EKS-RAN-00121

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00121

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	462.7	4.0E-139	1053	1311	259

Status

Unreviewed

Ensembl Protein

ENSRNOP00000063136

UniProt Accession

D4AC88;

Protein Name

Protein Synonyms/Alias

Protein Mst1r;

Gene Name

Mst1r

Gene Synonyms/Alias

Mst1r;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000032618	ENSRNOP00000063136	ENSRNOT00000066104

Organism

Rattus norvegicus

Functional Description

Protein Length

1372

Protein Sequence
(FASTA)

MGLLLPLLQA SLLLMLLLRL PEASTNLDWQ CPRIPFAASR DFSVKYVVPS FSAGGRVQAT 60

AVYEDSKNSA VFVAIRNRLH VLGPDLQYIE SLTTGPIGDP GCQTCASCGP GPHGPPNDTD 120

TLVLVMEPGL PALVSCGSTL QGRCFLHELE PQGEALHLAA PACLFSASNN KPEACTDCVA 180

SHLGTRVTVV EQGHASYFYV ASSLDPELAA SFSPRSVSIR RLKSDTSGFQ PGFPSLSVLP 240

KYLASYLIKY VHSFHSGDFV YFLTVQPMDV RSPPSALQTR LVRLNAIEPE IGDYRELVLD 300

CHFAPKRRRR SGAPKSLQAY QVLQAAHSAP VDAKLALDLS ISEGQEVLFG VFVAVKDSSS 360

GPNSVVCAFP INHLDNLIEE GVERCCHPSN SSLLTRRRGL DFFQTPSFCP NPPGAPSSRC 420

HYFPLMVHDS FTRVDLFNGL LGSVKVTALH VTRLGNVTVA HMGTEDGRIL QVEIARSLNY 480

LLYVSNFSLG SSGQPVHQDV SRLGNDLLFA SGDQVFKVPI QGPGCGHFLT CWRCLRAQRF 540

MGCGWCGDRC GRQKECPGSW QQDYCPPEIT EFHPHSGPLR GTTRLTLCGS NFYLRPDGVV 600

PEGTHQITVG QSPCRLLPKD SSTRRSGSQK EFIEELECEL EPLETQAVGT TNISLLITNM 660

PAGKHFRVEG VSVREDFSFM EPMLTSIKPD FGPRAGGTYL TLEGQSLSVG TSRAVLVNGT 720

QCRLEQVSEE KILCVTPPGA GTASVPLRLI GGAEVRGSRT FHYKEDPIVL DISPKCGYSG 780

SHVMVHGQHL TSAWHLTVSF NDGQSIVESR CAGQFLEQQH QCRLPEYMVR NPQGWATGNL 840

SLWGDGAAGF TLPGFRFLPP PSLPRTGPVL LKPEEHSVKV EYIGLGAVAD CVTVNVTVGG 900

EVCQHELRGD VVICPLPPSL QLGKDGVPLQ VCVDGGCHIL GQVVRSGPGR ASQRTLLIAL 960

LALILLVAGL AIALVCNSRR RKKQLGAYSL SPTTLSDFDN TASRPPNHEE SSEGQDGTSV 1020

PLLRTDSIRL QDLDKMLLAE VKDVLIPHEQ VVIHTDQVIG KGHFGVVYHG EYTDEAQNQI 1080

HCAIKSLSRI TEVQEVEAFL REGLIMRGLH HPNILALIGI MLPPEGLPRV LLPYMRHGDL 1140

LRFIRSPQRN PTVKDLISFG LQVACGMEYL AEQKFVHRDL AARNCMLDES FTVKVADFGL 1200

ARGILDKEYY SVRQHRHARL PVKWMALESL QTYRFTTKSD VWSFGVLLWE LLTRGAPPYP 1260

HIDPFDLSHF LVQGRRLPQP EYCPDSLYQV MLRCWEADPA ARPTFRALVL EVEQVASSLL 1320

GDHYVQLTAA YVNVGPGAVD DGSVFPEQGQ SSPLHHRSTS RPRPLSEPPL PT 1372

Nucleotide Sequence
(FASTA)

ATGGGGCTGC TTCTGCCGCT GCTACAGGCC TCTCTACTGC TGATGCTTCT TTTGCGGTTG 60

CCGGAGGCGT CTACCAACCT GGACTGGCAG TGCCCACGAA TACCCTTCGC AGCCTCCCGA 120

GACTTCAGTG TTAAGTACGT GGTCCCCAGT TTCTCCGCGG GAGGCCGGGT ACAGGCCACG 180

GCAGTCTACG AGGACAGTAA AAATAGTGCG GTGTTTGTGG CCATACGCAA TCGCCTGCAC 240

GTGCTTGGGC CTGACCTGCA GTATATAGAG AGCCTGACCA CTGGCCCTAT TGGGGACCCT 300

GGCTGCCAGA CTTGTGCGAG CTGTGGTCCA GGCCCTCATG GACCACCAAA CGACACAGAC 360

ACATTGGTGC TAGTGATGGA GCCGGGTTTG CCAGCCTTGG TCAGCTGCGG CTCAACCCTA 420

CAGGGCCGCT GCTTCCTGCA TGAGCTGGAG CCTCAGGGGG AAGCCTTGCA CTTAGCAGCT 480

CCAGCCTGCC TCTTCTCAGC AAGCAATAAC AAGCCTGAGG CCTGCACTGA CTGTGTAGCT 540

AGCCACCTGG GCACTCGTGT GACCGTGGTG GAGCAGGGCC ATGCTTCCTA CTTCTATGTG 600

GCATCTTCAC TAGACCCAGA GTTGGCCGCT AGCTTTAGCC CACGCTCAGT GTCCATCCGT 660

CGTTTAAAGT CTGATACGTC TGGATTCCAA CCAGGTTTTC CGTCGCTGTC TGTGCTGCCC 720

AAATATTTGG CCTCCTACCT CATCAAATAC GTTCATAGCT TCCACTCAGG AGACTTTGTC 780

TACTTTCTGA CTGTACAACC CATGGATGTC AGAAGCCCTC CCAGTGCCTT GCAAACGCGT 840

CTGGTCCGGC TCAATGCTAT AGAGCCAGAG ATTGGTGACT ACCGGGAGCT GGTCTTGGAC 900

TGTCACTTTG CACCTAAACG CCGTCGACGC AGTGGAGCCC CAAAGAGTCT ACAGGCCTAC 960

CAAGTGCTTC AGGCAGCCCA CTCTGCTCCA GTGGACGCCA AACTGGCTTT GGACCTGAGC 1020

ATTTCAGAGG GCCAGGAAGT GCTTTTTGGG GTTTTTGTGG CTGTCAAGGA CAGTAGCTCT 1080

GGCCCCAACT CTGTTGTGTG TGCCTTCCCC ATTAACCACC TGGACAACCT GATTGAAGAG 1140

GGGGTAGAAC GTTGCTGTCA CCCTTCTAAT TCTTCTCTCT TGACGAGGAG GAGAGGCCTT 1200

GACTTCTTCC AGACGCCTAG TTTTTGTCCT AATCCGCCTG GTGCTCCCAG CTCCCGGTGC 1260

CACTACTTCC CTTTGATGGT CCACGATAGC TTCACACGTG TGGACCTCTT CAATGGACTG 1320

TTAGGATCAG TGAAGGTCAC TGCACTGCAT GTGACGCGCC TTGGCAATGT TACAGTGGCC 1380

CACATGGGCA CGGAGGATGG GCGTATCCTA CAGGTGGAGA TAGCCAGGTC ACTCAACTAC 1440

TTGCTGTATG TGTCCAACTT CTCCCTGGGG AGCAGCGGAC AGCCTGTTCA CCAGGATGTC 1500

AGCCGCCTCG GGAATGACCT ACTCTTTGCC TCGGGGGACC AGGTCTTCAA GGTGCCCATC 1560

CAGGGCCCTG GCTGTGGTCA TTTTCTCACC TGTTGGCGTT GTCTGAGGGC ACAGCGTTTT 1620

ATGGGATGTG GATGGTGTGG AGACCGGTGT GGCCGGCAGA AGGAGTGTCC AGGCTCCTGG 1680

CAACAGGACT ACTGCCCACC TGAGATCACT GAGTTCCATC CCCACAGTGG ACCTCTAAGG 1740

GGCACTACGA GGCTCACCCT ATGTGGCTCC AACTTCTACC TGCGACCCGA TGGTGTGGTA 1800

CCTGAGGGAA CACACCAGAT CACTGTGGGC CAAAGTCCCT GCCGACTGCT GCCTAAGGAC 1860

TCTTCAACCC GTAGGTCAGG GTCGCAAAAG GAATTCATAG AGGAACTTGA ATGTGAGCTA 1920

GAACCCCTGG AGACCCAGGC CGTGGGAACC ACAAATATCA GCCTTCTTAT CACTAACATG 1980

CCAGCAGGCA AGCACTTCCG AGTGGAAGGC GTCTCTGTGC GGGAAGACTT CTCTTTCATG 2040

GAGCCAATGC TGACATCAAT AAAACCCGAC TTTGGCCCAC GGGCTGGGGG TACCTATCTC 2100

ACCCTTGAAG GCCAGAGCCT GTCTGTCGGC ACCAGCCGAG CTGTGTTGGT CAACGGAACT 2160

CAGTGCCGGC TGGAACAGGT CAGTGAGGAG AAGATCCTGT GTGTCACGCC TCCTGGAGCT 2220

GGCACAGCCA GCGTCCCCCT TCGTCTGATA GGGGGTGCCG AGGTGCGTGG CTCCCGCACC 2280

TTTCACTACA AGGAAGACCC TATTGTGTTG GACATCAGTC CCAAGTGTGG CTACAGCGGC 2340

TCCCACGTCA TGGTCCACGG CCAGCATCTG ACTTCAGCGT GGCACCTCAC AGTATCATTC 2400

AACGATGGAC AAAGTATAGT GGAGAGCAGG TGTGCAGGGC AGTTTCTGGA ACAGCAGCAC 2460

CAGTGTCGTC TGCCTGAATA CATGGTCCGA AACCCTCAGG GGTGGGCAAC AGGGAATCTG 2520

AGCCTCTGGG GGGATGGGGC AGCCGGCTTC ACGTTGCCTG GTTTCCGCTT CCTGCCCCCA 2580

CCCAGTCTCC CCAGAACTGG CCCAGTCCTG CTGAAGCCTG AAGAGCATTC AGTTAAGGTC 2640

GAGTATATTG GGCTGGGCGC TGTGGCGGAC TGTGTGACGG TGAACGTGAC CGTGGGTGGT 2700

GAGGTCTGCC AACATGAGCT CCGGGGGGAT GTGGTGATCT GCCCTCTGCC ACCTTCCCTG 2760

CAACTTGGCA AGGATGGTGT CCCGTTGCAG GTCTGTGTAG ATGGTGGGTG TCACATCCTG 2820

GGCCAGGTTG TTCGGTCAGG CCCAGGCAGG GCTTCACAGA GGACACTTCT TATTGCTCTT 2880

CTGGCCTTGA TCCTGCTCGT GGCTGGGCTG GCCATCGCAC TGGTCTGTAA CTCCCGAAGA 2940

CGGAAAAAGC AGCTAGGTGC TTATTCCCTC TCCCCGACAA CACTCTCTGA CTTTGATAAC 3000

ACAGCTTCCA GACCTCCAAA CCATGAAGAA TCTTCAGAGG GTCAGGATGG GACAAGTGTC 3060

CCGCTGCTGC GGACAGACTC TATCCGGCTC CAGGATCTGG ACAAGATGCT CCTAGCCGAG 3120

GTCAAGGATG TACTGATTCC CCATGAGCAA GTGGTCATCC ATACTGACCA AGTCATTGGC 3180

AAAGGCCACT TTGGCGTTGT CTACCACGGA GAATACACAG ACGAAGCACA GAATCAGATC 3240

CACTGTGCCA TCAAGTCTCT GAGTCGCATC ACGGAGGTAC AGGAGGTAGA GGCTTTCCTG 3300

CGGGAGGGGC TGATCATGCG TGGCCTCCAT CACCCAAACA TTCTGGCTCT CATCGGTATC 3360

ATGCTACCCC CAGAGGGTCT TCCCCGCGTG CTGTTGCCCT ATATGCGCCA TGGAGACCTG 3420

CTCCGTTTCA TTCGCTCCCC TCAGAGGAAC CCCACTGTGA AAGACCTCAT CAGCTTTGGC 3480

CTGCAGGTAG CCTGTGGCAT GGAGTACCTG GCAGAGCAGA AGTTCGTGCA CAGAGACCTG 3540

GCTGCTAGGA ACTGCATGCT GGACGAGTCG TTCACAGTCA AGGTGGCTGA CTTTGGTCTG 3600

GCACGTGGCA TCCTAGACAA GGAATACTAT AGTGTTCGAC AACATCGCCA TGCTCGCCTA 3660

CCTGTCAAGT GGATGGCACT GGAGAGCCTT CAGACCTACA GATTCACCAC CAAGTCTGAC 3720

GTGTGGTCAT TCGGTGTGTT ACTGTGGGAG CTACTAACAC GGGGTGCCCC GCCCTACCCC 3780

CATATTGATC CCTTCGACCT CTCTCACTTC CTGGTTCAGG GCCGCCGCCT GCCTCAGCCT 3840

GAGTATTGTC CCGATTCACT GTACCAGGTG ATGCTTCGAT GCTGGGAGGC TGATCCAGCA 3900

GCACGACCCA CCTTCAGAGC CCTAGTGCTG GAAGTAGAGC AGGTAGCGTC CTCACTGCTT 3960

GGGGACCACT ACGTGCAGCT GACCGCAGCT TACGTGAACG TAGGCCCCGG CGCGGTGGAT 4020

GATGGGAGTG TGTTTCCGGA ACAGGGGCAG TCCTCGCCCC TGCATCACAG GAGCACGTCA 4080

AGGCCCCGGC CCCTCTCAGA GCCACCTCTG CCCACTTGA 4119

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         +++++viGkGhfGvvy+ge++d+a+++i++a+ksl+rit++++ve+flregl+m++l+hp

Q: 1053  IHTDQVIGKGHFGVVYHGEYTDEAQNQIHCAIKSLSRITEVQEVEAFLREGLIMRGLHHP  1112

         5899********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         n+l+l+Gi+l++eglp v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyla+

Q: 1113  NILALIGIMLPPEGLPRVLLPYMRHGDLLRFIRSPQRNPTVKDLISFGLQVACGMEYLAE  1172

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         +kfvhrdlaarnc+lde++tvkvadfGlar +ldke+y+v+++r+arlpvkw+aleslqt

Q: 1173  QKFVHRDLAARNCMLDESFTVKVADFGLARGILDKEYYSVRQHRHARLPVKWMALESLQT  1232

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         ++ fttksdvwsfGvllwelltrga+py+++++fdl+++l +grrl++peycpd+ly+vm

Q: 1233  YR-FTTKSDVWSFGVLLWELLTRGAPPYPHIDPFDLSHFLVQGRRLPQPEYCPDSLYQVM  1291

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsi  260

         l+cw+a+pa+rp+f  lv

Q: 1292  LRCWEADPAARPTFRALVLE  1311

         **************999865

Domain Sequence
(FASTA)

IHTDQVIGKG HFGVVYHGEY TDEAQNQIHC AIKSLSRITE VQEVEAFLRE GLIMRGLHHP 60

NILALIGIML PPEGLPRVLL PYMRHGDLLR FIRSPQRNPT VKDLISFGLQ VACGMEYLAE 120

QKFVHRDLAA RNCMLDESFT VKVADFGLAR GILDKEYYSV RQHRHARLPV KWMALESLQT 180

YRFTTKSDVW SFGVLLWELL TRGAPPYPHI DPFDLSHFLV QGRRLPQPEY CPDSLYQVML 240

RCWEADPAAR PTFRALVLE 259

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0001725	; C:stress fiber
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0009615	; P:response to virus

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013