EKS-SAH-00150

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00150

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	358.0	3.8E-107	66	327	262

Status

Unreviewed

Ensembl Protein

ENSSHAP00000002909

UniProt Accession

G3VIA5;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000002574	ENSSHAP00000002909	ENSSHAT00000002942

Organism

Sarcophilus harrisii

Functional Description

Protein Length

473

Protein Sequence
(FASTA)

MAALFDIDLE TEEGSEGDGE PELSPADLDP DLRTAACLEP MGHYEEVELS ETCVNPGSEH 60

IGPHSFELLR VLGKGGYGKV FQVRKTQGTN MGKIFAMKVL RKAKIMRNAK DTAHTRAERS 120

ILEAVRHPFI VELIYAFQTS GKLYLILECL SGGELFMQLE REGIFMEDTA CFYLGEITLA 180

LGHLHSQGII YRDLKPENIM LSSQGHIKLT DFGLCKESIH EGSVTHTFCG TIEYMAPEIL 240

TRSGHNRAVD WWSLGSLMYD MLTGMPPFTA ENRKKTIDKI LRAKLALPAY LTPDARDLLK 300

KFLKRNPSQR LGGGPGDAAD VQKHPFFRHI NWQDLLALQV EPPFRPNLQS EEDVSQFDTR 360

FTKQTPVDSP DDSALGESAS QVFLGFTYVA PSVLEGIKEG FSFQPKLRSP RRLNSSPRTP 420

ISPLKFSPFE AFRPSPGPPE SMELPPPPVS SAPLPIRTPA GKKSKKGRGR SRR 473

Nucleotide Sequence
(FASTA)

ATGGCGGCGT TGTTCGATAT TGACCTGGAG ACCGAAGAAG GCAGCGAGGG CGACGGCGAG 60

CCGGAGCTCA GCCCTGCGGA TTTGGACCCG GATTTGAGGA CGGCTGCTTG TTTGGAGCCC 120

ATGGGGCACT ATGAAGAGGT GGAATTGTCA GAGACCTGTG TGAACCCTGG ATCCGAGCAC 180

ATCGGCCCCC ACTCTTTTGA GCTCCTCCGA GTCCTGGGCA AAGGGGGCTA TGGCAAGGTA 240

TTCCAGGTCC GGAAGACACA AGGCACCAAC ATGGGGAAGA TATTCGCCAT GAAGGTGTTG 300

AGGAAAGCAA AAATTATGCG CAACGCTAAG GACACGGCCC ACACGCGGGC TGAACGGAGC 360

ATCCTGGAGG CCGTGAGGCA CCCCTTCATC GTGGAGCTGA TCTATGCCTT CCAGACCAGT 420

GGCAAGCTCT ATCTCATCCT GGAATGTCTC AGTGGAGGGG AGCTCTTCAT GCAGCTGGAA 480

CGGGAGGGCA TCTTCATGGA GGACACAGCC TGTTTCTACT TAGGGGAGAT CACGCTGGCC 540

CTGGGCCACC TCCACTCCCA GGGCATCATC TACAGGGACC TGAAGCCTGA AAACATCATG 600

TTGAGCAGCC AAGGTCACAT CAAGCTGACG GACTTTGGCC TGTGTAAAGA GTCCATCCAT 660

GAGGGCTCCG TCACTCACAC CTTCTGCGGC ACCATAGAGT ACATGGCGCC CGAGATCCTC 720

ACTCGCAGTG GCCACAACCG GGCCGTGGAT TGGTGGAGCC TGGGATCCCT GATGTACGAC 780

ATGCTCACAG GAATGCCGCC CTTCACGGCA GAGAATCGCA AGAAGACGAT CGACAAGATC 840

CTGAGGGCGA AGCTGGCGCT GCCCGCCTAC CTCACGCCCG ATGCTCGGGA CCTGCTCAAG 900

AAGTTTTTGA AGAGAAACCC CAGCCAGCGA CTTGGGGGCG GACCCGGGGA TGCAGCGGAT 960

GTCCAGAAAC ACCCTTTCTT CCGTCACATC AACTGGCAAG ATCTCTTGGC TCTCCAAGTA 1020

GAACCTCCCT TCCGGCCCAA CCTGCAGTCG GAAGAGGACG TGAGCCAGTT TGACACTCGC 1080

TTCACGAAGC AGACGCCCGT GGACAGCCCC GACGATTCTG CGCTGGGTGA GAGCGCCAGC 1140

CAGGTCTTCT TGGGCTTCAC CTACGTGGCC CCCTCGGTCC TGGAGGGCAT CAAGGAAGGC 1200

TTCTCGTTCC AGCCCAAACT GCGGTCCCCT CGGCGCCTCA ACAGCAGTCC CCGCACCCCC 1260

ATCAGCCCCT TGAAATTCTC GCCTTTTGAA GCATTCCGAC CCAGCCCCGG CCCCCCGGAG 1320

TCCATGGAAC TACCCCCACC CCCGGTCAGT TCAGCCCCGC TTCCCATCCG GACTCCCGCC 1380

GGCAAGAAGT CCAAGAAGGG CCGGGGCCGT TCCAGGCGCT AG 1422

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrk+++++ gk++a+Kvl+ka++++  k++++t++er+iLe+v

Q: 66    FELLRVLGKGGYGKVFQVRKTQGTNMGKIFAMKVLRKAKIMRnaKDTAHTRAERSILEAV  125

         89**************************************9999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq++ klyl+le+l+GgeL+++l+++++f+e++a+f+l e++lal +lH

Q: 126   RHPFIVELIYAFQTSGKLYLILECLSGGELFMQLEREGIFMEDTACFYLGEITLALGHLH  185

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 186   SQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESI-HEGSVTHTFCGTIEYMAPEILTRSG  244

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG l+y+mLtG +Pft+e+rk+t+++il++k  l lpa+  l+++a+dl+k

Q: 245   HNRAVDWWSLGSLMYDMLTGMPPFTAENRKKTIDKILRAK--LALPAY--LTPDARDLLK  300

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++Rlg    +a+++++h+f+

Q: 301   KFLKRNPSQRLGGgpgDAADVQKHPFF  327

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK TQGTNMGKIF AMKVLRKAKI MRNAKDTAHT RAERSILEAV 60

RHPFIVELIY AFQTSGKLYL ILECLSGGEL FMQLEREGIF MEDTACFYLG EITLALGHLH 120

SQGIIYRDLK PENIMLSSQG HIKLTDFGLC KESIHEGSVT HTFCGTIEYM APEILTRSGH 180

NRAVDWWSLG SLMYDMLTGM PPFTAENRKK TIDKILRAKL ALPAYLTPDA RDLLKKFLKR 240

NPSQRLGGGP GDAADVQKHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013