EKS-SAH-00360

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAH-00360

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	349.1	2.1E-104	1199	1457	259

Status

Unreviewed

Ensembl Protein

ENSSHAP00000005000

UniProt Accession

G3VP94;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K4

Gene Synonyms/Alias

MAP3K4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSHAG00000004375	ENSSHAP00000004999	ENSSHAT00000005048
ENSSHAG00000004375	ENSSHAP00000005000	ENSSHAT00000005049

Organism

Sarcophilus harrisii

Functional Description

Protein Length

1464

Protein Sequence
(FASTA)

MKRMSTKHQR NNVGRPSGRS SLKEKMNAPN QLPHKDICKT VENVEEHSYK QEKKIRATLR 60

TTERDHKKNV QCSFMLDAVG GSLPKKPIPD VDLNKPYLSL GCSNAKLPVS MPIPIARTAR 120

QTSRTDCPLE RLKFFETLRL LLKLTSVSKK KDREQRGQEN TSAFWFNRSN ELIWLELQAW 180

HAGRTINDQD LFLYAARQAI PDIINEILTF KVDYGSFACV RNGASFNGTS VEGQSRAPPG 240

ANAVGYSNYH EHLQRQRVSF EQVKRIMEQL EYIEALYPSL QALQKDYEKY AAKDFQDRVQ 300

ALCLWLNITK DLNQKLRIMG TVLGIKNLSD IGWPVFEIPS PRPSKGNEPE EEGSDTEGEV 360

KELETTTDES EEEHVLDQGV KDFRRAMESS LDLQPQDHFS RKFDRLESED ESIGWGASEY 420

SAETGYSRYC LTSIYRPFVD KALKQMGLRK LIVRLHKLMD GSLQRARIAL VKSDHPLEFS 480

EFPDPMLCSD YIQLSNTTPS SEQKCSTVSW EELKSMDLPS FEPAFLVLCR VLLNVIHECL 540

KLRLEQRPAG EPSLLSIKQL VRECKEVLKG GLLMKQYYQF MLHEVLDDLE KIDCNIDSFE 600

EDLHKMLMVY FDYMRSWIKM LQQLPQASHS LKNLLEEEWN FTKEITHYIR GGEAQAGKLF 660

CDIAGMLLKS TGGFLDCGLQ ESCAEFWTSA DDSTASDEIR RSVIETSRAL KELFHEARER 720

ASKALGFAKM LRKDLEIAAE FIVSAPVQDL LDMLKSKQYV KVQIPGLENL QLFVPHTLAG 780

EKCVILQLLN AAAGKDCSKD SDDVVIEAYL LMTKHGDRDP ELDDHWSTWE GTPVKIVPQV 840

ETVDTLRSMQ VENLLLVVMQ SAHLVIQRKA FQQSIEGLVT LHQEQTSSQP IIAKALQQLK 900

DDALQLCNKI SDAIDQVDHI FTSEFDTEVD ESESATLQQY YREAMIQGYN FGFEYHKEVV 960

RLMSGTFRQK IGDKYISFAR KWMNYVLTKC ESGRGTRPRW ATQGFDFLQA IEPGFISALP 1020

EDDFLSLQAL MNECIGHVIG KPHSPVTAAI HRNSPRPVKV PRCHSDPPNP HLIIPTPDGF 1080

RGSSVPENDR LASIAAELQF RSLSRHSSPT EEREEPSYPK GDSSGPTRRS WELRTLISQN 1140

KDTASKQGPI EAVQKSVRLF EEKRYREMRR KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ 1200

RGNKIGEGQY GKVYTCISVD TGELMAMKEI RFQPNDHKTI KETADELKIF EGIKHPNLVR 1260

YFGVELHREE MYIFMEYCDE GTLEEVSRLG LQEHVIRLYS KQITIAINVL HEHGIVHRDI 1320

KGANIFLTSS GLIKLGDFGC SVKLKNNAQT MPGEVNSTLG TAAYMAPEVI TRAKGEGHGR 1380

AADIWSLGCV VIEMVTGKRP WHEYEHNFQI MYKVGMGHKP PIPERISPEG KDFLSHCLES 1440

DPKMRWTASQ LLDHSFVKVC TDEE 1464

Nucleotide Sequence
(FASTA)

ATGAAACGTA TGTCAACAAA ACACCAGAGG AATAATGTAG GGAGACCTTC TGGCCGCTCC 60

AGTTTAAAAG AAAAAATGAA TGCACCAAAT CAGCTTCCTC ACAAAGACAT TTGCAAAACA 120

GTAGAGAATG TGGAAGAACA CAGTTATAAG CAAGAAAAAA AGATCCGAGC CACTCTTAGA 180

ACAACAGAAC GGGATCATAA AAAAAATGTA CAGTGTTCAT TCATGTTAGA CGCAGTGGGT 240

GGGTCTTTGC CAAAAAAGCC AATTCCGGAT GTTGATCTCA ATAAGCCTTA CCTCAGCCTT 300

GGCTGTAGCA ATGCTAAGCT TCCGGTTTCT ATGCCTATAC CTATAGCCAG AACTGCACGC 360

CAGACTTCCA GGACTGATTG TCCTTTGGAA CGCTTAAAAT TCTTTGAAAC TTTACGACTT 420

CTGCTAAAGC TTACCTCAGT CTCAAAGAAA AAAGACAGGG AGCAGAGAGG GCAGGAAAAC 480

ACTTCTGCTT TCTGGTTTAA CCGATCCAAT GAACTCATTT GGCTGGAATT ACAAGCCTGG 540

CATGCCGGAC GGACCATTAA TGACCAGGAC CTTTTTTTAT ATGCTGCCCG TCAAGCCATC 600

CCCGATATTA TCAATGAAAT CCTCACATTC AAAGTAGATT ATGGGAGTTT TGCCTGTGTG 660

AGAAATGGAG CTAGTTTTAA TGGTACTTCA GTGGAAGGAC AGAGCAGAGC ACCCCCAGGA 720

GCCAATGCTG TGGGTTATTC AAACTATCAC GAACATCTCC AACGCCAGCG GGTCTCCTTT 780

GAACAGGTAA AGCGGATAAT GGAGCAGCTT GAATATATAG AAGCACTTTA TCCCTCTTTG 840

CAGGCTCTTC AAAAGGACTA TGAAAAATAT GCTGCAAAAG ATTTCCAAGA CAGGGTGCAG 900

GCACTCTGTC TGTGGCTAAA CATTACGAAA GACTTAAATC AGAAACTAAG GATTATGGGA 960

ACTGTTTTGG GCATCAAAAA TTTATCTGAC ATTGGCTGGC CAGTGTTTGA AATACCGTCT 1020

CCCCGACCTT CCAAAGGAAA CGAGCCGGAG GAGGAGGGGA GTGACACAGA AGGAGAAGTG 1080

AAGGAATTGG AAACTACCAC CGATGAAAGT GAAGAAGAAC ATGTTCTAGA TCAGGGTGTC 1140

AAGGACTTCA GGCGGGCCAT GGAGAGCAGT TTGGACCTCC AGCCCCAGGA CCATTTTTCA 1200

AGGAAGTTTG ACAGACTGGA GTCTGAAGAT GAATCTATTG GCTGGGGAGC GTCCGAGTAC 1260

AGTGCTGAAA CAGGCTATAG TAGATACTGT CTGACTTCTA TATATAGACC ATTTGTAGAC 1320

AAAGCTCTCA AACAGATGGG TTTGAGAAAA TTAATTGTAA GACTTCACAA GCTAATGGAT 1380

GGTTCTTTAC AAAGGGCCCG TATAGCACTG GTTAAGAGTG ATCATCCATT GGAGTTTTCT 1440

GAGTTCCCAG ATCCTATGTT GTGTTCAGAT TATATACAGT TGTCAAATAC AACACCGTCA 1500

TCAGAACAAA AGTGCAGCAC AGTGTCATGG GAAGAGCTGA AATCTATGGA TTTGCCATCA 1560

TTTGAGCCTG CATTTTTGGT CCTTTGTCGA GTGCTTCTTA ATGTTATCCA TGAGTGTCTC 1620

AAATTAAGAT TGGAACAGAG ACCTGCTGGG GAACCATCTC TCTTGAGTAT TAAGCAGCTG 1680

GTAAGAGAGT GTAAAGAGGT TCTGAAGGGT GGCCTGTTAA TGAAGCAATA TTATCAATTT 1740

ATGCTTCATG AAGTATTAGA TGATTTGGAA AAGATTGACT GCAATATAGA CTCTTTTGAA 1800

GAGGACCTGC ACAAAATGTT GATGGTGTAT TTTGATTACA TGAGAAGTTG GATCAAAATG 1860

TTACAGCAGT TACCTCAAGC ATCTCATAGT TTAAAAAATC TATTAGAAGA AGAATGGAAT 1920

TTCACCAAAG AAATAACTCA TTACATAAGA GGAGGAGAAG CACAGGCTGG AAAATTGTTT 1980

TGTGACATTG CAGGAATGCT GCTGAAATCT ACTGGAGGAT TTTTAGATTG TGGCCTGCAG 2040

GAAAGCTGTG CTGAATTCTG GACTAGTGCT GATGATAGCA CTGCTTCAGA TGAAATCAGG 2100

AGATCTGTTA TAGAGACCAG CAGAGCCCTG AAGGAGCTCT TTCATGAAGC TAGGGAAAGG 2160

GCTTCCAAAG CACTTGGCTT TGCTAAAATG CTAAGAAAGG ATCTGGAAAT AGCAGCAGAA 2220

TTCATAGTAT CAGCACCAGT ACAAGACCTT CTGGATATGT TGAAATCAAA ACAATATGTT 2280

AAGGTGCAAA TTCCTGGATT GGAAAATTTG CAGTTATTTG TTCCACATAC TCTTGCTGGG 2340

GAGAAATGTG TTATTTTGCA ACTACTGAAT GCAGCTGCAG GAAAGGACTG TTCGAAAGAT 2400

TCAGATGATG TAGTAATTGA AGCTTACTTA CTGATGACCA AGCATGGTGA TCGAGATCCT 2460

GAGTTAGATG ACCACTGGAG TACATGGGAA GGGACGCCTG TAAAAATAGT GCCTCAGGTG 2520

GAAACAGTTG ACACACTTAG AAGTATGCAG GTTGAAAATC TACTCTTGGT AGTCATGCAA 2580

TCTGCTCACC TTGTGATCCA GAGAAAAGCT TTCCAGCAAT CCATTGAAGG GCTTGTAACT 2640

TTGCACCAAG AACAGACTTC GAGTCAGCCA ATTATTGCCA AAGCTTTGCA GCAGCTAAAG 2700

GATGATGCAT TGCAGCTGTG CAACAAAATA AGTGATGCCA TTGACCAAGT AGACCACATA 2760

TTCACATCAG AATTTGATAC TGAAGTTGAT GAGTCAGAGT CTGCCACCTT GCAGCAGTAC 2820

TATCGTGAAG CCATGATTCA AGGTTACAAT TTTGGTTTTG AGTATCACAA AGAAGTTGTT 2880

CGTCTGATGT CTGGAACATT TAGACAGAAG ATTGGAGATA AATATATTAG CTTTGCCAGA 2940

AAGTGGATGA ATTATGTGCT AACTAAATGT GAGAGTGGTC GTGGCACCAG ACCCAGGTGG 3000

GCAACTCAAG GTTTTGATTT TCTGCAAGCA ATTGAACCAG GCTTTATTTC AGCACTTCCT 3060

GAAGATGACT TTTTGAGTTT ACAAGCTTTG ATGAATGAAT GCATTGGTCA TGTGATAGGA 3120

AAACCTCACA GTCCTGTTAC AGCAGCTATA CATCGGAACA GCCCCCGTCC TGTGAAGGTA 3180

CCCCGATGTC ACAGTGACCC TCCCAACCCA CATCTCATTA TCCCAACTCC TGATGGATTC 3240

AGGGGATCCA GTGTTCCAGA AAATGATCGT TTGGCCTCGA TAGCTGCTGA ATTGCAATTC 3300

AGATCATTGA GTCGACATTC AAGCCCCACT GAGGAGCGAG AAGAGCCTTC ATACCCAAAA 3360

GGAGATTCAA GTGGGCCAAC ACGAAGAAGT TGGGAGCTTC GGACTCTGAT CAGCCAAAAT 3420

AAAGACACCG CTTCTAAACA AGGACCCATA GAAGCTGTTC AAAAATCAGT TCGATTGTTT 3480

GAAGAAAAAC GTTATCGAGA AATGAGGAGA AAGAATATCA TTGGTCAAGT TTGTGACACC 3540

CCCAAATCAT ATGATAATGT CATGCATGTT GGATTACGAA AAGTGACCTT CAAATGGCAA 3600

AGAGGAAATA AAATTGGAGA AGGCCAGTAT GGAAAAGTCT ATACTTGTAT CAGTGTTGAT 3660

ACTGGTGAAT TGATGGCAAT GAAGGAAATT CGATTTCAGC CGAATGACCA CAAAACTATC 3720

AAAGAGACTG CAGATGAACT GAAAATATTT GAAGGCATTA AGCACCCCAA TCTGGTTCGG 3780

TATTTTGGTG TGGAGCTTCA TAGAGAAGAA ATGTATATTT TCATGGAATA TTGTGATGAG 3840

GGCACCCTGG AAGAAGTGTC AAGGCTGGGC CTTCAAGAAC ATGTTATTCG CTTGTACTCA 3900

AAGCAGATCA CCATTGCTAT TAATGTACTG CATGAGCATG GTATAGTTCA TCGTGACATC 3960

AAAGGAGCCA ATATCTTCCT TACATCATCT GGACTAATTA AATTGGGGGA TTTTGGATGC 4020

TCAGTCAAGT TAAAAAACAA TGCACAAACC ATGCCTGGAG AAGTGAACAG TACTCTCGGG 4080

ACTGCAGCGT ACATGGCACC TGAAGTCATC ACTCGAGCGA AAGGAGAAGG ACATGGGCGT 4140

GCAGCAGACA TCTGGAGTTT GGGTTGTGTT GTGATAGAAA TGGTTACTGG CAAGAGGCCT 4200

TGGCATGAGT ATGAGCACAA CTTTCAGATC ATGTATAAGG TTGGAATGGG ACATAAGCCA 4260

CCCATCCCTG AAAGGATAAG CCCTGAAGGA AAAGATTTCC TTTCCCATTG CCTCGAAAGT 4320

GATCCAAAGA TGAGATGGAC AGCTAGCCAG CTCCTCGACC ATTCGTTTGT CAAGGTTTGC 4380

ACAGATGAAG AATGA 4395

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         wq+++ ig+G++g+vy++++vdtgel+a+Ke++++p++++   ++k+ ++E+k+++ +kH

Q: 1199  WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHK---TIKETADELKIFEGIKH  1255

         99********************************999876...799**************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         +n+v+y+Gve ++ee++if+Ey+++G+l+++ +    l+e+vi+ y+kqi  ++++LHe+

Q: 1256  PNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL--GLQEHVIRLYSKQITIAINVLHEH  1313

         *******************************884..7***********************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntka.aelesltGtlaymaPEvikk.  178

         +ivHRDiKgaNi+l+ssg++kl+DFG+s +l+++++++ +e++s+ Gt+aymaPEvi++

Q: 1314  GIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMpGEVNSTLGTAAYMAPEVITRa  1373

         *******************************9988776256*****************98

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         k +g+gr+aDiWslgcvviem+tgkrP++e++++++im+kvg+ + kP+ipe++s+egkd

Q: 1374  KGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERISPEGKD  1432

         899******************************************.**************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++cle+dpk r++a++LL+h+f+

Q: 1433  FLSHCLESDPKMRWTASQLLDHSFV  1457

         ***********************96

Domain Sequence
(FASTA)

WQRGNKIGEG QYGKVYTCIS VDTGELMAMK EIRFQPNDHK TIKETADELK IFEGIKHPNL 60

VRYFGVELHR EEMYIFMEYC DEGTLEEVSR LGLQEHVIRL YSKQITIAIN VLHEHGIVHR 120

DIKGANIFLT SSGLIKLGDF GCSVKLKNNA QTMPGEVNST LGTAAYMAPE VITRAKGEGH 180

GRAADIWSLG CVVIEMVTGK RPWHEYEHNF QIMYKVGMGH KPPIPERISP EGKDFLSHCL 240

ESDPKMRWTA SQLLDHSFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013