EKS-SAH-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	512.7	2.9E-154	700	1005	306

Status

Unreviewed

Ensembl Protein

ENSSHAP00000004125

UniProt Accession

G3VLS0;

Protein Name

Protein Synonyms/Alias

Gene Name

LATS2

Gene Synonyms/Alias

LATS2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000003638	ENSSHAP00000004125	ENSSHAT00000004166
ENSSHAG00000003638	ENSSHAP00000004126	ENSSHAT00000004167
ENSSHAG00000003638	ENSSHAP00000004127	ENSSHAT00000004168

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1120

Protein Sequence
(FASTA)

MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KSSGQGLPVG AGSDTSLDTK ILVVKDATRQ 60

QQMKPTPKFG PYQKALREIR YSLLPFANES STVDVNRQML QELVKVGCDQ EMAIRALKQT 120

GSKNIEAALE YISKMGYVDP RNEQIVRVIK QTSSGKGSVP NNVTRRPSFE GTSESFPSYH 180

LSSAAYEGTG FGVEGANMLS DVPRQYMDFL LSAPQPSALT PTGPRPLGVS PHSAPGSHQH 240

QSKAYSANLE APGINYPVAN HSNQALQLPP AHSSNGPHYG RPHMTVQGEP MGYGIQRSPS 300

FQNKMQQDGG YANLPSKGQV VQSNSGHTFQ PAAPGLYMTH SHHKQSSPSS HQMHMMAARS 360

PAFANDFAEN PPQSLLTPSR NSLNMDLYDM NNQGWQPSTL SRRDSLQNPS LEAAPRPHVS 420

FRPDSHVPSR TNSFNNHQQP PVAVSIRTGP TGKTEASIPS PNTITAVTSA HILHPVKSVR 480

VLRPEPQTAV GPSHPAWLPP KTPAVEGLEM MEQHPLPKGS PNAYSLDVDY GSQEPRCPPP 540

PYPKHLLLPN SPEQFDINSL CAGVEQSLRG VPNSVSSQAE DSVERNDKSS KNSKVEKPGK 600

DIKQIQTSPV PVRKNSKDEE KRESRIKSYS PFAFKFYMEQ HVENVLKTYQ QKINRRLQLE 660

QEMAKAGLCE AEQEQMRKIL YQKESNYNRL KRAKMDKSMF VKIKTLGIGA FGEVCLAFKV 720

DTHALYAMKT LRKKDVLNRN QVAHVKAERD ILAEADNEWV VKLYYSFQDK DNLYFVMDYI 780

PGGDMMSLLI RMEVFPEHLA RFYIAELTLA IESVHKMGFI HRDIKPDNIL IDHDGHIKLT 840

DFGLCTGFRW THNSKYYQKG SHIRQDSMEP SDLWDDVSNC RCGDRLKTLE QRAKKQHQRC 900

LAHSLVGTPN YIAPEVLLRK GYTQLCDWWS VGVILFEMLV GQPPFLAPTP TETQLKVINW 960

ESTLHIPTQA KLSPEASDLI TKLCCAAENR LGRNGADEIK AHPFFSSMDF SGDIRRQPAP 1020

YVPKISHPMD TSNFDPVEED GPWNDVSGDS TKAWDTLTSS NSKHTEHAFY EFTFRRFFDD 1080

NGYPFRCPKP SGIEGTPSPN SDVENKELVD PTGDCQPVYV 1120

Nucleotide Sequence
(FASTA)

ATGAGGCCAA AGACTTTTCC TGCTACAACT TATTCTGGAA ACAGTAGACA AAGATTGCAA 60

GAGATTCGTG AAGGGTTAAA ACAGCCTTCC AAGTCCTCTG GTCAAGGGCT GCCTGTTGGA 120

GCAGGCAGTG ACACCTCCTT GGACACAAAA ATCTTGGTAG TAAAAGATGC CACAAGGCAG 180

CAGCAGATGA AACCTACTCC AAAGTTTGGA CCTTATCAAA AAGCTTTGAG GGAGATAAGA 240

TATTCTTTGC TACCTTTTGC CAATGAATCA AGCACAGTGG ATGTAAACCG GCAGATGTTA 300

CAAGAATTGG TCAAAGTAGG ATGTGATCAG GAGATGGCGA TAAGAGCACT CAAACAAACA 360

GGCAGTAAAA ACATTGAAGC TGCTCTGGAA TATATTAGCA AAATGGGTTA CGTGGACCCG 420

AGAAATGAGC AAATTGTGAG GGTCATTAAG CAGACCTCCT CAGGAAAAGG AAGTGTGCCA 480

AATAATGTCA CTCGGAGGCC GAGCTTTGAG GGAACCAGTG AATCTTTTCC ATCCTACCAC 540

CTCAGTAGTG CAGCCTATGA AGGGACGGGC TTTGGCGTGG AGGGGGCCAA CATGCTGAGC 600

GATGTGCCTA GACAGTACAT GGATTTTCTG CTCTCCGCCC CTCAGCCGTC GGCTCTGACT 660

CCTACAGGAC CACGGCCTCT TGGGGTCAGC CCTCACAGCG CCCCTGGTAG CCACCAGCAT 720

CAGTCCAAAG CCTATTCTGC CAATTTGGAG GCTCCAGGCA TTAATTATCC AGTTGCTAAT 780

CACAGCAACC AGGCTCTGCA GCTCCCTCCC GCTCACAGTT CCAACGGTCC CCACTACGGC 840

CGGCCACACA TGACAGTCCA GGGAGAACCG ATGGGGTACG GTATCCAGCG AAGTCCATCG 900

TTTCAAAACA AGATGCAGCA AGACGGGGGA TATGCAAACC TTCCCAGTAA AGGGCAGGTG 960

GTTCAGAGTA ACTCTGGTCA CACGTTTCAG CCAGCGGCCC CGGGCCTGTA CATGACGCAT 1020

TCTCATCACA AGCAGAGCAG CCCCTCCTCT CACCAGATGC ACATGATGGC CGCCCGGAGC 1080

CCCGCATTTG CTAACGACTT TGCAGAGAAT CCGCCGCAGA GTCTCCTCAC CCCGTCTCGA 1140

AACAGCCTGA ACATGGATTT GTATGACATG AACAATCAGG GCTGGCAGCC CTCTACTCTG 1200

TCACGGCGGG ACTCTTTACA AAACCCAAGC CTGGAGGCTG CCCCTCGACC GCACGTCTCC 1260

TTCCGGCCGG ACAGCCACGT GCCAAGTAGA ACTAACTCCT TCAACAACCA TCAGCAGCCC 1320

CCAGTGGCTG TGTCCATTCG GACAGGACCC ACCGGCAAAA CAGAGGCCTC TATCCCTTCC 1380

CCCAACACCA TCACCGCCGT CACTTCTGCC CACATTCTCC ATCCGGTAAA GAGTGTGAGG 1440

GTCTTGAGAC CTGAGCCTCA GACTGCCGTG GGCCCGTCAC ACCCTGCCTG GCTCCCCCCA 1500

AAGACCCCAG CTGTGGAAGG CCTGGAAATG ATGGAGCAGC ACCCTCTCCC CAAGGGAAGC 1560

CCAAACGCCT ACTCCCTGGA TGTTGATTAT GGCTCTCAGG AGCCAAGGTG CCCCCCGCCT 1620

CCATACCCCA AGCATCTGCT CCTTCCCAAC AGTCCAGAGC AGTTTGACAT AAATAGCCTT 1680

TGTGCGGGGG TAGAACAGAG CCTTCGAGGG GTTCCTAACT CAGTAAGCAG TCAGGCTGAG 1740

GACAGTGTTG AAAGGAATGA CAAAAGCAGC AAAAATTCCA AGGTGGAAAA GCCAGGGAAG 1800

GACATAAAGC AAATCCAAAC CTCTCCTGTC CCTGTTCGTA AGAACAGCAA AGATGAAGAG 1860

AAGAGAGAAT CTCGAATTAA GAGTTACTCC CCTTTTGCTT TTAAATTCTA TATGGAGCAG 1920

CATGTGGAGA ATGTCTTAAA AACCTACCAG CAGAAAATTA ACAGACGATT GCAGTTGGAG 1980

CAAGAGATGG CTAAAGCTGG TCTCTGTGAA GCTGAACAGG AACAAATGAG GAAGATCCTC 2040

TACCAGAAGG AGTCTAACTA CAACAGACTG AAGAGGGCCA AAATGGACAA ATCTATGTTT 2100

GTGAAAATTA AAACCCTGGG TATTGGTGCT TTTGGAGAAG TTTGTCTTGC TTTCAAAGTA 2160

GACACTCATG CCCTGTATGC CATGAAAACC CTGAGGAAGA AGGATGTTCT AAATCGTAAC 2220

CAGGTGGCTC ACGTCAAAGC AGAAAGGGAT ATATTGGCAG AAGCAGACAA TGAATGGGTG 2280

GTTAAACTCT ACTACTCCTT CCAAGACAAA GACAATTTGT ATTTTGTGAT GGACTACATC 2340

CCTGGTGGGG ACATGATGAG CCTGCTCATA AGGATGGAGG TCTTTCCAGA GCACCTGGCC 2400

AGATTTTATA TTGCAGAGTT GACTTTGGCC ATAGAGAGTG TTCATAAAAT GGGCTTTATT 2460

CACAGAGATA TCAAGCCAGA TAACATTTTG ATAGATCATG ATGGTCACAT CAAACTGACT 2520

GATTTTGGGC TATGTACTGG ATTCAGATGG ACTCACAATT CCAAATATTA CCAGAAAGGG 2580

AGTCACATCA GACAAGATAG CATGGAACCT AGTGACCTCT GGGATGACGT GTCAAATTGT 2640

CGATGTGGAG ACAGGCTAAA AACTCTAGAG CAAAGAGCTA AAAAGCAACA TCAGAGATGT 2700

TTGGCACATT CACTTGTTGG AACTCCGAAC TACATTGCCC CTGAAGTTCT CCTTCGTAAA 2760

GGCTACACTC AGCTCTGTGA CTGGTGGAGC GTCGGCGTGA TTCTCTTTGA AATGCTAGTG 2820

GGGCAACCCC CTTTCCTGGC CCCAACTCCC ACAGAAACCC AGCTGAAGGT CATAAACTGG 2880

GAAAGCACAC TTCACATTCC TACCCAAGCC AAGTTGAGCC CCGAGGCCAG TGACCTCATT 2940

ACTAAGCTCT GCTGCGCTGC TGAGAACCGG CTGGGCAGAA ACGGTGCTGA TGAGATCAAG 3000

GCCCATCCAT TCTTCAGCTC CATGGACTTC TCTGGGGACA TCCGGCGACA GCCAGCCCCC 3060

TATGTGCCAA AGATCAGTCA CCCAATGGAC ACCTCCAATT TTGATCCCGT AGAAGAAGAT 3120

GGCCCCTGGA ATGATGTCAG TGGAGATAGC ACTAAAGCCT GGGACACTCT GACTTCTTCG 3180

AACAGCAAAC ACACAGAGCA CGCCTTTTAT GAGTTTACTT TCAGAAGGTT CTTTGATGAC 3240

AATGGCTATC CATTTAGGTG CCCAAAGCCT TCAGGGATTG AAGGCACACC GTCTCCGAAC 3300

TCAGACGTGG AAAACAAAGA GCTGGTGGAT CCAACTGGGG ACTGTCAACC TGTGTACGTG 3360

TAA 3363

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         f k+k++g+GafGev+l+ k dt+++ya+k+lrkkd+l++nqvahvkaerdilaead+ew

Q: 700   FVKIKTLGIGAFGEVCLAFKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW  759

         889*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvklyysfqdk+nly+vm+y+PGGd+m+lli++e+++e+larfyiael+la+esvhk+Gf

Q: 760   VVKLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGF  819

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173

         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ +++++d++e s+

Q: 820   IHRDIKPDNILIDHDGHIKLTDFGLCTGFRWTHNSKYYQKGSHIRQDSMEPSDlwddvsn  879

         **************************************************9999******

S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228

              +lk+le+r+kk+++r+la+slvGtp+yiapevl++kgy++lcdwWs+Gvil+eml

Q: 880   crcgdRLKTLEQRAKKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEML  939

         ************************************************************

S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288

         vG+pPfla tp+et+ kvinw++tl++p++++ls+ea+dli++l++ ae+rlg++G+dei

Q: 940   VGQPPFLAPTPTETQLKVINWESTLHIPTQAKLSPEASDLITKLCCAAENRLGRNGADEI  999

         ************************************************************

S: 289   kkhpff  294

         k+hpff

Q: 1000  KAHPFF  1005

         *****9

Domain Sequence
(FASTA)

FVKIKTLGIG AFGEVCLAFK VDTHALYAMK TLRKKDVLNR NQVAHVKAER DILAEADNEW 60

VVKLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMEVFPEHL ARFYIAELTL AIESVHKMGF 120

IHRDIKPDNI LIDHDGHIKL TDFGLCTGFR WTHNSKYYQK GSHIRQDSME PSDLWDDVSN 180

CRCGDRLKTL EQRAKKQHQR CLAHSLVGTP NYIAPEVLLR KGYTQLCDWW SVGVILFEML 240

VGQPPFLAPT PTETQLKVIN WESTLHIPTQ AKLSPEASDL ITKLCCAAEN RLGRNGADEI 300

KAHPFF 306

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR009060	; UBA-like.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.
PF00627	; UBA; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013