EKS-RAN-00241

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00241

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	359.7	9.0E-108	20	271	252

Status

Unreviewed

Ensembl Protein

ENSRNOP00000062018

UniProt Accession

E9PSK5;

Protein Name

Protein Synonyms/Alias

Gene Name

Sik2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000043498	ENSRNOP00000062018	ENSRNOT00000066893

Organism

Rattus norvegicus

Functional Description

Protein Length

920

Protein Sequence
(FASTA)

MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI IDKSQLDAVN 60

LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK NGEIFDYLAN HGRLNESEAR 120

RKFWQILSAV DYCHSRKVVH RDLKAENLLL DNSMNIKIAD FGFGNFFKTG ELLATWCGSP 180

PYAAPEVFEG QQYEGPQLDI WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM 240

SEDCEHLIRR MLVLDPSKRL SIAQIKEHKW MLIEVPVQRP ILYPQEQENE PSIGEFNEQV 300

LRLMHSLGID QQKTIESLQN KSYNHFAAIY FLLVERLKSH RSSFPVEQRL DGRQRRPSTI 360

AEQTVAKAQT VGLPVTLHPP NLRLMRSTLL PQASNVEAFS FPASSCPAEA AFMEEECVDT 420

PKVNGCLLDP VPPVLVRKGC QSLPSSMMET SIDEGLETEG EAEEDPSQAF EAFQATRSGQ 480

RRHTLSEVTN QLVVLPRAGK VFSMSDSPSL DSVDSEYDMG SAQRDLNFPE DSPSLKDIML 540

ANQPSPRMTP FISLRPANPA MQALSSQRRE AHNRSPVSFR EGRRASDTSL TQGIVAFRQH 600

LQNLARTKGI LELNKVQLLY EQIRSDADPT LTSTAPQLQD LSSSCPQEEI SQRQESVSAL 660

SASMHPQLSP QRSLETPYLQ HRLQKPSLLP KAQNACPMYC KEPPRSLEQQ LQEHRLQQKR 720

LFLQKQSQLQ AYFNQMQIAE RSYPGPTQQL ALPHPETAPT PQQPPSFSLT QALSPVLEPS 780

SEQMRFSSFL SQYPDMQLQP LPSTPSPRAP PPLPSQLQQQ QQPPPPPPPP PPQQPGATPA 840

SLQFSYQTCG LPSTTSSAPS YPASCHYPVD GAQQSNLTGA ECPRSSGLQE ALSALPGLFD 900

YEMVEAVDPQ HNGVACPISR 920

Nucleotide Sequence
(FASTA)

ATGGTCATGG CGGATGGCCC GAGGCACTTG CAGCGCGGGC CGGTCCGGGT GGGGTTCTAC 60

GACATCGAGG GCACGCTGGG CAAGGGCAAC TTCGCCGTGG TGAAGCTGGG GCGGCACCGG 120

ATCACCAAGA CGGAGGTGGC TATAAAAATA ATAGACAAAT CTCAACTGGA TGCAGTAAAC 180

CTTGAGAAAA TCTACCGAGA AGTACAAATA ATGAAAATGC TCGACCATCC TCACATAATT 240

AAACTGTATC AGGTGATGGA GACCAAAAGT ATGTTGTACC TTGTGACAGA GTATGCCAAA 300

AACGGAGAAA TTTTTGATTA TCTTGCTAAT CATGGCCGGT TAAATGAATC TGAAGCCAGA 360

AGAAAATTCT GGCAAATTCT GTCTGCTGTT GATTATTGCC ACAGCCGGAA GGTAGTGCAC 420

CGTGACCTGA AGGCTGAAAA TCTCCTGCTG GATAACAGCA TGAATATCAA AATAGCAGAT 480

TTCGGCTTTG GAAATTTCTT TAAAACTGGT GAACTGCTGG CAACATGGTG TGGCAGCCCC 540

CCATATGCAG CCCCAGAAGT CTTTGAAGGG CAGCAATATG AAGGACCACA GCTGGATATA 600

TGGAGCATGG GAGTTGTTCT TTATGTCCTT GTCTGTGGAG CTCTGCCTTT TGATGGACCA 660

ACTCTCCCTA TTTTGAGACA GAGAGTTTTG GAAGGAAGAT TCCGGATTCC ATATTTCATG 720

TCAGAAGATT GTGAACACCT CATTAGAAGG ATGTTGGTCC TAGATCCTTC CAAACGGCTA 780

AGCATAGCTC AAATCAAGGA ACACAAGTGG ATGCTCATAG AGGTTCCTGT ACAGAGGCCT 840

ATTCTCTATC CACAAGAACA GGAAAACGAG CCGTCCATTG GAGAGTTTAA TGAACAGGTT 900

TTGCGACTGA TGCACAGCCT TGGGATTGAT CAGCAGAAGA CTATTGAGTC TTTGCAAAAC 960

AAGAGCTATA ATCACTTTGC TGCCATTTAT TTCTTGTTGG TGGAACGTCT GAAATCACAT 1020

AGAAGCAGTT TTCCTGTGGA GCAGAGACTT GATGGCCGCC AGCGCCGGCC TAGCACCATT 1080

GCTGAACAAA CAGTTGCCAA GGCACAAACC GTGGGGCTAC CAGTGACCTT GCATCCACCG 1140

AACCTGAGGC TGATGCGGTC TACCCTCCTC CCGCAGGCAT CCAATGTGGA GGCCTTTTCA 1200

TTTCCAGCAT CCAGCTGTCC AGCAGAAGCT GCCTTTATGG AGGAAGAGTG TGTTGACACG 1260

CCAAAGGTGA ATGGCTGTCT GCTTGACCCT GTACCCCCTG TCCTGGTGAG GAAGGGATGC 1320

CAGTCCCTGC CCAGCAGTAT GATGGAGACC TCCATTGATG AAGGATTGGA GACAGAAGGA 1380

GAGGCCGAGG AAGACCCCAG TCAGGCCTTT GAAGCTTTCC AGGCCACACG CAGTGGGCAG 1440

CGACGGCACA CTCTGTCAGA AGTGACTAAC CAATTGGTTG TGTTGCCCAG GGCAGGAAAA 1500

GTTTTCTCCA TGAGTGATAG CCCCTCCCTT GACAGTGTGG ACTCTGAGTA TGATATGGGG 1560

TCTGCCCAGA GGGACCTGAA CTTTCCAGAA GACAGCCCTT CCCTGAAGGA CATCATGTTG 1620

GCCAATCAGC CATCGCCTCG CATGACTCCT TTCATAAGCC TCAGACCTGC CAACCCAGCC 1680

ATGCAGGCTC TGAGCTCACA GAGGCGTGAA GCCCATAACC GGTCCCCTGT GAGCTTCCGA 1740

GAAGGCCGCA GAGCGTCTGA TACTTCCCTT ACGCAAGGAA TTGTAGCATT TAGACAGCAT 1800

CTTCAGAATC TTGCTAGAAC CAAAGGAATT CTGGAGTTGA ACAAAGTACA ATTGCTGTAT 1860

GAGCAAATTA GGTCAGATGC AGACCCTACC TTAACATCGA CTGCTCCTCA GCTCCAAGAC 1920

CTTTCGAGCA GTTGCCCTCA GGAGGAGATC TCTCAGCGGC AGGAAAGTGT CTCCGCCCTC 1980

TCTGCCAGCA TGCACCCTCA GCTTTCACCA CAGCGAAGCT TGGAAACCCC GTACCTGCAG 2040

CACCGACTCC AGAAGCCCAG TCTTCTGCCA AAGGCCCAGA ATGCTTGTCC GATGTATTGT 2100

AAAGAACCAC CTCGAAGCCT GGAACAGCAG CTACAGGAAC ACAGGCTCCA ACAGAAGCGA 2160

CTCTTCCTGC AGAAGCAGTC TCAGCTGCAA GCGTATTTTA ATCAGATGCA GATAGCAGAG 2220

CGCTCCTACC CTGGACCAAC TCAGCAGCTG GCTCTTCCCC ACCCGGAGAC TGCACCGACA 2280

CCTCAGCAGC CCCCATCCTT CAGCCTGACC CAGGCCCTCA GCCCTGTCCT GGAACCCTCT 2340

TCTGAGCAGA TGCGATTTAG CTCTTTCCTC AGCCAATACC CAGATATGCA GTTGCAGCCC 2400

CTGCCCTCTA CGCCCAGCCC CCGGGCTCCA CCTCCCTTAC CCTCACAACT GCAACAGCAG 2460

CAGCAGCCAC CACCCCCACC CCCACCCCCT CCACCACAGC AGCCAGGAGC TACTCCAGCC 2520

TCCTTACAGT TCTCCTATCA GACTTGTGGG CTGCCAAGCA CCACTTCTTC TGCACCAAGC 2580

TATCCTGCTT CCTGTCACTA TCCTGTGGAC GGAGCCCAAC AGAGCAACCT CACAGGGGCA 2640

GAGTGTCCCA GGAGCTCAGG ACTTCAGGAG GCCCTCTCTG CGCTCCCTGG ACTCTTTGAC 2700

TATGAAATGG TAGAAGCCGT GGACCCACAA CACAATGGAG TGGCTTGTCC AATCAGCAGA 2760

TGA 2763

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++  tlG+g+f+ Vkl +h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 20    YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI  79

         89999*******************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e+ear+ f q++sav+Y+hs+++v

Q: 80    IKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHSRKVV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+fk+g+ll t+cGsppYaaPe+++g++Yegp++D

Q: 140   HRDLKAENLLLDNSMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +s+++e+L+r++Lv dp+kR

Q: 200   IWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

         ++i +i++h+w+

Q: 260   LSIAQIKEHKWM  271

         ***********8

Domain Sequence
(FASTA)

YDIEGTLGKG NFAVVKLGRH RITKTEVAIK IIDKSQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK SMLYLVTEYA KNGEIFDYLA NHGRLNESEA RRKFWQILSA VDYCHSRKVV 120

HRDLKAENLL LDNSMNIKIA DFGFGNFFKT GELLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PTLPILRQRV LEGRFRIPYF MSEDCEHLIR RMLVLDPSKR 240

LSIAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008286	; P:insulin receptor signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR017090	; Ser/Thr_kinase_SIK1/2.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013