EKS-SAH-00431

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00431

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.5	5.6E-125	62	357	296

Status

Unreviewed

Ensembl Protein

ENSSHAP00000002283

UniProt Accession

G3VGH8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000002029	ENSSHAP00000002282	ENSSHAT00000002306
ENSSHAG00000002029	ENSSHAP00000002283	ENSSHAT00000002307

Organism

Sarcophilus harrisii

Functional Description

Protein Length

462

Protein Sequence
(FASTA)

GLDFYYCYQS CPTLHYLKCQ GFDKQVDVSY IAKYYNMSKS KVDNQFYSVE VGDSTFTVLK 60

RYQNLKPIGS GAQGIVCAAY DAVLDRNVAI KKLSRPFQNQ THAKRAYREL VLMKCVNHKN 120

IISLLNVFTP QKSLEEFQDV YLVMELMDAN LCQVIQMELD HERMSYLLYQ MLCGIKHLHS 180

AGIIHRDLKP SNIVVKSDCT LKILDFGLAR TAGTSFMMTP YVVTRYYRAP EVILGMGYKE 240

NVDIWSVGCI MGEMVRHKIL FPGRDYIDQW NKVIEQLGTP CPEFMKKLQP TVRNYVENRP 300

KYAGLTFPKL FPDSLFPADS EHNKLKASQA RDLLSKMLVI DPAKRISVDD ALQHPYINVW 360

YDPAEVEAPP PQIYDKQLDE REHTIEEWKE LIYKEVMNSE EKTKNGVVKG QPSPSGAAVN 420

SSESLPPSSS VNDISSMSTD QTLASDTDSS LETSAGPLGC CR 462

Nucleotide Sequence
(FASTA)

GGCCTTGACT TTTATTATTG TTATCAGTCT TGTCCAACTC TTCACTACCT AAAATGTCAG 60

GGATTTGATA AACAAGTGGA TGTGTCATAT ATTGCCAAAT ATTACAACAT GAGCAAAAGC 120

AAAGTAGACA ACCAGTTCTA CAGTGTAGAA GTGGGAGATT CAACATTCAC AGTTCTCAAA 180

CGCTACCAGA ATCTAAAGCC TATTGGCTCT GGGGCTCAGG GAATCGTTTG TGCTGCATAT 240

GATGCTGTCC TTGACAGAAA TGTGGCTATT AAGAAGCTCA GCAGACCATT TCAGAACCAA 300

ACACATGCAA AACGAGCTTA CAGGGAGCTG GTCCTCATGA AGTGTGTGAA TCATAAAAAT 360

ATTATCAGTT TATTAAATGT CTTCACACCA CAGAAATCAC TGGAAGAATT TCAAGATGTT 420

TACCTTGTGA TGGAATTGAT GGATGCAAAC TTGTGTCAGG TAATTCAAAT GGAATTGGAT 480

CATGAGCGCA TGTCTTACCT CCTATACCAA ATGTTATGTG GAATCAAGCA CCTTCATTCT 540

GCTGGGATCA TCCACAGGGA TTTAAAGCCT AGTAACATTG TGGTGAAGTC TGACTGCACA 600

TTGAAAATTC TGGACTTTGG ACTGGCCAGG ACTGCAGGCA CAAGCTTCAT GATGACTCCA 660

TATGTGGTGA CACGATATTA CAGAGCACCA GAAGTCATCT TGGGAATGGG CTACAAAGAG 720

AATGTGGATA TATGGTCTGT AGGATGCATT ATGGGAGAAA TGGTTCGTCA CAAAATCCTC 780

TTTCCAGGAA GGGATTATAT TGATCAATGG AACAAAGTAA TTGAACAATT AGGAACACCA 840

TGTCCAGAAT TCATGAAGAA ATTGCAACCC ACAGTAAGAA ACTACGTGGA GAATCGGCCC 900

AAGTATGCAG GTCTTACTTT CCCCAAGCTC TTTCCAGATT CCCTCTTCCC TGCTGACTCC 960

GAGCACAATA AACTTAAAGC CAGCCAAGCC AGGGACCTTT TGTCAAAGAT GCTAGTGATT 1020

GATCCAGCCA AAAGGATATC GGTGGATGAT GCCTTACAGC ATCCATACAT CAACGTCTGG 1080

TATGATCCTG CAGAAGTGGA GGCGCCTCCT CCACAGATAT ATGATAAACA ACTGGATGAA 1140

AGAGAACATA CCATTGAAGA ATGGAAAGAA TTGATCTATA AGGAAGTAAT GAATTCTGAA 1200

GAAAAGACTA AAAATGGAGT AGTAAAAGGA CAACCTTCTC CTTCAGGTGC AGCAGTGAAC 1260

AGCAGCGAGA GCCTCCCTCC ATCCTCTTCT GTCAACGACA TCTCCTCCAT GTCCACTGAC 1320

CAGACCCTGG CATCCGACAC TGACAGTAGC TTGGAGACCT CGGCAGGACC ACTTGGTTGT 1380

TGCAGGTGA 1389

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 62    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  121

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 122   ISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  180

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 181   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  237

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 238   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  296

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 297   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  356

         *****************************99*****************************

S: 289   l  289

Q: 357   I  357

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013