| Tag | Content |
|---|
| EKPD ID | EKS-RAN-00441 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| AGC/SGK | 528.2 | 5.4E-159 | 35 | 292 | 258 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000040718 |
| UniProt Accession | Q8R4U9; |
| Protein Name | Serine/threonine-protein kinase Sgk2 |
| Protein Synonyms/Alias | Serum/glucocorticoid-regulated kinase 2; |
| Gene Name | Sgk2 |
| Gene Synonyms/Alias | Sgk2; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Serine/threonine-protein kinase which is involved in theregulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up- regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. |
| Protein Length | 366 |
Protein Sequence
(FASTA) | | MASSPVGVPS PQPSRANGNI NLGPSANPNA RPTDFDFLKV IGKGNYGKVL LAKRKSDGAF 60 | | YAVKVLQKKS ILKNKEQSHI MAERNVLLKN VRHPFLVGLR YSFQTPEKLY FVLDYVNGGE 120 | | LFFHLQREHR FLEPRARFYT AEVASAIGYL HSLNIIYRDL KPENILLDCQ GHVVLTDFGL 180 | | CKECVEPEET TSTFCGTPEY LAPEVLRKEP YDRAVDWWCL GAVLYEMLHG LPPFFNTDVA 240 | | QMYENILHQP LQIPGGRTVA ACDLLQGLLH KDQRQRLGSK EDFLDIKNHM FFSPINWDDL 300 | | YHKRLTPPFN PNVEGPADLK FDPEFTQEAV SKSIGCTPDT MSSSSGASSA FLGFSYAQDD 360 | | DDILDS 366 |
|
Nucleotide Sequence
(FASTA) | | ATGGCCTCCA GCCCAGTTGG AGTTCCTAGC CCCCAGCCCT CTAGGGCCAA TGGGAACATC 60 | | AACCTGGGGC CATCAGCCAA CCCAAATGCC CGACCCACAG ACTTTGATTT CCTCAAAGTC 120 | | ATTGGCAAAG GGAACTATGG GAAGGTCCTA CTGGCCAAGC GCAAGTCAGA CGGAGCCTTC 180 | | TATGCCGTGA AGGTGCTGCA GAAGAAGTCC ATCTTAAAAA ACAAAGAGCA GAGCCACATC 240 | | ATGGCAGAAC GCAACGTGCT ACTGAAGAAC GTGCGGCACC CCTTCCTTGT GGGCCTGCGC 300 | | TACTCCTTCC AGACCCCAGA GAAGCTCTAC TTTGTGCTTG ACTATGTCAA CGGGGGAGAG 360 | | CTTTTCTTCC ATCTCCAGCG GGAACACAGG TTCCTGGAGC CCCGGGCCCG GTTCTACACG 420 | | GCAGAGGTGG CAAGCGCCAT CGGTTATCTT CACTCTCTCA ACATCATCTA CAGAGACCTG 480 | | AAGCCAGAAA ACATTCTCTT GGACTGCCAG GGTCACGTGG TACTGACAGA TTTCGGCCTT 540 | | TGCAAGGAAT GTGTAGAGCC CGAGGAGACC ACATCCACCT TCTGCGGCAC CCCTGAGTAC 600 | | TTGGCTCCAG AAGTCCTTCG TAAAGAGCCT TACGATCGAG CAGTCGACTG GTGGTGCTTA 660 | | GGGGCCGTTC TCTACGAGAT GCTGCACGGC CTGCCCCCCT TCTTCAACAC AGATGTGGCC 720 | | CAGATGTATG AGAACATTTT GCATCAGCCG CTACAGATCC CTGGAGGCCG GACAGTGGCT 780 | | GCCTGTGACC TCCTGCAGGG TCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAG 840 | | GAAGACTTTC TCGACATAAA GAACCACATG TTCTTCAGTC CCATAAATTG GGATGATCTG 900 | | TACCACAAGA GGCTGACTCC ACCCTTCAAC CCAAACGTGG AGGGACCCGC TGACTTGAAA 960 | | TTTGACCCAG AGTTCACCCA GGAGGCTGTG TCCAAGTCCA TTGGCTGCAC CCCTGACACC 1020 | | ATGTCCAGCA GTTCTGGGGC CTCAAGTGCA TTCCTCGGAT TCTCCTATGC ACAGGATGAT 1080 | | GATGACATCT TGGACTCTTG A 1101 |
|
| Domain Profile | S: 1 fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp 60 | fdflkvigkg++gkvllakrk+d++fyavkvlqkk+ilk+ke++himaernvllknv+hp | Q: 35 FDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQSHIMAERNVLLKNVRHP 94 | 9*********************************************************** |
| S: 61 flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln 120 | flvgl+ysfqt+eklyfvldyvnggelffhlqre++fleprarfy+ae+asa+gylhsln | Q: 95 FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQREHRFLEPRARFYTAEVASAIGYLHSLN 154 | ************************************************************ |
| S: 121 ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt 180 | i+yrdlkpenilld++ghvvltdfglcke++e e+ttstfcgtpeylapevlrk+pydr+ | Q: 155 IIYRDLKPENILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRA 214 | ************************************************************ |
| S: 181 vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk 240 | vdwwclgavlyeml+glppf+++dva+my+nil++plq+++g++vaa++ll++ll+kd++ | Q: 215 VDWWCLGAVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGGRTVAACDLLQGLLHKDQR 274 | ************************************************************ |
| S: 241 krlgakedfleiknhvff 258 | +rlg+kedfl+iknh+ff | Q: 275 QRLGSKEDFLDIKNHMFF 292 | *****************9 |
|
Domain Sequence
(FASTA) | | FDFLKVIGKG NYGKVLLAKR KSDGAFYAVK VLQKKSILKN KEQSHIMAER NVLLKNVRHP 60 | | FLVGLRYSFQ TPEKLYFVLD YVNGGELFFH LQREHRFLEP RARFYTAEVA SAIGYLHSLN 120 | | IIYRDLKPEN ILLDCQGHVV LTDFGLCKEC VEPEETTSTF CGTPEYLAPE VLRKEPYDRA 180 | | VDWWCLGAVL YEMLHGLPPF FNTDVAQMYE NILHQPLQIP GGRTVAACDL LQGLLHKDQR 240 | | QRLGSKEDFL DIKNHMFF 258 |
|
| Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |