EKS-SAH-00428

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00428

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	438.1	1.4E-131	24	314	291

Status

Unreviewed

Ensembl Protein

ENSSHAP00000001941

UniProt Accession

G3VFI7;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK14

Gene Synonyms/Alias

MAPK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000001726	ENSSHAP00000001941	ENSSHAT00000001962

Organism

Sarcophilus harrisii

Functional Description

Protein Length

366

Protein Sequence
(FASTA)

MSQERPKFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDKKTGLRV AVKKLSRPFQ 60

SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPAKSLEEFN DVYLVTHLMG ADLNNIVKCQ 120

KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 180

GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDRIL PPLDIDQLKL 240

ILRLVGTPGA ELLKKISSES ARNYIQSLTQ MPKMNFANVF IGANPLAVDL LEKMLVLDSD 300

KRITAAQALA HGYFAQYHDP DDEPVADPYD QSFESRDLLI DEWKSLTYDE VISFVPPPLD 360

QEEMES 366

Nucleotide Sequence
(FASTA)

ATGTCTCAGG AGAGGCCTAA GTTCTACCGG CAGGAGCTGA ACAAGACCAT CTGGGAGGTG 60

CCCGAGCGCT ACCAGAACCT GTCCCCGGTC GGCTCCGGAG CCTATGGGTC CGTGTGTGCT 120

GCTTTTGACA AAAAAACAGG ATTACGTGTG GCAGTGAAGA AGTTATCCAG ACCATTTCAG 180

TCTATCATCC ATGCAAAAAG GACTTATAGG GAGTTGCGAT TACTTAAGCA TATGAAACAT 240

GAAAATGTGA TTGGCCTTTT AGATGTTTTC ACACCTGCAA AATCTCTGGA GGAATTCAAT 300

GATGTGTATC TGGTGACACA TCTCATGGGG GCGGATCTGA ACAATATTGT GAAATGTCAA 360

AAACTCACTG ATGACCATGT ACAATTCCTT ATCTACCAGA TTCTCCGGGG CTTAAAGTAT 420

ATTCATTCAG CTGATATTAT ACACAGAGAC CTGAAACCTA GTAACTTAGC TGTGAATGAA 480

GACTGTGAGC TTAAGATCCT AGATTTTGGA CTGGCCCGGC ACACAGATGA TGAAATGACA 540

GGCTATGTGG CTACTAGGTG GTACAGGGCT CCTGAAATCA TGCTGAACTG GATGCATTAC 600

AACCAAACAG TTGATATTTG GTCAGTAGGA TGCATAATGG CAGAGCTGTT GACTGGAAGG 660

ACACTGTTTC CGGGTACAGA CCGTATCCTT CCACCATTAG ATATTGATCA GTTGAAGCTC 720

ATTTTAAGAC TCGTTGGAAC CCCAGGGGCT GAGCTTTTGA AGAAAATCTC TTCAGAGTCT 780

GCAAGAAATT ATATTCAATC TTTGACCCAG ATGCCGAAGA TGAACTTTGC AAATGTATTT 840

ATTGGTGCCA ATCCATTGGC TGTCGATCTG CTGGAGAAGA TGCTTGTATT GGACTCGGAT 900

AAGAGAATTA CGGCAGCTCA AGCCCTTGCC CATGGATACT TTGCTCAGTA CCATGATCCT 960

GATGATGAAC CAGTTGCAGA CCCCTATGAC CAGTCCTTTG AAAGCAGGGA TCTCCTGATA 1020

GATGAATGGA AAAGCCTGAC CTATGATGAA GTTATTAGCT TTGTGCCACC GCCACTCGAC 1080

CAAGAAGAGA TGGAGTCCTG A 1101

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+p+g+Gayg v++a+dk+t+ rva+kklsrpfq+ ++akrt+REl+llk++kheN+

Q: 24    YQNLSPVGSGAYGSVCAAFDKKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENV  83

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i lldvftp+++lee++dvYlvt+lm++dL++++k qkl+d+h+++l+yqilrglky+Hs

Q: 84    IGLLDVFTPAKSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHS  143

         ************************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsNl+vnedcelkildFGlar++d+e    +t+yvatrwYraPei+l++++

Q: 144   ADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMH  199

         **********************************9....*********************

S: 181   ytkavDiWsvGCIlaElltgkplfpgkde......idqlekilevlgtpseeflkkiese  234

         y+++vDiWsvGCI+aElltg++lfpg+d+      idql++il+++gtp +e lkki+se

Q: 200   YNQTVDIWSVGCIMAELLTGRTLFPGTDRilppldIDQLKLILRLVGTPGAELLKKISSE  259

         ****************************73333336************************

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         +arnyi+sl++++k++f+++f  a++ a+dLlek+Lvld+dkRi++++aL+h Y+

Q: 260   SARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHGYF  314

         ****************************************************995

Domain Sequence
(FASTA)

YQNLSPVGSG AYGSVCAAFD KKTGLRVAVK KLSRPFQSII HAKRTYRELR LLKHMKHENV 60

IGLLDVFTPA KSLEEFNDVY LVTHLMGADL NNIVKCQKLT DDHVQFLIYQ ILRGLKYIHS 120

ADIIHRDLKP SNLAVNEDCE LKILDFGLAR HTDDEMTGYV ATRWYRAPEI MLNWMHYNQT 180

VDIWSVGCIM AELLTGRTLF PGTDRILPPL DIDQLKLILR LVGTPGAELL KKISSESARN 240

YIQSLTQMPK MNFANVFIGA NPLAVDLLEK MLVLDSDKRI TAAQALAHGY F 291

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013