EKS-RAN-00201

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00201

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	525.6	2.9E-158	4	287	284

Status

Reviewed

Ensembl Protein

ENSRNOP00000006374

UniProt Accession

Q66HE7;

Protein Name

Cyclin-dependent kinase-like 1

Protein Synonyms/Alias

Gene Name

Cdkl1

Gene Synonyms/Alias

Cdkl1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000038720	ENSRNOP00000006374	ENSRNOT00000006374

Organism

Rattus norvegicus

Functional Description

Protein Length

352

Protein Sequence
(FASTA)

MEKYEKIGKI GEGSYGVVFK CRNRDTGQIV AIKRFLETED DPVIKKIALR EIRMLKQLKH 60

PNLVSLLEVF RRKRRLHLVF EYCHHTVLHE LDRYQRGVPE PLVKNITWQT LQAVNFCHKH 120

NCIHRDVKPE NILITKHSVI KLCDFGFARL LTGPGDYYTD YVATRWYRSP ELLVGDTQYG 180

PPVDVWAIGC VFAELLSGVP LWPGKSDVDQ LYLIRKTLGD LIPRHQQVFS MNQYFSGVKI 240

PDPEDMETLE LKFPNISYSA LGFLKGCLHM DPAERLTCEQ LLQHPYFDSI RDVGELARPH 300

DKPTRKTLRQ SRKHLTGLQH LPQLTSSSVL PALDRKKYHC GTRNFNYHFP NI 352

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ACGAAAAAAT TGGAAAGATT GGAGAAGGTT CCTATGGGGT AGTGTTCAAG 60

TGCAGAAACA GAGACACGGG TCAGATCGTG GCCATCAAGA GGTTTCTGGA AACCGAAGAT 120

GACCCTGTCA TAAAGAAAAT CGCCCTTCGA GAAATCCGCA TGCTCAAGCA ACTCAAGCAT 180

CCCAACCTCG TCAGCCTCCT GGAAGTCTTC CGCAGGAAGC GGCGGCTTCA CCTGGTGTTC 240

GAGTACTGCC ACCACACGGT GCTTCACGAG CTGGACAGAT ATCAGAGGGG GGTACCAGAG 300

CCTCTCGTGA AGAACATAAC TTGGCAGACA CTGCAGGCTG TGAATTTCTG CCATAAACAC 360

AACTGCATAC ACAGAGATGT GAAGCCGGAA AACATTCTCA TCACCAAACA CTCAGTCATT 420

AAGCTCTGTG ACTTTGGGTT TGCACGGCTT CTCACTGGAC CTGGTGACTA CTACACTGAC 480

TACGTGGCCA CCAGGTGGTA CCGCTCACCT GAGCTGCTAG TGGGAGACAC ACAGTATGGC 540

CCCCCAGTAG ATGTCTGGGC AATTGGGTGT GTGTTTGCTG AGTTGCTGTC CGGAGTGCCT 600

CTGTGGCCAG GAAAATCCGA TGTGGACCAG CTCTATCTGA TAAGGAAAAC CCTGGGGGAC 660

CTCATTCCCA GGCACCAGCA AGTATTTAGC ATGAATCAGT ACTTCAGTGG GGTGAAAATT 720

CCAGACCCTG AAGACATGGA AACACTTGAG TTGAAGTTTC CAAACATCTC CTACTCTGCT 780

CTGGGCTTCT TAAAGGGCTG CCTCCACATG GACCCTGCTG AGAGGCTGAC ATGTGAACAG 840

CTATTGCAGC ATCCGTATTT TGACAGCATT CGAGACGTTG GGGAATTGGC AAGACCACAT 900

GACAAACCAA CAAGGAAGAC CCTGAGACAG AGTAGAAAGC ACTTGACTGG GTTGCAGCAC 960

CTGCCTCAGC TAACCAGCAG CAGCGTCCTC CCCGCTCTGG ACAGGAAGAA GTACCACTGT 1020

GGTACCAGGA ACTTTAACTA CCACTTTCCA AATATTTAA 1059

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         yek+gk+GeGsyGvv+kcrn+dtgqivaik+fle+edd+++kkialrei++lkqlkh+nl

Q: 4     YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETEDDPVIKKIALREIRMLKQLKHPNL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+llevfrrk++l+lvfey+++tvl+el+ry++Gv+e lvk+i++q+l+a++fchk+n+i

Q: 64    VSLLEVFRRKRRLHLVFEYCHHTVLHELDRYQRGVPEPLVKNITWQTLQAVNFCHKHNCI  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrd+kpenili+k++v+klcdfGfarll++pgd+ytdyvatrwyr+pellvgdt+yG++v

Q: 124   HRDVKPENILITKHSVIKLCDFGFARLLTGPGDYYTDYVATRWYRSPELLVGDTQYGPPV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGc++aell+G pl+pgksdvdqly+irktlG+liprhq++fs+n++f+Gvk+p++

Q: 184   DVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQYFSGVKIPDP  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         ed+e+le k+p++++++l +lk+cl++dpaerl+ce+ll+h+yf

Q: 244   EDMETLELKFPNISYSALGFLKGCLHMDPAERLTCEQLLQHPYF  287

         *******************************************9

Domain Sequence
(FASTA)

YEKIGKIGEG SYGVVFKCRN RDTGQIVAIK RFLETEDDPV IKKIALREIR MLKQLKHPNL 60

VSLLEVFRRK RRLHLVFEYC HHTVLHELDR YQRGVPEPLV KNITWQTLQA VNFCHKHNCI 120

HRDVKPENIL ITKHSVIKLC DFGFARLLTG PGDYYTDYVA TRWYRSPELL VGDTQYGPPV 180

DVWAIGCVFA ELLSGVPLWP GKSDVDQLYL IRKTLGDLIP RHQQVFSMNQ YFSGVKIPDP 240

EDMETLELKF PNISYSALGF LKGCLHMDPA ERLTCEQLLQ HPYF 284

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0007049	; P:cell cycle
GO:0007507	; P:heart development

KEGG

rno:314198

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013