EKS-RAN-00075

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00075

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Musk	618.9	1.5E-186	337	616	280

Status

Unreviewed

Ensembl Protein

ENSRNOP00000041075

UniProt Accession

D3ZTU6;

Protein Name

Protein Synonyms/Alias

Muscle, skeletal receptor tyrosine protein kinase;

Gene Name

Musk

Gene Synonyms/Alias

Musk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000033567	ENSRNOP00000041075	ENSRNOT00000048457

Organism

Rattus norvegicus

Functional Description

Protein Length

630

Protein Sequence
(FASTA)

MPVPTISWIE NGNAVSSGSI QENVKDRVID SRLQLFITKP GLYTCIATNK HGEKFSTAKA 60

AATVSIAGRC KSQKESKGYC AQYRGEVCDA VLVKDSLVFF NTSYPDPEEA QELLIHTAWN 120

ELKAVSPLCR PAAEALLCNH LFQECSSGVL PTPMPICREY CLAVKELFCA KEWLAMEGKT 180

HRGLYRSGMH FLPVPECSKL PSMHQDPTAC TRLPYLDYKK ENITTFPSIT SSKPSVDIPN 240

LPASTSSFAV SPAYSMTVII SIMSCFAVFA LLTITTLYCC RRRREWKNKK RESAAVTLTT 300

LPSELLLDRL HPNPMYQRMP LLLNPKLLSL EYPRNNIEYV RDIGEGAFGR VFQARAPGLL 360

PYEPFTMVAV KMLKEEASAD MQADFQREAA LMAEFDNPNI VKLLGVCAVG KPMCLLFEYM 420

AYGDLNEFLR SMSPHTVCSL SHSDLSTRAR VSSPGPPPLS CAQLCIARQV AAGMAYLSER 480

KFVHRDLATR NCLVGENMVV KIADFGLSRN IYSADYYKAD GNDAIPIRWM PPESIFYNRY 540

TTESDVWAYG VVLWEIFSYG LQPYYGMAHE EVIYYVRDGN ILACPENCPL ELYNLMRLCW 600

SKLPADRPSF CSIHRILQRM CERAEGTVGV 630

Nucleotide Sequence
(FASTA)

ATGCCTGTCC CCACCATCAG CTGGATTGAA AACGGAAATG CTGTTTCTTC AGGTTCCATT 60

CAAGAGAATG TGAAAGACCG AGTGATTGAC TCAAGACTCC AGCTCTTTAT CACAAAGCCA 120

GGACTCTACA CATGCATAGC TACCAATAAG CATGGAGAGA AATTCAGTAC CGCAAAGGCT 180

GCAGCCACTG TCAGTATAGC AGGTAGGTGC AAATCACAGA AAGAAAGCAA AGGCTACTGT 240

GCCCAGTACA GAGGGGAGGT GTGTGATGCC GTCCTGGTGA AAGACTCTCT TGTCTTCTTC 300

AACACCTCCT ATCCCGACCC TGAGGAGGCC CAAGAGCTGC TGATCCACAC TGCGTGGAAT 360

GAACTCAAGG CTGTGAGCCC ACTCTGCCGA CCAGCTGCCG AGGCTCTGCT GTGTAATCAC 420

CTCTTCCAGG AGTGCAGCTC TGGAGTGCTA CCTACTCCTA TGCCCATTTG CAGAGAGTAC 480

TGCTTGGCAG TAAAGGAGCT CTTCTGTGCA AAGGAATGGC TGGCAATGGA AGGGAAGACC 540

CACCGCGGAC TCTACAGATC CGGGATGCAT TTCCTCCCGG TCCCGGAGTG CAGCAAGCTT 600

CCCAGCATGC ACCAGGACCC CACAGCCTGC ACAAGACTGC CGTATTTAGA TTATAAAAAA 660

GAAAACATAA CAACATTCCC GTCCATAACG TCCTCCAAGC CGAGCGTGGA CATTCCAAAC 720

CTGCCTGCCT CCACGTCTTC CTTCGCCGTC TCGCCTGCGT ACTCCATGAC TGTCATCATC 780

TCCATCATGT CCTGCTTTGC GGTGTTTGCT CTCCTCACCA TCACTACTCT CTATTGCTGC 840

CGAAGGAGGA GAGAGTGGAA AAATAAGAAA AGAGAGTCGG CAGCGGTGAC CCTCACCACA 900

TTGCCTTCCG AGCTCCTGCT GGACAGGCTG CATCCCAACC CCATGTACCA GAGGATGCCA 960

CTCCTTCTGA ATCCCAAGTT GCTCAGCCTG GAGTATCCGA GGAATAACAT CGAGTATGTC 1020

AGAGACATCG GAGAGGGAGC GTTTGGAAGG GTCTTTCAAG CGAGGGCCCC AGGCTTGCTT 1080

CCTTATGAAC CCTTCACTAT GGTGGCTGTG AAGATGCTGA AGGAGGAGGC CTCCGCAGAT 1140

ATGCAGGCAG ACTTTCAGAG GGAGGCAGCC CTCATGGCGG AGTTTGACAA CCCCAACATT 1200

GTGAAGCTCT TAGGTGTGTG TGCTGTTGGG AAGCCAATGT GCCTGCTCTT TGAATATATG 1260

GCCTATGGTG ACCTCAATGA GTTCCTCCGA AGCATGTCCC CTCACACTGT GTGCAGCCTC 1320

AGCCACAGTG ACCTGTCCAC GAGGGCTCGG GTGTCCAGCC CTGGTCCTCC ACCCCTGTCT 1380

TGTGCGCAGC TCTGTATTGC CAGGCAAGTG GCAGCTGGCA TGGCCTACCT GTCGGAGCGC 1440

AAGTTTGTCC ATCGGGACTT AGCTACCAGG AACTGCCTGG TTGGAGAGAA CATGGTGGTG 1500

AAAATTGCAG ACTTTGGCCT CTCTAGGAAC ATCTACTCCG CAGACTACTA CAAAGCTGAT 1560

GGAAACGATG CTATACCTAT CCGCTGGATG CCACCCGAGT CTATCTTCTA CAACCGCTAC 1620

ACCACGGAGT CAGATGTGTG GGCTTATGGC GTGGTCCTCT GGGAGATCTT CTCCTATGGA 1680

CTGCAGCCCT ACTATGGAAT GGCCCATGAG GAGGTCATTT ACTATGTGAG AGATGGTAAC 1740

ATCCTTGCCT GCCCTGAGAA CTGTCCCTTG GAACTGTACA ACCTTATGCG CCTATGTTGG 1800

AGCAAGCTGC CTGCAGACAG ACCCAGCTTC TGCAGTATCC ACCGGATCCT GCAGCGCATG 1860

TGCGAGAGAG CAGAGGGAAC GGTAGGCGTC TAA 1893

Domain Profile

S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60

         ieyvrd+gegafgrvfqarapgllpye+f++vavkmlkeeasadmqadf+reaal+aefd

Q: 337   IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  396

         89**********************************************************

S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120

         npnivkllgvcavgkpmcllfeymaygdlneflrs+sp+tvcslshsdls+ra+vssp++

Q: 397   NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGP  456

         ************************************************************

S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180

         +pls+a +lciarqvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iysad

Q: 457   PPLSCA-QLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD  515

         *****8.79***************************************************

S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240

         yykad+ndaipirwmp+esi+ynryt+esdvwaygvvlweifsy+lqpyyg+aheevi+y

Q: 516   YYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYY  575

         ************************************************************

S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281

         vrdgnilacpen+plely+lmrlcwsklpadrpsf+sihri

Q: 576   VRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRI  616

         ***************************************98

Domain Sequence
(FASTA)

IEYVRDIGEG AFGRVFQARA PGLLPYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60

NPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EFLRSMSPHT VCSLSHSDLS TRARVSSPGP 120

PPLSCAQLCI ARQVAAGMAY LSERKFVHRD LATRNCLVGE NMVVKIADFG LSRNIYSADY 180

YKADGNDAIP IRWMPPESIF YNRYTTESDV WAYGVVLWEI FSYGLQPYYG MAHEEVIYYV 240

RDGNILACPE NCPLELYNLM RLCWSKLPAD RPSFCSIHRI 280

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0031594	; C:neuromuscular junction
GO:0005886	; C:plasma membrane
GO:0045211	; C:postsynaptic membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0043525	; P:positive regulation of neuron apoptotic process
GO:2000541	; P:positive regulation of protein geranylgeranylation
GO:0001934	; P:positive regulation of protein phosphorylation
GO:0008582	; P:regulation of synaptic growth at neuromuscular junction
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0071340	; P:skeletal muscle acetylcholine-gated channel clustering

KEGG

InterPros

IPR020067	; Frizzled_dom.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF01392	; Fz; 1.
PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50038	; FZ; 1.
PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013