EKS-RAN-00158
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00158
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb495.63.6E-149418675258
StatusUnreviewed
Ensembl ProteinENSRNOP00000060054
UniProt AccessionF1LXV0;
Protein Name
Protein Synonyms/Alias Ribosomal protein S6 kinase alpha-1;
Gene NameRps6ka1
Gene Synonyms/Alias Rps6ka1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000042411ENSRNOP00000060054ENSRNOT00000068634
OrganismRattus norvegicus
Functional Description
Protein Length735
Protein Sequence
(FASTA)
MPLAQLKEPW PLMELVPLDP ENGQASGEEA GLQPSKDEGI LKEISITHHV KAGSEKADPS 60
HFELLKVLGQ GSFGKVFLVR KVTRPDNGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN 120
HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS 180
LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHT 240
HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN 300
PANRLGSGPD GAEEIKRHIF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP 360
RDSPGIPPSA GAHQLFRGFS FVATGLMEDD SKPRATQAPL HSVVQQLHGK NLVFSDGYIV 420
KETIGVGSYS VCKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD 480
DSKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLYTIS KTVEYLHSQG VVHRDLKPSN 540
ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL 600
GVLLYTMLAG YTPFANGPSD TPEEILTRIS SGKFTLNGGN WNTVSETAKD LVSKMLHVDP 660
HQRLTAKQVL QHPWITQKDK LPQSQLSHQD LQLVKGAMAA TYSALSSSKP TPQLKPIESS 720
ILAQRRVRKL PSTTL 735
Nucleotide Sequence
(FASTA)
ATGCCGCTCG CCCAGCTCAA GGAACCCTGG CCGCTCATGG AGCTGGTGCC GCTGGACCCG 60
GAGAATGGAC AGGCTTCAGG GGAAGAAGCT GGACTTCAGC CATCCAAGGA TGAGGGCATC 120
CTCAAGGAGA TCTCTATCAC ACACCACGTC AAGGCTGGCT CTGAGAAGGC TGATCCATCC 180
CATTTTGAGC TCCTCAAGGT TCTGGGCCAA GGATCCTTTG GCAAAGTCTT CCTGGTACGC 240
AAGGTCACCC GGCCTGACAA TGGGCACTTG TATGCCATGA AAGTATTAAA GAAGGCCACG 300
CTGAAAGTGC GTGACCGTGT TCGGACCAAG ATGGAGAGAG ACATCCTAGC TGACGTGAAC 360
CACCCCTTCG TAGTGAAACT GCACTATGCC TTCCAGACCG AGGGCAAGCT CTATCTTATT 420
CTGGACTTTC TGCGTGGTGG AGACCTGTTC ACACGACTCT CAAAGGAGGT TATGTTTACA 480
GAGGAGGATG TGAAGTTTTA CCTGGCTGAG CTGGCACTGG GCCTGGACCA CCTGCACAGC 540
TTGGGCATCA TTTACAGAGA CCTCAAGCCT GAGAATATCC TTTTGGATGA GGAGGGCCAC 600
ATCAAACTCA CTGACTTTGG CCTGAGCAAG GAGGCCATTG ACCACGAAAA GAAGGCCTAT 660
TCCTTCTGCG GGACGGTGGA GTACATGGCC CCCGAGGTTG TCAACCGCCA GGGCCACACC 720
CACAGTGCAG ATTGGTGGTC CTATGGGGTG TTGATGTTTG AGATGCTGAC GGGCTCCCTG 780
CCCTTCCAGG GGAAGGACCG GAAGGAGACC ATGACCTTGA TTTTGAAGGC AAAGCTAGGC 840
ATGCCCCAGT TTCTGAGCAC GGAAGCCCAG AGCCTCCTGC GGGCCCTGTT CAAGAGGAAT 900
CCTGCCAACC GGCTTGGCTC AGGCCCCGAT GGGGCTGAGG AAATTAAGAG ACATATCTTC 960
TACTCTACCA TTGACTGGAA TAAGCTCTAC CGCCGTGAGA TCAAGCCACC TTTCAAGCCC 1020
GCTGTGGCCC AGCCGGATGA CACCTTCTAC TTTGATACCG AGTTCACGTC ACGCACACCC 1080
AGGGATTCGC CGGGCATCCC CCCCAGTGCT GGTGCCCATC AGCTCTTCCG TGGCTTCAGC 1140
TTCGTGGCCA CCGGTCTGAT GGAGGATGAC AGCAAGCCTC GGGCCACCCA GGCTCCGCTG 1200
CACTCGGTGG TACAGCAACT CCACGGGAAG AACTTGGTTT TCAGCGATGG CTACATAGTA 1260
AAGGAGACGA TCGGCGTGGG CTCCTACTCT GTGTGTAAGC GCTGTGTCCA CAAGGCCACC 1320
AACATGGAGT ACGCAGTCAA AGTCATCGAC AAAAGCAAAA GAGATCCCTC CGAAGAGATC 1380
GAGATTCTTC TGCGGTATGG ACAGCACCCC AACATCATCA CCCTGAAAGA TGTGTATGAC 1440
GACAGTAAGC ACGTATACCT GGTGACAGAG CTGATGAGGG GCGGGGAGCT GCTGGATAAG 1500
ATCCTACGGC AGAAATTCTT CTCAGAGCGG GAGGCCAGCT TCGTCCTGTA CACCATCAGC 1560
AAGACTGTGG AATACTTGCA CTCCCAAGGG GTCGTCCACA GGGACCTCAA ACCCAGTAAC 1620
ATCCTGTATG TGGATGAGTC TGGGAACCCC GAATGCCTAC GAATATGCGA CTTTGGCTTT 1680
GCCAAGCAGC TACGGGCTGA GAACGGGCTT CTCATGACAC CTTGCTACAC AGCCAACTTT 1740
GTGGCACCTG AGGTGCTGAA GCGTCAGGGC TACGATGAAG GCTGTGACAT ATGGAGCCTG 1800
GGCGTTCTGC TGTACACGAT GCTGGCAGGA TACACTCCAT TTGCCAATGG GCCCAGTGAT 1860
ACCCCAGAGG AGATCCTCAC CCGGATCAGC AGTGGGAAGT TCACCCTCAA CGGGGGAAAC 1920
TGGAACACGG TTTCAGAGAC AGCCAAGGAC TTAGTATCTA AGATGCTGCA TGTGGACCCC 1980
CACCAGCGCC TCACAGCCAA ACAGGTTCTG CAGCACCCGT GGATCACCCA GAAAGACAAG 2040
CTCCCCCAGA GCCAGTTGTC CCACCAAGAC CTGCAGCTTG TGAAGGGGGC CATGGCAGCT 2100
ACATATTCTG CACTCAGTAG CTCCAAACCC ACCCCCCAGC TCAAGCCAAT CGAGTCGTCC 2160
ATCCTGGCCC AGCGGCGGGT GAGGAAGCTG CCATCCACCA CCCTGTGA 2208
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         y+vke++GvGsysvckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd
Q: 418   YIVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  477
         679*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vydd k+vylv+el++GGelld+i+++kffsereas +l+t++k+veylh+qGvvhrdlk
Q: 478   VYDDSKHVYLVTELMRGGELLDKILRQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLK  537
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nilyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+
Q: 538   PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  597
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslGvllytmlaGy+pfangp+dt+eeil++i +Gkf+l+G++w++vse+akdlvsk+l+
Q: 598   WSLGVLLYTMLAGYTPFANGPSDTPEEILTRISSGKFTLNGGNWNTVSETAKDLVSKMLH  657
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl+++q+l+h+w+
Q: 658   VDPHQRLTAKQVLQHPWI  675
         *****************8
Domain Sequence
(FASTA)
YIVKETIGVG SYSVCKRCVH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDSKHVYL VTELMRGGEL LDKILRQKFF SEREASFVLY TISKTVEYLH SQGVVHRDLK 120
PSNILYVDES GNPECLRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180
WSLGVLLYTM LAGYTPFANG PSDTPEEILT RISSGKFTLN GGNWNTVSET AKDLVSKMLH 240
VDPHQRLTAK QVLQHPWI 258
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00153
EKS-BOT-00160
EKS-CAE-00123
EKS-CAJ-00166
EKS-CAF-00167
EKS-CAP-00160
EKS-DAR-00450
EKS-EQC-00159
EKS-ERE-00040
EKS-FEC-00151
EKS-GAG-00138
EKS-GAA-00191
EKS-GOG-00161
EKS-HOS-00166
EKS-LAC-00172
EKS-LOA-00161
EKS-MAM-00159
EKS-MAE-00059
EKS-MEG-00129
EKS-MIM-00076
EKS-MOD-00160
EKS-MUM-00165
EKS-MUP-00163
EKS-MYL-00171
EKS-NOL-00154
EKS-ORN-00201
EKS-ORC-00148
EKS-ORL-00188
EKS-OTG-00166
EKS-PAT-00151
EKS-PES-00143
EKS-POA-00157
EKS-PRC-00043
EKS-SAH-00155
EKS-SUS-00142
EKS-TAG-00190
EKS-TAR-00208
EKS-TEN-00200
EKS-XET-00151
EKS-XIM-00195
Gene Ontology
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0004674; F:protein serine/threonine kinase activity
GO:0043066; P:negative regulation of apoptotic process
GO:2000491; P:positive regulation of hepatic stellate cell activation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013