EKS-RAN-00307

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00307

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	385.6	1.2E-115	766	1027	262

Status

Unreviewed

Ensembl Protein

ENSRNOP00000042114

UniProt Accession

D4A5D3;

Protein Name

Protein Synonyms/Alias

Budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) (Predicted); Protein Bub1;

Gene Name

Bub1

Gene Synonyms/Alias

Bub1; Bub1_predicted; rCG_26316;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000032778	ENSRNOP00000042114	ENSRNOT00000051783

Organism

Rattus norvegicus

Functional Description

Protein Length

1059

Protein Sequence
(FASTA)

MDNLGNVFRM FEAHMQSYKG NDPLGEWESF MKWVEENFPD NKEHLVTILE HLMKEFLDKK 60

NYHNDSRFIS YCLKFAEYNS DRHQFFEFLY SQGVGTKSSY LYLSWAGHLE AQGEQQHASA 120

IFQTGIHNQA EPMELLQQQY RLFQARLTGT HLPDQATTSE PLHSAQILNQ VMLTKSSPET 180

ENSACVPRSQ GSECSGVAPS TCDEKSNIRE QRVIMISKSE CSVSSSMAPK PEAQQVMYCK 240

EKLIRGDSEF SFEELRAQKY NQRKKHEQWV SEDRNYMKRK EANAFEEQLL KQKMDELHKK 300

LHQVVELSHK DLPASENRPD ANLVCVGQNT CSHQELRGLS LSSINQQTSE NSGEKPLEEP 360

SVPLMVNAVN STLLFPAISL PSLPIPVSGQ SETDSRGVNQ SIREFMTQSG PDKKEVCETN 420

KVANINDFHT TPNTSLGMVQ GTPCKVQPSP TVHTKEALGF IMDMFQAPTL PDISDDKDEW 480

PSLDQNEDAF EAQFQKNAVF SEDWGVKKIM TLSSAFPIFE DGNKENYGLP QPKNKPLGAR 540

TFGERSLSKC SSRSNEMPHT DEFMDDSTVC GIRYNKTLAP SPKSIGDFTS AAQLSSTPFH 600

KFPADPLQIP EDKENVVATQ YTHMALDSCK ENMVDPSKDR KLGLIQEKIS ASLSCPSQPA 660

TGGLLTQEAV FSLETYKCTG TDRAIMEDLS DASAGLQVEW VQTSSFGNVN APNFTIENPW 720

DDELILKLLS GLSKPVTSYS NTFEWQSKLP AIKTKTEFQL GSLLVYVNHL LGEGAFAQVF 780

EAIHGDTKSK QKCILKVQKP ANSWEFYIGM QLMERLKPEV HHMFIKFYSA HLFQNGSILV 840

GELYSYGTLL NVINLYKNTS EKVMPQALVI TFAIRMLYMV EQVHSCEIIH GDIKPDNFIL 900

GHRFLEQDDE DLATGLTLID LGQSIDMKLF PKGTVFTGKC ETSGFQCPEM LSNKPWNYQV 960

DYYGVAASIY CMLFGTYMKV KNEGGVWKPE GLFRRLPHLD MWEEFFHIML NIPDCHNLPS 1020

LDFLRQKMNK LLEQQYSNKI KTLRNRLIVL LSEYKRSRK 1059

Nucleotide Sequence
(FASTA)

ATGGACAACC TCGGAAATGT CTTTCGTATG TTTGAAGCCC ATATGCAAAG CTACAAGGGT 60

AATGACCCAC TTGGAGAATG GGAAAGCTTT ATGAAGTGGG TAGAAGAAAA TTTTCCTGAC 120

AATAAAGAAC ACTTGGTGAC AATATTAGAA CATTTAATGA AGGAATTCTT AGATAAGAAG 180

AACTACCACA ATGATTCAAG ATTCATCAGT TATTGCTTAA AATTTGCTGA GTACAACAGT 240

GACCGTCATC AGTTTTTTGA GTTTCTGTAC AGCCAGGGAG TTGGAACCAA GTCATCATAT 300

CTATACCTGT CCTGGGCAGG GCATCTGGAA GCCCAGGGAG AGCAGCAGCA TGCCAGTGCT 360

ATTTTTCAAA CAGGAATTCA CAATCAGGCT GAACCTATGG AACTACTACA ACAACAATAC 420

AGGCTATTCC AGGCACGCCT TACTGGAACA CATTTGCCAG ATCAAGCTAC AACCTCAGAA 480

CCTTTGCATA GTGCACAGAT TTTAAACCAA GTTATGTTAA CAAAGTCAAG TCCAGAAACA 540

GAAAACTCAG CTTGCGTTCC TAGGAGTCAG GGTTCAGAAT GTTCTGGTGT GGCACCTTCT 600

ACTTGTGACG AAAAGTCTAA TATTAGGGAA CAAAGAGTGA TCATGATTTC CAAGTCAGAA 660

TGCTCTGTCA GCTCATCTAT GGCACCCAAG CCTGAAGCTC AGCAAGTTAT GTACTGCAAA 720

GAAAAGCTTA TCCGTGGAGA TTCGGAATTT TCATTTGAAG AGCTGAGAGC CCAGAAATAC 780

AATCAACGAA AGAAGCATGA ACAGTGGGTT AGTGAAGACA GAAATTATAT GAAAAGGAAA 840

GAAGCAAATG CTTTTGAAGA GCAATTATTA AAACAGAAAA TGGATGAACT TCACAAGAAA 900

TTGCATCAAG TGGTGGAATT GTCTCACAAG GACCTGCCTG CTTCTGAGAA CAGGCCTGAC 960

GCTAATCTAG TATGTGTGGG ACAAAATACA TGCTCCCACC AAGAACTGAG GGGTCTAAGT 1020

CTTTCATCCA TCAATCAGCA GACCTCAGAG AACTCAGGAG AGAAACCACT GGAAGAACCT 1080

TCTGTTCCTC TTATGGTAAA TGCTGTTAAC AGCACTTTGC TGTTCCCAGC CATCAGCCTG 1140

CCATCTCTTC CTATTCCTGT AAGTGGCCAG TCAGAGACAG ATTCCAGAGG TGTGAATCAA 1200

AGTATTCGTG AATTCATGAC ACAGAGTGGA CCAGACAAAA AAGAAGTATG TGAAACAAAT 1260

AAAGTTGCCA ACATTAATGA CTTTCATACA ACTCCAAACA CATCATTGGG AATGGTTCAA 1320

GGAACACCAT GCAAAGTGCA GCCATCACCA ACTGTCCACA CCAAGGAAGC ATTAGGTTTC 1380

ATCATGGATA TGTTTCAGGC TCCAACACTT CCTGACATTT CTGATGATAA AGATGAATGG 1440

CCATCTCTAG ACCAAAATGA AGATGCATTT GAAGCCCAGT TTCAAAAAAA TGCAGTATTT 1500

TCAGAGGACT GGGGAGTTAA AAAGATTATG ACTTTATCAT CTGCTTTTCC TATTTTTGAA 1560

GACGGAAACA AAGAAAATTA TGGCTTACCA CAGCCTAAAA ATAAGCCTTT AGGAGCTAGG 1620

ACCTTTGGAG AACGATCTCT CAGCAAATGT TCATCAAGAT CAAATGAAAT GCCTCACACT 1680

GATGAGTTTA TGGATGACTC AACAGTATGT GGTATTCGCT ACAACAAAAC CCTAGCTCCC 1740

AGTCCTAAAA GTATAGGAGA CTTTACATCT GCTGCCCAGC TTTCATCTAC ACCATTCCAC 1800

AAATTTCCAG CAGATCCATT GCAGATTCCA GAAGATAAAG AAAATGTGGT AGCCACACAA 1860

TATACACATA TGGCTTTGGA TTCTTGTAAA GAAAACATGG TGGACCCCTC AAAAGACAGA 1920

AAGCTTGGTC TAATTCAAGA GAAAATTTCA GCATCTTTAT CCTGTCCTAG TCAGCCTGCC 1980

ACAGGTGGTT TGCTCACCCA GGAAGCAGTG TTCAGCCTTG AGACTTATAA ATGCACAGGC 2040

ACTGACCGTG CGATCATGGA AGACCTATCA GATGCCAGCG CTGGGCTCCA AGTTGAATGG 2100

GTGCAGACTA GTTCATTTGG AAATGTTAAT GCTCCAAACT TTACTATTGA GAACCCATGG 2160

GATGATGAAT TGATTCTTAA ACTTCTATCT GGGCTTTCTA AGCCAGTTAC TTCCTATTCA 2220

AATACTTTTG AGTGGCAGAG TAAACTTCCA GCCATCAAGA CCAAGACAGA ATTCCAGTTG 2280

GGTTCTTTGC TGGTCTATGT GAATCACCTT CTTGGAGAAG GAGCCTTTGC TCAAGTCTTT 2340

GAAGCTATTC ATGGAGATAC CAAAAGTAAA CAGAAATGTA TTTTGAAGGT GCAGAAACCT 2400

GCCAACTCCT GGGAATTCTA CATTGGGATG CAGCTGATGG AAAGACTAAA GCCAGAAGTA 2460

CATCACATGT TCATCAAGTT TTATTCTGCT CACTTATTCC AGAATGGCAG CATATTAGTA 2520

GGGGAGCTCT ATAGCTATGG GACATTACTA AATGTCATTA ACCTCTATAA AAATACCTCT 2580

GAGAAAGTGA TGCCCCAAGC TCTCGTCATT ACTTTCGCTA TCAGAATGCT TTACATGGTT 2640

GAACAAGTCC ACAGCTGCGA AATCATTCAT GGAGACATTA AGCCAGATAA CTTCATACTA 2700

GGACACAGAT TTTTGGAACA GGATGATGAA GACTTAGCTA CCGGCTTGAC ATTGATTGAC 2760

CTGGGTCAGA GTATAGATAT GAAACTTTTC CCTAAAGGAA CTGTATTTAC AGGAAAGTGT 2820

GAAACATCTG GTTTTCAGTG CCCTGAGATG CTCAGTAACA AGCCATGGAA CTACCAGGTT 2880

GATTACTATG GAGTTGCTGC ATCAATATAT TGTATGCTCT TTGGCACTTA CATGAAAGTA 2940

AAAAATGAAG GAGGAGTCTG GAAACCTGAA GGTCTTTTTA GAAGGCTTCC TCATTTGGAT 3000

ATGTGGGAGG AATTCTTTCA CATCATGTTG AATATACCGG ATTGTCATAA TCTTCCATCT 3060

TTGGACTTTC TGAGACAAAA GATGAACAAG TTACTTGAAC AACAATATTC CAACAAAATT 3120

AAGACCTTGC GCAATAGGCT AATTGTGCTT CTTTCAGAAT ATAAGCGTTC AAGAAAATAA 3180

Domain Profile

S: 2     eiekeigeGayakvykaeh.dsksgelvalKvekpansWefYIclqlkeRlkeeellksi  60

         ++++++geGa+a+v++a h d+ks+++++lKv+kpansWefYI +ql+eRlk +e+++++

Q: 766   YVNHLLGEGAFAQVFEAIHgDTKSKQKCILKVQKPANSWEFYIGMQLMERLK-PEVHHMF  824

         79**************************************************.88*****

S: 61    ieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiveklH  120

         i+++sa+lfq++s+lv e++sygtll++in++k++++kvm+++lv+++++++l++ve++H

Q: 825   IKFYSAHLFQNGSILVGELYSYGTLLNVINLYKNTSEKVMPQALVITFAIRMLYMVEQVH  884

         ************************************************************

S: 121   eveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllpdgtkfkgkaktd  180

         ++eIiHgD+kPdnf+lg+r+ ++ d ++ ++gl liD+g+siDmkl+p+gt f+gk++t+

Q: 885   SCEIIHGDIKPDNFILGHRFLEQDD-EDLATGLTLIDLGQSIDMKLFPKGTVFTGKCETS  943

         **********************988.7799******************************

S: 181   afeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllkkelwe  240

         +f+c+eml++k+w+YqvD++g+aa i+++lfg+y++v++egg wk++  ++rl++ ++we

Q: 944   GFQCPEMLSNKPWNYQVDYYGVAASIYCMLFGTYMKVKNEGGVWKPEGLFRRLPHLDMWE  1003

         ************************************************************

S: 241   kiferlLNisdastlpsleelveek  265

         ++f+ +LNi+d+++lpsl+ l++ k

Q: 1004  EFFHIMLNIPDCHNLPSLDFLRQ-K  1027

         *********************95.4

Domain Sequence
(FASTA)

YVNHLLGEGA FAQVFEAIHG DTKSKQKCIL KVQKPANSWE FYIGMQLMER LKPEVHHMFI 60

KFYSAHLFQN GSILVGELYS YGTLLNVINL YKNTSEKVMP QALVITFAIR MLYMVEQVHS 120

CEIIHGDIKP DNFILGHRFL EQDDEDLATG LTLIDLGQSI DMKLFPKGTV FTGKCETSGF 180

QCPEMLSNKP WNYQVDYYGV AASIYCMLFG TYMKVKNEGG VWKPEGLFRR LPHLDMWEEF 240

FHIMLNIPDC HNLPSLDFLR QK 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008283	; P:cell proliferation
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

rno:296137

;

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013