EKS-SAH-00158
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SAH-00158
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb424.31.8E-127373632260
StatusUnreviewed
Ensembl ProteinENSSHAP00000003878
UniProt AccessionG3VL23;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSHAG00000003415ENSSHAP00000003878ENSSHAT00000003917
OrganismSarcophilus harrisii
Functional Description
Protein Length732
Protein Sequence
(FASTA)
AYGKVFLVRK AGGHDAGKLY AMKVLRKAAI VQRAKTQEHT RTERSVLELV RQAPFLVTLH 60
YAFQTDAKLH LILDYVSGGE MFTHLYQREH FTEAEVQVYG GEIVLALEHL HKLGIIYRDM 120
KLENVLLDSE GHIVLTDFGL SKEFLSEEKE RTFSFCGTIE YMAPEIIRGK SGHGKSVDWW 180
SLGILLFELL TGASPFTLEG ERNTQAEVSR RILKCTPPFP SRIGPVAQDL LKRLLEKDPK 240
KRLGSGPQGA QEVKDHPFFQ GLDWVALAAR KVPAPFRPQI RSELDVGNFA EEFTRLEPVY 300
SPPGSPPPGD PRVFQGYSFV APSILFDRNN AVMTDVLELP GGGDRPGRAA VARSAMMQDS 360
AFFQLYELDL REPALGQGSF SVCRRCRQRQ SGQEFAVKIL SRRLEVNTQR EIAALRLCQS 420
HPNVVKLHEV HHDQYHTYLV LELLRGGELL EHIRKKQHFS ESEASQILRS LVSAVSYMHE 480
EAGVVHRDLK PENILYADES PGAPVKIIDF GFARLRPQSP AGPMQTPCFT LQYAAPELLT 540
HQGYDESCDL WSLGVILYMM LSGQVPFQGG PGRGGQSQAA EIMRKIREGR FSLDGEAWQG 600
VSEEAKELVR GLLTVDPAKR LKLADLRDSS WLQDGSARSS PPLRTPDVLE SAGPAVRSGV 660
NATFMAFNRG KREGFFLKSV ENAPLAKRRK MKLGSSEPAH KGSPAPAPST QARGAPPAKG 720
APRRAKGPLP SS 732
Nucleotide Sequence
(FASTA)
GCCTACGGGA AGGTGTTCCT GGTGCGGAAG GCCGGCGGGC ACGATGCAGG GAAGCTTTAC 60
GCCATGAAGG TGCTTCGCAA GGCCGCCATC GTGCAGCGGG CCAAGACGCA GGAACACACG 120
CGCACGGAGC GCTCGGTGCT GGAGCTGGTG CGCCAGGCGC CCTTCCTGGT CACGCTGCAC 180
TACGCCTTCC AGACCGATGC CAAGCTGCAC CTCATCCTGG ACTACGTGAG TGGGGGGGAG 240
ATGTTCACCC ACCTCTACCA ACGGGAACAC TTCACGGAGG CCGAAGTGCA GGTCTACGGG 300
GGCGAGATCG TGCTGGCCCT GGAGCATCTG CACAAGCTGG GGATCATTTA CCGAGACATG 360
AAGCTGGAGA ACGTCTTGTT GGACTCGGAA GGCCACATCG TCCTCACGGA TTTCGGCCTG 420
AGCAAGGAAT TCCTGTCTGA GGAGAAAGAA CGTACCTTCT CCTTCTGTGG CACCATCGAG 480
TATATGGCTC CCGAGATCAT CCGAGGGAAA TCCGGCCACG GCAAGTCTGT AGACTGGTGG 540
AGCCTGGGAA TCCTTCTTTT TGAGCTGCTG ACCGGGGCGT CCCCCTTCAC TCTGGAGGGT 600
GAGAGGAACA CGCAGGCTGA GGTCTCCCGG CGGATTTTGA AATGTACTCC TCCCTTTCCC 660
TCCCGGATCG GGCCAGTTGC TCAGGACCTG CTGAAGAGGC TCCTGGAGAA GGACCCCAAA 720
AAGCGGCTGG GGTCAGGGCC GCAGGGGGCC CAGGAGGTCA AGGATCACCC CTTCTTCCAG 780
GGTTTGGATT GGGTAGCTCT GGCTGCCCGG AAAGTCCCAG CCCCATTCCG GCCTCAGATC 840
CGCTCTGAGC TGGACGTGGG CAACTTTGCG GAAGAATTTA CGCGGCTGGA GCCTGTCTAT 900
TCCCCCCCTG GCAGCCCGCC CCCCGGCGAC CCTCGCGTCT TCCAGGGTTA CTCCTTCGTA 960
GCCCCTTCCA TTCTGTTTGA CCGGAACAAT GCCGTGATGA CCGATGTCCT GGAGCTGCCG 1020
GGAGGTGGGG ACCGGCCCGG TCGGGCGGCT GTAGCCAGGA GTGCCATGAT GCAGGACTCC 1080
GCCTTCTTCC AGCTCTATGA GCTGGACCTC CGGGAGCCCG CCCTGGGCCA GGGCAGTTTT 1140
TCAGTGTGTC GCCGCTGTCG CCAGCGTCAG AGTGGACAGG AGTTTGCCGT CAAGATCCTC 1200
AGCCGCAGGC TGGAGGTGAA CACCCAGAGA GAGATAGCAG CCCTGAGGCT TTGCCAGTCG 1260
CACCCTAATG TGGTCAAGCT CCACGAAGTG CATCACGACC AGTACCACAC GTACCTGGTG 1320
CTGGAGCTCC TGCGGGGTGG GGAGCTGCTG GAGCACATCC GCAAGAAGCA GCATTTCAGT 1380
GAGTCGGAGG CCAGCCAGAT CCTGCGCAGC CTGGTCTCTG CCGTCAGCTA CATGCACGAA 1440
GAGGCCGGGG TCGTGCACCG GGACCTCAAG CCGGAGAACA TTCTGTATGC TGACGAGTCC 1500
CCCGGAGCCC CCGTGAAGAT CATCGACTTT GGCTTTGCCC GGCTGCGGCC TCAGAGCCCC 1560
GCGGGGCCCA TGCAGACGCC CTGCTTCACC CTGCAGTACG CGGCCCCCGA GCTGCTCACC 1620
CACCAGGGCT ACGATGAGTC CTGCGATCTC TGGAGCCTTG GGGTCATCCT GTACATGATG 1680
CTGTCAGGGC AGGTACCCTT CCAGGGGGGC CCTGGCCGGG GCGGGCAGAG CCAGGCAGCC 1740
GAGATCATGC GGAAGATCCG GGAGGGCCGA TTCAGCCTGG ACGGGGAGGC CTGGCAGGGC 1800
GTCTCGGAGG AAGCCAAGGA GCTGGTCCGA GGACTCCTGA CGGTGGACCC CGCCAAGCGG 1860
CTGAAGCTGG CCGACCTCCG GGACAGCAGC TGGCTGCAGG ATGGCAGCGC CCGTTCCTCC 1920
CCGCCCCTCA GGACCCCCGA TGTGCTAGAG TCTGCCGGGC CTGCTGTGCG CTCAGGGGTC 1980
AATGCCACTT TTATGGCGTT CAACCGAGGC AAGAGGGAGG GCTTCTTTCT GAAGAGTGTG 2040
GAGAACGCCC CCCTGGCCAA ACGGCGGAAG ATGAAGCTAG GCAGCTCCGA GCCAGCCCAT 2100
AAGGGCTCCC CGGCCCCCGC CCCCTCCACC CAGGCGCGGG GAGCCCCCCC GGCCAAGGGG 2160
GCTCCCCGCC GAGCCAAAGG CCCCCTACCC TCCTCCTAG 2199
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ + +t++ei++l+++++hpn+v+l++v++
Q: 373   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEVNTQREIAALRLCQSHPNVVKLHEVHH  432
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d+ ++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+y+he+ Gvvhrdlkpe
Q: 433   DQYHTYLVLELLRGGELLEHIRKKQHFSESEASQILRSLVSAVSYMHEEaGVVHRDLKPE  492
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+des++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++qGyde+cdlw
Q: 493   NILYADESPGAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLTHQGYDESCDLW  551
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei+ ki+eG+fsl+Geaw++vseeak+lv++
Q: 552   SLGVILYMMLSGQVPFqggpGRGGQSQAAEIMRKIREGRFSLDGEAWQGVSEEAKELVRG  611
         ****************88888999************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkl++l+ +swl
Q: 612   LLTVDPAKRLKLADLRDSSWL  632
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEVNTQREI AALRLCQSHP NVVKLHEVHH 60
DQYHTYLVLE LLRGGELLEH IRKKQHFSES EASQILRSLV SAVSYMHEEA GVVHRDLKPE 120
NILYADESPG APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLTHQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGGPG RGGQSQAAEI MRKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK LADLRDSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-EQC-00155
EKS-FEC-00154
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SUS-00141
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013