN  743

         5789**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G+ +e++ +kif+E+v+gGsls+ll+ k+g+l+  e++i +ytkqilegl+yLH+

Q: 744   IVQYLGSFSENGFIKIFMEQVPGGSLSALLRsKWGPLKdnEQTIGFYTKQILEGLKYLHD  803

         *******************************9*****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+k

Q: 804   NQIVHRDIKGDNVLINTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDK  860

         ***************************************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc++iem+tgk+Pf el+e++a+mfkvg+ k++Peipe++s+e+k+

Q: 861   GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA  920

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         f+ kc+e dp+kr++a++LL +efl

Q: 921   FILKCFEPDPDKRACANDLLVDEFL  945

         **********************996

Domain Sequence
(FASTA)

DRVVLGKGTY GIVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKH LKHKNIVQYL 60

GSFSENGFIK IFMEQVPGGS LSALLRSKWG PLKDNEQTIG FYTKQILEGL KYLHDNQIVH 120

RDIKGDNVLI NTYSGVLKIS DFGTSKRLAG INPCTETFTG TLQYMAPEII DKGPRGYGKA 180

ADIWSLGCTI IEMATGKPPF YELGEPQAAM FKVGMFKVHP EIPESMSAEA KAFILKCFEP 240

DPDKRACAND LLVDEFL 257

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008656	; F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004672	; F:protein kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0000186	; P:activation of MAPKK activity
GO:0070301	; P:cellular response to hydrogen peroxide
GO:0010421	; P:hydrogen peroxide-mediated programmed cell death
GO:0008631	; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254	; P:JNK cascade
GO:0043065	; P:positive regulation of apoptotic process

KEGG

InterPros

IPR025136	; DUF4071.
IPR013761	; SAM/pointed.

Pfam

PF13281

; DUF4071; 1.

SMARTs

Prosites

Prints

Created Date

20-Feb-2013